检索结果-南通市图书馆

Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 106-108页

作者： gloria Garavito-De Egea Alex Dominguez-Vargas Jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

A Single JAZ Repressor Controls the Jasmonate Pathway in Marchantia polymorpha

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2019年第2期12卷 185-198页

作者： Isabel Monte Jose M. Franco-Zorrilla gloria garcia-Casado Angel M. Zamarreno Jose M. garcia-Mina Ryuichi Nishihama Takayuki Kohchi Roberto Solano Department of Plant Molecular Genetics Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Environmental Biology Department University of Navarra Navarre Spain Graduate School of Biostudies Kyoto University Kyoto 606-8502 Japan

JAZ proteins are negative regulators of jasm onate responses,acting both as repressors of transcription factors and as co-receptors of JA-lle. The high redundancy of JAZ genes in angiosperms has hindered the characterization of a complete depletion of JAZ function. Moreover, the recent discovery that dn- OPDA is the jasmonate ligand in Marchantia polymorpha demonstrates that JA-lle is not the sole COI1/ JAZ ligand in land plants and highlights the importance of studying JAZ co-receptors in bryophytes? Here, we have exploited the low gene redundancy of the liverwort M. polymorpha to characterize the single MpJ4Z in this early diverging plant lineage. We clarify the phylogenetic history of the TIFY family, demonstrate that MpJAZ is the ortholog of AtJAZ with a conserved function, and characterize its repressor activity of dn-OPDA resp on ses. Our results show that, con sistent with previous findings in Arabidopsis, MpJAZ represses jasmonates biosynthesis, senescence, and plant defenses, and promotes cell growth and reproductive fitness, highlighting the power of studies in Marchantia.

关键词： Jasmonate repressors Marchantia Hormone signaling evolution gene redundancy

Stathmin as a surrogate marker of phosphatidylinositol-3-kinase pathway activity:Towards precision medicine in HPV-negative head&neck squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2022年第3期9卷 820-825页

作者： Andrew T.Turk Dario garcia-Carracedok David T.Kent Elizabeth Philipone Juana Maria garcia-Pedrero Salvatore M.Caruana Lanny G.Close gloria H.Su Department of Pathology and Cell Biology and Columbia UniversityNew YorkNY 10032USA Department of Otolaryngology Columbia UniversityNew YorkNY 10032USA Department of Otolaryngology Vanderbilt UniversityNashvilleTN 37232USA Department of Otolaryngology Hospital Universitario Central de Asturias and Instituto Universitario de Oncologia Del Principado de AsturiasOviedo 33006Spain

In order to assess Stathmin as an immunohistochemical(IHC)indicator of phosphatidylinositol 3-kinase(PI3K)pathway activity in HPV-negative head&neck squamous cell carcinoma(HNSCC),we compared Stathmin IHC to expression of other pathway *** also evaluated the relationship between Stathmin IHC and the mutational status of four key pathway ***,we ascertained whether Stathmin IHC correlates with tumor grade or primary *** exists between high Stathmin expression and high pAKT1 expression,indicating a role for Stathmin IHC as a marker of pathway *** analysis did not show correlation between Stathmin IHC and mutation of the four genes *** also observed an association between high Stathmin expression and oropharyngeal primary *** results suggest utility of Stathmin IHC as an indicator of PI3K pathway activity,and thereby demonstrate potential relevance of Stathmin IHC in the context,of HNSCC.

关键词： Cancer Head&neck squamous cell carcinoma Pathology Stathmin

Short-term effectiveness of golimumab for ulcerative colitis: Observational multicenter study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第47期22卷 10432-10439页

作者： Marta Maia Bosca-Watts Xavier Cortes Marisa Iborra Jose Maria Huguet Laura Sempere gloria garcia Rafa Gil Mari Fe garcia Marga Munoz Pedro Almela Nuria Maroto Jose Maria Paredes Inflammatory Bowel Disease Unit Digestive Disease DepartmentUniversity of ValenciaUniversity Clinic Hospital of Valencia46010 ValenceiaSpain Digestive Disease Department Hospital of Sagunto46010 ValenciaSpain Gastroenterology Department and CIBEREHD Hospital Universitari i Politecnic La Fe46026 ValenciaSpain Digestive Disease Department General Hospital of Valencia46014 ValenciaSpain Digestive Disease Department General Hospital of Alicante03010 AlacantSpain Digestive Disease Department San Juan University Hospital of Alicante46015 ValenciaSpain Digestive Disease Department Arnau Hospital of Valencia Digestive Disease Department General University Hospital of Elche03203 AlicaneSpain Digestive Disease Department General Hospital of Castellon12004 Castellón de la PlanaSpain Digestive Disease Department Hospital of Manises46940 ManisesSpain Digestive Disease Department Peset University Hospital of Valencia46017 ValenciaSpain

AIM To evaluate the real-world effectiveness of golimumab in ulcerative colitis(UC) and to identify predictors of *** We conducted an observational, prospective and multi-center study in UC patients treated with golimumab, from September 2014 to September 2015. Clinical activity was assessed at wk 0 and 14 with the physician's global clinical assessment(PGA) and the partial Mayo score. Colonoscopies and blood tests were performed, following daily-practice clinical criteria, and the results were recorded in an SPSS *** Thirty-three consecutive patients with moderately to severely active UC were included. Among them, 54.5% were female and 42 years was the average age. Thirty percent had left-sided UC(E2) and 70% had extensive UC(E3). All patients had an endoscopic Mayo score of 2 or 3 at baseline. Twenty-seven point three percent were anti-tumor necrosis factor(TNF) treatment na?ve, whereas 72.7% had previously received infliximab and/or adalimumab. Sixty-nine point seven percent showed clinical response and were steroid-free at wk 14(a decrease from baseline in the partial Mayo score of at least 3 points). Based on PGA, the clinical remission and clinical response rates were 24% and 55% respectively. Withdrawal of corticosteroids was observed in 70.8% of steroid-dependent patients at the end of the study. Three out of 10 clinical non-responders needed a colectomy. Mean fecal calprotectin value at baseline was 300 μg/g, and 170.5 μg/g at wk 14. Being anti-TNF treatment na?ve was a protection factor, which was related to better chances of reaching clinical remission. Twenty-seven point three percent of the patients required treatment intensification at 14 wk of followup. Only three adverse effects(AEs) were observed during the study; all were mild and golimumab was not *** This real-life practice study endorses golimumab's promising results, demonstrating its short-term effectiveness and confirming it as a safe drug during t

关键词： Golimumab Ulcerative colitis Real-life results

Physical exercise in the prevention and treatment of Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2020年第5期9卷 394-404页

作者： Adrian De la Rosa gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera Freshage Research Group Department of PhysiologyFaculty of MedicineUniversity of Valenciaand CIBERFESInsitute of Health Research-INCLIVAValencia 46010Spain INRA UMR866 Muscle dynamics and metabolismUniversity of MontpellierF-34060MontpellierFrance Department of Physiotherapy Faculty of PhysiotherapyUniversity of ValenciaValencia 46010Spain Physical Education and Sports Department University of ValenciaValencia 46010Spain

Dementia is one of the greatest global challenges for health and social care in the 21st ***’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing *** lifestyle factors may increase,or reduce,an individual’s risk of developing *** has been written over the ages about the benefits of exercise and physical *** the risk factors associated with AD is a low level of physical *** relationship between physical and mental health was established several years *** this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of *** adults who exercise are more likely to maintain *** address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal *** will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood *** changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias *** interventions that include the adoption of an active lifestyle should be recommended for older populations.

关键词： Aerobic exercise Dementia Exercise training Lifestyle factors Multidomain interventions Resistance exercise

Women with Blood Hypertension: A Dialogical Reflection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Nursing 2018年第3期8卷 188-195页

作者： garcia-Reza Cleotilde Sosa-García Betsy Corina Silvia Teresa Carvalho de Araujo Diaz-Oviedo Araceli gloria Solano Solano Departament of Nursing in Investigation Autonomous University of State of Mexico Toluca Mexico Departament of Nutrition Autonomous University of State of México Toluca Mexico Departament of Nursing in Investigation University Federal of Rio de Janeiro Rio de Janeiro Brasil Departament of Investigation Nursing Autonomous University of San Luis Potosí San Luis Potosí Mexico Department of Nursing Autonomous University of Hidalgo Pachuca Mexico

The article reflects on the “philosophy of dialogue” of Martín Buber for the analysis of the relationship of women who live with arterial hypertension. With the theoretical proposal of Buber, considering the social context from the world view of the disease, this leads to relationships of suffering and anguish, but with dialogue among the people who live with this disease it is observed in specific cases of chronic disease. Likewise, the panorama of the problem is the interaction between the social being and the disease, in order to generate a dialogue between the disease and the women who live daily this condition.

关键词： Dialogic Health Arterial Hypertension Women Care

局部晚期乳腺癌患者双时相18F-FDGPET/CT显像的纹理特征及基于标准摄取值的相关参数

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华核医学与分子影像杂志 2018年第6期38卷 454-455页

作者：唐军 Ana María garcia-Vicente David Molina Julián Pérez-Beteta Mariano AmoSalas Alicia Martínez-González gloria Bueno María Jesús Tello-Galán Angel Soriano-Castrejón 上海交通大学医学院附属苏州九龙医院核医学科 Nuclear Medicine Department University General Hospital Ciudad RealSpain

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显... 详细信息

目的探讨双时相18F-脱氧葡萄糖(FDG)PET/CT显像对纹理特征分析和基于标准摄取值(SUV)的相关参数的影响及其相互关系。方法该前瞻性研究纳入56例局部晚期乳腺癌(LABC)患者,患者均行常规18F-FDG PET/CT显像(注药后1 h显像,PET-1)和延迟显像(注药后3 h显像,PET-2)。图像经软件分割后计算得到基于SUV的相关参数[最大SUV(SUVmax)、平均SUV(SUVmean)和SUV峰值(SUVpeak)]、代谢肿瘤体积(MTV)和病灶糖酵解总量(TLG)。同时计算18项三维纹理特征分析参数,其中包括行程长度矩阵(RLM)特征、共生矩阵(CM)特征和能量特征(空间能量和总能量)。研究PET-1和PET-2上述参数的差别。结果 PET-1、PET-2间基于SUV的相关参数和MTV的差异有统计学意义,与PET-1相比,PET-2的SUV相关参数更高,但MTV更低。PET-1、PET-2间有明显差异的纹理特征分析参数为短行程增强(RSE)、低灰度行程增强(LGLRE)、短行程高灰度增强(SRHGLE)、行程百分比(RP)、长行程增强(LRE)、灰度非均匀性(GLNU)、同质性(HOM)和差异性(DIS)。纹理特征分析参数与MTV和TLG相关。结论双时相18F-FDG PET/CT显像图像的纹理特征分析参数间有明显差异。因此,18F-FDG PET/CT显像时应考虑到代谢特征的动态变化,即延迟显像时肿瘤组织表现出的异质性更强,且瘤体越大异质性越强。

关键词：双时相18F-FDG PET/CT 乳腺肿瘤肿瘤异质性纹理特征

Overexpression Of Protein P16ink4a As A Marker Of Squamous Intraepithelial Lesions Induced By High Risk Hpv Infection In Mexican Women

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Overexpression Of Protein P16ink4a As A Marker Of Squamous I...

Evolution on the Water Quality in Sergipe Hinterland Reservoirs, Northeast Brazil

24th International Papillomavirus Conference and Clinical Workshop

作者： Luz del Carmen Alarcon-Romero Elba Reyes-Maldonado Berenice Illades-Aguiar Eugenia Flores-Alfaro Amafia Vences Velazquez gloria Fernondez-Tilapa Esther Ivonne Lopez-Bayghen Ethel A garcia-Latorre Patricia Romero Neri Victor Gabriel Hernandez Chavez Marco Antonio Teron-Porcayo Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Depatamento de Genetica y Biologia Molecular CIVESTAV-IPNMexicoD.F Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Clinica de Displasias ChilpancingoGuerreroMexico Departamento de Anatomia patologica Hospital de Cardiologia Centro Medico Nacional Siglo XXI del IMSSMexicoD.F Instituto Estatal de Cancerologia‘Dr Arturo Beltran Ortega’ AcapulcoGuerreroMexico

＜正＞Background:Expression of the high-risk human papillomavirus（hr-hpv）e7-gene replicating epithelial cells results in disruption of the prb-e2f complex and degradation of prb This leads to strong overexpression o...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering(B) 2017年第7期6卷 345-351页

作者： Carlos Alexandre Borges garcia Anairam Piedade de Souza Melol Helenice Leite garcia Cristiane da CunhaNascimento Silvanio Silvario Lopes da Costa Maria Caroline Silva Mendonaa Jose do Patrocinio Hora Alves Marcus Aure1io Soares Cruz Rennan Geovanny Oliveira Araujo Post-Graduate Program in Water Resources Federal University of Sergipe Sao Cristavao-----SE 49100-000 Brazil Chemical Engineering Department Federal University of Sergipe Sao Cristovao----SE 49100-000 Brazil Campus Aracaju Federal Instituteof Sergipe Aracaju--SE 49055-260 Brazil Embrapa Coastal Tablelands Brazilian Agricultural Research Corporation Aracaju-SE 49025-04 Brazil Institute of Chemistry Federal University of Bahia Salvador-Ba 40170-115 Brazil

Population growth has consequences for intense use of aquatic ecosystems. Samples were taken, between 2013 and 2014, in the reservoirs ＂Algodoeiro＂ and ＂gloria＂ in Sergipe, Brazil. TSI （Trophic State Index） and WQI （Water Quality Index） were used. It was determined the parameters such as conductivity, dissolved oxygen, total nitrogen, total phosphorus and chlorophyll. TSI has been applied, in ＂Algodoeiro＂, which was classified as mesotrophic. With the increase of rainfall in 2014, this reservoir changed its condition to eutrophic. ＂gloria＂ reservoir was already classified in super-eutrophication. Regarding the WQI, the reservoirs were classified in Class IV, indicating a critically degraded condition.

关键词： Water quality environmental degradation limnological studies TSI (Trophic State Index) RWQI (Reservoir WaterQuality Index).