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A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid glen jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

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The code of light:do neurons generate light to communicate and repair?

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Neural Regeneration Research 2022年第6期17卷 1251-1252页

作者： Cecile Moro Ann Liebert Catherine Hamilton Nicolas Pasqual glen jeffery Jonathan Stone John Mitrofanis Universite Grenoble Alpes CEALETIClinatecGrenobleFrance Department of Anatomy University of SydneySydneyAustralia Vie Integrative GrenobleFrance Institute of Ophthalmology University College LondonLondonUK Department of Physiology University of SydneySydneyAustralia

A great challenge in neuroscience has been to understand how neurons *** neuroanatomists of the 19th Century could see neurons stretching processes to contact other neurons,but could not see the detail of the *** thought that neurons formed a syncytium,with continuity of membranes from one to the *** the ensuing two hundred years or so,we have come to understand that the circuity of the brain is not formed by a syncytium of neurons;rather,individual neurons communicate with each other with a range of biological *** are highly active cells,with their activity being electrical and their communication being either chemical,electrical or gaseous.

关键词： communicate stretching electrical

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A Framework for a Subwatershed-Scale Screening Tool to Support Development of Resiliency Solutions and Flood Protection Priority Areas in a Low-Lying Coastal Community

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Journal of Geoscience and Environment Protection 2021年第10期9卷 180-205页

作者： Frederick Bloetscher Gerardo Rojas Anthony Abbate Tucker Hindle jeffery Huber Richard Jones Weibo Liu Daniel Eduardo Meeroff Diana Mitsova Sudhagar Nagarajan glen Oglesby Colin Polsky Hongbo Su Eva Suarez Ramesh Teegavarapu Jared Weaver Zhixiao Xie Yan Yong Caiyun Zhang Florida Atlantic University Boca Raton USA

Flood risk analysis is the instrument for local officials to create a sound strategy and adaptation plans for the impacts of inundation due to heavy rains, climate change and sea level rise. Hence, cities with aging infrastructure are retrofitting their stormwater management systems to mitigate the impacts. However determining the most at risk areas and the options for corrections is more challenging. As a result, there is an urgent need to develop a screening tool to analyze watersheds and identify the most at-risk areas. High-quality, open source data and sophisticated spatial analysis techniques allow engineers to create innovative ways to conduct watershed wide inundation analysis. In this study, the investigators developed a screening tool to identify at-risk properties by combining readily available data on topography, groundwater, surface water, tidal information for coastal communities, soils, open space, and rainfall data. Once the screening tool is developed, the means to identify and prioritize improvements to be funded with scarce capital funds is the next step. A tool box of solutions was developed to address flood risk and vulnerability. Testing of the screening tool was conducted in Broward County, Florida and shows encouraging results. Comparison with FEMA Flood maps and repetitive

关键词： Flooding Watershed Flood Modeling Screening Tool Risk Infrastructure

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