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Paraparesis induced by extramedullary haematopoiesis

World Journal of Radiology 2011年第3期3卷 82-84页

作者： Paolo Savini Arianna Lanzi Giorgio Marano Chiara Carli Moretti Giovanni Poletti giuseppe musardo Francesco giuseppe Foschi giuseppe Francesco Stefanini Department of Internal Medicine Faenza Hospital Department of Radiology Faenza Hospitalviale Stradone 948018 FaenzaItaly Department of Pathology Ravenna Hospitalviale Randi 548121 RavennaItaly

We describe a case of worsening paraparesis induced by spinal cord compression at T6-T7 levels associated with compensatory extramedullary haematopoiesis from a compound heterozygote for haemoglobin E and for β-*** e... 详细信息

关键词： Extramedullary hematopoiesis Thalassemia Anemia Spinal cord compression Laminectomy

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MGUS:Proposal for outpatient management

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World Journal of Hematology 2012年第2期1卷 5-7页

作者： Paolo Savini Giorgio Marano Arianna Lanzi Barbara Castagnari giuseppe musardo Annalia Molinari Claudia Cellini giuseppe Francesco Stefanini Department of Internal Medicine Faenza Hospital viale Stradone 9 48018 FaenzaItaly Department of Haematology Ravenna Hospital viale Randi 5 48100 Ravenna Italy Haematology Unit Rimini Hospital via L.Settembrini 2 47900 Rimini Italy

The term monoclonal gammopathy of undetermined significance(MGUS) indicates the presence of a monoclonal protein(M-protein) without features of multiple myeloma, Waldenstrom's macroglobulinemia, primary amyloidosis or malignant lymphoproliferative disorders(LPD). While several guidelines on the treatment of LPD exist, many doubts and perplexities still exist on who should treat a MGUS, when and how. Even where MGUS does not require any therapy, the risk of progression to a LPD is 1% per year. This risk does not diminish over time and persists even in patients(pts) whose condition has remained stable for decades, and a prolonged follow up is, therefore, recommended. We met primary care doctors to share and agree on criteria for the management of outpatients with MGUS. Our aim is to draw up guidelines or, at least, suggestions that may help to determine which MGUS pts could be cared for by the primary care doctor and which should be followed by the hematologist. We suggest that once a MGUS is diagnosed, the primary care physician will attend patients with M-protein 15 g/L, or M-protein Ig A > 10 g/L, or Ig M > 10 g/L, or any M-protein with end-organ damage(not attributable to any others causes) or with signs and symptoms of LPD, or rapidly increasing M-protein(> 5 g/L per year).

关键词： Monoclonal gammopathy Multiple myeloma Macroglobulinaemia End-organ damage Serum protein electrophoresis

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