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一个新发现的患利德尔综合征家庭中,患者呈现似原发性高血压的临床表型

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中华高血压杂志 2012年第2期20卷 198-198页

作者： Ermanno Rossi Enrico Farnetti Davide Nicoli Marco Sazzini Franco Perazzoli giuseppe Regolisti Chiara Grasselli Rosaria Santi Aurelio Negro Vincenzo Mazzeo Franco Mantero Donata Luiselli Bruno Casali 罗冬梅叶鹏

利德尔综合征（Liddle’s syndrome，LS）是一个拟似盐皮质激素过多的，由单基因异常造成的，表现为血压升高的综合征。目前在年轻低钾性高血压患者的鉴别诊断中考虑该疾病的存在。该研究的目的是：①评估一个新近发现的来自意大利西西... 详细信息

利德尔综合征（Liddle’s syndrome，LS）是一个拟似盐皮质激素过多的，由单基因异常造成的，表现为血压升高的综合征。目前在年轻低钾性高血压患者的鉴别诊断中考虑该疾病的存在。该研究的目的是：①评估一个新近发现的来自意大利西西里地区携带上皮钠通道P617L功能增强性13亚基的家族的临床表型。该研究组曾经报道在一个与新发现无关的西西里患者中存在这种基因突变并表现包括低血钾的典型LS症状。②确定新发现的家庭和先前发现家庭是否存在一种尚未明确的生物关系。

关键词：高血压患者临床表型综合征原发性高血压家庭盐皮质激素上皮钠通道基因异常

Nuclear imaging in detection and monitoring of cardiotoxicity

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World Journal of Radiology 2014年第7期6卷 486-492页

作者： Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi Department of Advanced Biomedical Sciences Federico II University SDN Foundation Institute of Diagnostic and Nuclear Development

Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and *** coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor *** ventricular dysfunction is the most typical manifestation and can lead to heart *** ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial *** non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic *** echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical *** aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity.

关键词： Cardiotoxicity Cardiac nuclear imaging Early diagnosis Scintigraphy Positron emission tomography

尼美舒利及其他非甾体类抗炎药物肝毒性的队列研究

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英国医学杂志中文版 2004年第3期7卷 190-190页

作者： giuseppe Traversa Clara Bianchi Roberto Da Cas Iosief Abraha Francesca Menniti-Ippolito Mauro Venegoni 李伟

目的:与其他非甾体类抗炎药物相比较,评价尼美舒利(nimesulide)急性肝毒性的危险性。设计:回顾性队列研究和巢式病例对照研究。地点:意大利翁布里亚地区(Umbria region)。参与者:1997年1月～2001年12月31日间400000例当前、近期或者... 详细信息

目的:与其他非甾体类抗炎药物相比较,评价尼美舒利(nimesulide)急性肝毒性的危险性。设计:回顾性队列研究和巢式病例对照研究。地点:意大利翁布里亚地区(Umbria region)。参与者:1997年1月～2001年12月31日间400000例当前、近期或者过去应用过非甾体类抗炎药物者(近2百万个处方)。

关键词：尼美舒利非甾体类抗炎药药物毒性肝损伤

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成功的协会会员策略

中国社会组织 2019年第23期 55-55页

作者：朱塞佩·马莱塔企业法律顾问协会欧洲企业法律顾问协会

会员是协会最重要的"原材料"。这一点并没有看上去那么明显。企业法律顾问协会(ACC)等协会在85个国家开展活动,发布调查报告和白皮书,主办国际活动,向国际法庭提交简报。但是,如果没有一群人愿意为享受某种利益或促进某种事业而缴纳会费... 详细信息

会员是协会最重要的"原材料"。这一点并没有看上去那么明显。企业法律顾问协会(ACC)等协会在85个国家开展活动,发布调查报告和白皮书,主办国际活动,向国际法庭提交简报。但是,如果没有一群人愿意为享受某种利益或促进某种事业而缴纳会费,这些成就就毫无意义。企业法律顾问协会拥有4.5万名成员,这在一定程度上解释了其庞大的产出来源。

关键词：国际法庭毫无意义开展活动白皮书企业法律顾问协会调查报告

神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐

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国际脑血管病杂志 2019年第2期27卷 84-97页

作者： Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti Pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) Department of Medic al-Surgical Intensive Care Medicine Faculty of Biology and Medicine Centre Hospitalier Universitaire VauDOIs (CHUV) Lhiversity of Lausanne Rue du Bugnon 46 B4 08.623 1011 Lausanne Switzerland Department of Intensive Care Medicine St James's Lhiversity Hospital James's St Ushers P.O. Box 580 Dublin & Ireland Service de Reanimation Medic o-chirurgic ale Hopital Pasteur 2 UniversiteCote d'Azur CHU de Nice 06000 Nice France Unite CNRS 7275 Sophia-Antipolis France Department of Intensive Care Erasme Hospital University Libre de Bruxelles Brussels Belgium Neurosciences Critical Care Departments of Anesthesiology and Critical Care Medicine Neurology and Neurosurgery Johns Hopkins Lhiversity Baltimore MD USA Department of Neurology University of California San Francisco San Francisco CA LKA Service de Reanimation Polyvalente Hopital Pasteur 2 CHU de Nice 30 Voie Romaine CS 51069 06001 Nice Cedex 1 France Division of Anaesthesia University of Cambridge Addenbrooke's Ffospital Box 93 Hfills Road Cambridge Cambridgeshire CB2 2QQ UK Department of Intensive Care 4131 Copenhagen University Hospital- Rigshospitalet Copenhagen Denmark Department of Neuroanesthesia and Neurocritic al Care The National Ffospital for Neurosurgery and Neurology Lhiversity College London Hospitals London UK Anesthesia and Intensive Care Operative th it S. Martino Hospital Belluno Italy Hospital Nacional Professor Alejandro Posadas Buenos Aires Argentina Department of Neurosciences IRCCS-Istituto di Ricerche Farmacotogiche Mario Negri Milan Italy School of Medicine and Surgery University of Milan-Bicocca Milan Italy Neurointensive Care San Gerardo Hospital ASST-Monza 20900 Monza Italy 南方医科大学南方医院神经内科广州510515 Neurological Intensive Care Lhit Department of Neurology Medical University of Innsbruck Innsbruck Austria Department of Intensive Care Medicine University Hospitals Leuven Louvain Belgium Neuroscience Intensive Care Unit Department of Anesthesia and C

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会... 详细信息

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。

关键词：循证医学指南液体治疗创伤性脑损伤蛛网膜下腔出血脑出血卒中甘露醇高渗神经重症监护

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夸特罗科蒂商务中心俄罗斯圣彼德堡

世界建筑导报 2018年第5期33卷 97-99页

作者： yusuke aizawa momoko asano ilan balouka filippo carcano erica cazzaniga cristina castelli maiko chiriki giuseppe crocco ola abetskaya alessandro laner alessandro mauri luca mazzeo elena migliorati hirotaka oishi an-drea palaia miguel pallares nicola pelucchi elena petko laura ines quatela daniele reimondo daniela scarpa marta sesana roberto songini olga strikha sarah trianni enrico venturini andrea martiradonna(摄)

夸特罗科蒂（Quattro Corti）商务中,15落成于俄罗斯古城圣彼德堡，紧邻圣以撒大教堂。该项目是在保留原有两座大楼立面的基础上，构造新的现代化建筑。设计以新型金属结构屋顶重新连接了原有建筑斜坡式的楼顶。屋顶在选材和形状上与城... 详细信息

夸特罗科蒂（Quattro Corti）商务中,15落成于俄罗斯古城圣彼德堡，紧邻圣以撒大教堂。该项目是在保留原有两座大楼立面的基础上，构造新的现代化建筑。设计以新型金属结构屋顶重新连接了原有建筑斜坡式的楼顶。屋顶在选材和形状上与城市天际线完美相融。屋顶之下是四个庭院，既保证了内部空间享有充足光源，又可以用于举行艺术造型、展览等公共活动。庭院立面覆盖以角度不同的反光玻璃板。

关键词：商务中心俄罗斯现代化建筑城市天际线金属结构内部空间艺术造型公共活动

滑坡形成的海底地形与西南亚得里亚海深水珊瑚生长之间的相互影响

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海洋地质 2009年第1期25卷 48-48页

作者： Fabio Trincardi Marco Taviani Andre Freiwald Federica Foglini giuseppe Verdicchio Daniel Minisini 杨丽娟（译）闫章存（校对）海洋研究所意大利埃尔兰根-伦堡大学德国爱迪生能源公司意大利埃尼公司意大利不详

在西南亚得里亚海大陆边缘150km长的区段内，从陆架外缘到坡底，都存在强烈的边坡失稳现象。已固结的更新世沉积单元的崩塌形成了从块状滑坡到细粒浊积岩的堆积物，侵蚀开阔陆坡以及巴里峡谷陡峭的谷壁。这带陆缘还受到成瀑布般落下陆... 详细信息

在西南亚得里亚海大陆边缘150km长的区段内，从陆架外缘到坡底，都存在强烈的边坡失稳现象。已固结的更新世沉积单元的崩塌形成了从块状滑坡到细粒浊积岩的堆积物，侵蚀开阔陆坡以及巴里峡谷陡峭的谷壁。这带陆缘还受到成瀑布般落下陆架、接近海底时流速超过60cm／s的高密度水季节性作用的影响。这些现象的共同作用形成了各种底形，其中部分底形（例如崩塌块的硬化表面）证实是各种底栖的硬海底有机生物最好的安身之处。这种变形的垮塌形成的地貌加上冷的富营养海水的泻落，

关键词：亚得里亚海海底地形珊瑚生长深水坡形大陆边缘失稳现象

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World Journal of Clinical Oncology 2013年第2期4卷 52-57页

作者： Pasquale Rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico Davide Bosso Antonella Virtuoso Michela Izzo Tania Policastro Luca Vaccaro Gianfranco Cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri giuseppe Di Lorenzo Genitourinary Cancer Section and Rare-Cancer Center Medical Oncology DivisionUniversity Federico II80131 NapoliItaly Department of Dermatology University Federico II of Naples80131 NapoliItaly

AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective *** some cases,the human herpes virus 8 status was assessed by *** patients were staged according to the Mediterranean KS staging system.A multivariable model was constructed using a forward stepwise selection procedure.A P value<0.05 was considered statistically significant,and all tests were ***:Thirty-two cases were included in this *** average age at diagnosis was 70 years,with a male/female ratio of approximately 2:***-four percent of the cases had classic *** patients received systemic chemotherapy containing one of the following agents:vinca alkaloid,taxane,and pegylated liposomal *** patients(31.5%)experienced a partial response,and a complete response was achieved in four patients(12.4%)and stable disease in sixteen cases(50%).Two patients(6.2%)were refractory to the systemic *** median progression-free survival(PFS)was 11.7 mo,whereas the median overall survival was 28.5 *** multivariate analysis,the presence of nodular lesions(vs macular lesions only)was significantly related to a lower PFS(hazard ratio:3.09;95%CI:1.18-8.13,P=0.0133).CONCLUSION:Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic *** data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy.

关键词： Kaposi’s sarcoma Human herpes virus 8 Paclitaxel Pegylated liposomal doxorubicin Vinblastine

Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience

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World Journal of Transplantation 2016年第1期6卷 239-248页

作者： Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta Department of Surgery Wake Forest School of Medicine Department of Internal Medicine Wake Forest School of Medicine Department of Pharmacy Wake Forest School of Medicine Department of Pathology Wake Forest School of Medicine

AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all ***: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively

关键词： Donor age Donor weight En bloc kidney transplant Kidney donor profile index Single kidney transplant Small pediatric donor