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Optimal flow conditions of a tracheobronchial model to reengineer lung structures

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Acta Mechanica Sinica 2017年第2期33卷 284-294页

作者： Stefano Casarin Federico Aletti giuseppe Baselli Marc Garbey LASIE UMR CNTS Univeristy of La Rochelle La Rochelle France Houston Methodist Hospital Research Institute Houston TX USA Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano Milan Italy

The high demand for lung transplants cannot be matched by an adequate number of lungs from donors. Since fully ex-novo lungs are far from being feasible, tissue engineering is actively considering implantation of engineered lungs where the devitalized structure of a donor is used as scaffold to be repopulated by stem cells of the receiving patient. A decellularized donated lung is treated inside a bioreactor where transport through the tracheobronchial tree (TBT) will allow for both deposition of stem cells and nourishment for their subsequent growth, thus developing new lung tissue. The key concern is to set optimally the boundary conditions to utilize in the bioreactor. We propose a predictive model of slow liquid ventilation, which combines a one-dimensional (1-D) mathematical model of the TBT and a solute deposition model strongly dependent on fluid velocity across the tree. With it, we were able to track and drive the concentration of a generic solute across the airways, looking for its optimal distribution. This was given by properly adjusting the pumps’ regime serving the bioreactor. A feedback system, created by coupling the two models, allowed us to derive the optimal pattern. The TBT model can be easily invertible, thus yielding a straightforward flow/pressure law at the inlet to optimize the efficiency of the bioreactor.

关键词： Bioreactor Lung rehabilitation Network flow Tissue engineering Transport of solute

Towards automated validation of charted soundings:Existing tests and limitations

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Geo-Spatial Information Science 2019年第4期22卷 290-303,I0006页

作者： Christos Kastrisios Brian Calder giuseppe Masetti Peter Holmberg Center for Coastal and Ocean Mapping/UNH-NOAA Joint Hydrographic Center University of New HampshireDurhamNHUSA U.S.Department of Commerce National Oceanic and Atmospheric AdministrationNational Ocean ServiceOffice of Coast SurveyHydrographic Survey DivisionSeattleWAUSA

The nautical chart is one of the fundamental tools in navigation used by mariners to plan and safely execute *** compilation follows strict cartographic constraints with the most prominent being that of the ***,the cartographer is called to make the selection of the bathymetric information for portrayal on charts in a way that,at any location,the expected water depth is not deeper than the source *** validate the shoal-biased pattern of selection two standard tests are used,*** triangle and edge *** date,some efforts have been made towards the automation of the triangle test,but the edge test has been largely *** the context of research on a fully automated solution for the compilation of charts at different scales from the source information,this paper presents an algorithmic implementation of the two tests for the validation of selected *** a case study with real-world data,it presents the improved performance of the implementation near and within depth curves and coastlines and points out the importance of the edge test in the validation *** also presents the,by definition,intrinsic limitation of the two tests as part of a fully automated solution and discusses the need for a new test that will complement or supersede the existing ones.

关键词： Automated nautical cartography nautical chart generalization chart safety constraint sounding generalization nautical surface test sounding selection category zone of confidence

Synthesis and characterization of lanthanum bonded agar-carbomer hydrogel:a promising tool for biomedical research

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Journal of Rare Earths 2011年第3期29卷 259-264页

作者： Filippo Rossi Marco Santoro Tommaso Casalini giuseppe Perale Dipartimento di Chimica Materialied Ingegneria Chimica"G.Natta"Politecnico di MilanoVia Mancinelli7

Agar-Carbomer（branched poly（acrylic acid）） hydrogel,an injectable bio-resorbable scaffold with a controlled nanostructure specifically designed for neural cell housing,was developed together with a new protocol for building three dimensional biohybrid cell/hydrogel *** order to overcome classic structural analysis inconveniences due to the high water amount,which affects instruments results and reliability,agar-Carbomer hydrogels were synthesized by microwave-assisted block copolymerization together with La3＋ *** glycol,glycerol and buffered saline solution were used as cross-linking agents and solvent,*** properties were not affected by the presence of lanthanum,and were checked via swelling and rheological ***,the presence of La3＋ within the polymeric network was characterized by thermogravimetric analysis,environmental scanning electron microscopy and Fourier transformed infrared *** results showed that the rare earth presented uniform distribution in the hydrogel network due to the formation of chemical bonds after polymerization without being modified its luminescence emission spectrum that allowed hydrogel *** results made the obtained host-guest system a useful tool for analytical research studies concerning regenerative medical applications that could also be potentially taken up with in vivo experiments.

关键词： hydrogel acrylic acid agarose lanthanum luminescence drug delivery rare earths

Optimal dual antiplatelet therapy strategy in elderly patients with acute coronary syndrome

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Journal of Geriatric Cardiology 2021年第3期18卷 210-218页

作者： Monica Verdoia Rocco Gioscia giuseppe De Luca Cardiologia e UnitàCoronarica Ospedale degli InfermiASL BiellaItaly/Division of CardiologyAzienda Ospedaliera-Universitaria“Maggiore della Carità”Universitàdel Piemonte OrientaleNovaraItaly

One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carrying together a significant burden of comorbidities and a higher risk of *** particular,both ischemic and haemorrhagic risk are markedly enhanced in advanced age,and strictly interconnected,challenging the management of dual antiplatelet therapy(DAPT)in these *** recent development of several therapeutic options in terms of duration and combination of antiplatelet agents have offered a wider spectrum of opportunities for a more individualized approach in the management of DAPT after an ACS,although the criteria for the selection of the most appropriate strategy in each patient still lack *** particular,dose-adjustment,early aspirin discontinuation,laboratory-driven tailoring and shorter or extended DAPT have been addressed with promising safety and efficacy *** present review provides an updated overview on the emerging evidencefrom randomized clinical trials and subanalyses dedicated to the management of DAPT in elderly patients presenting with ACS.

关键词： patients coronary markedly

Effect of stepover and torch tilting angle on a repair process using WAAM

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Advances in Manufacturing 2022年第4期10卷 541-555页

作者： Francesco Baffa giuseppe Venturini Gianni Campatelli Emanuele Galvanetto Department of Industrial Engineering University of FlorenceFlorenceItaly

To sustain the transition to a greener economy and greener manufacturing,it is necessary to develop new approaches and technologies to repair metal components;this will result in a drastic reduction in energy and material *** this study,wire arc additive manufacturing(WAAM)was used to deposit a layer of new material on an existing surface,with the objective of finding the optimal configuration that maximized the layer quality and material *** parameters considered are the stepover among the deposited beads and the inclination of the torch with respect to the repaired *** inclination angle is crucial when repairing complex surfaces,like those of a mold,owing to accessibility issues,the torch cannot be maintained orthogonal to the surfaces along the entire *** configurations were tested in order to assess the quality of the materials in terms of the presence of material voids,depth of penetration,and the heat affected zone(HAZ)and to understand the effects of these variables on the material efficiency and thickness of the repairing *** should be noted that by adopting deposition parameters set to have a low heat input,the use of a tilting angle has beneficial effects on the quality of the deposited layer and the process *** and geometrical measurements were carried out to assess the effect of these two variables depositing a layer of plain carbon steel.

关键词： Wire arc additive manufacturing(WAAM) Repairing·Torch inclination Stepover Remanufacturing

Target Capturing in an Ellipsoidal Region for a Swarm of Double Integrator Agents

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IEEE/CAA Journal of Automatica Sinica 2022年第5期9卷 801-811页

作者： Antonio Bono Luigi D'Alfonso giuseppe Fedele Veysel Gazi IEEE Department of Informatics ModelingElectronics and Systems EngineeringUniversity of CalabriaRende 87036Italy Dept.Electrical and Electronics Eng. Faculty of EngineeringMarmara UniversityIstanbul 34722 Department of Control and Automation Engineering Faculty of Electrical and Electronics EngineeringYildiz Technical UniversityEsenler 34220Turkey

In this paper we focus on the target capturing problem for a swarm of agents modelled as double integrators in any finite space *** agent knows the relative position of the target and has only an estimation of its velocity and *** that the estimation errors are bounded by some known values,it is possible to design a control law that ensures that agents enter a user-defined ellipsoidal ring around the moving *** know the relative position of the other members whose distance is smaller than a common detection ***,in the case of no uncertainty about target data and homogeneous agents,we show how the swarm can reach a static configuration around the moving *** simulations are reported to show the effectiveness of the proposed strategy.

关键词： Agents-based systems cooperative control swarms target-capturing

Quantitative Progress Evaluation of Post-stroke Patients Using a Novel Bimanual Cable-driven Robot

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Journal of Bionic Engineering 2021年第6期18卷 1331-1343页

作者： Thiago Alves Rogério Sales Gonçalves giuseppe Carbone Laboratory of Automation and Robotics School of Mechanical EngineeringFederal University of UberlândiaUberlândia38400-902Brazil Department of Mechanical Energy and Management EngineeringUniversity of Calabria87036RendeItaly

Rehabilitation is the most effective way to reduce motor impairments in post-stroke *** process demands several hours with a specialized *** resources and personnel shortages,the literature reports a high interest in robotic assisted rehabilitation ***,cable-driven robotic architectures are attracting significant research interest for post-stroke ***,the existing cable-driven robots are mostly unilateral devices allowing the rehabilitation only of the most affected *** leaves unaddressed the rehabilitation of bimanual activities,which are predominant within the common Activities of Daily Living(ADL).Thus,this paper presents a specific novel design to achieve bimanual rehabilitation tasks that has been named as BiCAR ***,this paper provides a full insight on the BiCAR system as well as on its dedicated developed software *** particular,BiEval software has been developed as based on a serious game strategy and a virtual reality environment to track the patient exercising duration,motion ranges,speeds,and forces over time for achieving a quantitative assessment of the rehabilitation ***,the paper presents the BiCAR/BiEval capabilities by referring to a pilot Randomized Controlled Trial(RCT).The clinical trials have been used to validate the BiCAR/BiEval in terms of engineering feasibility and user acceptance to achieve an innovative cost-oriented integrated hardware/software device for the bimanual assistive rehabilitation of post-stroke patients.

关键词： Cable-driven robots Low cost Stroke rehabilitation Bimanual Progress tracking Serious games

Mass Transport/Diffusion and Surface Reaction Process with Lattice Boltzmann

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Communications in Computational Physics 2011年第5期9卷 1362-1374页

作者： giuseppe De Prisco Xiaowen Shan Exa Corporation 55 Network DriveBurlingtonMassachusetts 01773USA Ingrain Inc 3733 Westheimer RoadHoustonTexas 77027USA

Multi-component flow with chemical reactions is a common problem in different industrial applications:the mixing chamber of a reaction injection molding(RIM)machine;the dynamics of diesel soot particles interacting with a porous-ceramic particulate filter;reactive transport in porous media;bio-chemical processes involving enzyme-catalyzed *** all these cases,mass diffusion/convection and wall or volume chemical interactions among components play an important *** the present paper we underline the importance of diffusion/convection/reaction mechanisms in bio-chemical processes using the Lattice Boltzmann(LB)*** bio-application where we studied diffusion/convection/reaction mechanisms is the quorum-sensing pathway for the bio-synthesis of the AI-2,a molecule that allows the bacteria to launch a coordinated attack on a host immune system(see[9,10]for more details of the bio-application).The overall goal is to create a micro-device to screen potential drugs that inhibit AI-2 *** Michaelis-Menten saturation kinetic model is implemented at the reactive surface and the results are shown in terms of two dimensionless numbers:Damkohler(Da)and Peclet(Pe)*** high Pe number a small conversion of reactants into products is obtained at the reactive surface,but the overall flux of products is high;moreover,a fast saturation of the conversion of reactants to products is obtained for high Da *** trade-off for setting the Pe and Da numbers depends on the specific application and the technologies used in the micro-device(e.g.,sensitivity of the detector,cost of reactants).

关键词： Lattice Boltzmann multi-component diffusion-reaction

Risk factors from HBV infection among blood donors:A systematic review

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 344-349页

作者： giuseppe La Torre Rosella Saulle Department of Public Health and Infectious Diseases "Sapienza" University of Rome

Objective:To perform a systematic review of the scientific literature to identify risk factors associated with hepatitis B viruses(HBV) infection among blood ***:The literature search was carried out on Pub Med and Scopus databases using the keywords "risk factors" "HBV infection" and "blood donors".No date or language restrictions were applied to the *** literature review was completed in *** selection process and the reporting of the review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** Newcastle Ottawa scale was using to evaluate the quality of each single primary ***:Out of 172 records resulted in the search,5 papers were included in the final analysis because they are within acceptance *** of the selected studies were cross-sectional and three of them were case-control *** association resulted with some demographic and behavioral risk factors,such as marital status,dental treatment/procedure history,no stable relationship or multiple partners and family history of HBV ***:The systematic review performed encourages to conduct further research among blood donors in order to fully understand risk factors among donors in more extensive thus to provide valuable information about surveillance.

关键词： Risk factors HBV Infection Blood donors Systematic review