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High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

World Journal of Gastroenterology 2008年第10期14卷 1549-1552页

作者： Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano giuseppe de caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni department of Medicine and Pharmacology University Hospital Messina 98125 Italy department of Statistics University oMessina Messina 98125 Italy

AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.

关键词： D-dimers Liver cirrhosis Ascites Hepatocellular carcinoma Hyperfibrinolysis

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Yield Response to deficit Irrigation and Partial Root-Zone Drying in Processing Tomato （Lycopersicon esculentum Mill,）

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Journal of Agricultural Science and Technology(A) 2012年第2期2卷 209-219页

作者： Eugenio Nardella Marcella Michela Giuliani giuseppe Gatta Antonio de caro department of Agro-environmental Sciences Chemistry and Crop Protection （DiSACD） University of Foggia Foggia 71122 Italy

Due to the global expansion of irrigated areas and the limited availability of irrigation water, it is necessary to optimize water use in order to maximize crop yields under water deficit conditions. To evaluate the yield response of two processing tomato hybrids （Ercole and Genius） grown under different irrigation treatments, a field trial was conducted during the 2008 growing season in Southern Italy. Three irrigation treatments were used： the restitution of 70% of maximum evapotranspiration （ETc） both under ＂deficit Irrigation＂（70DI） and ＂Partial Root-zone Drying＂（70PRD） strategies; full irrigated （FI： 100% ETc）. The two water deficit irrigation treatments （DI and PRD） showed stomatal conductance values lower than FI treatment and saved a substantial amount of water maintaining reasonable marketable yield. Moreover, PRD strategy showed slightly higher ＂Water Use Efficiency＂（WUE） values than DI. Finally, ＂yield response factor＂（Ky） showed always values less than unity, indicating the possibility to adopt, within certain limited condition, both DI and PRD in field-grown processing tomato cultivated in Southern Italy. In conclusion, in our experimental conditions, deficit irrigation practices seem to be acceptable relatively to processing tomato yield aspects and Ky could be promoted as a useful indicator for irrigation in water deficit conditions.

关键词： Tomato deficit irrigation partial root-zone drying WUE Ky.

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B1a lymphocytes in the rectal mucosa of ulcerative colitis patients

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World Journal of Gastroenterology 2012年第2期18卷 144-149页

作者： Lino Polese Riccardo Boetto giuseppe de Franchis Imerio Angriman Andrea Porzionato Lorenzo Norberto Giacomo Carlo Sturniolo Veronica Macchi Raffaele de caro Stefano Merigliano department of Surgical and Gastroenterological Sciences University of PadovaVia Giustiniani 235128 PadovaItaly department of Laboratory Medicine Padova University HospitalVia Giustiniani 235128 PadovaItaly department of Human Anatomy and Physiology University of PadovaVia Gabelli 6535128 PadovaItaly

AIM:To assess B1a cell expression in the rectal mucosa of ulcerative colitis (UC) patients in comparison with healthy ***:Rectal mucosa biopsies were collected from 15 UC patients and 17 healthy ***5 + B cells were analysed by three colour flow cytometry from rectal mucosal samples after mechanical disaggregation by Medimachine.Immunohistochemical analysis of B and T lymphocytes was also *** between,on the one hand,rectal B1a cell concentrations and,on the other,erythrocyte sedimentation rate and C-reactive protein levels and clinical,endoscopic and histological disease activity indices were ***:Rectal B-lymphocyte (CD19 + /CD45 +) rate and concentration were higher in UC patients compared with those in healthy controls (47.85% ± 3.12% vs 26.10% ± 3.40%,P=0.001 and 501 ± 91 cells/mm 2 vs 117 ± 18 cells/mm 2,P density (CD5 + CD19 +) was higher in UC patients than in healthy controls (85 ± 15 cells/mm 2 vs 31 ± 6.7 cells/mm 2,P=0.009).Rectal B1a cell (CD5/CD19 +) rate correlated inversely with endoscopic classification (Rs=-0.637,P defined.

关键词： B1 cell CD5 Flow cytometry Rectum Ulcerative colitis

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