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The neural bases of vitality forms

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National Science Review 2020年第1期7卷 202-213页

作者： giuseppe Di cesare Marzio Gerbella Giacomo Rizzolatti Cognitive Architecture for Collaborative Technologies Unit Italian Institute of Technology 2. Department of Medicine and Surgery Neuroscience Unit University of Parma Istituto di Neuroscienze Consiglio nazionale delle Ricerche

Unlike emotions, which are short-lasting events accompanied by viscero-motor responses, vitality forms are continuous internal states that modulate the motor behaviors of individuals and are devoid of the autonomic modifications that characterize real emotions. Despite the importance of vitality forms in social life, only recently have neurophysiological studies been devoted to this issue. The first part of this review describes f MRI experiments, showing that the dorso-central insula is activated during the execution, the perception and the imagination of arm actions endowed with different vitality forms as well as during the hearing and the production of speech conveying vitality forms. In the second part, we address the means by which the dorso-central insula modulates the networks for controlling action execution and how the sensory and interoceptive information is conveyed to this insular sector. Finally, we present behavioral data showing the importance of vitality forms in social interactions.

关键词： action observation social interactions emotions insula mirror mechanism

Preoperative and postoperative risk factors for periprosthetic joint infection in primary total hip arthroplasty:A 1-year experience

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World Journal of Orthopedics 2022年第10期13卷 903-910页

作者： giuseppe Ferdinando Tella cesare Donadono Francesco Castagnini Barbara Bordini Monica Cosentino Michele Di Liddo Francesco Traina Ortopedia-Traumatologia e Chirurgia protesica e dei reimpianti d'anca e di ginocchio IRCCS Istituto Ortopedico RizzoliBologna 40125Italy Laboratorio di Tecnologia Medica IRCCS Istituto Ortopedico RizzoliBologna 40125Italy

BACKGROUND Periprosthetic joint infection(PJI)in primary total hip replacement(THR)is one of the most important threats in orthopedic surgery,so one important surgeon’s target is to avoid or early diagnose a *** the incidence of PJI is very low(0.69%)in our department,with an average follow-up of 595 d,this infection poses a serious threat due to the difficulties of treatment and the lower functional outcomes after *** To study the incidence of PJI in all operations occurring in the year 2016 in our department to look for predictive signs of potential *** We counted 583 THR for 578 patients and observed only 4 cases of infection(0.69%)with a mean follow-up of 596 d(min 30,max 1451).We reviewed all medical records to collect the data:duration and time of the surgery,presence,type and duration of the antibiotic therapy,preoperative diagnosis,blood values before and after surgery,transfusions,presence of preoperative drugs(in particularly anticoagulants and antiaggregant,corticosteroids and immunosuppressants),presence of some comorbidities(high body mass index,blood hypertension,chronic obstructive pulmonary disease,cardiac ischemia,diabetes,rheumatological conditions,previous local infections).RESULTS No preoperative,intraoperative,or postoperative analysis showed a higher incidence of *** did not find any class with evident major odds of *** our study,we did not find any border value to predict PJI and all patients had similar values in both groups(non-PJI and PJI).Only some categories,such as female patients,showed more frequency of PJI,but this difference related to sex was not statistically *** We did not find any category with a higher risk of PJI in THR,probably due to the lack of few cases of infection.

关键词： Primary total hip replacement Periprosthetic joint infection Preoperative risk factors Postoperative risk factors Preoperative and postoperative blood value Total hip arthroplasty

Dimethyl ether as circular hydrogen carrier:Catalytic aspects of hydrogenation/dehydrogenation steps

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Journal of Energy Chemistry 2021年第7期30卷 55-77页

作者： Enrico Catizzone cesare Freda Giacobbe Braccio Francesco Frusteri giuseppe Bonura ENEA–Italian Agency for New Technologies Department of Energetic TechnologiesLaboratory of Thermochemical Processes for Waste and Biomass ValorisationRotondellaItaly CNR-ITAE–Consiglio Nazionale delle Ricerche Istituto di Tecnologie Avanzate per l’Energia‘‘Nicola Giordano”Via S.Lucia Sopra Contesse 5I-98126 MessinaItaly

The intermittent nature of renewable resources requires for most applications the development of efficient and cost-effective technologies for steady supply of electrical *** storage of energy in the form of hydrogen chemically bound within organic molecules(rather than physically as compressed gas or cooled liquid)represents an alternative approach that is attracting great research *** to other liquid organic hydrogen carriers(LOHCs),dimethyl ether(DME)appears to have the largest potential impact on society,especially if inserted in technological chains of CO_(2) sequestration and utilization,so to determine an effective mitigation of environmental issues,without any net effect on the carbon ***,the steps of H2 storage and H2 release can take place in two coupled chemical processes,constituted by the exothermic synthesis of DME via CO_(2) hydrogenation and the endothermic steam reforming of DME,***,the latest advances in the development of heterogeneous bifunctional and hybrid catalysts for the direct hydrogenation of CO_(2) to DME are thoroughly reviewed,with special emphasis on thermodynamics,catalyst design and process *** many aspects behind the mechanism of DME synthesis from H2-CO_(2) streams are still to be uncovered,the recent progress in the research on H2 release by DME steam reforming is increasing the interest for effectively closing this binary H2 loop,in view of future green deals and sustainable research developments.

关键词： DME CO_(2)hydrogenation Steam Reforming Hybrid catalysts Hydrogen carrier

Antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis

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World Journal of Gastroenterology 2011年第36期17卷 4099-4103页

作者： Michela Barollo Valentina Medici Renata DIncà Antara Banerjee giuseppe Ingravallo Marco Scarpa Surajit Patak cesare Ruffolo Romilda Cardin Giacomo Carlo Sturniolo Department of Surgical and Gastroenterological Sciences University of PadovaPadova 35128Italy Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of CaliforniaDavisCA 95616United States Department of Pathology University of BariBari 70121Italy Department of Oncological Surgery Veneto Oncological InstitutePadova 35128Italy

AIM:To evaluate whether combination therapy with antitumour necrosis factor α (TNFα) antibody and Zn acetate is beneficial in dextran sodium sulphate (DSS) ***:Colitis was induced in CD1-Swiss mice with 5% DSS for 7 *** experimental mice were then randomised into the following subgroups:standard diet + DSS treated (induced colitis group);standard diet + DSS + subcutaneous 25 μg anti-TNFα treated group;Zn acetate treated group + DSS + subcutaneous 25 μg anti-TNFα;standard diet + DSS + subcutaneous 6.25 μg anti-TNFα treated group and Zn acetate treated group + DSS + subcutaneous 6.25 μg anti-TNFα.Each group of mice was matched with a similar group of sham control *** and histological features were scored *** of the colonic mucosa were assessed for myeloperoxidase activity as a biochemical marker of inflammation and DNA adducts (8OH-dG) as a measure of oxidative ***:DSS produced submucosal erosions,ulcers,inflammatory cell infiltration and cryptic abscesses which were reduced in both groups of mice receiving either anti-TNFα alone or combined with *** effect was more pronounced in the latter group (vs Zn diet,P < 0.02).Myeloperoxidase activity (vs controls,P < 0.02) and DNA adducts,greatly elevated in the DSS fed colitis group (vs controls,P < 0.05),were significantly reduced in the treated groups,with a more remarkable effect in the group receiving combined therapy (vs standard diet,P < 0.04).CONCLUSION:DSS induces colonic inflammation which is modulated by the administration of anti-TNFα.Combining anti-TNFα with Zn acetate offers marginal benefit in colitis severity.

关键词：肿瘤坏死因子综合治疗醋酸锌结肠炎抗氧化实验性 DNA加合物过氧化物酶活性

Balanced propofol sedation administered by nonanesthesiologists:The first Italian experience

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World Journal of Gastroenterology 2011年第33期17卷 3818-3823页

作者： Alessandro Repici Nico Pagano cesare Hassan Alessandra Carlino Giacomo Rando giuseppe Strangio Fabio Romeo Angelo Zullo Elisa Ferrara Eva Vitetta Daniel de Paula Pessoa Ferreira Silvio Danese Massimo Arosio Alberto Malesci Department of Gastroenterology IRCCS Istituto Clinico HumanitasVia Manzoni 5620089 RozzanoMilanItaly Department of Anaesthesiology IRCCS Istituto Clinico HumanitasVia Manzoni 5620089 RozzanoMilanItaly

AIM:To assess the efficacy and safety of a balanced approach using midazolam in combination with propofol,administered by nonanesthesiologists,in a large series of diagnostic ***:Consecutive patients undergoing diagnostic colonoscopy were sedated with a single dose of midazolam(0.05 mg/kg)and lowdose propofol(starter bolus of 0.5 mg/kg and repeated boluses of 10 to 20 mg).Induction time and deepest level of sedation,adverse and serious adverse events,as well as recovery times,were prospectively *** intubation and adenoma detection rates were also ***:Overall,1593 eligible patients were *** median dose of propofol administered was 70 mg(range:40120 mg),and the median dose of midazolam was 2.3 mg(range:24 mg).Median induction time of sedation was 3 min(range:14 min),and median recovery time was 23 min(range:1040 min).A moderate level of sedation was achieved in 1561(98%) patients,whilst a deep sedation occurred in 32(2%) *** oxygen desaturation requiring further oxygen supplementation occurred in 8(0.46%;95% CI:0.2%0.8%)*** serious adverse event was *** intubation and adenoma detection rates were 93.5%and 23.4%(27.8%for male and 18.5%for female,subjects),***:A balanced sedation protocol provided a minimalization of the dose of propofol needed to target a moderate sedation for colonoscopy,resulting in a high safety profile for nonanesthesiologist propofol sedation.

关键词：镇静剂异丙酚管理平衡意大利诱导时间恢复时间血氧饱和度

Mesenteric and portal vein thrombosis associated with hyperhomocysteinemia and heterozygosity for factor V Leiden mutation

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World Journal of Gastroenterology 2005年第48期11卷 7700-7701页

作者： giuseppe Famularo Giovanni Minisola Giulio cesare Nicotra Claudio De Simone Department of Internal Medicine

TO THE EDITORA 79-year-old man was hospitalized because of worsening upper abdominal pain which started two days before admission and was continuously present. His personal and family historywas uneventful, he did not smoke and denied toxic habits or using any medications, including over the-counter medications, herbal remedies or any vitamin supplements.

关键词：肠系膜静脉疾病血栓形成基因突变杂合性

Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis

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World Journal of Gastroenterology 2005年第34期11卷 5303-5308页

作者： Lino Polese Imerio Angriman giuseppe De Franchis Attilio Cecchetto Giacomo C.Sturniolo Renata D'Incà Marco Scarpa cesare Ruffolo Lorenzo Norberto Mauro Frego Davide F D'Amico Department of Gastroenterological and Surgical Sciences. Surgical Unit University of Padova Italy Department of Laboratory Medicine University of Padova Italy Department of Pathology University of Padova Italy Department of Gastroenterological and Surgical Sciences Gastroenterological Unit University of Padova Italy

AIM: To focus on the role of CD40 and CD40L in their ***: We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CD40 by B lymphocytes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy ***: Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlatedwith the presence of spondyloarthropathy, but not with pouchitis, or inflammatory ***: High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations.

关键词： CD40 CD40L 基因表达大肠炎滋补剂

Probiotic monotherapy and Helicobacter pylori eradication: A systematic review with pooled-data analysis

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World Journal of Gastroenterology 2018年第1期24卷 139-149页

作者： giuseppe Losurdo Rossella Cubisino Michele Barone Mariabeatrice Principi Gioacchino Leandro Enzo Ierardi Alfredo Di Leo Section of Gastroenterology Department of Emergency and Organ TransplantationUniversity "Aldo Moro"Piazza Giulio Cesare National Institute of Gastroenterology "S De Bellis" Research Hospital

AIM To define probiotic monotherapy effect on Helicobacter pylori(H. pylori) status by performing a systematic *** Methods of analysis and inclusion criteria were based on PRISMA recommendations. Relevant publications were identified by searching Pub Med, MEDLINE, Science Direct, and EMBASE. The end-point was to estimate eradication rate and urea breath test delta value before and after probiotic monotherapy across all studies and, overall, with a pooled data analysis. Adverse events of probiotic therapy were evaluated. The data were expressed as proportions/percentages, and 95%CIs were calculated. For continuous variables, we evaluated the weighted mean difference. Odd ratios(ORs) were calculated according to the Peto method for the comparison of eradication rates between probiotics and *** Eleven studies were selected. Probiotics eradicated H. pylori in 50 out of 403 cases. The mean weighted eradication rate was 14%(95%CI: 2%-25%, P =0.02). Lactobacilli eradicated the bacterium in 30 out of 235 patients, with a mean weighted rate of 16%(95%CI: 1%-31%). Saccharomyces boulardii achieved eradication in 6 out of 63 patients, with a pooled eradication rate of 12%(95%CI: 0%-29%). Multistrain combinations were effective in 14 out of 105 patients, with a pooled eradication rate of 14%(95%CI: 0%-43%). In the comparison of probiotics vs placebo, we found an OR of 7.91 in favor of probiotics(95%CI: 2.97-21.05, P < 0.001). Probiotics induced a mean reduction in delta values higher than placebo(8.61% with a 95%CI: 5.88-11.34, vs 0.19% for placebo, P < 0.001). Finally, no significant difference in adverse events was found between probiotics and placebo(OR = 1, 95%CI: 0.06-18.08).CONCLUSION Probiotics alone show a minimal effect on H. pylori clearance, thus suggesting a likely direct role.

关键词： Helicobacter pylori probiotics eradication meta-analysis breath test