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Molecular structure, pharmacokinetics and clinical evidence of brolucizumab: a narrative review

Annals of Eye Science 2021年第4期6卷 49-60页

作者： Francesco Pignatelli Alfredo Niro Fedele Passidomo giuseppe addabbo Eye Clinic Hospital“SS.Annunziata”ASL TarantoTarantoItaly

Macular neovascularization(MNV)is the hallmark of neovascular age-related macular degeneration(nAMD),one of the leading causes of vision loss in the developed *** current MNV standard of care including frequent intravitreal anti-vascular endothelial growth factor(VEGF)injections,although has revolutionized favorably the treatment,places a substantial burden on patients,caregivers,and *** is a newly developed single-chain antibody fragment that inhibits activation of VEGF receptor 2 with in vitro affinity and potency comparable to commercially-available anti-VEGF *** small molecular weight and its design allow for high solubility and retinal tissue penetration,and improve binding affinity to the *** a high clearance rate leading to minimal systemic exposure was *** has shown similar gains in visual acuity compared with other anti-VEGF molecules but a higher and earlier resolution of nAMD related fluid,achieving sustained macular dryness with longer mantainance injection interval ranging from 8 to 12 weeks after monthly loading *** cases of ocular inflammation also including retinal vasculitis and retinal vascular occlusions referred to an immune-mediated reaction posed safety concerns on selected patients and mantainance treatment interval shorter than 8 *** present review summarizes several key points including the molecular structure and pharmacokinetics,the preclinical and clinical evidence of brolucizumab administration evaluating its efficacy,tolerability,and safety,extended dosing regimens and other indications still under clinical investigation.

关键词： Neovascular age-related macular degeneration(nAMD) anti-vascular endothelial growth factor(anti-VEGF) single-chain antibody fragment brolucizumab

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Experimental Characterization of a Binary Actuated Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 445-453页

作者： CARBONE giuseppe Department of Engineering and Mathematics Sheffield Hallam UniversitySheffieldUnited Kingdom Laboratory of Robotics and Mechatronics University of Cassino and South LatiumCassino(Fr)Italy

This paper describes the BAPAMAN（Binary Actuated Parallel MANipulator） series of parallel manipulators that has been conceived at Laboratory of Robotics and Mechatronics（LARM）. Basic common characteristics of BAPAMAN series are described. In particular, it is outlined the use of a reduced number of active degrees of freedom, the use of design solutions with flexural joints and Shape Memory Alloy（SMA） actuators for achieving miniaturization, cost reduction and easy operation features. Given the peculiarities of BAPAMAN architecture, specific experimental tests have been proposed and carried out with the aim to validate the proposed design and to evaluate the practical operation performance and the characteristics of a built prototype, in particular, in terms of operation and workspace characteristics.

关键词： parallel manipulators binary actuation experimental characterization

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Arbitrary full-state hybrid projective synchronization for chaotic discrete-time systems via a scalar signal

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Chinese Physics B 2012年第6期21卷 94-99页

作者： giuseppe Grassi Dipartimento Ingegneria Innovazione Universitàdel Salento-73100 Lecce-Italy

In this paper we present a new projective synchronization scheme, where two chaotic （hyperchaotic） discrete-time systems synchronize for any arbitrary scaling matrix. Specifically, each drive system state synchronizes with a linear combination of response system states. The proposed observer-based approach presents some useful features： i） it enables exact synchronization to be achieved in finite time （i.e., dead-beat synchronization）; ii） it exploits a scalar synchronizing signal; iii） it can be applied to a wide class of discrete-time chaotic （hyperchaotic） systems; iv） it includes, as a particular case, most of the synchronization types defined so far. An example is reported, which shows in detail that exact synchronization is effectively achieved in finite time, using a scalar synchronizing signal only, for any arbitrary scaling matrix.

关键词： chaos synchronization full-state hybrid projective synchronization observer-based syn-chronization chaotic discrete-time systems dead beat control attractor scaling

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Fuzzy-entropy based robust optimization criteria for tuned mass dampers

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Earthquake Engineering and Engineering Vibration 2010年第2期9卷 285-294页

作者： giuseppe Carlo Marano giuseppe Quaranta Sara Sgobba Department of Environmental Engineering and Sustainable Development Technical University of Bari Department of Structural Engineering and Geotechnics University of Rome "La Sapienza" Faculty of Engineering International University UNINETTUNO

Tuned mass dampers (TMD) are well known as one of the most widely adopted devices in vibration control passive strategies. In the past few decades,many methods have been developed to find the optimal parameters of a TMD installed on a structure and subjected to a random base excitation process,but most of them are usually based on an implicit assumption that all of the structural parameters are deterministic. However,in many real cases this simplification is unacceptable,so robust optimal design criteria becomes aviable alternative to better support engineers in the design process. In Robust Design Optimization (RDO) approaches,indeed the solution must be able to not only minimize the performance but also to limitits variation induced by uncertainty. Most of the currently available RDO methods are based on a probabilistic description of the model uncertainty,even if in many cases they are not able to explicitly include the influence of all the possible sources of uncertainties. Therefore,in this study,a fuzzy version of the robust TMD design optimization problem is proposed. The consistency of the fuzzy approach is studied with respect to the available non-probabilistic formulations reported in the literature and an application to an example of a robust design of a linear TMD subjected to base random vibrations in the presence of fuzzy uncertainties. The results show that the proposed fuzzy-based approach is able to give a set of optimal solutions both in terms of structural efficiency and sensitivity to mechanical and environmental uncertainties.

关键词： tuned mass damper random vibration robust design fuzzy variable expected value fuzzy entropy

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Novel four-wing and eight-wing attractors using coupled chaotic Lorenz systems

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Chinese Physics B 2008年第9期17卷 3247-3251页

作者： giuseppe Grassi Dipartimento di Ingegneria dell’Innovazione Università del Salento

This paper presents the problem of generating four-wing （eight-wing） chaotic attractors. The adopted method consists in suitably coupling two （three） identical Lorenz systems. In analogy with the original Lorenz system, where the two wings of the butterfly attractor are located around the two equilibria with the unstable pair of complex-conjugate eigenvalues, this paper shows that the four wings （eight wings） of these novel attractors axe located around the four （eight） equilibria with two （three） pairs of unstable complex-conjugate eigenvalues.

关键词： chaotic attractors multi-wing attractor coupled Lorenz systems dynamical behaviours

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Reliability based multiobjective optimization for design of structures subject to random vibrations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 15-25页

作者： giuseppe Carlo MARANO Department of Environmental Engineering and Sustainable Development Technical University of Bari viale del Turismo 10-74100 Taranto Italy

Based on a multiobjective approach whose objective function (OF) vector collects stochastic reliability performance and structural cost indices, a structural optimization criterion for mechanical systems subject to random vibrations is presented for supporting engineer’s design. This criterion differs from the most commonly used conventional optimum design criterion for random vibrating structure, which is based on minimizing displacement or acceleration variance of main structure responses, without considering explicitly required performances against failure. The proposed criterion can properly take into account the design-reliability required performances, and it becomes a more efficient support for structural engineering decision making. The multiobjective optimum (MOO) design of a tuned mass damper (TMD) has been developed in a typical seismic design problem, to control structural vibration induced on a multi-storey building structure excited by nonstationary base acceleration random process. A numerical example for a three-storey building is developed and a sensitivity analysis is carried out. The results are shown in a useful manner for TMD design decision support.

关键词： Structural optimization Multiobjective optimization (MOO) Random vibration Tuned mass damper (TMD)

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Knowledge-Enhanced Conversational Agents

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Journal of Computer Science & Technology 2024年第3期39卷 585-609页

作者： Fabio Caffaro giuseppe Rizzo LINKS Foundation 10138 TurinItaly

Humanity has fantasized about artificial intelligence tools able to discuss with human beings fluently for *** efforts have been proposed ranging from ELIZA to the modern vocal *** the large interest in this research and innovation field,there is a lack of common understanding on the concept of conversational agents and general over expectations that hide the current limitations of existing *** work proposes a literature review on the subject with a focus on the most promising type of conversational agents that are powered on top of knowledge bases and that can offer the ground knowledge to hold conversation autonomously on different *** describe a conceptual architecture to define the knowledge-enhanced conversational agents and investigate different domains of *** conclude this work by listing some promising research pathways for future work.

关键词： conversational agent dialogue system knowledge enhancing artificial agent intelligent conversation

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Consequences of a two-time relativistic Bohmian model

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Communications in Theoretical Physics 2024年第7期76卷 63-73页

作者： giuseppe Raguni Departamento de Fisica Universidad de MurciaE-30071 MurciaSpain

Effects of a Bohmian type quantum-relativistic theory are *** model is obtained by introducing a new and independent time parameter whose relative motions are not directly observable and cause quantum uncertainties of the physical *** the usual de Broglie-Bohm theories,the Quantum Potential does not directly affect the observable motion,but determines the one that is relative to the new time *** turns out that the Zitterbewegung of a free particle,of which a more general law is obtained,is the key example of these hidden motions and,through it,it seems possible to give physical reality to the Feynman's paths.A relativistic revision of the uncertainty principle is also derived from the theory.

关键词： Quantum Mechanics Foundations de Broglie-Bohm theory Zitterbewegung uncertainty principle verification extra dimensions

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Experimental Characterization of Operation of a Waist-Trunk System with Parallel Manipulators

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Chinese Journal of Mechanical Engineering 2011年第5期24卷 713-722页

作者： CECCARELLI Marco CARBONE giuseppe Laboratory of Robotics and Mechatronics (LARM) University of Cassino

An extensive research activity has been focused on the upper and lower limbs of humanoid robots. However, due to mechanical design difficulties and complex control of multi-body system, the torso of humanoid robot is somehow a neglected or simplified design part. In this paper, operation performance of a new waist-trunk system as torso for humanoid robots is presented through results of lab experimental tests. The proposed waist-trunk system is composed of two 3 DOFs （degrees of freedom） parallel manipulators, which are connected in a serial chain architecture. A prototype is built by using two prototypes of CaPaMan （Cassino Parallel Manipulator）, which are convenient stiff architectures with easy-operation characteristics. Experimental tests are carried out with the aims to imitate lateral-bending and transverse-rotation movements of human torso. Operation performances like displacements, accelerations, and actuation torque are measured for a performance evaluation and design characterization of the used manipulator solution imitating human torso. Experimental test results are illustrated and discussed to show the practical operation feasibility of the proposed architecture and the operation characteristics of the built prototype.

关键词： humanoid robots waist-trunk system parallel manipulators experimental robotics

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Fractional-order systems without equilibria:The first example of hyperchaos and its application to synchronization

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Chinese Physics B 2015年第8期24卷 224-232页

作者： Donato Cafagna giuseppe Grassi Dipartimento Ingegneria Innovazione Università del Salento

A challenging topic in nonlinear dynamics concerns the study of fractional-order systems without equilibrium *** particular, no paper has been published to date regarding the presence of hyperchaos in these systems. This paper aims to bridge the gap by introducing a new example of fractional-order hyperchaotic system without equilibrium points. The conducted analysis shows that hyperchaos exists in the proposed system when its order is as low as 3.84. Moreover, an interesting application of hyperchaotic synchronization to the considered fractional-order system is provided.

关键词： fractional-order systems equilibrium points hyperchaotic systems synchronization

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