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Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer:A meta-analysis and systematic review

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Asian Journal of Urology 2024年第2期11卷 191-207页

作者： Stefano Salciccia Marco Frisenda giulio Bevilacqua Pietro Viscuso Paolo Casale Ettore De Berardinis Giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati Francesco Del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci Department of Urology Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly Department of Urology Humanitas20089 RozzanoMIItaly

Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic ***: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect ***: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.

关键词： Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyteratio Meta-analysis Radical prostatectomy Metastatic

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Challenges and advancing strategies of endoscopic submucosal dissection for early gastric cancer:The puzzle of eCura C1

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 439-444页

作者： giulio Calabrese Guido Manfredi Marcello F Maida Francesco V Mandarino Endrit Shahini Francesco Pugliese Paolo Cecinato Liboria Laterza Emanuele Sinagra Sandro Sferrazza Department of Gastroenterology and Endoscopy ARNAS Civico–Di Cristina–BenfratelliPalermo 90127SiciliaItaly Department of Gastroenterology and Digestive Endoscopy Ospedale MaggioreCrema 26013Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100SiciliaItaly Department of Gastroenterology and Digestive Endoscopy IRCCS Ospedale San RaffaeleMilan 20132LombardyItaly Department of Gastroenterology National Institute of Gastroenterology-IRCCS“Saverio de Bellis”Castellana GrotteBari 70013Italy Department of Digestive and Interventional Endoscopy Niguarda HospitalASST NiguardaMilan 20162LombardyItaly Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’OrsolaBologna 40138Emilia-RomagnaItaly Department of Gastroenterology and Endoscopy Fondazione Instituto San Raffaele GiglioCefalù90015PalermoItaly

In this editorial,we explore the challenges of managing noncurative resections in early gastric cancer after endoscopic submucosal dissection(ESD),starting from the consideration recently made by Zhu et ***,we evaluate the management of eCura C1 lesions,where decisions regarding further interventions are pivotal yet *** among endoscopists,surgeons,and pathologists is underscored to refine risk assessment and personalize therapeutic *** advancements in ESD techniques and interdisciplinary collaboration offer opportunities for outcome optimization in managing eCura C1 ***,despite needing further clinical validation,molecular biomarkers have emerged as promising tools for enhancing *** manuscript highlights the ongoing research attempts to define treatment paradigms effectively and evaluates the potential of emerging options,ultimately aiming to improve patient care and outcomes in this complex clinical scenario.

关键词： Early gastric cancer Endoscopic submucosal dissection eCura Non-curative resection Multidisciplinary approach

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The local Hlder exponent for the entropy of real unimodal maps In Memory of Lei Tan

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Science China Mathematics 2018年第12期61卷 2299-2310页

作者： giulio Tiozzo Department of Mathematics University of TorontoTorontoON M5S 2E4Canada

We consider the topological entropy h(θ) of real unimodal maps as a function of the kneading parameter θ(equivalently, as a function of the external angle in the Mandelbrot set). We prove that this function is locally Hlder continuous where h(θ) > 0, and more precisely for any θ which does not lie in a plateau the local Hlder exponent equals exactly, up to a factor log 2, the value of the function at that *** confirms a conjecture of Isola and Politi(1990), and extends a similar result for the dimension of invariant subsets of the circle.

关键词： entropy unimodal maps quadratic polynomials Hlder exponent

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Structured magnetic resonance imaging and endoanal ultrasound anal fistulas reporting template(SMART):An interdisciplinary Delphi consensus

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3288-3300页

作者： Iwona Sudoł-Szopińska Pankaj Garg Anders Mellgren Antonino Spinelli Stephanie Breukink Francesca Iacobellis Małgorzata Kołodziejczak Przemysław Ciesielski Christian Jenssen SMART Collaborative Group giulio Aniello Santoro Department of Radiology National Institute of GeriatricsRheumatology and RehabilitationWarsaw 02-637Poland Department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia Department of Surgical Oncology King Faisal Specialist Hospital&Research CenterRiyadh 11211Saudi Arabia Department of Biomedical Sciences Humanitas UniversityPieve Emanuele-MilanItaly IRCCS Humanitas Research Hospital Rozzano-MilanItaly Department of Surgery Maastricht and NUTRIM Institute of Nutrition and Translational Research in Metabolism GROW-Research Institute for Oncology and Reproductionthe Netherlands Department of General and Emergency Radiology A.Cardarelli HospitalNaples 80131CampaniaItaly Warsaw Proctology Center St.Elizabeth HospitalWarsaw 02-616Poland Department of Internal Medicine Hospital Märkisch OderlandStrausberg 15344BrandenburgGermany Brandenburg Institute for Clinical Ultrasound Neuruppin 16186BrandenburgGermany Third Referral Pelvic Floor Center Division of Surgery 2AULSS n.2 Marca TrevigianaDISCOG University of PaduaTrevisoItaly 不详

BACKGROUND There is still considerable heterogeneity regarding which features of cryptoglandular anal fistula on magnetic resonance imaging(MRI)and endoanal ultrasound(EAUS)are relevant to surgical *** a con-sequence,the quality and completeness of the report are highly dependent on the training and experience of the *** To develop a structured MRI and EAUS template(SMART)reporting the minimum dataset of information for the treatment of anal *** This modified Delphi survey based on the RAND-UCLA appropriateness for consensus-building was conducted between May and August *** hundred and fifty-one articles selected from a systematic review of the lite-rature formed the database to generate the evidence-based statements for the Delphi *** questions were anonymously voted by an interdisciplinary multidisciplinary group for a maximum of three iterative *** degree of agreement was scored on a numeric 0–10 *** consensus was defined as a score≥8 for≥80%of the *** Eleven scientific societies(3 radiological and 8 surgical)endorsed the *** three rounds of voting,the experts(69 colorectal surgeons,23 radiologists,2 anatomists,and 1 gastroenterologist)achieved consensus for 12 of 14 statements(85.7%).Based on the results of the Delphi process,the six following features of anal fistulas were included in the SMART:Primary tract,secondary extension,internal opening,presence of collection,coexisting le-sions,and sphincters *** A structured template,SMART,was developed to standardize imaging reporting of fistula-in-ano in a simple,systematic,time-efficient way,providing the minimum dataset of information and visual diagram useful to refer-ring physicians.

关键词： Anal fistulas Fistula-in-ano Template Reporting Magnetic resonance imaging Endoanal ultrasound

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Optical nonlinearity goes ultrafast in 2D semiconductor-based nanocavities

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Light(Science & Applications) 2022年第6期11卷 1016-1018页

作者： Armando Genco giulio Cerullo Dipartimento di Fisica Politecnico di MilanoPiazza Leonardo da Vinci 3220133 MilanoItaly

Hybrid systems of silver nanodisks strongly coupled to monolayer tungsten-disulfide(WS_(2))show giant room-temperature nonlinearity due to their deeply sub-wavelength localized nature,resulting in ultrafast modificati... 详细信息

关键词： nonlinearity silver disulfide

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刚性与弹性平衡的英国乡村规划框架与政策

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国际城市规划 2024年第4期39卷 33-41页

作者：忻晟熙朱利奥·韦尔迪尼郭青源同济大学建筑与城市规划学院上海同济城市规划设计研究院英国威斯敏斯特大学建筑与城市学院联合国教科文组织、世界旅游组织伦敦政治经济学院地理与环境系

乡村振兴战略的多元目标要求乡村规划系统必须有效平衡刚性和弹性。英国拥有丰富的乡村规划治理经验,其规划体系“管理为主,蓝图为辅”的柔性特征对中国的空间规划改革具有启示意义。本文首先简要分析了中英乡村不同的社会经济状况,随... 详细信息

乡村振兴战略的多元目标要求乡村规划系统必须有效平衡刚性和弹性。英国拥有丰富的乡村规划治理经验,其规划体系“管理为主,蓝图为辅”的柔性特征对中国的空间规划改革具有启示意义。本文首先简要分析了中英乡村不同的社会经济状况,随后分别阐释了英国柔性的规划编制和管控机制。在此基础上,笔者梳理了英国在乡村保护和乡村发展两个领域的主要议题和政策举措,展示了规划实践中的刚弹平衡方法,旨在推动我国有针对性地借鉴英国的经验。

关键词：乡村规划国土空间规划开发控制乡村振兴英国

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Quantum superreplication of states and gates

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Frontiers of physics 2016年第3期11卷 61-79页

作者： giulio Chiribella Yuxiang Yang Department of Computer Science The University of Hong Kong Pokfulam Road Hong Kong China

Although the no-cloning theorem forbids perfect replication of quantum information, it is sometimes possible to produce large numbers of replicas with vanishingly small error. This phenomenon, known as quantum superreplication, can occur for both quantum states and quantum gates. The aim of this paper is to review the central features of quantum superreplication and provide a unified view of existing results. The paper also includes new results. In particular, we show that when quantum superreplication can be achieved, it can be achieved through estimation up to an error of size O（M/N2）, where N and M are the number of input and output copies, respectively. Quantum strategies still offer an advantage for superreplication in that they allow for exponentially faster reduction of the error. Using the relation with estimation, we provide i） an alternative proof of the optimality of Heisenberg scaling in quantum metrology, ii） a strategy for estimating arbitrary unitary gates with a mean square error scaling as log N/N2, and iii） a protocol that generates O（N2） nearly perfect copies of a generic pure state U｜0） while using the corresponding gate U only N times. Finally, we point out that superreplication can be achieved using interactions among k systems, provided that k is large compared to M2/N2.

关键词： quantum cloning quantum metrology quantum superreplication Heisenberg limit,quantum networks

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Influence of Process Parameters and Sr Addition on the Microstructure and Casting Defects of LPDC A356 Alloy for Engine Blocks

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Journal of Materials Science & Technology 2016年第6期32卷 515-523页

作者： giulio Timelli Daniele Caliari Jovid Rakhmonov Department of Management and Engineering University of PadovaStradeUa S.Nicola3 1-36100 VicenzaItaly

The effects of Sr addition and pressure increase on the microstructure and casting defects of a low-pressure die cast （LPDC） AISi7Mg0.3 alloy have been studied. Metallographic and image analysis techniques have been used to quantitatively examine the microstructural changes and the amount of porosity occurring at different Sr levels and pressure parameters. The results indicate that an increase in the filling pressure induces lower heat dissipation of the liquid close to the die/core surfaces, with the formation of slightly greater dendrite arms and coarser eutectic Si particles. On the other hand, the increase in the Sr level leads to finer microstructural scale and eutectic Si. The analysed variables, within the experimental conditions, do not affect the morphology of eutectic Si particles. Higher applied pressure and Sr content generate castings with lower amount of porosiW. However, as the filling pressure increases the flow of metal inside the die cavity is more turbulent, leading to the formation of oxide films and cold shots. In the analysed range of experimental conditions, the design of experiment methodology and the analysis of variance have been used to develop statistical models that accurately predict the average size of secondary dendrite arm spacing and the amount of porosity in the low-pressure die cast AISiTMg0.3 alloy.

关键词： Aluminium alloys Engine block Microstructure Casting defects Sr addition Process parameters

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On the electrophysiology of the atrial fast conduction system:an uncertain quantification study

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Acta Mechanica Sinica 2021年第2期37卷 264-278页

作者： giulio Del Corso Roberto Verzicco Francesco Viola GSSI(Gran Sasso Science Institute) L'AquilaItaly University of Roma Tor Vergata RomeItaly POF Group University of TwenteEnschedeThe Netherlands

Cardiac modeling entails the epistemic uncertainty of the input parameters,such as bundles and chambers geometry,electrical conductivities and cell parameters,thus calling for an uncertainty quantification(UQ)*** the cardiac activation and the subsequent muscular contraction is provided by a complex electrophysiology system made of interconnected conductive media,we focus here on the fast conductivity structures of the atria(internodal pathways)with the aim of identifying which of the uncertain inputs mostly influence the propagation of the depolarization ***,the distributions of the input parameters are calibrated using data available from the literature taking into account gender *** output quantities of interest(Qols)of medical relevance are defined and a set of metamodels(one for each Qol)is then trained according to a polynomial chaos expansion(PCE)in order to run a global sensitivity analysis with non-linear variance-based SoboF indices with confidence intervals evaluated through the bootstrap *** most sensitive parameters on each Qol are then identified for both genders showing the same order of importance of the model inputs on the electrical ***,the probability distributions of the Qols are obtained through a forward sensitivity analysis using the same trained *** results that several input parameters-including the position of the internodal pathways and the electrical impulse applied at the sinoatrial node一have a little influence on the Qols ***-versa the electrical activation of the atrial fast conduction system is sensitive on the bundles geometry and electrical conductivities that need to be carefully measured or calibrated in order for the electrophysiology model to be accurate and predictive.

关键词： Uncertainty quantification Global sensitivity analysis Forward analysis Atrial modelling Electrophysiology Monodomain model

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Tight-binding models for ultracold atoms in optical lattices：general formulation and applications

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Science China(Physics,Mechanics & Astronomy) 2016年第6期59卷 1-23页

作者： Michele Modugno Julen Ibanez-Azpiroz giulio Pettini Departamento de Fisica Teorica e Historia de la Ciencia Universidad del Pais Vasco UPV/EHU Bilbao 48080 Spain IKERBASQUE Basque Foundation for Science Bilbao 48011 Spain Peter Griinberg Institute and Institute for Advanced Simulation Forschungszentrum Jiilich & JARA Jiilich D-52425 Germany Dipartimento di Fisica e Astronomia Universita di Firenze and INFN Sesto Fiorentino 50019 Italy

Tight-binding models for ultracold atoms in optical lattices can be properly defined by using the concept of maximally localized Wannier functions for composite bands. The basic principles of this approach are reviewed here, along with different applications to lattice potentials with two minima per unit cell, in one and two spatial dimensions. Two independent methods for computing the tight-binding coefficients—one ab initio, based on the maximally localized Wannier functions, the other through analytic expressions in terms of the energy spectrum—are considered. In the one dimensional case, where the tight-binding coefficients can be obtained by designing a specific gauge transformation, we consider both the case of quasi resonance between the two lowest bands, and that between s and p orbitals. In the latter case, the role of the Wannier functions in the derivation of an effective Dirac equation is also reviewed. Then, we consider the case of a two dimensional honeycomb potential, with particular emphasis on the Haldane model, its phase diagram, and the breakdown of the Peierls substitution. Tunable honeycomb lattices, characterized by movable Dirac points, are also considered. Finally, general considerations for dealing with the interaction terms are presented.

关键词： ultracold atoms optical lattices tight-binding models Wannier functions effective Dirac equation honeycomb lattices

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