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Efficacy of Plerixafor for Peripheral Stem Cell Mobilisation in Autologous Transplantation: A Single Centre Study

Journal of Cancer Therapy 2020年第8期11卷 483-490页

作者： Kiran Pura Krishnamurthy D. V. Ganesha girish Badarkhe Diganta Hazarika Radheshyam Naik Department of Medical Oncology HealthCare Global Enterprises Ltd. Bangalore India Department of Medical Oncology St John’s Medical College Hospital Bangalore India Department of Hematology Healthcare Global Enterprises Ltd. Bangalore India Department of Pathology Healthcare Global Enterprises Ltd. Bangalore India

Plerixafor is a stem cell mobilising agent, and when administered along with G-CSF has been shown to improve CD34+ stem cell collections in lymphoma and multiple myeloma patients compared to G-CSF alone. Patients who failed to mobilize 6 cells/kg on Day 1 collection received Plerixafor and G CSF for further collections. Study population was divided into two groups as plerixafor yes (PY) who are poor mobilizers and Plerixafor No (PN) who are good mobilizers. Out of 49 patients, 28 patients were in PY group and 21 patients in PN group. Median value of apheresis CD34 of day 1 was 1.75 (range 0.258 to 8.52) in PY group and 2.63 (range 1.06 to 6.29) in PN group and that of day 2 was 3.845 (range 0.317 to 13.89) in PY group and 3.18 (range 0.88 to 6.348) in PN group. Median value of total apheresis CD34 was 8.10 (range 4.33 to 18.66) in PY group and 7.58 (range 4.06 to 9.8) in PN group. Median day of neutrophil engraftment was 11.5 (range 9 - 22) in PY group and 11 (range 9 - 36) in PN group whereas median day of platelet engraftment was 14 (range 9 - 98) in PY group and 13 (range 11 - 98) in PN group. It can be concluded that the use of plerixafor not only enabled poor mobilizers of Lymphoma and Multiple Myeloma to collect adequate stem cells to proceed to ASCT, but also had early neutrophil and platelet engraftment which was comparable with good mobilizers.

关键词： Plerixafor Poor Mobilizers ASCT

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Static pressures, intra-access blood flow and dynamic Kt/V profiles in the prediction of dialysis access function

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World Journal of Nephrology 2019年第3期8卷 59-66页

作者： Abhilash Koratala Bhagwan Dass Kawther F Alquadan Simrun Sharma girish Singhania Abutaleb A Ejaz Division of Nephrology Hypertension and Transplantation University of Florida Gainesville FL 32610 United States Division of Nephrology and Hypertension University of Utah Salt Lake City UT 84112 United States

BACKGROUND Hemodialysis machine-generated circuit pressures and clearance profiles are potential predictors of quality assurances. In our practice, we previously we observed that elevated static access pressures were associated with abnormal Kt/V values, high access recirculation and deviation of the Kt/V profile (Abnormal Kt/V profile) from normally expected values (Normal Kt/V profile). AIM To hypothesize that static or derived access pressures would correlate with direct intra-access blood flow rates and that clearance (Kt/V) profiles would correlate with measured Kt/V values. METHODS Static access pressures, real-time adequacy of dialysis and intra-access blood flow were investigated in end stage renal disease patients undergoing hemodialysis. Wilcoxon-Mann-Whitney test, chi-square test or Fisher’s exact test was used to investigate differences between the groups;Spearman’s rank correlation test to investigate relationships between static pressures, direct intra-access pressures and Kt/V profiles;and multinomial logistic regression models to identify the independent effect of selected variables on Kt/V profiles. Odds ratio were calculated to measure the association between the variables and Kt/V profiles. RESULTS One hundred and seven patients were included for analysis. There were no significant differences between genders, and types of vascular access between the normal vs. abnormal clearance (Kt/V) profile groups. No significant correlation could be demonstrated between static access pressures and Kt/V profiles, static access pressures and intra-access blood flow, intra-access blood flow and Kt/V profiles, measured Kt/V and Kt/V profiles or recirculation and Kt/V profiles. CONCLUSION In this study utilizing measured versus estimated data, we could not validate that dialysis machine generated elevated static pressures predict intra-access blood flow disturbances or that abnormal Kt/V profiles predict access recirculation or inadequate dialysis. These parameter

关键词： Static Intra-access Pressures Hemodialysis Kt/V

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Isolation of Multi-Drug Resistant Paenibacillus sp. from Fertile Soil： An Imminent Menace of Spreading Resistance

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Journal of Life Sciences 2010年第5期4卷 15-19页

作者： Pallavi B. Pednekar Roopesh Jain Narsinh L. Thakur girish B. Mahajan Department of Biotechnology The KET＇s V.G. Vaze College Mumbai University Navi-mumbai 400709 India Department of Natural Products Piramal Life Sciences Limited Mumbai 400063 India Bio-organic chemistry Laboratory National Institute of Oceanography （CSIR） Goa 403004 India

There are a good number of reports in the literature stating spread of resistance from normal soil flora to nosocomial microorganism through various ways. Similarly during the study of antimicrobial susceptibility pattern in the microflora, a multidrug resistant bacterium has been isolated from soil collected in Maharashtra state （India）. The bacterium exhibited a resistance to various classes of antibiotics namely glycopeptide, beta-lactams, aminoglycosides, macrolides and lincosomides. The bacterial strain showed its resemblance to the genus Paenibacillus. This constitutes the first report of its kind as to the multi-drug resistance trait in the genus Paenibacillus phenotype, especially in close phylogenetic neighbour of Paenibacillus daejeonensis. The resistance pattern displayed by this strain particularly highlights the possible presence of multiple resistant determinants in microflora of the soil rhizosphere. In view of the recent reports about the Paenibacillus spp. in clinical derived strains, such multi-drug resistance factors in this genus adds to menace of transmission of resistance to common soil originating pathogen. The data also supports the fact that the resistances to certain antibiotics need not always be due to exposure to particular antibiotic or similar substance.

关键词： Paenibacillus daejeonensis multi-drug resistant Paenibacillus

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Hoffa＇s fracture with ipsilateral fibular fracture in a 16-year-old girl： An approach to a rare injury

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chinese Journal of Traumatology 2015年第3期18卷 178-180页

作者： Abhijeet Salunke G.I. Nambi Saranjeet Singh Prem Menon G.N. girish Danakrisna Vachalam Department of Orthopaedic Surgery Pramukswami Medical College Sri Krishna Hospital Karamsad 388325 Anand Gujarat India

Hoffa＇s fracture is an uncommon fracture of the femoral condyle with coronal orientation of the fracture line. The mechanism of injury in pediatric Hoffa＇s fracture is road traffic accident, sports injury, and trivial injury. Clinical examination and proper imaging is important for diagnosis of pediatric Hoffa＇s fracture because of high chances of missing these injuries which can lead to nonunion and malunion at the fracture site. Open reduction and anatomical reduction of intraarticular fragment is the gold standard treatment of these fractures. We present a rare case of Hoffa＇s fracture in a 16-year-old girl with asso- ciated ipsilateral fibular fracture.

关键词： Fractures Bone Pediatrics Fibula Intraarticular fractures

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用于生产聚酯工业丝的Bepex固相聚合系统

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合成纤维 2009年第11期38卷 51-52页

作者： girish M.Bhatt 金磊

由于新原料、没备和技术的发展，聚酯长丝和短纤不断开发出新的应用领域。用于工业领域的聚酯长丝虽然并非新生事物，但在过去的几十年里就质量、性能和价格方面而言可渭进展神速。工业应用领域中用于造纸的滤网、传送带织物以及汽车应... 详细信息

由于新原料、没备和技术的发展，聚酯长丝和短纤不断开发出新的应用领域。用于工业领域的聚酯长丝虽然并非新生事物，但在过去的几十年里就质量、性能和价格方面而言可渭进展神速。工业应用领域中用于造纸的滤网、传送带织物以及汽车应用领域中的安全气囊、安全带和帘子线都要求使用高性能的聚酯长丝。

关键词：聚酯工业丝固相聚合系统生产聚酯长丝工业应用工业领域安全气囊

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Incidence of Urinary Tract Infections and Its Aetiological Agents among Pregnant Women in Karnataka Region

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Advances in Microbiology 2013年第6期3卷 473-478页

作者： Manjula N. G. girish C. . Math A. Patil Subhashchandra M. Gaddad channappa T. Shivannavar Department of Post Graduate Studies and Research in Microbiology Gulbarga University Gulbarga India

Urinary tract infection (UTI) is the most common medical complications of pregnancy together with anaemia and hypertension and it occurs approximately in 5%-10% of all pregnancies. The aim of this study was to determine the incidence of UTI and prevalence of uropathogens among pregnant women. During the study period from December 2009 to August 2010, 417 urine samples were analyzed. UTI was diagnosed by growth of at least 105 CFU/ml of a urinary tract pathogen in a culture of a midstream urine sample. The isolated bacteria were identified by biochemical tests. The results showed that 49.4% of pregnant women have UTI. E. coli which was the most frequently isolated organism (56.79%), followed by Klebsiella sps (19.9%), Pseudomonas sps (6.3%), and Proteus sps (5.8%). Other pathogens isolated were Enterobacter (3.8%), Citrobacter (1.4%) and Enterococcus sps (0.9%). Of the variables examined, the highest prevalence rate was observed where, 53.3% of the infected women were in the age group 36 to 40 years, 54.15% were in their 3rd trimester;also the highest infection rate (70.2%) was observed in 7th month of pregnancy, concluding that old age pregnancy increased parity prone for UTI apart from individual hygiene and economical status.

关键词： UTI Pregnancy Uropathogens E coli ASB

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Caerulomycin A—An Antifungal Compound Isolated from Marine Actinomycetes

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Advances in Microbiology 2014年第9期4卷 567-578页

作者： Vaibhav Ambavane Pradipta Tokdar Rajashri Parab E. S. Sreekumar girish Mahajan Prabhu Dutt Mishra Lisette D’Souza Prafull Ranadive Bioorganic chemistry Laboratory CSIR-National Institute of Oceanography Dona Paula Goa India Natural Products Department Piramal Enterprises Limited Mumbai India

Actinomycetes have been prolific sources of novel secondary metabolites with a range of biological activities that may ultimately find application as therapeutic compounds. Hence several drug discovery companies are engaged in isolation of novel bioactive metabolites from these microbial sources. Antibiotics form the major class of such bioactive metabolites and have been widely used for treating infectious diseases. One of the most critical problems in clinical practice is the increase of prevalence of drug resistant strains, especially azole resistance among fungi. Due to this, there is a constant need for development of new antifungal antibiotics having novel scaffolds and/or mechanism of action. In our in-house screening program in the quest of novel and superior antifungal compounds, an actinomycetes strain PM0525875 was isolated from a marine invertebrate. The extracts of this microbe showed potent in-vitro antifungal activity against drug resistant fungal strains. The antifungal active peak from the extract obtained by shake flask fermentation was identified by chromatographic and other analytical techniques during bioactivity guided isolation. Later the fermentation conditions were optimized in 30 L fermentor for the production of sufficient amount antifungal compound for complete structural characterization. Consequently the fermented broth extract was subjected to bioactivity-guided fractionation, to isolate the active principle using different preparative chromatographic techniques followed by its characterization. The active principle was characterized to be Caerulomycin A. Minimum inhibitory concentration (MIC) of the compound was found in the range of 0.39 - 1.56 μg/ml against pathogenic fungal test strains. The phylogenetic analysis of producer strain using 16S rRNA sequence showed closest match with Actinoalloateichus cyanogriseus. Herewith we report the isolation of Caerulomycin A from marine invertebrate-associated Actinoalloteichus sp. using optim

关键词： Caerulomycin A Antifungal Non-Polyene Actinoalloateichus cyanogriseus Marine Actinomycetes

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21世纪的生物学教育展望

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中学生物教学 1995年第2期 8-9,13页

作者： Emmett L. Wright girish Govindarajan 高震上海教育学院生物系 200333

科学技术和地球人类及其他生命环境的互相作用的整体化,看来不是遥远的事。例如先进的农业技术已促使阿拉伯土地灌溉和施肥高效系统出现,使农业生产力大大提高,形成了世界上广泛的“绿色革命”。科学技术带给我们很多的利益,但同时也促... 详细信息

科学技术和地球人类及其他生命环境的互相作用的整体化,看来不是遥远的事。例如先进的农业技术已促使阿拉伯土地灌溉和施肥高效系统出现,使农业生产力大大提高,形成了世界上广泛的“绿色革命”。科学技术带给我们很多的利益,但同时也促使自然资源过量耗损,不断地破坏生态系统,造成无可挽回的损害。如果教育能影响地球社会的生存,那么对社会、道德和环境互相作用的探索是十分紧迫的。学校教学大纲中的技能培养。

关键词：生物学教育生物学教学 21世纪生物学课程生物圈生态系统生物学教师课程标准科学技术整体化

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用于高环境温度的住宅吸收式制冷机

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家电科技 2021年第1期1卷 12-13页

作者： girish Kini Sriram chandrasekaran Michael Tambasco Srinivas Garimella 不详

本文提出了一种独立、紧凑、热驱动的氨水吸收式制冷机设计。该制冷机设计用在高于40℃的环境温度下提供10.5 kW的冷却能力。新设计的热质交换器结构紧凑,并最小化相应的几何形状及物理尺寸。这项研究将高效换热器设计的优化与微型换热... 详细信息

本文提出了一种独立、紧凑、热驱动的氨水吸收式制冷机设计。该制冷机设计用在高于40℃的环境温度下提供10.5 kW的冷却能力。新设计的热质交换器结构紧凑,并最小化相应的几何形状及物理尺寸。这项研究将高效换热器设计的优化与微型换热器技术相结合,展示了氨水吸收式冷却器的紧凑高效性,同时在较高的排热温度下,该冷却器能够提供较高的性能系数(COP)。热交换器是在原型系统中制造和组装的,系统流程图和原型如图1所示。

关键词：吸收式制冷机系统流程图环境温度热质交换热交换器物理尺寸几何形状冷却能力

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喜马拉雅山区压力之下的土地利用状况:系统响应

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人类环境杂志 1997年第2期26卷 122-124页

作者： girish C.S.Negi Varun Joshi 闵庆文 G.B.Pant Institute of Himalayan Environment Development Garhwal Unit P.O.Box-92 Srinagar-Garhwal 246 174India

引言在印度格尔瓦喜马拉雅山区,一些地方正在经历着耕地向荒地转变的过程。这一区域农业在生态学与经济学上都不能持续发展的主要因素有:靠雨水耕作(只有18.4%的耕地可以灌溉)、小规模、零碎的土地分布在崎岖的地形上(70%的地块<1hm^2,... 详细信息

引言在印度格尔瓦喜马拉雅山区,一些地方正在经历着耕地向荒地转变的过程。这一区域农业在生态学与经济学上都不能持续发展的主要因素有:靠雨水耕作(只有18.4%的耕地可以灌溉)、小规模、零碎的土地分布在崎岖的地形上(70%的地块<1hm^2,且可能分布在30块从0.01到0.058hm^2不等的小梯田上);由于土地/人口比高而作物的产出/投入比低而使作物产量不高;采用集约经营农业的规模有限;用于畜牧业以及为农田培肥的植被稀少等。该区域居民的主要职业是务农,这就要求大量的饲料以饲养性畜。

关键词：喜玛拉雅山区土地利用状况系统响应

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