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2D vs 3D laparoscopic right colectomy:A propensity score-matching comparison of personal experience with systematic review and meta-analysis

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World Journal of Gastrointestinal Surgery 2021年第6期13卷 597-619页

作者： Gianluca Costa Pietro Fransvea Luca Lepre Fabio Rondelli Alessandro Costa Michela Campanelli Giorgio Lisi Maria Rosaria Mastrangeli giovanni guglielmo laracca giovanni Maria Garbarino Graziano Ceccarelli Surgery Center Campus Bio-MedicoRome 00128Italy Department of Emergency and Trauma Surgery Fondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy General Surgery Unit Santo Spirito in Sassia HospitalRome 00193Italy Department of Surgical Science University of PerugiaSanta Maria Teaching HospitalTerni 05100Italy Catholic University“Our Lady of Good Council”School of Medicine Tirane 1023Albania Department of Emergency Surgery Tor Vergata University HospitalRome 00133Italy Department of General Surgery Sant'Eugenio HospitalRome 00144Italy Department of Medical Surgical Science and Translational Medicine Sapienza University of RomeSant'Andrea HospitalRome 00189Italy General Surgery Unit San Giovanni Battista HospitalFoligno 06034Italy

BACKGROUND The benefits of laparoscopic approach for right colectomy have been well ***,the technical difficulty to construct the intra-corporeal anastomosis is still *** To analyze the results of 3D and 2D laparoscopic right colectomy and to compare it to the published series through a systematic review and *** A retrospective study with propensity score matching analysis of patients undergoing laparoscopic right colectomy at Umbria2 Hospitals from January 2014 to March 2020 was performed.A systematic review was accomplished comparing 2D and 3D right *** In the personal series 47 patients of the 2D group were matched to 47 patients of the 3D *** 3D group showed a favorable trend in terms of mean operative time(170.7±32.9 min vs 183.8±35.4 min;P=0.053)and a significant lower anastomotic time(16.9±2.3 min vs 19.6±2.9 min,P<0.001).The complete mesocolic excision(CME)subgroups analysis showed a shorter anastomotic time(16.5±1.8 min vs 19.9±3.0 min;P<0.001)and operative time(175.0±38.5 min vs 193.7±37.1 min;P=0.063)in the 3D *** studies and our series were included in the meta-analysis with 551 patients(2D group:291;3D group:260).The pooled analysis demonstrated a significant difference in favour of the 3D group regarding the operative time(P<0.001)and the anastomotic time(P<0.001)while no differences were identified between groups in terms of blood loss(P=0.827),LNH yield(P=0.243),time to first flatus(P=0.333),postoperative complications(P=0.718)and length of stay(P=0.835).CONCLUSION The meta-analysis results showed that 3D laparoscopic right colectomy shortens operative and anastomotic time without affecting the standard *** our series,the advantage of the 3D system becomes evident when CME and/or more complex associated procedure are requested significantly reducing both the total operative and the anastomotic time.

关键词： Colon cancer Right colectomy Laparoscopy Complete mesocolic excision Two-dimensional Three-dimensional

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti giovanni Camardese Daniela Chieffo Antonio Gasbarrini giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà giovanni Lughezzani guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

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Hepatitis B in pregnancy

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World Journal of Gastroenterology 2012年第34期18卷 4677-4683页

作者： guglielmo Borgia Maria Aurora Carleo giovanni Battista Gaeta Ivan Gentile Department of Public Medicine and Social Security Section of Infectious DiseasesUniversity of Naples "Federico Ⅱ"80131 NaplesItaly Department of Internal Medicine Section of Infectious DiseasesSecond University of Naples80131 NaplesItaly

Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Management of HBV infection in pregnancy is difficult because of several peculiar and somewhat controversial aspects. The aim of the present review is to provide a tool that may help physicians to correctly manage HBV infection in pregnancy. This review focuses on (1) the effect of pregnancy on HBV infection and of HBV infection on pregnancy; (2) the potential viral transmission from mother to newborn despite at-birth prophylaxis with immunoglobulin and vaccine; (3) possible prevention of mother-to-child transmission through antiviral drugs, the type of antiviral drug to use considering their efficacy and potential teratogenic effect, and the timing of their administration and discontinuation; and (4) the evidence for the use of elective caesarean section vs vaginal delivery and the possibility of breastfeeding.

关键词：肝炎 B 病毒怀孕治疗 Tenofovir Lamivudine Telbivudine Entecavir 母乳喂养选任的 caesarean 节

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Lumen-apposing-metal stent misdeployment in endoscopic ultrasound-guided drainages:A systematic review focusing on issues and rescue management

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World Journal of Gastroenterology 2023年第21期29卷 3341-3361页

作者： Elia Armellini Flavio Metelli Andrea Anderloni Anna Cominardi giovanni Aragona Michele Marini FabioPace Department of Gastroenterology ASST-BergamoestSeriate 24068BergamoItaly Gastroenterology and Digestive Endoscopy Unit Fondazione IRCCS Policlinico San MatteoPavia 27100Italy Department of Gastroenterology “Guglielmo da Saliceto”HospitalPiacenza 29121Italy Department of General Surgery ASST-BergamoestSeriate 24068Italy

BACKGROUND The introduction of lumen-apposing metal stents(LAMS)for endoscopic ultrasound(EUS)-guided drainages has marked a turning point in the field of interventional ultrasound and it is gathering worldwide diffusion in different clinical ***,the procedure may conceal unexpected *** misdeployment is the most frequent cause of technical failure and it can be considered a procedure-related adverse event when it hampers the conclusion of the planned procedure or results in significant clinical *** misdeployment can be managed successfully by endoscopic rescue maneuvers to allow the completion of the *** date,no standardized indication is available to guide an appropriate rescue strategy depending on the type of procedure or of *** To evaluate the incidence of LAMS misdeployment during EUS-guided choledochoduodenostomy(EUS-CDS),gallbladder drainage(EUS-GBD)and pancreatic fluid collections drainage(EUS-PFC)and to describe the endoscopic rescue strategies adopted under the *** We conducted a systematic review of the literature on PubMed by searching for studies published up to October *** search was carried out using the exploded medical subject heading terms“lumen apposing metal stent”,“LAMS”,“endoscopic ultrasound”and“choledochoduodenostomy”or“gallbladder”or“pancreatic fluid collections”.We included in the review on-label EUS-guided procedures namely EUS-CDS,EUS-GBD and *** those publications reporting EUS-guided LAMS positioning were *** studies reporting a technical success rate of 100%and other procedure-related adverse events were considered to calculate the overall rate of LAMS misdeployment,while studies not reporting the causes of technical failure were *** reports were considered only for the extraction of data regarding the issues of misdeployment and rescue *** following data were collected from each study:Author,year of publicat

关键词： Lams misdeployment Endoscopic ultrasound-guided drainage Lams maldeployment Biliary drainage Gallbladder drainage Pancreatic fluid collections Lumen-apposing metal stents

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Effectiveness and versatility of biological prosthesis in transplanted patients

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World Journal of Transplantation 2017年第1期7卷 43-48页

作者： giovanni Vennarecci Gianluca Mascianà Edoardo De Werra giovanni Battista Levi Sandri Daniele Ferraro Mirco Burocchi giovanni Tortorelli Nicola guglielmo Giuseppe Maria Ettorre Division of Surgical Oncology and Liver Transplantation San Camillo Hospital POIT San Camillo-INMI Lazzaro Spallanzani

AIM To emphasize the effectiveness and versatility of prosthesis, and good tolerance by patients with incisional hernia(IH). METHODS From December 2001 to February 2016, 270 liver transplantations were performed at San Camillo Hospital. IH occurred in 78 patients(28.8%). IH usually appeared early within the first year post-orthotopic liver transplantation. In the first era, fascial defect was repaired by primary closure for defects smaller than 2.5 cm or with synthetic mesh for greater defects. Recently, we started using biological mesh(Permacol?, Covidien). We present a series of five transplanted patients submitted to surgery for abdominal wall defect correction repaired with biological mesh(Permacol?, Covidien). RESULTS In our cases, the use of biological prosthesis(Permacol?, Covidien) have proven to be effective and versatile in repairing hernia defects of different kinds; patients did not suffer infections of the prosthesis and no recurrence was observed. Furthermore, the prosthesis remains intact even in the years after surgery. CONCLUSION The cases that we presented show that the use of biological mesh(Permacol?, Covidien) in transplanted patients may be safe and effective, being careful in the management of perioperative immunosuppression andrenal and graft function, although the cost of the product itself has been the main limiting factor and there is need for prospective studies for further evaluations.

关键词： Incisional hernia Liver transplantation Heart transplantation Biological mesh Surgery Morbidity Risk factors Immunosuppression Infection Recurrence

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Analysis of human skin tissue by a skin-meter: A preliminary study

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Open Journal of Molecular and Integrative Physiology 2012年第4期2卷 107-111页

作者： Sergio Mazzulla Annarita Carino Antonino Miano Fiorenzo Mignini giovanni Bartolomei guglielmo Martino Department of Cellular Biology University of Calabria Cosenza Italy Department of Chemistry University of Calabria Cosenza Italy Department of Public Healthy and Experimental Medicine University of Camerino Camerino Italy

The aim of this study is to evaluate the skin elasticity in individuals who practise spinning. Mechanical eva- luations were conducted, under environmental and physical established conditions, during a physical training period. A total of 12 volunteers aged 35 ± 5 years were enrolled in this study, (60 min) before (control) and (60 min) after practicing spinning. Skin elasticity and area were measured by a Skin Meter and analysed with the Skin Meter software 1.3. In subjects who practiced spinning, the data shown a sig-nificant effect: on elasticity, evaluated as the ratio of final retraction (UA) and final distension (UF), on viscoelasticity express as the ratio delayed distension (UV) and immediate distension (UE);and on measurements of skin area vs control subjects. Skin Meter can be useful for a non-invasive screening of skin condition with also a potential extension in subjects with skin pathologies or to monitor skin oxidative stress in sportive subjects.

关键词： Skin Meter Elasticity Skin Parameters Spinning

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深成岩体膨胀与共轴构造变形之间相互干涉作用的三维计算机模拟及其野外应用

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地质科学译丛 1996年第1期13卷 35-41页

作者： giovanni guglielmo 吴春明 Bureau of Economic Geology University of Texas at AustinAustinTX 78713-7508USA Jr

与深成岩体有关的和与构造有关的应变场的相互作用,基本上控制了造山带的地质构造。不过,人们对这种构造的几何形态和演化却知之甚少。例如:(1)区域构造共轴变形时,这种构造的几何形态如何?(2)构造的几何形态又是如何随递进变形而变化的... 详细信息

与深成岩体有关的和与构造有关的应变场的相互作用,基本上控制了造山带的地质构造。不过,人们对这种构造的几何形态和演化却知之甚少。例如:(1)区域构造共轴变形时,这种构造的几何形态如何?(2)构造的几何形态又是如何随递进变形而变化的?对诸如此类的问题,本文进行了应变形态、应变量级的三维计算机模拟,演示了由深成岩体膨胀和均匀共轴构造变形产生的面理、线理图象。该模拟指出,深成岩体膨胀和区域单轴缩短作用相互作用所产生的应变图象,与区域单轴扩张或区域共轴变形产生的应变图象不同。例如,区域缩短作用在岩体周围产生油炸面圈状收缩环,区域扩张则在岩体周围产生苹果状的压扁区;缩短作用只产生一个围绕岩体的连续的油炸面圈状低应变区,扩张作用则在岩体两端产生两个独立的椭球状低应变区。另外,区域缩短作用产生有二维三角形切面的面理环,线理则呈同心状围绕最大缩短轴分布,区域扩张作用则在岩体两端产生两个独立的面理锥、线理锥。所有这些构造元素和应变元素都因岩体膨胀率增大移离岩体,因构造变形率增大移向岩体。尽管对岩体周围构造的研究通常都需要结合显微构造测量、辐向测量和野外测量,该模拟得到的构造模式图还是可以用来估计:(1)岩体周围构造的几何形态及其起源和演化特征;(2)变斑晶内包裹体痕迹的形成机理;(3)与岩体相关的应变对围岩内测得的应变的影响;(4)区域运动系统的类型及其定向。

关键词：深成岩岩体膨胀共轴构造相互干涉计算机模拟

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深成岩体膨胀和非共轴构造变形之间干涉作用的三维计算机模拟及野外意义

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地质科学译丛 1994年第1期11卷 42-47页

作者： giovanni guglielmo Jr 吕貽峰 Department of Geological Sciences University of CaliforniaSanta BarbaraCA93106USA

深成岩体侵位使造山带内构造复杂化的原因是由于区域构造应变场和局部岩体膨胀应变场之间相互干涉控制构造的几何形态。关于这类构造的产生仍存在许多疑问,如,(1)与岩体有关的应变在多大范围内促使这些构造形成?(2)构造的三维几何形态如... 详细信息

深成岩体侵位使造山带内构造复杂化的原因是由于区域构造应变场和局部岩体膨胀应变场之间相互干涉控制构造的几何形态。关于这类构造的产生仍存在许多疑问,如,(1)与岩体有关的应变在多大范围内促使这些构造形成?(2)构造的三维几何形态如何?(3)构造几何形态如何随递进变形而交化?本文介绍了在非共轴构造环境中膨胀岩体周围构造在三度空间上的位置、样式及运动学演化的计算机模拟。模拟产生四个参数的图象:应变椭球体形态和量级、面理和矿物拉伸线理的方位。凹透镜状高应变区出现在岩体的两侧,而呈椭球体状的低应变区在岩体两端。面理、拉伸线理和压缩区在岩体周围构成不规则的三维环。较高的构造应变率促使该环向岩体方向迁移,而较高的岩体膨胀应变和应变率则使环向远离岩体方向迁移,但环的迁移率较之构造变形率或岩体膨胀率要缓慢得多。虽然天然应变场分析总是结合放射性年龄测定、构造和显微构造分析及应变测量进行的,但模拟应变图象还是可以为野外研究工作提供实际指导。特别是这些模拟图象可用于判断:(1)环绕岩体的构造的成因、几何形态和演化;(2)韧性剪切带的方位和三维运动方向;(3)造山带内与岩体有关的应变分布到围岩变形。

关键词：深成岩岩体膨胀构造变形计算机模拟

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Case Report: Caseous Calcification of the Mitral Annulus in an 88-Year-Old Woman

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Open Journal of Internal Medicine 2020年第4期10卷 337-341页

作者： Giuseppe Fede Giuseppe Abate Paola Belluardo Carmelo Di Tommasi Maria Luisa Guarrella Nicoletta Guccione guglielmo Piccione Salvatore Solarino Giuseppe Sulsenti giovanni Tasca Sabina Ficili Department of Cardiovascular Disease Maggiore Hospital Modica Italy

The caseous calcification of the mitral annulus (CCMA) is a rare variant of the mitral annulus calcification (MAC), with prevalence of 0.067% in general population. It is usually an asymptomatic condition but rarely it can cause severe mitral valve dysfunction, embolization, and conduction abnormalities. Transthoracic echocardiography (TTE) is a useful diagnostic tool. However, it can be necessary a multi-modality imaging approach for a differential diagnosis among other intra-cardiac masses. We are presenting a case of CCMA in an 88-year-old woman admitted to our department for acute decompensation of chronic heart failure. TTE has shown pathognomonic findings of CCMA. Tridimensional trans-esophageal echocardiography (3D TEE) gave a better characterization of the CCMA, avoiding further diagnostic procedures.

关键词： Mitral Valve Caseous Calcification Tridimensional Echocardiography

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