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Future perspective of focal therapy for localized prostate cancer

Asian Journal of Urology 2021年第4期8卷 354-361页

作者： Luke P.O’Connor Shayann Ramedani Michael Daneshvar Arvin K.George Andre Luis Abreu giovanni E.cacciamani Amir H.Lebastchi Urologic Oncology Branch National Cancer InstituteNational Institutes of HealthBethesdaMDUSA College of Medicine The Pennsylvania State UniversityHersheyPAUSA Department of Urology University of MichiganAnn ArborMIUSA Center for Image-Guided and Focal Therapy for Prostate Cancer Institute of Urology and Catherine and Joseph Aresty Department of UrologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Institute of Urology and Catherine and Joseph Aresty Department of Urology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Objective:To summarize the recent literature discussing focal therapy for localized prostate ***:A thorough literature review was performed using PubMed to identify recent studies involving focal therapy for the treatment of localized prostate ***:In an effort to decrease the morbidity associated with prostate cancer treatment,many urologists are turning to focal therapy as an alternative treatment *** this approach,the cancer bearing portion of the prostate is targeted while leaving the benign tissue *** magnetic resonance imaging remains the gold standard for visualization during focal therapy,but new imaging modalities such as prostate specific membrane antigen/positron emission tomography and contrast enhanced ultrasound are being ***,several biomarkers,such as prostate cancer antigen 3 and prostate health index,are used in conjunction with imaging to improve risk stratification prior to focal ***,there are several novel technologies such as nanoparticles and transurethral devices that are under investigation for use in focal ***:Focal therapy is proving to be a promising option for the treatment of localized prostate ***,further study is needed to determine the true efficacy of these exciting new technologies.

关键词： Focal therapy Prostate cancer Multiparametric magnetic resonance imaging Imaging Innovation Technology

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Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities(quotient testosterone/tumour volume)

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Asian Journal of Urology 2016年第1期3卷 26-32页

作者： Antonio B.Porcaro Aldo Petrozziello Matteo Brunelli Filippo Migliorini giovanni cacciamani Davide De Marchia Nicolo’de Luyk Irene Tamanini Beatrice Caruso Maria A.Cerruto Claudio Ghimenton Walter Artibani Clinica Urologica Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly Medicina Interna/Endocrinologia Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly Anatomia Patologica Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly Medicina di Laboratorio Ospedale Policlinico ed Ospedale Civile MaggioreAzienda Ospedaliera Universitaria IntegrataVeronaItaly

Objective:To investigate potential associations of preoperative total testosterone(TT)with tumor volume(TV)and grade of prostate cancer(PCa).Methods:Patients who were under medications impacting on the hypothalamic-pituitaryadrenal-testis-prostate axis were *** was measured preoperatively at least 1 month after biopsies and TV was calculated on the removed prostate *** continuous variables included total prostate specific antigen(PSA),percentage of positive cores(Pt)and weight(W)of the removed *** were categorized according to the pathologic Gleason score(pGS)in 3 groups(pGS 6,7 and>7).Invasion of the seminal vesicles was coded as seminal vesicle invasion(SVI).Results:The median levels of TT were significantly and increasingly higher from pGS 6(14.7 nmol/L)to pGS 7(15.0 nmol/L)and pGS>7(18.8 nmol/L).The median values of TV were also detected significantly and increasingly higher from pGS 6(5.6 mL)to pGS 7(8.1 mL)and pGS>7(14.8 mL).The median preoperative levels of PSA were also increasing from pGS 6(5.9 μg/L)to pGS 7(6.2 μg/L)and pGS>7(7.7 μg/L).There was a significant and positive correlation of TV to PSA,TT and *** linear regression analysis showed that TV was significantly and independently predicted by TT,PSA and *** grade PCa(pGS>7)independently associated with TV,TT,Pt and *** median density values of TT relative to TV(quotient TT/TV)significantly decreased from pGS 6(2.6 nmol/L/mL)to pGS 7(1.9 nmol/L/mL)and pGS>7(1.4 nmol/L/mL).The median density values of PSA relative to TV(quotient PSA/TV)also significantly decreased from pGS(1.1 μg/L/mL)to pGS 7(0.7 μg/L/mL)and pGS>7(0.6 μg/L/mL).Conclusion:The investigation shows that TT relates to volume and grade of PCa;moreover,the density of TT relative to TV inversely associates with rate of increase of cancer that depends on the grade of the tumour.

关键词： Total testosterone Tumour volume Prostate-specific antigen Prostate cancer Pathology Gleason score

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Artificial intelligence for renal cancer:From imaging to histology and beyond

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Asian Journal of Urology 2022年第3期9卷 243-252页

作者： Karl-Friedrich Kowalewski Luisa Egen Chanel E.Fischetti Stefano Puliatti Gomez Rivas Juan Mark Taratkin Rivero Belenchon Ines Marie Angela Sidoti Abate Julia Muhlbauer Frederik Wessels Enrico Checcucci giovanni cacciamani Department of Urology and Urological Surgery University Medical Centre MannheimMannheimGermany Department of Emergency Medicine Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Urology Department University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Department of Urology Hospital Clinico San CarlosMadridSpain Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Urology and Nephrology Department Virgen del Rocı´o University HospitalManuel Siurot s/nSevilleSpain Department of Surgery Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly USC Institute of Urology University of Southern CaliforniaLos AngelesCAUSA

Artificial intelligence(AI)has made considerable progress within the last decade and is the subject of contemporary *** trend is driven by improved computational abilities and increasing amounts of complex data that allow for new approaches in analysis and *** cell carcinoma(RCC)has a rising incidence since most tumors are now detected at an earlier stage due to improved *** creates considerable challenges as approximately 10%e17%of kidney tumors are designated as benign in histopathological evaluation;however,certain co-morbid populations(the obese and elderly)have an increased peri-interventional *** offers an alternative solution by helping to optimize precision and guidance for diagnostic and therapeutic *** narrative review introduced basic principles and provide a comprehensive overview of current AI techniques for ***,AI applications can be found in any aspect of RCC management including diagnostics,perioperative care,pathology,and *** commonly applied models include neural networks,random forest,support vector machines,and ***,for implementation in daily practice,health care providers need to develop a basic understanding and establish interdisciplinary collaborations in order to standardize datasets,define meaningful endpoints,and unify interpretation.

关键词： Kidney cancer Imaging Technology Artificial intelligence Machine learning

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New imaging technologies for robotic kidney cancer surgery

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Asian Journal of Urology 2022年第3期9卷 253-262页

作者： Stefano Puliatti Ahmed Eissa Enrico Checcucci Pietro Piazza Marco Amato Stefania Ferretti Simone Scarcella Juan Gomez Rivas Mark Taratkin Jose Marenco Ines Belenchon Rivero Karl-Friedrich Kowalewski giovanni cacciamani Ahmed El-Sherbiny Ahmed Zoeir Abdelhamid MEl-Bahnasy Ruben De Groote Alexandre Mottrie Salvatore Micali Urology Department University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Urology Department Faculty of MedicineTanta UniversityTantaEgypt Department of Surgery Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Urology Polytechnic University of Marche RegionUmberto I Hospital“Ospedali Riuniti”AnconaItaly Uro-technology and SoMe Working Group of the Young Academic Urologists Working Party European Association of UrologyArnhemthe Netherlands Department of Urology Hospital Clinico San CarlosMadridSpain Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Department of Urology Fundacio´n Instituto Valenciano de Oncologı´aValenciaSpain Urology and Nephrology Department Virgen del Rocı´o University HospitalManuel Siurot Sin NumeroSevilleSpain Department of Urology and Urological Surgery University Medical Centre MannheimMannheimGermany USC Institute of Urology University of Southern CaliforniaLos AngelesCAUSA Department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium

Objective:Kidney cancers account for approximately 2%of all newly diagnosed cancer in *** the primary treatment options for kidney cancer,urologist may choose between radical or partial nephrectomy,or ablative ***,robotic-assisted partial nephrectomy(RAPN)for the management of renal cancers has gained popularity,up to being considered the gold ***,RAPN is a challenging procedure with a steep learning ***:In this narrative review,different imaging technologies used to guide and aid RAPN are ***:Three-dimensional visualization technology has been extensively discussed in RAPN,showing its value in enhancing robotic-surgery training,patient counseling,surgical planning,and intraoperative *** imaging technologies such as intracorporeal ultrasound,near-infrared fluorescent imaging,and intraoperative pathological examination can also be used to improve the outcomes following ***,artificial intelligence may play a role in the field of RAPN ***:RAPN is a complex surgery;however,many imaging technologies may play an important role in facilitating it.

关键词： Kidney cancer Imaging Technology Robotic

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Prostate chronic inflammation type Ⅳ and prostate cancer risk in patients undergoing first biopsy set:Results of a large cohort study

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Asian Journal of Urology 2015年第4期2卷 224-232页

作者： Antonio Benito Porcaro giovanni Novella Matteo Balzarro Guido Martignoni Matteo Brunelli giovanni cacciamani Maria ACerruto Walter Artibani Urologic Clinic University HospitalOspedale PoliclinicoAzienda Ospedaliera Universitaria IntegrataVeronaItaly Department of Pathology University HospitalOspedale PoliclinicoAzienda Ospedaliera Universitaria IntegrataVeronaItaly

Objective:In prostate specimens,chronic inflammatory infiltrate(CII)type Ⅳ has been detected,but its association with prostate cancer(PCa)is *** aim of the present study is to investigate on associations of CII with PCa detection in patients undergoing prostate first biopsy ***:Ultrasound transrectal-guided biopsies by the transperineal approach were retrospectively evaluated in 441 consecutive *** study excluded patients who were in active surveillance,prostate specific antigen(PSA)30 ng/mL,re-biopsies,incidental PCa after transurethral resection of the prostate(TURP),less than 14 cores or *** of population and subpopulations(with or without PCa)was performed by statistical methods which included ManneWhitney(U test),KruskaleWallis test,Chi-squared statistic,logistic *** logistic regression models predicting mean probability of PCa detection were ***:PCa detection rate was 46.03%.Age,PSA,prostate volume(PV),prostate intraepithelial neoplasia(PIN)and CII were the significant independent predictors of PCa ***(OR Z 0.934)and CII(OR Z 0.192)were both negative independent *** was a significant negative independent predictor in multivariate logistic regression models predicting the mean probability of PCa detection by age,PSA and *** inverse association of CII with PCa does not necessary mean protection because of PSA ***:In a population of patients undergoing prostate first biopsy set,CII was a strong negative independent predictor of PCa *** type Ⅳ should be considered as an adjunctive parameter in re-biopsy or active surveillance protocols.

关键词： Prostate Prostate cancer Prostate specific antigen Prostate biopsy Chronic inflammation Prostate volume Biopsy Gleason score

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