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Asian Journal of Andrology 2017年第2期19卷 219-222页

作者： giorgio cavallini Gynepro-Medical Group Andrological Section via Tranquillo Cremona 8 40137 Bologna Italy

The aim of this study was to ascertain whether some patients with psychogenic erectile dysfunction （PED） who chose psychotherapy spontaneously improved their sexual function immediately after diagnosis. Two hundred eighty-five patients with PED were retrospectively studied. Complete resolution of PED was analyzed regarding age, primary or secondary PED, marital status, domestic status, prevailing attitude of the female partner to the dysfunction, duration of their partnership, social status, duration of PED, International Index of Erectile Function score, and prevailing attitude of the patient after a diagnosis of PED. The data were analyzed using post-hoc tests. PED was resolved in 32.3% of the patients immediately after diagnosis. These patients were older, more frequently affected by secondary ED, more frequently living with their partner, and more frequently resigned or happy with the diagnosis of PED than the patients who did not resolve their PED. A nonchalant or cooperative female attitude to PED improved the possibility of PED resolution. The other variables did not influence PED resolution. Our data showed that a clear-cut diagnosis of psychogenic erectile deficiency and some psychosocial factors were critical for the management of some patients with PED.

关键词： diagnosis psychogenic erectile dysfunction recovery of sexual function visit

Relationships between biological aging and male reproductive monitors

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Asian Journal of Andrology 2020年第3期22卷 330-332页

作者： giorgio cavallini Fabrizio Scroppo Private Outpatient Clinic Via Mascheraio 46Ferrara 44121Italy Department of Urology and Andrology Ospedale di Circolo and Macchi FoundationViale L.Borri 57Varese 21100Italy

Dear Editor,Advanced paternal age affects testicular function,reproductive hormones,and sperm parameters,but it is unclear whether chronological age or biological age exercises a greater sway on reproductive ***,the authors carried out this prospective,multicenter,observational study,in which sperm concentration;motility and morphology;ejaculated volume;testicular volume;and the blood concentrations of follicle-stimulating hormone(FSH),luteinizing hormone(LH),and total testosterone(T)were related to chronological and biological age.

关键词： function. stimulating aging

Multivariate analysis to predict letrozole efficacy in improving sperm count of non-obstructive azoospermic and cryptozoospermic patients： a pilot study

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Asian Journal of Andrology 2013年第6期15卷 806-811,I0009-I0010页

作者： giorgio cavallini Giulio Biagiotti Elisa Bolzon Andros-ltalia Outpatient Clinic of Ferrara Ferrara 44121 Italy Androsqtalia Outpatient Clinic of Perugia PeruRia 06128 Italy

We tested the hypothesis that letrozole increases sperm count in non-obstructive azoospermic or cryptozoospermic patients with a testosterone （T）/17-beta-2-oestradiol （E2） ratio 〈 10. Forty-six patients with no chromosomal aberrations were randomized into two groups： 22 received letrozole 2.5 mg per day for 6 months （Group 1：6 azoospermic＋ 16 cryptozoospermic patients）, while 24 received a placebo （Group 2：5 azoospermic＋19 cryptozoospermic patients）. The following data were collected： two semen analyses, clinical history, scrotal Duplex scans, body mass index （BMI）, Y microdeletion, karyotype and cystic fibrosis screens and follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, E2, T and prolactin levels. Both before and after letrozole or placebo administration, the patients underwent two semen analyses and hormonal assessments. The differences were evaluated using the Mann-Whitney Utest. The relationships between sperm concentration after letrozole administration with respect to FSH, TIE2 ratio, bilateral testicle volume and BMI before letrozole administration were assessed using multivariate analysis. The side effects were assessed using the chi-square test. Group 1 had sperm concentration （medians： 400-1.290× 10^6 ml^-1; P〈0.01） and motility （medians： class A from 2% to 15%; P〈0.01）, FSH, LH and T significantly increased, while Group 2 did not. E2 levels diminished significantly in Group 1, but not in Group 2. Eight patients in Group 1 demonstrated side effects, whereas no patient side effects were observed in Group 2. The sperm concentration after letrozole administration is inversely related to TIE2, FSH and BMI; a direct relationship emerged between sperm concentration and testicular volume.

关键词： cryptozoospermia letrozole male infertility non-obstructive azoospermia

Preliminary study of letrozole use for improving spermatogenesis in non-obstructive azoospermia patients with normal serum FSH

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Asian Journal of Andrology 2011年第6期13卷 895-897页

作者： giorgio cavallini Giovanni Beretta Giulio Biagiotti Andros-Italia Outpatient Clinic of Ferrara Via Mascheraio 46 Ferrara 44121 Italy Centro Italiano Fertilita e Sessualita Via della Fortezza 6 Firenze 50129 Italy Andros Italia Sede di Perugia Via Martiri dei Lager 58 Perugia 06128 Italy

We investigated whether letrozole （2.5 mg day-1） improves sperm count in non-obstructive azoospermia （NOA） patients. Four men were included in this study, and they had folliculo-stimulating hormone and other hormone levels within the normal range and no varicoceles or chromosomal aberrations. These four patients were administered letrozole for 3 months. Sperm count, testicular volume, gonadotropin, testosterone （T） and estradiol （E2） blood levels were assessed before, during and 1 week after the suspension of treatment. All patients showed spermatozoa in their ejaculate, increased gonadotropin and T levels and lower E2 levels （P〈0.05 in all cases）, when letrozole was administered. This suggests that letrozole treatment might improve sperm count in an NOA sub-population; however, more studies, including the proper controls, are needed to confirm its efficacy.

关键词： letrozole medical treatment non-obstructive azoospermia spermatogenesis

Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy： a preliminary report

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Asian Journal of Andrology 2012年第4期14卷 591-598页

作者： giorgio cavallini Maria Cristina Magli Andor Crippa Anna Pia Ferraretti Luca Gianaroli Medicitalia Andrological Section Outpatient Clinic of Ferrara Ferrara 44100 Italy Laboratory of Assisted Reproduction Societa Italiana di Medicina della Riproduzione (SISMER) Bologna 40138 Italy Operative Unit of Assisted Reproduction Societa Italiana di Medicina della Riproduzione (SISMER) Bologna 40138 Italy

The objective of this study was to investigate whether medical therapy can reduce sperm aneuploidy levels and irfiprove the results of intracytoplasmic sperm injection （ICSI） in patients with severe idiopathic oligoasthenoteratospermia （OAT）. Thirty-three infertile couples requiring ICSI because of severe idiopathic OAT after at least one unsuccessful ICSI cycle were considered. Semen parameters （concentration, motility and morphology）, the percentage of aneuploid sperm and the results of ICSI （the number of oocytes fertilized, embryos transferred, biochemical pregnancies, clinical pregnancies and live births） were compared before and after a 3-month course of treatment with L-carnitine 1 g given twice per day＋acetyI-L-carnitine 500 mg given twice per day＋one 30-mg cinnoxicam tablet every 4 days. Aneuploidy was assessed using fluorescent in situ hybridisation （FISH） performed on chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22. The results showed that 22 of the 33 patients had a reduced frequency of aneuploid sperm and improved sperm morphology after treatment （group 1）, and 11 showed no change （group 2）. The numbers of biochemical pregnancies, clinical pregnancies and live births were significantly higher in group I than in group 2. No significant difference was found between the groups regarding the numbers of oocytes fertilized and embryos transferred. The side effects were negligible. The numbers of ICSI pregnancies and live births in severe idiopathic OAT patients improved with a course of L-carnitine, acetyI-L-carnitine and cinnoxicam.

关键词： acetyI-L-carnitine cinnoxicam ICSl L-carnitine male infertility oligoasthenoteratospermia sperm aneuploidy

Male idiopathic oligoasthenoteratozoospermia

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Asian Journal of Andrology 2006年第2期8卷 143-157页

作者： giorgio cavallini Operative Unit of Andrology Società Italiana di Medicina della Riproduzione(SISMER)Via Mazzini 1240138 BolognaItaly

Idiopathic oligoasthenoteratozoospermia （iOAT） affects approximately 30% of all infertile men. This mini-review discussed recent data in this field. Age, non-inflammatory functional alterations in post-testicular organs, infective agents （Chlamydia trachomatis, herpes virus and adeno-associated viruses）, alterations in gamete genome, mitochondrial alterations, environmental pollutants and ＂subde＂ hormonal alterations are all considered possible causes of iOAT. Increase of reactive oxygen species in tubules and in seminal plasma and of apoptosis are reputed to affect sperm concentration, motility and morphology, iOAT is commonly diagnosed by exclusion, nevertheless spectral traces of the main testicular artery may be used as a diagnostic tool for iOAT. The following can be considered therapies for iOAT： 1） tamoxifen citrate （20 mg/d）＋ testosterone undecanoate （120 mg/d）（pregnancy rate per couple/month [prcm]： 3.8%）; 2） folic acid （66 mg/d）＋ zinc sulfate （5 mg/d）; 3） L-carnitine （2 g/d） alone or in combination with acetyl-L- canitine （1 g/d）（prcm： 2.3%）; and 4） both camitines ＋ one 30 mg cinnoxicam suppository every 4 days （prcm： 8.5%）. Alpha-blocking drugs improved sperm concentration but not morphology, motility or pregnancy rate. Tranilast （300 mg/d） increased sperm parameters and pregnancy rates in an initial uncontrolled study. Its efficacy on sperm concentration （but not on sperm motility, morphology or prcm） was confirmed in subsequent published reports. The efficacy of tamoxifen ＋ testosterone undecanoate, tamoxifen alone, and recombinant follicle-stimulating hormone is still a matter for discussion. （Asian J Andro12006 Mar; 8： 143-157）

关键词： idiopathic oligoasthenoteratozoospermia male infertility diagnosis pathogenesis

Pilot study to determine improvements in subjective penile morphology and personal relationships following a Nesbit plication procedure for men with congenital penile curvature

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Asian Journal of Andrology 2008年第3期10卷 512-519页

作者： giorgio cavallini Stefano Caracciolo Andrological Operative Unit Headquarters of Societg7 ltaliana di Studi di Medicina della Riproduzione via Mazzini 12Bologna 40138 Italy Section of General and Clinical Psychology University of Ferrara - Medical School Via Fossato di Mortara 64bFerrara 44100 Italy

Aim： To determine whether the surgical straightening of congenital penile curvature can improve intromission comfort, penile features, personal relationships and psychogenic erectile dysfunction （ED）. Methods： Fifty-four patients （mean age 24 years, range 20-31 years） whose congenital penile deviation due to physiological curvature was ≥ 25 degrees, as measured on a graph, and who were experiencing penetration discomfort were assessed specifically for the present study. Of these, 14 patients suffered from psychogenic ED. The assessment included a case history, an objective examination, a pharmacologically-induced erection with prostaglandin E1 10-20 g, a graph taken during erection, a basal and dynamic Duplex ultrasonograph, penile length measurement, nocturnal penile tumescence recording, hormonal profiles and a psychological interview to evaluate the quality of their personal relationships according to Hinde＇s parameters （contents, number, features, frequency, ability to perceive limits of mutuality, subjective perception of the other person[s], and reliability）. All patients underwent the Nesbit procedure. The initial assessment was repeated at 3 and 12 months after surgery. Data analyses were carried out using the z test. Results： Subjective judgement of cosmetic penile features and vaginal intromission comfort improved significantly after surgery whereas the quality of personal relationships and ED did not. Conclusion： The surgical straightening of congenital penile curvature improved intromission comfort and penile features, but it failed to improve interpersonal relationships or psychogenic ED.

关键词： congenital penile curvature Nesbit procedure penile surgery personal relationships

The number of spermatozoa collected with testicular sperm extraction is a novel predictor of intracytoplasmic sperm injection outcome in non-obstructive azoospermic patients

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Asian Journal of Andrology 2011年第2期13卷 312-316页

作者： giorgio cavallini Maria Cristina Magli Andor Crippa Silvia Resta Giovanni Vitali Anna Pia Ferraretti Luca Gianaroli Andros-ltalia Outpatient Clinic of Ferrara 44121 Ferrara Italy Operative Unit of Laboratory of Assisted Reproduction Societe Italiana di Studi di Medicina della Riproduzione（S.I.S.ME.R.） 40138 Bologna Italy Operative Unit of Andrology Societ Italiana di di Studi di Medicina della Riproduzione 40138 Bologna Italy a Operative Unit of AssistedReproduction Societ＆ Italiana di di Studi di Medicina della Riproduzione 40138 Bologna Italy

The purpose of this study was to determine the relationships between monitors of spermatogenesis and predictors of the intracytoplasmic sperm injection （ICSI） outcome in patients with non-obstructive azoospermia （NOA） undergoing testicular sperm extraction （TESE）. Seventy-nine patients with NOA （mean age： 43.6±5.2 years）, each of whom yielded （97 000±3040） spermatozoa with conventional TESE, were considered in our analysis. Their partners （mean age： 35.8±5.1 years） underwent a total of 184 ICSI cycles; 632 oocytes were collected, 221 oocytes were injected, 141 oocytes were fertilized, 121 embryos were obtained, 110 embryos were transferred, 14 clinical pregnancies were achieved and only one miscarriage occurred. Multivariate regression analysis indicated relationships between the percentage of fertilized oocytes, transferred embryos and clinical pregnancies with the following variable values： female partner＇s age, number of spermatozoa collected, testicular volume, male partner＇s levels of follicle stimulating hormone （FSH）, number of oocytes collected, number of oocytes injected and number of ICSI cycles. A significant inverse relationship was found between female partner＇s age or male partner＇s FSH levels and biochemical pregnancies. A significant direct relationship emerged between the number of ICS! cycles and the percentage of oocytes fertilized, embryos transferred and biochemical pregnancies, and between the number of spermatozoa collected per testicular biopsy and biochemical pregnancies. The number of spermatozoa was positively linked to the number of clinical pregnancies, independent of the number of ICSI cycles and the number of oocytes collected/injected. The number of spermatozoa collected, FSH level and testicular volume are monitors of spermatogenesis linked to ICSI success.

关键词： conventional TESE ICSI outcomes non-obstructive azoospermia

Molybdenum disulfide as hydrogen evolution catalyst:From atomistic to materials structure and electrocatalytic performance

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Journal of Energy Chemistry 2023年第12期87卷 256-285,I0007页

作者： Mohsin Muhyuddin giorgio Tseberlidis Maurizio Filippo Acciarri Oran Lori Massimiliano D'Arienzo Massimiliano cavallini Plamen Atanassov Lior Elbaz Alessandro Lavacchi Carlo Santoro Department of Materials Science University of Milano-BicoccaVia Roberto Cozzi 55Building U520125 MilanItaly Istituto per lo Studio dei Materiali Nanostrutturati (ISMN)Consiglio Nazionale delle Ricerche(CNR)Via P.Gobetti 101BolognaItaly Department of Chemical and Biomolecular Engineering University of CaliforniaIrvineCA 92697United States Department of Chemistry and the Institute of Nanotechnology and Advanced Materials Bar-Ilan UniversityRamat-Gan 5290002Israel Institute of Chemistry of the Organometallic Compounds-National Research Council(ICCOM-CNR) Via Madonna del Piano1050019 Sesto Fiorentino(FI)Italy

Hydrogen production via water electrolysis defines the novel energy vector for achieving a sustainable ***,the true progress of the given technology is hindered by the sluggish and complex hydrogen evolution reaction(HER)occurring at the cathodic side of the system where overpriced and scarce Pt-based electrocatalysts are usually ***,efficient platinum group metals(PGMs)-free electrocatalysts to carry out HER with accelerated kinetics are urgently *** this scenario,molybdenum disulfide(MoS_(2))owing to efficacious structural attributes and optimum hydrogen-binding free energy(ΔG_(H*))is emerging as a reliable alternative to ***,the performance of MoS_(2)-based electrocatalysts is still far away from the benchmark *** HER activity of MoS_(2)can be improved by engineering the structural parameters i.e.,doping,defects inducement,modulating the electronic structure,stabilizing the 1 T phase,creating nanocomposites,and altering the morphologies using appropriate fabrication ***,we have comprehensively reviewed the majority of the scientific endeavors published in recent years to uplift the HER activity of MoS_(2)-based electrocatalysts using different *** in the major fabrication strategies including hydrothermal synthesis methods,chemical vapor deposition,exfoliation techniques,plasma treatments,chemical methodologies,*** tune the structural parameters and hence their ultimate influence on the electrocatalytic activity in acidic and/or alkaline media have been thoroughly *** study can provide encyclopedic insights about the fabrication routes that have been pursued to improve the HER performance of MoS_(2)-based electrocatalysts.

关键词： Hydrogen evolution reaction Molybdenum disulphide Electrocatalysts Synthesis techniques Sustainable energy production Water electrolysis