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Douglas-fir climate sensitivity at two contrasting sites along the southern limit of the European planting range

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Journal of Forestry Research 2020年第6期31卷 2193-2204页

作者： Cristiano Castaldi Maurizio Marchi giorgio Vacchiano Piermaria Corona CREA-Research Centre for Forestry and Wood Viale S.Margherita 8052100 ArezzoItaly Universitàdegli Studi di Milano DISAAVia Celoria 220133 MilanItaly

Douglas-fir(Pseudotsuga menziesii(Mirb.)Franco)is an important exotic tree species that was planted across a large part of Europe during the last *** both experimental trials and conventional forest plantations,the trees grow at a high rate and produce high-quality *** present study investigated climate-growth relationships of Douglas-fi r at two Italian sites that contrast in climate:a Mediterranean area in southern Italy(Mercurella site)and a cooler,moister site in the northern Apennines without summer aridity(Acquerino).The relationship between tree-ring chronologies and monthly climatic variables was evaluated by a moving average and correlation *** showed that the minimum temperature in February and in March play a key role for Douglas-fi r at both sites,with a positive eff ect on *** the northern site,it is also highly sensitive to late summer temperatures(negative correlation)and spring–summer precipitation(positive correlation).Growth rates in southern latitudes were high even in Europe and in the Mediterranean environment,with low sensitivity to climatic fl *** the basis of our results,further common garden experiments should test adaptation and the interaction between genetics and environment of second-or third-generation seeds from old stands across Europe such as done by the old International Union of Forest Research Organizations(IUFRO)or the European Douglasfi r Improvement Research Cooperative(EUDIREC)experimentation programmes.

关键词： Pseudotsuga menziesii Tree ring analysis Dendroclimatology Forest plantations Exotic forest species

Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

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Neural Regeneration Research 2023年第4期18卷 773-778页

作者： Luigi Manni giorgio Conti Antonio Chiaretti Marzia Soligo Institute of Translational Pharmacology National Research Council of Italy(CNR)RomeItaly Intensive Pediatric Therapy and Pediatric Trauma Center Department of EmergencyAnesthesiological and Reanimation SciencesFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly Institute of Pediatrics Department of Woman and Child HealthFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Traumatic brain injury is one of the main causes of mortality and disability *** brain injury is characterized by a primary injury directly induced by the impact,which progresses into a secondary injury that leads to cellular and metabolic damages,starting in the first few hours and days after primary mechanical *** date,traumatic brain injury is not targetable by therapies aimed at preventing and/or limiting the outcomes of secondary damage but only by palliative *** growth factor is a neurotrophin targeting neuronal and non-neuronal cells,potentially useful in preventing/limiting the outcomes of secondary damage in traumatic brain *** potential has further increased in the last two decades since the possibility of reaching neurotrophin targets in the brain through its intranasal delivery has been ***,molecules intranasally delivered to the brain parenchyma may easily bypass the blood-brain barrier and reach their therapeutic targets in the brain,with favorable kinetics,dynamics,and safety *** the first part of this review,we aimed to report the traumatic brain injury-induced dysfunctional mechanisms that may benefit from nerve growth factor *** the second part,we then exposed the experimental evidence relating to the action of nerve growth factor(both in vitro and in vivo,after administration routes other than intranasal)on some of these *** the last part of the work,we,therefore,discussed the few manuscripts that analyze the effects of treatment with nerve growth factor,intranasally delivered to the brain parenchyma,on the outcomes of traumatic brain injury.

关键词： intranasal delivery nerve growth factor pharmacology traumatic brain injury

Contrast-enhanced ultrasound with sulphur-hexafluoride in diagnosis of early HCC in cirrhosis

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Hepatoma Research 2019年第6期5卷 16-24页

作者： Antonio giorgio Pietro Gatti Paolo Matteucci Valentina giorgio Department of Medicine Interventional Ultrasound UnitAthena Clinical InstituteCaserta 81016Italy Department of Medicine Brindisi General HospitalBrindisi 72100Italy Radiation Oncology Institute Campus Biomedico UniversityRome 00128Italy Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthRoma 00168Italy

Contrast-enhanced ultrasound(CEUS)with pure blood stream contrast agents allow the study of blood supply of focal liver lesions and especially of hepatocellular carcinoma(HCC)in *** sensitivity and specificity in diagnosis of small tumors is very *** review summarizes the recent results on CEUS with SonoVue,which is one of the second generation contrast agents,in the diagnosis of early HCC in cirrhosis emphasizing its increasing role in routine clinical practice.

关键词： Hepatocellular carcinoma contrast-enhanced ultrasound cirrhosis early hepatocellular carcinoma

Osmium complexes in catalysis of olefin hydrogenation and isomerization

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Chinese Journal of Catalysis 2016年第11期37卷 1824-1836页

作者： giorgio Chelucci Gérard A.Pinna Giansalvo Pinna Maurizio Solinas Barbara Sechi 意大利萨萨里大学农业系意大利萨萨里大学化学与药学系意大利生物化学研究所

This review focuses on the evolution of the use of osmium complexes as catalysts in the hydrogenation and isomerization of *** systems show good catalytic activities and selectivities in the hydrogenation of olefins via both dihydrogen and transfer *** systems therefore have significant potential to become a powerful tool in organic synthesis.

关键词： Osmium complexes Hydrogenation Transfer hydrogenation Alkene isomerization Olefins

On the scale-up criteria for bubble columns

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Petroleum 2019年第2期5卷 114-122页

作者： giorgio Besagni Lorenzo Gallazzini Fabio Inzoli Department of Energy Politecnico di MilanoVia Lambruschini 4a20156MilanoItaly

It is generally admitted that experimental data obtained in“laboratory-scale”bubble columns are representative of“industrial-scale”reactors if the well-known three“Wilkinson et ***-up criteria”are satisfied:(a)the diameter of the bubble column is larger than 0.15 m,(b)the sparger openings are larger than 1e2mm and(c)the aspect ratio is larger than *** aim of this communication is to contribute to the existing *** this end,this communication collects relevant experimental investigation and include new experimental data:in particular,we have experimentally studied the combined effect of the aspect ratio(within the range of 1e15)and the sparger design(considering both“coarse”and“fine”spargers)on the gas holdup in a large-diameter and large-scale gas-liquid bubble *** bubble column has been operated both in the batch mode and in the counter-current *** air has been used as the gaseous phase in all the experiments,while the liquid phase has included deionized water and different aqueous solutions of organic(i.e.,ethanol)and inorganic(i.e.,sodium chloride,NaCl)active *** is found that the“Wilkinson et ***-up criteria”are valid for the air-water case in the batch mode for“very-coarse”***,they are no more valid when considering different liquid velocity,and/or aqueous solutions of active agents,and other sparger openings.

关键词： Bubble column Scale-up Gas sparger Gas holdup Liquid phase properties

A new method of dynamic mesh used in continuous guide vane closure of a reversible pump-turbine in generating mode

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Journal of Hydrodynamics 2019年第5期31卷 976-985页

作者： Xiu-li Mao Yuan Zheng giorgio Pavesi Zhan-shan Xie College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Department of Industrial Engineering University of PaduaPadovaItaly

In this paper,a new method of dynamic mesh based on two functional controls is used in the continuous guide vane closure,and the three-dimensional numerical simulation is carried out to investigate the transient flow characteristics for a Francis-type reversible pump-turbine in the turbine mode in the load regulation scenario,with the detached eddy simulation(DES)turbulent *** transient flow characteristics during the closure of the guide vanes are illustrated by analyzing the signals of the mass flow,the torque and the pressure fluctuations in the frequency and time-frequency *** is shown by the simulated results that a continuous assessment of the transient flow characteristics during the guide vane closure may be made by using the new method of the dynamic ***,the flow field analysis involves both the onset and the development of the unsteady phenomena progressively based on an organized guide vane closure *** flow pattern in the return channel maintains a relatively stable flow field before the last stage of the closure,as compared with the unstable flow field in other *** identify the unit variation under the fluid-dynamical conditions,the influence of the three-dimensional unsteady flow structures in the passage is analyzed and its evolution during this transient process is characterized by the fluid-dynamics and the spectral analysis.

关键词： Francis-type reversible turbine dynamic mesh guide vane closure flow characteristics

Editorial on "Role of thermal ablation in the management of colorectal liver metastasis"

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 62-64页

作者： Antonio giorgio Pietro Gatti Massimo De Luca Paolo Matteucci Valentina giorgio Liver Unit and Interventional Ultrasound Unit Athena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine Unit Brindisi General HospitalBrindisiItaly Liver Unit Cardarelli HospitalNaplesItaly Radiation Oncology Unit Campus BiomedicoRomaItaly Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthRomaItaly

The last 30 years have shown the increasing role of Ablation in the treatment of malignant liver tumors. By the introduction of percutaneous ethanol injection (PEI) as first ablation tool for percutaneous treatment of hepatocellular carcinoma (HCC) in cirrhosis that firstly showed very high efficacy (1), several ablation techniques (mainly thermal) have been introduced in clinical practice aimed at destroying primary and secondary hepatic tumors as alternative or substitute tools to surgery. Radiofrequency ablation (RFA) was the first thermal technique that showed a good efficacy to ablate liver metastases (2). Among the secondary liver tumors, colorectal liver metastases (CRLM) represent the unique indication for ablation (2). Unlike HCC in cirrhosis where the role of RFA is well defined as first line therapy for HCC nodules < or equal to 2 cm or as alternative to surgery in 1-3 HCC nodules with the maximum diameter<3 cm (3), in the case of CRLM it is not possible to reproduce the same paradigm. Liver resection remains the standard of care for CRLM and the indications to ablation remain confined to nonresectable patients (4). The review article by Takahashi and Berber recently published in HBSN wells illustrates the current role of ablation in treatment of CRLM (5).

关键词： colorectal metastasis surgery

Surgery for hepatocellular carcinoma can provide the same life-expectancy as transplant of that of general population

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 151-152页

作者： giorgio Ercolani Michele Cucchi Department of Medical and Surgical Sciences DIMECAlma Mater StudiorumUniversity of BolognaBolognaItaly General Surgery MorgagniPierantoni HospitalForlì(FC)Italy

When deciding for the optimal treatment to adopt in patients suffering from hepatocellular carcinoma(HCC),the surgical approach is commonly considered as the most curative option(1,2).The scarcity of donors for liver transplantation(LT)led surgeons to bridge patients until an eventual future transplant(salvage LT),opting in first instance and when feasible for hepatic resection(HR)also for those patients otherwise transplantable(2).In the study published by Pinna and colleagues in Annals of Surgery 2018,it was verified in what measure LT and HR can provide for HCC the same mortality expected in the general population,defining the so called"statistical cure"(3).

关键词： Surgery hepatocellular otherwise

Non-celiac gluten sensitivity： questions still to be answered despite increasing awareness

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Cellular & Molecular Immunology 2013年第5期10卷 383-392页

作者： Umberto Volta Giacomo Caio Francesco Tovoli Roberto De giorgio Department of Medical and Surgical Sciences St. Orsola-Malpighi Hospital University of Bologna Bologna Italy

Recently, the increasing number of patients worldwide who are sensitive to dietary gluten without evidence of celiac disease or wheat allergy has contributed to the identification of a new gluten-related syndrome defined as non-celiac gluten sensitivity. Our knowledge regarding this syndrome is still lacking, and many aspects of this syndrome remain unknown. Its pathogenesis is heterogeneous, with a recognized pivotal role for innate immunity; many other factors also contribute, inctuding tow-grade intestinal inflammation, increased intestinal barrier function and changes in the intestinal microbiota. Gluten and other wheat proteins, such as amylase trypsin inhibitors, are the primary triggers of this syndrome, but it has also been hypothesized that a diet rich in fermentable monosaccharides and polyols may elicit its functional gastrointestinal symptoms. The epidemiology of this condition is far from established; its prevalence in the general population is highly variable, ranging from 0.63% to 6%. From a clinical point of view, non-celiac gluten sensitivity is characterized by a wide array of gastrointestinal and extraintestinal symptoms that occur shortly after the ingestion of gluten and improve or disappear when gluten is withdrawn from the diet. These symptoms recur when gluten is reintroduced. Because diagnostic biomarkers have not yet been identified, a double-blind placebo-controlled gluten challenge is currently the diagnostic method with the highest accuracy. Future research is needed to generate more knowledge regarding non-celiac gluten sensitivity, a condition that has global acceptance but has only a few certainties and many unresolved issues.

关键词： celiac disease epithelial barrier function gut inflammation non-celiac gluten sensitivity wheat allergy