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Ablative therapies for intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 192-194页

作者： Antonio giorgio Pietro Gatti Paolo Matteucci Valentina giorgio Interventional Ultrasound Unit Tortorella Clinical HospitalSalernoItaly Internal Medicine Division Ostuni HospitalOstuni BRItaly Radiation Oncology Institute Campus Biomedico UniversityRomeItaly Pediatric Gastroenterology Unit Sacred Heart UniversityPoliclinico GemelliRomeItaly

Among the 3 sub-types of cholangiocarcinoma (CH), [intrahepatic CH, hylar (CH) and extrahepatic (CH)], intrahepatic cholangiocarcinoma (ICC) accounts for up 8–10% of cholangiocarcinomas and 10–20% of all primary liv... 详细信息

关键词： carcinoma liver for

Multi-frame and multi-dimensional historical digital cities: the Como example

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International Journal of Digital Earth 2014年第4期7卷 336-350页

作者： Luana Valentini Maria Antonia Brovelli giorgio Zamboni Politecnico di Milano-Polo di Como DIIARComoItaly

In this article,we present the realisation of a multi-frame and multi-dimensional WebGIS that allows users to simultaneously analyse a specific portion of the Earth taking into account the historical information,*** graphical panels have been realised:one for the usual 2D view and one for a more realistic 3D *** panels display historical maps of the city,the current orthophoto and the digital topographical *** 3D frame is based on NASA World Wind,an open source virtual globe from where 3D buildings are shown extruding the 2D shapes using their mean *** to a specifically designed graphical user interface,it is also possible to dynamically thematise the buildings on the globe according to different criteria(*** construction time span)so that only the geometries fulfilling the request are turned *** the proposed application,a synchronisation between the two panels has been implemented,in order to maintain a constant alignment of the two *** application is also open to the time *** fact,assigning to each geometry two dates(e.g.‘year of construction’and‘year of demolition’),it is possible to dynamically view how buildings have changed over time,both in their shape and *** developments of this work will concern the possibility of implementing a city model with a higher level of detail.

关键词： web application multi-frame multi-dimensional time historical maps 3D

Douglas-fir climate sensitivity at two contrasting sites along the southern limit of the European planting range

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Journal of Forestry Research 2020年第6期31卷 2193-2204页

作者： Cristiano Castaldi Maurizio Marchi giorgio Vacchiano Piermaria Corona CREA-Research Centre for Forestry and Wood Viale S.Margherita 8052100 ArezzoItaly Universitàdegli Studi di Milano DISAAVia Celoria 220133 MilanItaly

Douglas-fir(Pseudotsuga menziesii(Mirb.)Franco)is an important exotic tree species that was planted across a large part of Europe during the last *** both experimental trials and conventional forest plantations,the trees grow at a high rate and produce high-quality *** present study investigated climate-growth relationships of Douglas-fi r at two Italian sites that contrast in climate:a Mediterranean area in southern Italy(Mercurella site)and a cooler,moister site in the northern Apennines without summer aridity(Acquerino).The relationship between tree-ring chronologies and monthly climatic variables was evaluated by a moving average and correlation *** showed that the minimum temperature in February and in March play a key role for Douglas-fi r at both sites,with a positive eff ect on *** the northern site,it is also highly sensitive to late summer temperatures(negative correlation)and spring–summer precipitation(positive correlation).Growth rates in southern latitudes were high even in Europe and in the Mediterranean environment,with low sensitivity to climatic fl *** the basis of our results,further common garden experiments should test adaptation and the interaction between genetics and environment of second-or third-generation seeds from old stands across Europe such as done by the old International Union of Forest Research Organizations(IUFRO)or the European Douglasfi r Improvement Research Cooperative(EUDIREC)experimentation programmes.

关键词： Pseudotsuga menziesii Tree ring analysis Dendroclimatology Forest plantations Exotic forest species

The airborne contagiousness of respiratory viruses:A comparative analysis and implications for mitigation

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Geoscience Frontiers 2022年第6期13卷 257-264页

作者： Alex Mikszewski Luca Stabile giorgio Buonanno Lidia Morawska International Laboratory for Air Quality and Health Queensland University of TechnologyBrisbaneQueenslandAustralia CIUS Building Performance Lab The City University of New YorkNew YorkNYUSA Department of Civil and Mechanical Engineering University of Cassino and Southern LazioCassinoFRItaly Global Centre for Clean Air Research(GCARE) Department of Civil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUnited Kingdom

The infectious emission rate is a fundamental input parameter for airborne transmission risk assessment,but data are limited due to reliance on estimates from chance superspreading *** study assesses the strength of a predictive estimation approach developed by the authors for SARS-CoV-2 and uses novel estimates to compare the contagiousness of respiratory *** applied the approach to SARS-CoV-1,SARS-CoV-2,MERS,measles virus,adenovirus,rhinovirus,coxsackievirus,seasonal influenza virus and Mycobacterium tuberculosis(TB)and compared quanta emission rate(ER)estimates to literature *** calculated infection risk in a prototypical classroom and barracks to assess the relative ability of ventilation to mitigate airborne *** median standing and speaking ERestimate for SARS-CoV-2(2.7 quanta h)is similar to active,untreated TB(3.1 quanta h),higher than seasonal influenza(0.17 quanta h-1),and lower than measles virus(15 quanta h).We calculated event reproduction numbers above 1 for SARS-CoV-2,measles virus,and untreated TB in both the classroom and barracks for an activity level of standing and speaking at low,medium and high ventilation rates of 2.3,6.6 and 14 L per second per person(L sp),*** predictive ERestimates are consistent with the range of values reported over decades of *** congregate settings,current ventilation standards are unlikely to control the spread of viruses with upper quartile ERqvalues above 10 quanta h,such as SARS-CoV-2,indicating the need for additional control measures.

关键词： SARS-CoV-2(COVID-19)airborne transmission Quanta emission rate Ventilation Measles Influenza

Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

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Neural Regeneration Research 2023年第4期18卷 773-778页

作者： Luigi Manni giorgio Conti Antonio Chiaretti Marzia Soligo Institute of Translational Pharmacology National Research Council of Italy(CNR)RomeItaly Intensive Pediatric Therapy and Pediatric Trauma Center Department of EmergencyAnesthesiological and Reanimation SciencesFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly Institute of Pediatrics Department of Woman and Child HealthFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Traumatic brain injury is one of the main causes of mortality and disability *** brain injury is characterized by a primary injury directly induced by the impact,which progresses into a secondary injury that leads to cellular and metabolic damages,starting in the first few hours and days after primary mechanical *** date,traumatic brain injury is not targetable by therapies aimed at preventing and/or limiting the outcomes of secondary damage but only by palliative *** growth factor is a neurotrophin targeting neuronal and non-neuronal cells,potentially useful in preventing/limiting the outcomes of secondary damage in traumatic brain *** potential has further increased in the last two decades since the possibility of reaching neurotrophin targets in the brain through its intranasal delivery has been ***,molecules intranasally delivered to the brain parenchyma may easily bypass the blood-brain barrier and reach their therapeutic targets in the brain,with favorable kinetics,dynamics,and safety *** the first part of this review,we aimed to report the traumatic brain injury-induced dysfunctional mechanisms that may benefit from nerve growth factor *** the second part,we then exposed the experimental evidence relating to the action of nerve growth factor(both in vitro and in vivo,after administration routes other than intranasal)on some of these *** the last part of the work,we,therefore,discussed the few manuscripts that analyze the effects of treatment with nerve growth factor,intranasally delivered to the brain parenchyma,on the outcomes of traumatic brain injury.

关键词： intranasal delivery nerve growth factor pharmacology traumatic brain injury

On the scale-up criteria for bubble columns

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Petroleum 2019年第2期5卷 114-122页

作者： giorgio Besagni Lorenzo Gallazzini Fabio Inzoli Department of Energy Politecnico di MilanoVia Lambruschini 4a20156MilanoItaly

It is generally admitted that experimental data obtained in“laboratory-scale”bubble columns are representative of“industrial-scale”reactors if the well-known three“Wilkinson et ***-up criteria”are satisfied:(a)the diameter of the bubble column is larger than 0.15 m,(b)the sparger openings are larger than 1e2mm and(c)the aspect ratio is larger than *** aim of this communication is to contribute to the existing *** this end,this communication collects relevant experimental investigation and include new experimental data:in particular,we have experimentally studied the combined effect of the aspect ratio(within the range of 1e15)and the sparger design(considering both“coarse”and“fine”spargers)on the gas holdup in a large-diameter and large-scale gas-liquid bubble *** bubble column has been operated both in the batch mode and in the counter-current *** air has been used as the gaseous phase in all the experiments,while the liquid phase has included deionized water and different aqueous solutions of organic(i.e.,ethanol)and inorganic(i.e.,sodium chloride,NaCl)active *** is found that the“Wilkinson et ***-up criteria”are valid for the air-water case in the batch mode for“very-coarse”***,they are no more valid when considering different liquid velocity,and/or aqueous solutions of active agents,and other sparger openings.

关键词： Bubble column Scale-up Gas sparger Gas holdup Liquid phase properties

A new method of dynamic mesh used in continuous guide vane closure of a reversible pump-turbine in generating mode

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Journal of Hydrodynamics 2019年第5期31卷 976-985页

作者： Xiu-li Mao Yuan Zheng giorgio Pavesi Zhan-shan Xie College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Department of Industrial Engineering University of PaduaPadovaItaly

In this paper,a new method of dynamic mesh based on two functional controls is used in the continuous guide vane closure,and the three-dimensional numerical simulation is carried out to investigate the transient flow characteristics for a Francis-type reversible pump-turbine in the turbine mode in the load regulation scenario,with the detached eddy simulation(DES)turbulent *** transient flow characteristics during the closure of the guide vanes are illustrated by analyzing the signals of the mass flow,the torque and the pressure fluctuations in the frequency and time-frequency *** is shown by the simulated results that a continuous assessment of the transient flow characteristics during the guide vane closure may be made by using the new method of the dynamic ***,the flow field analysis involves both the onset and the development of the unsteady phenomena progressively based on an organized guide vane closure *** flow pattern in the return channel maintains a relatively stable flow field before the last stage of the closure,as compared with the unstable flow field in other *** identify the unit variation under the fluid-dynamical conditions,the influence of the three-dimensional unsteady flow structures in the passage is analyzed and its evolution during this transient process is characterized by the fluid-dynamics and the spectral analysis.

关键词： Francis-type reversible turbine dynamic mesh guide vane closure flow characteristics

Deep panoramic depth prediction and completion for indoor scenes

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Computational Visual Media 2024年第5期10卷 903-922页

作者： Giovanni Pintore Eva Almansa Armando Sanchez giorgio Vassena Enrico Gobbetti Visual and Data-intensive Computing CRS4Cagliari 09134Italy Gexcel srl Elmas(CA)09097Italy Department of Civil EnvironmentArchitectural Engineeringand Mathematics(DICATAM)Universita degli Studi di Brescia(UNIBS)Brescia(BS)25123Italy.

We introduce a novel end-to-end deeplearning solution for rapidly estimating a dense spherical depth map of an indoor *** input is a single equirectangular image registered with a sparse depth map,as provided by a variety of common capture *** is inferred by an efficient and lightweight single-branch network,which employs a dynamic gating system to process together dense visual data and sparse geometric *** exploit the characteristics of typical man-made environments to efficiently compress multiresolution features and find short-and long-range relations among scene ***,we introduce a new augmentation strategy to make the model robust to different types of sparsity,including those generated by various structured light sensors and LiDAR *** experimental results demonstrate that our method provides interactive performance and outperforms stateof-the-art solutions in computational efficiency,adaptivity to variable depth sparsity patterns,and prediction accuracy for challenging indoor data,even when trained solely on synthetic data without any fine tuning.

关键词： machine learning image processing and computervision visionand scene understanding 3D stereo scene analysis

Editorial on "Role of thermal ablation in the management of colorectal liver metastasis"

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 62-64页

作者： Antonio giorgio Pietro Gatti Massimo De Luca Paolo Matteucci Valentina giorgio Liver Unit and Interventional Ultrasound Unit Athena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine Unit Brindisi General HospitalBrindisiItaly Liver Unit Cardarelli HospitalNaplesItaly Radiation Oncology Unit Campus BiomedicoRomaItaly Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthRomaItaly

The last 30 years have shown the increasing role of Ablation in the treatment of malignant liver tumors. By the introduction of percutaneous ethanol injection (PEI) as first ablation tool for percutaneous treatment of hepatocellular carcinoma (HCC) in cirrhosis that firstly showed very high efficacy (1), several ablation techniques (mainly thermal) have been introduced in clinical practice aimed at destroying primary and secondary hepatic tumors as alternative or substitute tools to surgery. Radiofrequency ablation (RFA) was the first thermal technique that showed a good efficacy to ablate liver metastases (2). Among the secondary liver tumors, colorectal liver metastases (CRLM) represent the unique indication for ablation (2). Unlike HCC in cirrhosis where the role of RFA is well defined as first line therapy for HCC nodules < or equal to 2 cm or as alternative to surgery in 1-3 HCC nodules with the maximum diameter<3 cm (3), in the case of CRLM it is not possible to reproduce the same paradigm. Liver resection remains the standard of care for CRLM and the indications to ablation remain confined to nonresectable patients (4). The review article by Takahashi and Berber recently published in HBSN wells illustrates the current role of ablation in treatment of CRLM (5).

关键词： colorectal metastasis surgery