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Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation

Asian Journal of Andrology 2020年第3期22卷 302-308页

作者： giorgia spaggiari Antonio R M Granata Daniele Santi Unit of Endocrinology Department of BiomedicalMetabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModena 41126Italy Unit of Endocrinology Department of Medical SpecialtiesAzienda Ospedaliero-Universitaria of ModenaOspedale Civile of BaggiovaraModena 41126Italy.

Testicular volume(TV)is proposed to be a positive predictor of male fertility status,because of the relation known between the TV and the seminiferous tubule *** of the measurement methodology,the role of TV and testicular ultrasound(US)assessments is still debated in andrological clinical *** this retrospective cohort study,we evaluated TV and testis US role in the diagnostic workup of andrological *** consecutive outpatients undergoing single-operator testis US(Modena,Italy)from March 2012 to March 2018 were enrolled,matching sonographic,hormonal,and seminal data.A total of 302 men were referred and evaluated for gynecomastia,suspected hypogonadism,couple infertility(Cl),or sexual *** the hypogonadal group,TV was lower compared to that in other groups(P<0.001),and a significant,direct correlation between TV and testosterone level was observed in nonandrogen-treated patients(R=0.911,P<0.001),suggesting that testicular size could be related to the testosterone-secreting *** the Cl group,normozoospermic patients showed higher TV compared to men with impaired semen quality(P=0.003)and azoospermia(P=0.003).However,TV was not able to discriminate between patients presenting normal and altered semen *** the contrary,testis US inhomogeneity was more frequent in patients with impaired sperm quality(55.0%;P=0.007)and azoospermia(40.0%;P=0.012),compared to patients with normozoospermia(5%),identifying thereby the sonographic pattern as an informative parameter of the fertility ***,in the Cl workup,US evaluation seems to be more informative than the TV assessment alone.

关键词： male hypogonadism male infertility testicular diseases testis

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Determination of particulate polycyclic aromatic hydrocarbons in ambient air by gas chromatography-mass spectrometry after molecularly imprinted polymer extraction

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Journal of Environmental Sciences 2023年第2期124卷 644-654页

作者： Maria Chiara Pietrogrande giorgia Demaria Mara Russo Department of Chemical Pharmaceutical and Agraricultural SciencesUniversity of FerraraVia Fossato di Mortara 17/1944121 FerraraItaly

A solid phase extraction procedure(SPE)is described for the quantitative analysis of polycyclic aromatic hydrocarbons(PAHs)in atmospheric particulate matter(PM),as ubiquitous environmental pollutants routinely measured in air qualitymonitoring.A SPE cartridge was used based on a molecular imprinted polymer(MIP-SPE)properly tailored for selective retention of PAHs with 4 and more benzene fused *** performance of the clean-up procedure was evaluated with the specific concern of selective purification towards saturated hydrocarbons,which are the PM components mostly interfering GC analysis of target *** optimized operative conditions,the MIP-SPE provided analyte recovery close to 95%for heavier PAHs,from benzo(α)pyrene to benzo(ghi)perylene,and close to 90%for four benzene rings PAHs,with good reproducibility(RSDs:2.5%-5.9%).Otherwise,C_(17)-C_(32) n-alkanes were nearly completely *** proposed method was critically compared with Solid Phase Micro Extraction(SPME)using a polyacrylate *** methods were successfully applied to the analysis of ambient PM2.5 samples collected at an urban polluted *** the two procedures,the MIP-SPE provided the highest recovery(R%≥93%)for PAHs with 5 and more benzene rings,but lower for lighter *** contrast,SPME showed a mean acceptable R%value(∼80%)for all the investigated PAHs,except for the heaviest PAHs in the most polluted samples(R%:110%-138%),suggesting an incomplete purification from the interfering n-hydrocarbons.

关键词： Polycyclic aromatic hydrocarbons Atmospheric particle matter Molecularly imprinted polymers-solid-phase extraction Solid phase micro extraction GC/MS analysis

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Taste sensitivity and divergence in host plant acceptance between adult females and larvae of Papilio hospiton

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Insect Science 2018年第5期25卷 809-822页

作者： giorgia Sollai Maurizio Biolchini Roberto Crnjar Department of Biomedical Sciences Section of Physiology University of Cagliari 09042 Monserrato (CA) Italy

On the island of Sardinia the lepidopteran Papilio hospiton uses Ferula com- munis as exclusive host plant. However, on the small island of Tavolara, adult females lay eggs on Seseli tortuosum, a plant confined to the island. When raised in captivity on Seseli only few larvae grew beyond the first-second instar. Host specificity of lepidopterans is determined by female oviposition preferences, but also by larval food acceptance, and adult and larval taste sensitivity may be related to host selection in both cases. Aim of this work was：（i） to study the taste sensitivity of larvae and ovipositing females to saps of Ferula and Seseli; （ii） to cross-compare the spike activity of gustatory receptor neurons （GRNs） to both taste stimuli; （iii） to evaluate the discriminating capability between the two saps and determine which neural code/s is/are used. The results show that：（i） the spike responses of the tarsal GRNs of adult females to both plant saps are not different and therefore they cannot discriminate the two plants; （ii） larval L-lat GRN shows a higher activity in response to Seseli than Ferula, while the opposite occurs for the phagostimulant neurons, and larvae may discriminate between the two saps by means of multiple neural codes; （iii） the number of eggs laid on the two plants is the same, but the larval growth performance is better on Ferula than Seseli. Taste sensitivity differences may explain the absence of a positive relationship between oviposition preferences by adult females and plant acceptance and growth performance by larvae.

关键词： chemoreception feeding acceptance host-plant discrimination neural cod-ing oviposition preference Papilionidae

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Multiallelic and multilocus simple sequence repeats(SSRs)to assess the genetic diversity of a Salix *** collection

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Journal of Forestry Research 2021年第1期32卷 263-271页

作者： giorgia Carletti Luigi Cattivelli Lorenzo Vietto Giuseppe Nervo Council for Agricultural Research and Economics(CREA)-Research Centre for Forestry and Wood Casale MonferratoALItaly Council for Agricultural Research and Economics(CREA)-Research Centre for Genomics and Bioinformatics Fiorenzuola d’ArdaPCItaly

Salix L.(willow)is the largest genus of the family Salicaceae and plays an important role in riparian habitats,wetlands and in shrub *** to the diff erent implications for the species belonging to this family,it is fundamental to identify molecular tools characterizing relevant clones.A set of six multilocus and multiallelic simple sequence repeat(SSRs)markers are presented,leading to 390 polymorphic fragments considered as single dominant markers and able to discriminate successfully 92 *** *** 24 Salix *** polymorphic fragments have been used to perform genetic diversity studies,and to investigate population structures and cluster analysis in a germplasm *** results highlight the capability of the six SSRs to be powerful genetic resources in applied forestry research,both to distinguish *** clones from Salix *** to perform genetic population studies for breeding programs.

关键词： Microsatellites Salix Genetic diversity

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Mature versus emerging technologies for CO2 capture in power plants： Key open issues in post-combustion amine scrubbing and in chemical looping combustion

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 315-325页

作者： giorgia De Guido Matteo Compagnoni Laura A. Pellegrini Ilenia Rossetti Department of Chemistry Materials and Chemical Engineering "Giulio Natta" Politecnico di Milano Piazza Leonardo da Vinci 32 20133 MilanItaly Department of Chemistry Universita degli Studi di Milano INSTM Unit Milano-Universita and CNR-ISTM Via Camillo Golgi 19 20133 Milan Italy

Carbon capture and storage （CCS） have acquired an increasing importance in the debate on global wanning as a mean to decrease the environmental impact of energy conversion technologies, by capturing the CO2 produced from the use of fossil fuels in electricity generation and industrial processes. In this respect, post-combustion systems have received great attention as a possible near-term CO2 capture technology that can be retrofitted to existing power plants. This capture technology is, however, energy-intensive and results in large equipment sizes because of the large volumes of the flue gas to be treated. To cope with the demerits of other CCS technologies, the chemical looping combustion （CLC） process has been recently considered as a solution for CO2 separation. It is typically referred to as a technology without energy penalty. Indeed, in CLC the fuel and the combustion air are never mixed and the gases from the oxidation of the fuel （i.e., CO2 and H2O） leave the system as a separate stream and can be separated by condensation of H2O without any loss of energy. The key issue for the CLC process is to find a suitable oxygen carrier, which provides the fuel with the activated oxygen needed for combustion. The aim of this work is to explore the feasibility of using perovskites as oxygen carriers in CLC and to consider the possible advantages with respect to the scrubbing process with amines, a mature post-combustion technology for CO2 separation.

关键词： CO2 capture monoethanolamine chemical looping combustion oxygen carder perovskites

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Metabolic reprogramming as an emerging mechanism of resistance to endocrine therapies in prostate cancer

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Cancer Drug Resistance 2021年第1期4卷 143-162页

作者： Paolo Chetta giorgia Zadra University of Milan Milan 20122Italy Current Address:Boehringer Ingelheim RCV GmbH&Co.KG Dr.-Boehringer-Gasse 5-11Vienna 1121Austria Department of Oncologic Pathology Dana-Farber Cancer Institute and Brigham Women’s HospitalHarvard Medical SchoolBostonMA 02215USA Current Address:Institute of Molecular Genetics National Research CouncilPavia 27100Italy

Prostate cancer(PCa)is the second leading cause of cancer-related death in the *** receptor(AR)signaling is the driver of both PCa development and progression and,thus,the major target of current in-use ***,despite the survival benefit of second-generation inhibitors of AR signaling in the metastatic setting,resistance mechanisms inevitably ***,novel strategies are required to circumvent resistance occurrence and thereby to improve PCa *** the key cellular processes that are regulated by androgens,metabolic reprogramming stands out because of its intricate links with cancer cell *** this review,we discuss how cancer metabolism and lipid metabolism in particular are regulated by androgens and contribute to the acquisition of resistance to endocrine *** describe the interplay between genetic alterations,metabolic vulnerabilities and castration *** PCa cells adapt their metabolism to excess nutrient supply to promote cancer progression,we review our current knowledge on the association between diet/obesity and resistance to anti-androgen *** briefly describe the metabolic symbiosis between PCa cells and tumor microenvironment and how this crosstalk might contribute to PCa *** discuss how tackling PCa metabolic vulnerabilities represents a potential approach of synthetic lethality to endocrine ***,we describe how the continuous advances in analytical technologies and metabolic imaging have led to the identification of potential new prognostic and predictive biomarkers,and non-invasive approaches to monitor therapy response.

关键词： Metabolic reprogramming prostate cancer castration resistance endocrine therapies metabolomics metabolic imaging therapy respo nse

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Source apportionment of PAHs and n-alkanes bound to PM1 collected near the Venice highway

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Journal of Environmental Sciences 2017年第4期29卷 77-89页

作者： Gabrio Valotto Giancarlo Rampazzo Francesco Gonella Gianni Formenton Silvia Ficotto giorgia Giraldo Department of Environmental Sciences Informatics and Statistics Uniuersita Ca Foscari Venezia 1-30123 Venezia Italy Department of Molecular Sciences and Nanosystems Uniuersita Ca Foscari Venezia 1-30123 Venezia Italy Dipartimento Provinciale di Venezia Agenzia Regionale per la Preuenzione e Protezione Ambientale del Veneto 1-30174 Mestre Italy

n-Alkanes and polycyclic aromatic hydrocarbons（PAHs） bound to atmospheric particulate matter（PM1） were investigated in a traffic site located in an urban area of Venice Province（Eastern Po Valley, Italy） during the cold season. Considering the critical situation affecting the Veneto Region concerning the atmospheric pollution and the general lack of information on PM1 composition and emission in this area, this experimental study aims at determining the source profile, their relative contributions and the dispersion of finer particles. Four sources were identified and quantified using the Positive Matrix Factorization receptor model：（1） mixed combustions related to the residential activities,（2）agricultural biomass burning in addition to the resuspension of anthropogenic and natural debris carried by the wind,（3）gasoline and （4）diesel traffic-related combustions. The role of local atmospheric circulation was also investigated to identify the pollutant sources.

关键词： PM1 PAHs n-Alkanes Diesel Gasoline Biomass burning

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Quality and origin of mountain food products: the new European label as a strategy for sustainable development

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Journal of Mountain Science 2019年第2期16卷 428-440页

作者： Deborah BENTIVOGLIO Sara SAVINI Adele FINCO giorgia BUCCI Emanuele BOSELLI Department of Agricultural Food and Environmental Sciences (D3A) Polytechnic University of Marche Chemical Safety Department Experimental Station for the Food Preserving Industry (SSICA) Faculty of Science and Technology Free University of Bolzano-Bozen

Mountain farming provides high-quality food products due to the peculiar characteristics of the raw materials combined with traditional processing conditions. However, these products and their intrinsic characteristics are not clearly recognized by consumers on the market. Nowadays, Protected Designation of Origin(PDO), Protected Geographical Indication(PGI) and Traditional Specialities Guaranteed(TSG) certifications include products originating in mountain areas, even if a large part of mountain foodstuff is not protected by these certifications and foods not made in mountain areas are often labeled as ―mountain food products‖. For this reason, the European Union has set a specific Regulation in 2012 to recognize and protect mountain food and to make the consumers safer about the origin information. The objective of this paper is twofold: firstly, it presents the recent aspects related to European legislation of mountain food product; secondly, it aims at reviewing the main features of nutritional quality and technology of dairy and meat products, as the most widespread mountain food products, and the main protocols used to evaluate the authenticity of these food products. The promotion of mountain food product through a specific label and the use of tracing methods, which are able to verify the authenticity of the origin of these products, may play a pivotal role in increasing the consumer‘s loyalty towards these products and could be a way to boost a sustainable development of these economically marginal rural areas. However, the analytical protocols developed so far(stable isotopes, macro and microelements, radionuclides, spectroscopic, molecular techniques, volatile substances profile, terpenes) are in many cases still at the experimental level due to the extreme variability of the mountain origin of the products to be tested.

关键词： Mountain products Label Food technology Sustainable development Dairy products Meat products

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Influence of rejuvenators on bitumen ageing in hot recycled asphalt mixtures

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第3期5卷 157-168页

作者： giorgia Mazzoni Edoardo Bocci Francesco Canestrari Department of Civil and Construction Engineering and Architecture Università Politecnica delle Marche Faculty of Engineering eCampus University

The use of reclaimed asphalt pavement （RAP） in new hot mix asphalt （HMA） by means of hot recycling techniques generates the advantage linked to the exploitation of both lytic and bituminous component, consequently leading to the decrease of both virgin aggregates and bitumen supplying. However, many agencies and public administration authorise RAP percentages ranges from 10% to 30% in hot recycling. The main reason for such a low amount of allowable RAP content is related to the aged bitumen contained in the RAP materials, which is more brittle than a virgin bitumen leading to a final mixture more susceptible to fatigue, thermal and reflection cracking. The use of rejuvenators has the potential to restore rheology and chemical components of aged RAP bitumen, thus allowing a significant increase in the amount of RAP to be properly implemented in HMA. The experimental investigation is described in this paper and carried out through a dynamic shear rheometer （DSR） which provides the rheological characterisation of a paving grade bitumen during its overall service life including its reuse in hot recycling by adopting different rejuvenators. Results show that rejuvenators modify bitumen chemistry and consequently rheology by enhancing the viscous response. Moreover, it was observed that oxidation is less harmful, in terms of stiffness increase, on the 50/50 aged bitumen - virgin bitumen blends （rejuvenated or not） than on the virgin bitumen. Moreover, the addition of a rejuvenator in a bituminous blend containing 50% of bitumen reactivated from RAP could lead to a corresponding composite bituminous phase less subjected to ageing phenomena and even less stiff at the end of service life than the associated virgin bitumen alone.

关键词： Rejuvenator Reclaimed asphalt pavement Bitumen Ageing Dynamic shear rheorneter (DSR)

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Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus

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World Journal of Gastroenterology 2016年第40期22卷 8991-8998页

作者： Sandro Passaretti giorgia Mazzoleni Cristian Vailati Pier Alberto Testoni Gastroenterology and Gastrointestinal Endoscopy Division IRCCS San Raffaele Scientific Institute Vita-Salute San Raffaele University

AIM To investigate the relationship between pathological oropharyngeal(OP) acid exposure and esophageal motility in patients with extra-esophageal *** In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease(GERD). We enrolled only patients with a reflux symptom index(RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry(HRM). Patients were divided into two groups on the basis of a normal or pathological p H-metric finding(Ryan Score) and all manometric characteristics of the two groups were *** We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure(median 71 mmH g vs 126 mmH g, P = 0.004) and the median proximal contractile integral(median 215.5 cm·mmH g·s vs 313.5 cm·mmH g·s, P = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mm Hg isobaric contour(38.7% vs 15.38%, P < 0.0001).CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.

关键词： Esophagus Motility Oropharyngeal reflux Gastroesophageal reflux disease High resolution manometry pH-metry

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