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Environment & Health 2024年第2期2卷 68-75页

作者： giorgia Barbieri Federica Gigliucci Gianfranco Brambilla Stefano Morabito Department of Veterinary Public Health and Food Safety Istituto Superiore di Sanità29900161 RomeItaly

The recycling of biowaste from municipal wastewater treatment plants(WWTPs)in agriculture represents a circular economy-driven source of water and nutrients to support food system ***,biowaste may represent the source of emerging hazards of anthropogenic and animal origin that can transfer from agricultural soils to related food production,posing a risk to consumers’health,as in the case of outbreaks due to the consumption of ready-to-eat leafy vegetables contaminated with pathogenic *** this perspective,we propose a combined strategy based on both classical methods and culture-independent metagenomics approaches to identify microbial hazards relevant to foodborne diseases in WWTP-related *** virulence genes targeted by real-time PCR,performed before and after the enrichment of the raw samples,may represent a proxy for the viability of pathogens,the presence of which is then confirmed via classical microbiological *** analysis of shotgun metagenomic sequences could assess the presence of genes associated with resistance to specific antimicrobials followed by phenotypic confirmation via cultivation of the raw samples in the presence of the predicted *** 16S rDNA analysis supports biowaste traceability based on their taxonomic *** strategy would support a“One Health”Action based on a cross-cutting assessment of emerging food-borne risks along the food chain.

关键词： Emerging hazards Foodborne pathogens Metagenomics Circular economy One Health Cross-cutting approach

Malarial pigment enhances heat shock protein-27 in THP-1 cells:new perspectives for in vitro studies on monocyte apoptosis prevention

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 934-938页

作者： Mauro Prato Valentina Gallo Elena Valente Amina Khadjavi giorgia Mandili Giuliana Giribaldi Department of Genetics Biology and BiochemistryUniversity of Torino Medical SchoolTorinoItaly

Objective:To investigate the effect of malarial pigment(hemozoin,HZ) on expression of heat shock proteins(HSPs) and cell viability in human monocytes by using a stable cell line(THP-1 cells).Methods:THP-1 cells were fed with native HZ or treated with pro-apoptotic molecule gliotoxin for 9 ***,the protein expression of HSP-27 and HSP-70 was evaluated by western ***,HZ-fed cells were cultured up to 72 h and cell viability parameters(survival,apoptosis and necrosis rates) were measured by flow cytometric analysis. Results:HZ increased basal protein levels of HSP-27 without altering those of HSP-70 in THP-1 cells,and promoted long-term cell survival without inducing *** expected,gliotoxin inhibited HSP-27 protein expression and promoted long-term cell ***: Present data show that HZ prevents cell apoptosis and enhances the expression of anli-apoptotic HSP-27 in THP-1 cells,confirming the previous evidences obtained from HZ-fed immunopurified *** the use of a stable cell line is pivotal to perform HSP-27 silencing experiments, monocytic THP-1 cells could be a good candidate line for such an approach,which is heavily required to clarify the role of HSP-27 in survival of impaired HZ-fed monocytes during falciparum malaria.

关键词： Hemozoin Plasmodium falciparum Malaria Monocyte THP-1 cells Phagocytosis Apoptosis Heat shock protein-27

Transient measurement of phononic states with covariance-based stochastic spectroscopy

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Light(Science & Applications) 2022年第3期11卷 68-75页

作者： giorgia Sparapassi Stefano MCavaletto Jonathan Tollerud Angela Montanaro Filippo Glerean Alexandre Marciniak Fancesca Giusti Shaul Mukamel Daniele Fausti Physics Department University of TriesteTriesteItaly Elettra-Sincrotrone Trieste S.C.p.A. TriesteItaly Department of Chemistry and Department of Physics&Astronomy University of CaliforniaIrvineCAUSA Optical Sciences Centre Swinburne UniversityMelbourneAustralia

We present a novel approach to transient Raman spectroscopy,which combines stochastic probe pulses and a covariance-based detection to measure stimulated Raman signals in alpha-quartz.A coherent broadband pump is used to simultaneously impulsively excite a range of different phonon modes,and the phase,amplitude,and energy of each mode are independently recovered as a function of the pump-probe delay by a noisy-probe and covariance-based *** experimental results and the associated theoretical description demonstrate the feasibility of 2D-Raman experiments based on the stochastic-probe schemes,with new capabilities not available in equivalent mean-value-based 2D-Raman *** work unlocks the gate for nonlinear spectroscopies to capitalize on the information hidden within the noise and overlooked by a mean-value analysis.

关键词： stochastic spectroscopy coherent

COVID-19 and the gastrointestinal tract:Source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?

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World Journal of Gastroenterology 2021年第14期27卷 1406-1418页

作者： Jacopo Troisi giorgia Venutolo Meritxell Pujolassos Tanyà Matteo Delli Carri Annamaria Landolfi Alessio Fasano Metabolomics Section Theoreo srl-Spin-off Company of the University of SalernoMontecorvino Pugliano 84090SAItaly Department of Chemistry and Biology“A.Zambelli” University of SalernoFisciano 84084SAItaly European Biomedical Research Institute of Salerno Salerno 84125SAItaly Department of Medicine Surgery and Dentistry“Scuola Medica Salernitana”University of SalernoBaronissi 84081SAItaly Mucosal Immunology and Biology Research Center and Center for Celiac Research Harvard Medical SchoolMassachusetts Gen Hosp ChildrenMucosal Immunology and Biology Research CenterBostonMA 02114United States

Gastrointestinal(GI)symptoms have been described in a conspicuous percentage of coronavirus disease 2019(COVID-19)*** clinical evidence is supported by the detection of viral RNA in stool,which also supports the hypothesis of a possible fecal-oral transmission *** involvement of GI tract in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is corroborated by the theoretical assumption that angiotensin converting enzyme 2,which is a SARS-CoV-2 target receptor,is present along the GI *** have pointed out that gut dysbiosis may occur in COVID-19 patients,with a possible correlation with disease severity and with complications such as multisystem inflammatory syndrome in ***,the question to be addressed is whether dysbiosis is a consequence or a contributing cause of SARS-CoV-2 *** such a scenario,pharmacological therapies aimed at decreasing GI permeability may be beneficial for COVID-19 *** the possibility of a fecal-oral transmission route,water and environmental sanitation play a crucial role for COVID-19 containment,especially in developing countries.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal symptoms Gut microbiome Dysbiosis Zonulin Fecal-oral transmission

Building Tresigallo:The City of Edmondo Rossoni(1933-1939)

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Journal of Civil Engineering and Architecture 2024年第7期18卷 311-317页

作者： giorgia Sala Department of Architecture University of FerraraFerrara 44121Italy

Between 1933 and 1939 Minister Edmondo Rossoni transformed his hometown,a modest village,into a modern center of industrialized *** wanted to experiment a new economic,political,and social model within the Ferrara countryside and,at the same time,aimed to consolidate his power over the *** Minster asked the young and trusted engineer Carlo Frighi to give substance to his project.A provincial construction site was quickly transformed into a dynamic workshop that attracts many workers and involves designers and craftsmen from all over *** has emerged from a bibliographic and archival survey that refocused the history of a town that still confronts,through its architecture,its history,and a difficult legacy.

关键词： Tresigallo Edmondo Rossoni city of autarky urban refunding

Characterization and catalytic activity of soft-templated Ni0-CeO_(2) mixed oxides for CO and CO_(2) co-methanation

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 251-268页

作者： Luciano Atzori Maria giorgia Cutrufello Daniela Meloni Barbara Onida Delia Gazzoli Andrea Ardu Roberto Monaci Maria Franca Sini Elisabetta Rombi Department of Chemical and Geological Sciences University of Cagliari09042 Monserrato(CA)Italy Department of Materials Science and Chemical Engineering CR-INSTM for Materials with Controlled PorosityPolytechnic of Turin10129 TurinItaly Department of Chemistry University of Rome“La Sapienza”00185 RomeItaly

Nanosized NiO,CeO_(2) and NiO-CeO_(2) mixed oxides with different Ni/Ce molar ratios were prepared by the soft template *** the samples were characterized by different techniques as to their chemical composition,structure,morphology and *** the catalysts submitted to the same reduction pretreatment adopted for the activity tests the surface basic properties and specific metal surface area were also *** and CeO_(2) nanocrystals of about 4 nm in size were obtained,regardless of the Ni/Ce molar *** Raman and X-ray photoelectron spectroscopy results proved the formation of defective sites at the NiO-CeO_(2) interface,where Ni species are in strong interaction with the *** microcalorimetric and Fourier transform infrared analyses of the reduced samples highlighted that,unlike metallic nickel,CeO_(2) is able to effectively adsorb CO_(2),forming carbonates and hydrogen *** reduction in H2 at 400°C for 1 h,the catalytic performance was studied in the CO and CO_(2) co-methanation *** tests were performed at atmospheric pressure and 300°C,using CO/CO_(2)/H_(2) molar compositions of 1/1/7 or 1/1/5,and space velocities equal to 72000 or 450000 cm^(3)∙h^(-1)∙gcat^(-1).Whereas CO was almost completely hydrogenated in any investigated experimental conditions,CO_(2) conversion was strongly affected by both the CO/CO_(2)/H_(2) ratio and the space *** faster and definitely preferred CO hydrogenation was explained in the light of the different mechanisms of CO and CO_(2) *** a selected sample,the influence of the reaction temperature and of a higher number of space velocity values,as well as the stability,were also *** that the Ni content is optimized,the NiCe system investigated was very promising,being highly active for the CO_(x) co-methanation reaction in a wide range of operating conditions and stable(up to 50 h)also when submitted to thermal stress.

关键词： soft template method Ni0-CeO_(2)catalystss CO and CO_(2)co-mtharation synthetic natural gas production

The Salt Overly Sensitive （SOS） Pathway： Established and Emerging Roles

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Molecular Plant 2013年第2期6卷 275-286页

作者： Hongtao Ji José M. Pardo giorgia Batelli Michael J. Van Oosten Ray A. Bressan Xia Li The State Key Laboratory of Plant Cell and Chromosome Engineering Center of Agricultural Resources Research Institute of Genetics andDevelopmental Biology Chinese Academy of Sciences Shijiazhuang Hebei 050021 PR China Instituto de Recursos Naturales y Agrobiologia Consejo Superior de Investigaciones Cientificas Sevilla-41012 Spain CNR Institute of Plant Genetics (CNR-IGV) Via Universita' i33 80055 Portici Italy Department of Agricultural Engineering and Agronomy University of Naples Federico II Via Universit~ 100 80055 Portici Italy Center for Plant Environmental Stress Physiology Purdue University West Lafayette IN 47907-2010 USA Department Biological Sciences King Abdulaziz University Kingdom of Saudi Arabia

Soil salinity is a growing problem around the world with special relevance in farmlands. The ability to sense and respond to environmental stimuli is among the most fundamental processes that enable plants to survive. At the cellular level, the Salt Overly Sensitive （SOS） signaling pathway that comprises SOS3, SOS2, and SOS1 has been proposed to mediate cellular signaling under salt stress, to maintain ion homeostasis. Less well known is how cellularly heterog- enous organs couple the salt signals to homeostasis maintenance of different types of cells and to appropriate growth of the entire organ and plant. Recent evidence strongly indicates that different regulatory mechanisms are adopted by roots and shoots in response to salt stress. Several reports have stated that, in roots, the SOS proteins may have novel roles in addition to their functions in sodium homeostasis. SOS3 plays a critical role in plastic development of lateral roots through modulation of auxin gradients and maxima in roots under mild salt conditions. The SOS proteins also play a role in the dynamics of cytoskeleton under stress. These results imply a high complexity of the regulatory networks involved in plant response to salinity. This review focuses on the emerging complexity of the SOS signaling and SOS protein functions, and highlights recent understanding on how the SOS proteins contribute to different responses to salt stress besides ion homeostasis.

关键词： auxin ion homeostasis root system architecture salt stress the SOS signaling pathway.

Alzheimer’s Disease, Early Diagnosis

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Advances in Alzheimer's Disease 2020年第3期9卷 33-46页

作者： Andrisani Giovanni Andrisani giorgia Department of Research Private Clinic “Studio Andrisani” Matera Italy Private Practice “Tandzorg Delft Centrum” Delft Netherland

Aim: In this review paper we propose a method to make an early diagnosis of the Alzheimer’s Disease (AD), the most common form of neurodegenerative dementia. Background: Glymphatic System (GS) is the main means of eliminating waste substances in the central nervous system (CNS);if it does not work properly, waste substances accumulate in CNS until to cause AD. Basal Forebrain is the most important component of a much broader system of cholinergic cells distributed throughout the Central Nervous System (CNS). This structure regulates attention, learning and memory and its destruction is considered responsible for the cognitive AD alterations. The characteristics of AD patients, that interest us most, are the lack of Acetylcholine, and the Orexin excess;we think that the hypothalamus produces more Orexin to stimulate cholinergic cells, indispensable for a correct CNS functioning. We want to identify these patients by detecting the Orexin excess. Early Diagnosis Model. Of course we could take a cerebrospinal fluid sample and dose Orexin but this method is risky and painful for the patient’s health, therefore unsuitable for large numbers of patients. We propose a fairly simple method for the early diagnosis of AD: if we temporarily eliminate the Orexin excess, with Dual Orexin Receptor Antagonist (DORA), i.e. Suvorexant, we can intercept the Orexin increase and demonstrate the decrease in Acetylcholine with a Functional Magnetic Resonance or a Polysomnography, many years before the AD symptoms occur.

关键词： Glymphatic System Acetilcholine Adenosine Orexin Dual Orexin Receptor Antagonist

Lifesaving transarterial embolization using absorbable gelatin sponge particles for massive bleeding of ruptured metastatic hepatic melanoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 194-196页

作者： Panagiotis Lainas giorgia Amy Rodda George Rafek Maude Millereux Carmelisa Dammaro Pierre Trouiller Sophie Maitre Ibrahim Dagher Department of Minimally Invasive Digestive Surgery Antoine-Beclere HospitalAP-HPClamart F-92140France Paris-Saclay University Orsay F-91405France Department of Radiology Antoine-Beclere HospitalAP-HPClamart F-92140France Department of Intensive Care Unit Antoine-Beclere HospitalAP-HPClamart F-92140France

To the Editor:Melanoma is an aggressive malignant tumor that arises from melanocytic cells. It usually originates from the epithelial tissues of the skin, retina and anorectal canal. Melanoma is characterized by early metastases, even from thin primary tumors. The most common sites of distant metastasis are: skin, lung, brain, liver, bone and intestine. Liver involvement occurs in 14% to 20% of cases [1] , but the diagnosis is usually performed incidentally on imaging studies, since these lesions are seldom symptomatic. Rarely, metastatic hepatic melanoma can manifest as an acute condition of massive bleeding due to spontaneous rupture of one or more hepatic lesions, with disastrous outcomes for patients in most cases. In the current literature, very few cases of spontaneous rupture of metastatic hepatic melanoma have been reported, all with fatal outcomes [2–5] . Indeed, when such a condition occurs, prompt management and bleeding control strategies are essential for long-term survival of these patients.

关键词： hepatic melanoma involvement

Granulo-monocyto apheresis is more effective in mild ulcerative colitis than in moderate to severe disease

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World Journal of Gastroenterology 2014年第45期20卷 17155-17162页

作者： Chiara De Cassan Edoardo Savarino Piero Marson Tiziana Tison giorgia Hatem Giacomo Carlo Sturniolo Renata D'Incà Division of Gastroenterology Department of Surgery Oncology and Gastroenterology University of Padua Apheresis Unit Blood Transfusion Service University of Padua

AIM: To evaluate whether the effectiveness of Granulo-monocyto apheresis (GMA), a technique that consists of the extracorporeal removal of granulocytes and monocytes from the peripheral blood, might vary according to ... 详细信息

关键词： Ulcerative colitis Granulo-monocyto-apheresis Inflammatory bowel disease Therapy Severity