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Being Chine.e or Being Different:Chine.e Undergraduates’Use of Discourses of Chine.ene.s

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Frontiers of Education in China 2014年第3期9卷 303-326页

作者： gillian SKYRME School of Humanities Massey UniversityPalmerston North 4442New Zealand

Myths about“the Chine.e learne.”developed from an outsider perspective abound in the Western *** focus of this article,however,is how discourses of Chine.ene.s were used by the Chine.e international students themselves who,as undergraduate students in a ne. Zealand university,were the subjects of my doctoral *** examine. the students’notions of Chine.ene.s and how these served in explaining their own narratives,either through identifying with,or distancing themselves from,“Chine.e”traits,indicating alternatively a shared experience of the challenges of the ne. academic culture,or marking themselves out as having a special ability to thrive within *** way they used them,the discourses seemed to serve a purpose of fortifying their sense of identity and *** the end of their study,they were able to reflect carefully on their experiences and discuss ne. third space identities in which both Chine.e and ne. Zealand values were forging ne. realities for them.

关键词： Chine.e undergraduate Chine.e identity ne.otiation of identity

Induction of IgA and sustaine. deficiency of cell proliferative response in chronic hepatitis C

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World Journal of Gastroenterology 2008年第44期14卷 6844-6852页

作者： Yalena Amador-Caizares Liz Alvarez-Lajonchere Ivis Guerra Ingrid Rodríguez-Alonso gillian martíne.-donato Julián Triana Eddy E González-Horta Angel Pérez Santiago Dueas-Carrera Centro de Ingeniería Genética y Biotecnología Ave 31e/ 158 and 190PlayaP.O. Box 6162HavanaCuba

AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMC） proliferative responses against hepatitis C virus （HCV） antigens were evaluated in HCV chronically infected patients. METHODS： Paired serum and PBMC samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay （ELISA） and carboxyfluorescein succinimidyl ester staining. RSULTS： Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM （P = 0.027） and IgG （P = 0.0006） was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid （P = 0.017） and NS3 （P = 0.005） after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage （P = 0.036）. IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of CD4＋ or CD8＋ T cells, being the capsid poorly recognized. CONCLUSION： These results confirm that while the cellular immune.response is narrow and weak, a broad and vigorous humoral response occurs in HCV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation.

关键词： Hepatitis C Antibody response Lymphoproliferation Core Envelope

HCV-specific immune.responses induced by CIGB-230 in combination with IFN-α plus ribavirin

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World Journal of Gastroenterology 2014年第1期20卷 148-162页

作者： Yalena Amador-Caizares gillian martíne.-donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera Centro de Ingeniería Genética y Biotecnología Playa 10600HavanaCuba Center for Infection and Immunity of Lille (CIIL) Inserm U1019CNRS UMR8204Institut Pasteur de LilleUniv Lille Nord de FranceF-59000 LilleFrance Instituto de Gastroenterología Vedado 10400HavanaCuba Hospital Clínico Quirúrgico "Hermanos Amejeiras" Havana 10200Cuba Centro de Inmunoensayos Havana 11300Cuba

AIM: To analyze hepatitis C virus (HCV)-specific immune.responses in chronically infected patients under triple therapy with interferon-α (IFN-α) plus ribavirin and CIGB-230.

关键词： Clinical trial DNA vaccine Enzyme-linked immunospot Hepatitis C virus Leukopenia

Rare case of sclerosing mesenteritis and low grade follicular lymphoma

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World Journal of Clinical Cases 2016年第4期4卷 108-111页

作者： Seema Shah gillian Mahy Enrico Roche the Townsville Hospital

An unusual case of long standing sclerosing mesenteritis;initially presented with recurrent abdominal pain and a mesenteric mass with surrounding fat oedema and stranding with a pseudocapsule and fat ring sign were clearly visualised on the initial computed tomography *** showed diffuse thickening at the root of the mesentery and histology from this specimen revealed fat ne.rosis and reactive lymphoid tissue consistent with sclerosing *** treatment with steroids and tamoxifen relieved the symptoms and the *** was maintaine. on *** years later he developed a recurrence of his symptoms and abdominal mass that responded to a course of *** years following this,he developed a follicular Hodgkin’s lymphoma.

关键词： Sclerosing mesenteritis Computerised tomography scan Magne.ic resonance imaging scans Tamoxifen Steroids Hodgkin’s lymphoma

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Alice in space

Segmented sedentary time and physical activity patterns throughout the week from wrist-worn ActiGraph GT3X+ accelerometers among children 7-12 years old

作者： gillian Beer.

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Journal of Sport and Health Science 2020年第2期9卷 179-188页

作者： gillian McLellan Rosie Arthur Samantha Donne.ly Duncan S.Buchan School of Health and Life Sciences The University of the West of ScotlandInstitute of Clinical Exercise and Health ScienceBlantyreG72 OLHScotlandUK

Background:This study examine. the volume and patterns of physical activity(PA) and sedentary time(ST) across different segments of the week among boys and ***:A total of 188 children aged 7-12 years wore a wrist-mounted ActiGraph GT3 X+accelerometer for 7 *** spent in PA and ST was calculated using ActiLife *** mean number of minutes of light PA,moderate PA,vigorous PA,moderate-to-vigorous PA(MVPA),and ST were calculated per weekday(before school,during school,and after school) and per weekend day(morning and afternoon-evening).Results:After school represented the greatest accumulation of ST compared with before school and during school *** engaged in225.4 min/day of ST(95% confidence interval(CI):216-235),and girls engaged in 222.2 min/day of ST(95%CI:213-231).During school,boys engaged in significantly more MVPA than girls(46.1 min/day(95%CI:44-48) vs.40.7 min/day(95%CI:39-43)).Across the whole weekday,boys participated in significantly more MVPA than girls(103.9 min/day(95%CI:99-109) vs.95.7 min/day(95%CI:90-101)).The weekend afternoon—evening segment represented the larger accumulation of ST,where boys were significantly more sedentary than girls(367.5 min/day(95%CI:353-382) vs.339.8 min/day(95%CI:325-355),respectively).Conclusion:Our findings suggest that children are highly sedentary and spend little of their time in school in MVPA,especially *** breaks in school elicit increases in light PA and *** work should consider the use of more active breaks within school time to encourage PA and reduce ST.

关键词： Accelerometry School Segments Weekday Youth

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Apoptosis is not an invariable compone.t of in vitro models of cortical cerebral ischaemia

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Cell Research 2004年第3期14卷 241-250页

作者： Paul Alexander JOne.,gillian Ruth MAY,Joyce Ann MCLUCKIE,Akinori IWASHITA,John SHARKEY Fujisawa Institute of ne.roscience Division of ne.roscience University of Edinburgh 1 George Square Edinburgh UK Medical Information Eli Lilly and Company Ltd Lilly House Priestley Road Basingstoke RG24 9NL UK Fujisawa Institute of ne.rosdence Division of ne.roscience University of Edinburgh 1 George Square Edinburgh UK Medicinal Biology Research Laboratories Fujisawa Pharmaceuticals Co.Ltd. 2-1-6 Kashima Yodogawa-ku Osaka 532-5814 Japan Fujisawa Institute of ne.roscience Division of ne.roscience University of Edinburgh 1 George Square Edinburgh UK

Characterising the mechanisms of cell death following focal cerebral ischaemia has been hampered by a lack of an in vitro assay emulating both the apoptotic and ne.rotic features observed in vivo. The present study systematically characterised oxygen-glucose-deprivation (OGD) in primary rat cortical ne.rone. to establish a reproducible model with compone.ts of both cell-death endpoints. OGD induced a time-dependent reduction in cell viability, with 80% cell death occurring 24 h after 3 h exposure to 0% O2 and 0.5 mM glucose. Indicative of a ne.rotic compone.t to OGD induced cell death, N-methyl-D-aspartate (NMDA) receptor inhibition with MK-801 attenuated ne.ronal loss by 60%. The lack of protection by the caspase inhibitors DEVD-CHO and z-VAD-fmk suggested that under these conditions ne.rone. did not die by an apoptotic mechanism. Moderating the severity of the insult by decreasing OGD exposure to 60 min did not reduce the amount of ne.rosis, but did induce a small degree of apoptosis (a slight reductio

关键词： oxygen-glucose-deprivation caspase cortical ne.rosis.

Metabolism of tissue macrophages in homeostasis and pathology

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Cellular & Molecular Immunology 2022年第3期19卷 384-408页

作者： Stefanie K.Wculek gillian Dunphy Ignacio Heras-Murillo Annalaura Mastrangelo David Sancho Immunobiology Laboratory Centro Nacional de Investigaciones Cardiovasculares(CNIC)Melchor Fernández Almagro 3Madrid28029Spain

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to gene.ate cellular ene.gy and structural *** emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune.*** are embryo-or adult bone.marrow-derived leukocytes that are key for healthy tissue homeostasis but can also contribute to pathologies such as metabolic syndrome,atherosclerosis,fibrosis or *** metabolism has largely been studied in ***,different organs contain diverse macrophage populations that specialize in distinct and often tissue-specific *** context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their particular microenvironment and conditions their response in pathological ***,we outline.current knowledge on the metabolic requirements and adaptations of macrophages located in tissues during homeostasis and selected diseases.

关键词： Tissue macrophages metabolism homeostasis pathology tissue regene.ation

Brains for Dementia Research: The Importance of Cohorts in Brain Banking

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ne.roscience Bulletin 2019年第2期35卷 289-294页

作者： Paul T.Francis gillian M.Hayes Helen Costello David R.Whitfield Wolfson Centre for Age-Related Diseases King's College London

Background:The Historical Importance of Studies of Human Brain in Dementia Research The collection of brain and related tissue has a long history(1)In terms of dementia,a more systematic examination of the relationship between brain pathology and clinical symptoms can be traced to Alois Alzheimer’s group in Munich in the early 1900s(2)The use of human brain tissue is essential to increase our understanding of dementia as it gives us the gold standard of disease pathogene.is and clues as to the molecular mechanisms that underpin the various diseases and conditions.

关键词： Importance of Cohorts Dementia Research mechanisms

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