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A Novel Interpretation of Structural Dot Plots of Genomes Derived from the Analysis of Two Strains of Neisseria meningitidis

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Genomics, Proteomics & Bioinformatics 2010年第3期8卷 159-169页

作者： Wilfred R. Cuff Venkata R.S.K. Duvvuri Binhua Liang Bhargavi Duvvuri gillian E. Wu Jianhong Wu Raymond S.W. Tsang Public Health Agency of Canada Canadian Science Centre for Human and Animal Health Winnipeg Canada Center for Disease Modelling York Institute for Health Research York University Toronto Canada Department of Biology York University Toronto Canada Department of Medical Microbiology University of Manitoba Winnipeg Canada School of Kinesiology and Health Sciences York University Toronto Canada Department of Mathematics and Statistics York University Toronto Canada.

Neisseria meningitidis is the agent of invasive meningococcal disease, including cerebral meningitis and septicemia. Because the diseases caused by different clonal groups （sequence types） have their own epidemiological characteristics, it is important to understand the differences among the genomes of the N. meningitidis clonal groups. To this end, a novel interpretation of a structural dot plot of genomes was devised and applied; exact nu- cleotide matches between the genomes ofN. meningitidis serogroup A strain Z2491 and serogroup B strain MC58 were identified, leading to the specification of various structural regions. Known and putative virulence genes for each N. meningitidis strain were then classified into these regions. We found that virulence genes of MC58 tend more to the translocated regions （chromosomal segments in new sequence contexts） than do those of Z2491, notably tending towards the interface between one of the translocated regions and the collinear region. Within the col- linear region, virulence genes tend to occur within 16 kb of gaps in the exact matches. Verification of these tendencies using genes clustered in the cps locus was sufficiently supportive to suggest that these tendencies can be used to focus the search for and understanding of virulence genes and mechanisms of pathogenicity in these two organisms.

关键词： structural dot plots virulence genes translocation match regions MUMmer Neisseria meningitidis

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Determination of Cyanide Content in Three Sweet Cassava Cultivars in Three Local Government Areas of Benue State, Nigeria

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Food and Nutrition Sciences 2015年第12期6卷 1078-1085页

作者： Simon Terver Ubwa Monday Abel Otache gillian Ogbene Igbum Tseaa Shambe Department of Chemistry Benue State University Makurdi Nigeria

The cyanide content of the parenchyma (pulp) of three sweet cassava cultivars: Alhaji (Tropical Manihot Selection;TMS 98/0581), Ochengbila (Tropical Manihot Selection;TMS 98/0505), and Onono (Tropical Manihot Selection;TMS 98/0524) from three local government areas of Benue State were studied. Their contents were: TMS 98/0581 (41.46 - 53.40) mg/kg, TMS 98/0505 (45.12 - 58.93) mg/kg and TMS 98/0524 (46.38 - 58.08) mg/kg for all the local government areas. For the peels, it ranged from (63.41 - 108.96) mg/kg for all cultivars. The cyanide content of the cultivars varies from one local government to another and also from one farm to another. No appreciable loss of cyanide was observed after four days of storage. The cyanide content of boiled and roasted cassava parenchyma was (5.26 - 7.85) mg/kg and (9.73 - 10.55) mg/kg respectively for all the cultivars. Air dried parenchyma at (26°C - 32°C for one week and oven dried parenchyma at 60°C for four hours ranged from (16.05 - 18.83) mg/kg and (21.82 - 24.04) mg/kg respectively for all cultivars.

关键词： Cassava Cultivar Cyanide Content Place of Growth Roasted Boiled

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大脑垃圾清理战

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快乐青春（经典阅读）（中学生必读） 2016年第11期 68-69页

作者： gillian

头昏脑涨、记忆力减退、烦躁易怒……这可能是因为你的大脑垃圾太多了!此时最好的做法就是清理大脑里的垃圾，甚至给大脑洗个澡。

关键词：大脑垃圾清理记忆力

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寻香北海道

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运动休闲 2016年第1期 128-131页

作者： gillian

日本是一个去过一次还想再去一次的国家，这里的整洁有序、尊卑有次让我这个有洁癖兼强迫症的人倍感舒适。对于之前去过东京的我来说，再选择日本，只有一个原因，就是北海道。

关键词：北海道强迫症再选择日本

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青春期和围绝经期妇女的避孕措施

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国际内科双语杂志（中英文） 2006年第9期6卷 10-12,37-39页

作者： gillian Penney 英国阿伯丁大学的高级讲师和阿伯丁产科医院计划生育临床推行机构的荣誉主任

这篇文章对生育年龄两端妇女避孕措施的观点做了总结。·青春期是指从开始发育到成熟之间的阶段。·围绝经期是指从有规律的排卵性月经到排卵和月经停止之间的过渡期。

关键词：围绝经期妇女避孕措施青春期生育年龄排卵性月经

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大脑垃圾清理战

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运动休闲 2016年第1期 140-141页

作者： gillian

头昏脑涨、记忆力减退、烦躁、易怒……以上种种问题，可能是因为你的大脑“垃圾”太多了。大脑垃圾太多怎么办？美容人士常说的所谓“淋巴排毒”，其实就是通过加强淋巴管液的流动，促进细胞新陈代谢废物的排出。然而，脑内并没有淋巴... 详细信息

头昏脑涨、记忆力减退、烦躁、易怒……以上种种问题，可能是因为你的大脑“垃圾”太多了。大脑垃圾太多怎么办？美容人士常说的所谓“淋巴排毒”，其实就是通过加强淋巴管液的流动，促进细胞新陈代谢废物的排出。然而，脑内并没有淋巴管这样的结构——人类大脑是全身代谢最旺盛的器官之一，为什么偏偏没有淋巴管？脑细胞产生的“垃圾”怎么办？。

关键词：垃圾大脑清理新陈代谢脑细胞记忆力

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打好大脑垃圾清理战。吃住都很有讲究

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快乐青春（经典阅读）（中学生必读） 2017年第8期 79-80页

作者： gillian

侧卧有助于大脑自我清理大脑内的类淋巴系统可以通过一系列的清理和溶解，辨认并处理掉大脑里的“废物”。研究者运用核磁共振成像技术，研究不同睡姿（仰卧、侧卧、俯卧）下老鼠的大脑中类淋巴系统的运输速率。

关键词：大脑清理核磁共振成像技术垃圾研究者系统速率

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改变

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疯狂英语（新悦读） 2022年第10期 39-39,76页

作者： gillian Kingsley 不详

杰玛下了校车,感到很痛苦。今天是她一生中最糟糕的日子之一……Gemma jumped off the school bus feeling *** had been one of the worst days of her *** could she show her face at school ever again?It was total *** would not ... 详细信息

关键词：校车 Today again

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Semantic Data Models for Semistructured Data

Semantic Data Models for Semistructured Data

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第二十一届中国数据库学术会议

作者： Tok Wang Ling Mong Li Lee gillian Dobbie Department of Computer Science National University of Singapore Department of Computer Science University of Auckland New Zealand

Semistructured data has become more prevalent on the Web,and XML has become the de facto standard for semistructured data,with much of the data stored in flat *** is a growing concern for the effective management and efficient storage and retrieval of semistructured *** paper provides an overview of the data models that have been developed for capturing the semantics that are crucial for the effective management of semistructured *** data models include DTD,DOM,OEM,DataGuide,and *** semantics include the representation of objects,relationships,attributes of objects,key attributes,functional dependencies,degrees of relationships,participation constraints in relationships,attributes of relationships,*** will also demonstrate the usefulness of these semantics in minimizing redundancy in the storage of semistructured data,and in the validation of views.

关键词： Semistrutctured data Semantics Data model XML

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LOV to BLUF： Flavoprotein Contributions to the Optogenetic Toolkit

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Molecular Plant 2012年第3期5卷 533-544页

作者： John M. Christie Jayde Gawthorne gillian Young Niall J. Fraser^c and Andrew J. Roe Institute of Molecular Cell and Systems Biology College of Medical Veterinary and Life Sciences University of Glasgow UK Institute of Infection immunity and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow UK Institute of Cardiovascular and Medical Sciences College of Medical Veterinary and Life Sciences University of Glasgow UK

Optogenetics is an emerging field that combines optical and genetic approaches to non-invasively interfere with cellular events with exquisite spatiotemporal control. Although it arose originally from neuroscience, optogenetics is widely applicable to the study of many different biological systems and the range of applications arising from this tech- nology continues to increase. Moreover, the repertoire of light-sensitive proteins used for devising new optogenetic tools is rapidly expanding. Light, Oxygen, or Voltage sensing （LOV） and Blue-Light-Utilizing flavin adenine dinucleotide （FAD）（BLUF） domains represent new contributors to the optogenetic toolkit. These small （100-140-amino acids） flavoprotein modules are derived from plant and bacterial photoreceptors that respond to UV-A/blue light. In recent years, considerable progress has been made in uncovering the photoactivation mechanisms of both LOV and BLUF domains. This knowledge has been applied in the design of synthetic photoswitches and fluorescent reporters with applications in cell biology and biotechnology. In this review, we summarize the photochemical properties of LOV and BLUF photosensors and highlight some of the recent advances in how these flavoproteins are being employed to artificially regulate and image a variety of biological processes.

关键词： Blue-Light.Utilizing FAD chromophore flavin fluorescence light, oxygen or voltage optogenetics photo- receptor protein engineering

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