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Reaction mechanisms in massive nuclei collisions and perspectives for synthesis of heavier superheavy elements

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Nuclear Science and Techniques 2013年第5期24卷 98-106页

作者： giardina g NASIROV A K mANDAgLIO g CURCIARELLO F De LEO V FAZIO g ROmANIUK m Dipartimento di Fisica e di Scienze della Terra dell'Università di messina Istituto Nazionale di Fisica Nucleare Sezione di Catania Joint Institute for Nuclear Research Institute of Nuclear Physics Centro Siciliano di Fisica Nucleare e Struttura della materia Catania 95125Italy

We discuss a hardship in synthesis of heaviest super heavy elements in massive nuclei reactions due to the hindrance to complete fusion of reacting nuclei caused on the onset of quasifission process which strongly competes with complete fusion and due to the strong increase of fission yields along the de-excitation cascade of the compound nucleus in comparison with the evaporation residue *** hindrance to formation of compound nucleus and evaporation residue is determined by the characteristic of the entrance channel.

关键词：超重元素反应机制合成碰撞聚变反应残余物复合核核反应

Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

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Neural Regeneration Research 2023年第6期18卷 1243-1248页

作者： Paola Ruffo Francesca De Amicis Emiliano giardina Francesca Luisa Conforti medical genetics Laboratory Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly Department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaRendeItaly genomic medicine Laboratory UILDm IRCCS Fondazione Santa LuciaRomeItaly Department of Biomedicine&Prevention Tor Vergata University of RomeRomeItaly

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression *** the epigenome and epitranscriptome directs the fate of the transcript influencing the functional outcome of each *** this context,non-coding RNAs play a decisive role in addressing the expression regulation at the gene and chromosomal ***-noncoding RNAs,consisting of more than 200 nucleotides,have been shown to act as epigenetic regulators in several key molecular processes involving neurodegenerative disorders,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***-noncoding RNAs are abundantly expressed in the central nervous system,suggesting that their deregulation could trigger neuronal degeneration through RNA *** evaluation of their diagnostic significance and therapeutic potential could lead to new treatments for these diseases for which there is no cure.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis epigenetic mechanism Huntington’s disease long-noncoding RNAs neurodegenerative disease non-coding RNAs Parkinson’s disease

Studies of heavy ion reactions around Coulomb barrier

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Studies of heavy ion reactions around Coulomb barrier

S100b protects ImR-32 cells against Ab(1-42) induced neurotoxicity via modulation of apoptotic genes expression

“创新——核科学技术发展的不竭源泉”——中国核学会2009年学术年会

作者： A.Richard A.K.Nasirov g.mandaglio m.manganaro g.giardina K.Hagino China Institute of Atomic Energy Universite de Strasbourg(Uds) 67037 StrasbourgFrance Joint Institute of Nuclear Research 141980 DubnaRussia

The angular distributions of fission fragments for the S+W reaction near Coulomb barrier energies were *** experimental fission excitation function is *** measured fission cross sections are decomposed into fusion-fission,quasifission and fast fission contributions by the dinuclear system *** hindrance to complete fusion both at small and large collision energies is *** fusion excitation functions of S+ Zr in an energy range from above to below Coulomb barrier were measured and *** obvious effect of positive Q-value neutron transfers has been observed in the S+Zr *** addition,the excitation functions of quasielastic scattering at a backward angle have been measured for the systems of O + Pb,Pt,W,and Sm at energies well below the Coulomb barrier. Considering the coupling effects,the extracted diffuseness parameters are close to the values extracted from the systematic analysis of elastic and inelastic scattering data.

关键词： fusion-fission quasifission fusion enhancement neutron transfer surface diffuseness parameter

来源： cnki会议评论

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Advances in Alzheimer's Disease 2013年第3期2卷 99-108页

作者： m. Elisabetta Clementi Beatrice Sampaolese Doriana Triggiani Antonio Tiezzi Bruno giardina 1CNR-ICRm Institute of Chimica del Riconoscimento molecolare Department for Innovation in Biological Agro-food and Forest Systems (DIBAF) Tuscia University Viterbo Italy Institute of Biochemistry and Clinical Biochemistry Catholic University School of Medicine Rome Italy

Amyloid beta (1-42) peptide is considered responsible for the formation of senile plaques that accumulate in the brain of patients with Alzheimer’s disease (AD). In the past years considerable attention has been focused on identifying new protective substances that prevent or almost retard the appearance of amyloid beta (1-42)-related neurotoxic effects. In this study, human neuroblastoma cells (ImR-32) was used as system model to evaluate the protective role of S100b, a neurotrophic factor and neuronal survival protein, that is highly expressed by reactive astrocytes in close vicinity of beta-amyloid deposits, against amyloid beta (1-42)-dependent toxicity. Our results show that at nanomolar concentrations, S100b protects cells against Aβmediated cytotoxicity, as assessed by mTS vitality test. The protective mechanism seems to be related to the effect on bcl-2 (an anti-apoptotic gene) expression, which is highly down-regulated by amyloid beta (1-42) treatment, while resulted more expressed in the presence of S100b. On the contrary, Bax, a proapoptotic gene, resulted down-regulated by the treatment with S100 compared with the results obtained in the presence of amyloid beta (1-42) peptide. However, at micromolar doses, S100b is toxic for ImR-32 cells and its toxicity adds to that of the Aβpeptide, suggesting that additional molecular mechanisms may be involved in theneurotoxic process.

关键词： S100b Neurodegeneration Oxidate methionine Apoptotic genes Expression

Latest results from.gRAAL collaboration

维普期刊数据库评论

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维普期刊数据库

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Chinese Physics C 2009年第12期33卷 1249-1253页

作者： V. Vegna V. Bellini J.P. Bouquet L. Casano A. D'Angelo J.P. Didelez R. Di Salvo A. Fantini D. Franco g. gervino F. ghio g. giardina B. girolami A. giusa m. guidal E. Hourany A.S. Ignatov R. Kunnel A. Lapik A. Lleres P. Levi Sandri F. mammoliti g. mandaglio m. manganaro m. moricciani A.N. mushkarenkov V.g. Nedorezov C. Randieri D. Rebreyend N.V. Rudnev g. Russo C. Schaerf m.L. Sperduto m.C. Sutera A.Turinge Dip. di Fisica Università degli Studi di Roma 'Tor Vergata' via della Ricerca Scientifica 1 I-00133 Roma Italy INFN - Sezione di Roma 'Tor Vergata' via della Ricerca Scientifica 1 I-00133 Roma Italy Dip. di Fisica e Astronomia Università di Catania via Santa Sofia 44 I-95123 Catania Italy INFN - Sezione di Catania via Santa Sofia 44 I-95123 Catania Italy LPSC Universit Joseph Fourier Grenoble 1 CNRS/IN2P3 Institut National Polytechnique de Grenoble 53 Avenue des Martyres 38026 Grenoble France IPNO Universit de Paris-Sud 11 CNRS/IN2P3 15 rue Georges Clemenceau 91406 Orsay France Dip. di Fisica Sperimentale Università di Torino via P.Giuria I-00125 Torino Italy INFN - Sezione di Torino via P.Giuria I-00125 Torino Italy Istituto Superiore di Sanità viale Regina Elena 299 I-00161 Roma Italy INFN - Sezione di Roma piazzale Aldo Moro 2 I-00185 Roma Italy Dip. di Fisica Universitàdi Messina salita Sperone 31 I-98166 Messina Italy Institute for Nuclear Research RAS 117312 Moscow Russia INFN - Laboratori Nazionali di Frascati via E.Fermi 40 I-00044 Frascati Italy INFN - Sezione di Catania via Santa Sofia 44 I-95123 Catania Italy

The gRAAL experimental set-up consists of a polarized and tagged photon beam that covers an energy range from a minimum of 600 meV up to a maximum of 1500 meV, of a liquid Hydrogen or Deuterium target and of the 4π Lagrange detector optimized for photon detection. It allows the study of pseudo-scalar and vector meson photoproduCtion on the nucleon in the energy range corresponding to the second and the third resonance regions. In the following, the ∑ beam asymmetries in η and π0 photoproduction on quasi-free nucleon are shown. Also single and double polarization observables in K＋A photoproduction on free proton are shown; they are important to confirm the role of new or poorly known resonances in the 1900 meV mass region.

关键词： polarized photon meson photoproduction polarization observables

葡萄糖诱导的体外培养人脐静脉内皮细胞膜中葡糖基磷脂酰肌醇锚式补体活化膜调节物(CD59,CD55)的下调

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德国医学 2001年第6期18卷 331-332页

作者： A.Accardo-Palumbo g.Triolo g.Colonna-Romano m.Potestio m.Carbone A.Ferrante E.giardina g.Caimi g.Triolo 周新荣 Department of Internal medicine Section of Clinical ImmunologyRheumatology and AllergyUniversity of Palermo 华中科技大学同济医学院附属同济医院

研究表明糖尿病血管病变发生的主要原因是内皮细胞功能异常,高血糖又是加速内皮功能紊乱的重要原因之一。糖尿病患者中还可发现补体系统活性增加,导致糖尿病患者肾脏血管壁、肾小球及系膜区补体分子沉积;血浆中可溶性非细胞裂解的C5b-9... 详细信息

研究表明糖尿病血管病变发生的主要原因是内皮细胞功能异常,高血糖又是加速内皮功能紊乱的重要原因之一。糖尿病患者中还可发现补体系统活性增加,导致糖尿病患者肾脏血管壁、肾小球及系膜区补体分子沉积;血浆中可溶性非细胞裂解的C5b-9的浓度及代表内皮功能紊乱的von Willebrand因子浓度增加。补体介导的自体细胞损伤有以下几种调节因子:衰败加速因子(DAF、CD55)、膜共因子蛋白(mCP、CD46)、C3b受体、唾液酸和膜溶解反应抑制物(mIRL、CD59)等。

关键词：糖尿病血管病变葡萄糖脐静脉内皮细胞膜葡萄基磷脂酰肌醇锚式补体活化膜调节物

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长期羟基脲治疗过程中的口腔鳞癌形成

世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 19-19页

作者： De Benedittis m. Petruzzi m. giardina C. 牛新武 Via Pitagora 2/A 70033 Corato (Bari)Italy

Hydroxyurea (HU) is commonly used for the treatment of chronic myelogenous leukaemia, polycythemia vera and essential thrombocythaemia. Patients receiving HU present a number of side-effects including skin/mucosa changes and tumours. mucocutaneous abnormalities include xerosis, ichthyosiform lesions, dark brown pigmentation of skin folds and nails, malleolar ulcers, oral mucositis and oral ulcers. Cutaneous squamous/basal cell carcinomas have also often been reported following long- term administration of HU. HU-induced carcinogenesis is due to both the mutagenic potential of this agent and to an impairment of DNA repair mechanisms after dam.ge by external factors such as ultraviolet radiation. Oral cancer following long-term treatment with HU has been reported only once, in a patient with concomitant multiple skin tumours. We present the unique case of a patient with polycythemia vera who developed oral cancer after 15 years of HU therapy.

关键词：口腔鳞癌羟基脲慢性髓性白血病皮肤肿瘤基底细胞癌鱼鳞病皮肤干燥皮肤黏膜肿瘤形成口腔溃疡