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Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders:A systematic review and meta-analysis

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World Journal of Psychiatry 2021年第8期11卷 477-490页

作者： Andrea Miuli gianna sepede Gianfranco Stigliano Alessio Mosca Francesco Di Carlo Giacomo d’Andrea Aliseo Lalli Maria Chiara Spano Mauro Pettorruso Giovanni Martinotti Massimo Di giannantonio Department of Neuroscience Imaging and Clinical Sciences“G.d'Annunzio”University of ChietiChieti 66100Italy Department of Psychiatry Affective Neuropsychiatry Sahlgrenska University HospitalGöteborg 40530Sweden Department of Pharmacy Clinical ScienceUniversity of HertfordshireHerts AL109ABItaly

BACKGROUND Nowadays there is an increasing use of transcranial magnetic stimulation(TMS)both in neurological and psychiatric *** Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression,TMS has been widely used in the context of mood disorders(MD).However,growing reports regarding the possibility of developing hypomanic/manic switch(HMS)have generated concern regarding its use in *** To investigate the actual risk of developing HMS due to TMS in the treatment of *** We led our research on PubMed,Scopus and Web of Science on March 22,2020,in accordance to the PRISMA guidelines for systematic *** double blind/single blind studies,written in English and focused on the TMS treatment of MD,were included.A meta-analysis of repetitive TMS protocol studies including HMS was conducted using RevMan 5.4 *** assessment of Risk of Bias was done using Cochrane risk of bias *** protocol was registered on PROSPERO with the CRD42020175811 *** Twenty-five studies were included in our meta-analysis:Twenty-one double blind randomized controlled trials(RCT)and four single blind-RCT(*** subjects involved in active stimulation=576;*** subjects involved in sham protocol=487).The most frequently treated pathology was major depressive episode/major depressive disorder,followed by resistant depression,bipolar depression and other *** majority of the studies used a repetitive TMS protocol,and the left dorsolateral prefrontal cortex was the main target *** effects were reported in eight studies and HMS(described as greater energy,insomnia,irritability,anxiety,suicidal attempt)in four *** comparing active TMS vs sham treatment,the risk of developing HMS was not significantly different between *** Applying the most usual protocols and the appropriate precautionary measures,TMS seems not to be related to HMS development.

关键词： Hypomanic/manic switch Transcranial magnetic stimulation Active vs sham comparison Mood disorders Adverse event Safety

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Craving variations in patients with substance use disorder and gambling during COVID-19 lockdown:The Italian experience

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World Journal of Clinical Cases 2022年第3期10卷 882-890页

作者： Maria Chiara Alessi Giovanni Martinotti Domenico De Berardis Antonella Sociali Chiara Di Natale gianna sepede Daniela Pia Rosaria Cheffo Laura Monti Pietro Casella Mauro Pettorruso Stefano Sensi Massimo Di giannantonio Department of Neuroscience ImagingClinical SciencesUniversity G.d'AnnunzioChieti-Pescara 66100Italy Department of Pharmacy PharmacologyClinical SciencesUniversity of HertfordshireHertfordshire AL109ABUnited Kingdom National Health Care System Mazzini HospitalTeramo 64100Italy Department of Mental Health UOS Psicologia Ospedaliera Fondazione Policlinico Gemelli IRCSSRome 00118Italy Department of Mental Health and Addiction Services ASL Roma 1Rome 00118Italy

BACKGROUND Following the development of the coronavirus disease-2019(COVID-19)pandemic in Italy,a strict lockdown was imposed from March 9 to May 5,*** risks of self-medication through alcohol or psychoactive substance abuse were increased,as well as the tendency to adopt pathological behaviors,such as gambling and internet *** To evaluate the impact of the COVID-19 pandemic and associated containment measures on craving in a group of patients suffering from substance use disorder and/or gambling disorder who were in treatment in outpatient units or in residency programs as *** One hundred and fifty-three patients completed a structured questionnaire evaluating craving and other behaviors using a visual analogue scale(VAS).Forty-one subjects completed a pencil and paper questionnaire during the *** clinician provided an online questionnaire to 112 patients who had virtual assessments due to lockdown *** analyses were performed using Statistica version *** parameters are presented as the mean±SD and qualitative parameters as number and percentage per *** Kolmogorov-Smirnov test was used to check for normality of *** of variance and Duncan post hoc test were employed to analyze differences among subgroup *** associations between variables were measured using Pearson's correlation.A P value of<0.05 was considered *** The variation in craving between the present and the month before showed VASrelated reductions of craving in 57%,increases in 24%,and no significant change in 19%of the *** level of craving was significantly higher(F=4.36;P<0.05)in outpatients(n=97;mean=3.8±3.1)living in their own home during the quarantine compared with inpatients(n=56;mean=2.8±2.8)in residential *** for tetrahydrocannabinol was the greatest(4.94,P<0.001)among various preferred *** The unexpected result of this study may be explaine

关键词： Substance use disorder Addiction COVID-19 Craving Psychopathology

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Sustained attention in psychosis:Neuroimaging findings

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World Journal of Radiology 2014年第6期6卷 261-273页

作者： gianna sepede Maria Chiara Spano Marco Lorusso Domenico De Berardis Rosa Maria Salerno Massimo Di giannantonio Francesco Gambi Department of Neuroscience and Imaging Institute for Advanced Biomedical Technologies University "G. D’Annunzio" of Chieti "G. d’Annunzio" University of Chieti 66013 Chieti Scalo (CH) Italy Department of Mental Health National Health Trust 64100 Teramo Italy

To provide a systematic review of scientific literatureon functional magnetic resonance imaging(fMRI) stud-ies on sustained attention in psychosis. We searchedPubMed to identify fMRI studies pertaining sustainedattention in both affective and non-affective psycho-sis. Only studies conducted on adult patients using asustained attention task during fMRI scanning wereincluded in the final review. The search was conductedon September 10 th, 2013. 15 fMRI studies met our in-clusion criteria: 12 studies were focused on Schizophre-nia and 3 on Bipolar Disorder Type Ⅰ(BDI). Only halfof the Schizophrenia studies and two of the BDI stud-ies reported behavioral abnormalities, but all of themevidenced significant functional differences in brain re-gions related to the sustained attention system. Alteredfunctioning of the insula was found in both Schizophre-nia and BDI, and therefore proposed as a candidate trait marker for psychosis in general. On the other hand, other brain regions were differently impaired in affective and non-affective psychosis: alterations of cingulate cortex and thalamus seemed to be more common in Schizophrenia and amygdala dysfunctions in BDI. Neural correlates of sustained attention seem to be of great interest in the study of psychosis, highlight-ing differences and similarities between Schizophrenia and BDI.

关键词： Sustained attention Affective psychosis Non-affective psychosis Schizophrenia Bipolar disorder Functional magnetic resonance imaging Insula

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Functional magnetic resonance imaging of internet addiction in young adults

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World Journal of Radiology 2016年第2期8卷 210-225页

作者： gianna sepede Margherita Tavino Rita Santacroce Federica Fiori Rosa Maria Salerno Massimo Di giannantonio Department of Basic Medical Sciences Neurosciences and Sense Organs University "A. Moro" Department of Neuroscience Imaging and Clinical Sciences University "G.d’Annunzio"

AIM: To report the results of functional magnetic resonance imaging(f MRI) studies pertaining internet addiction disorder(IAD) in young ***: We conducted a systematic review on Pub Med, focusing our attention on f MRI studies involving adult IAD patients, free from any comorbid psychiatric condition. The following search words were used, both alone and in combination: f MRI, internet addiction, internet dependence, functional neuroimaging. The search was conducted on April 20^(th), 2015 and yielded 58 records. Inclusion criteria were the following: Articles written in English, patients' age ≥ 18 years, patients affected by IAD, studies providing f MRI results during resting state or cognitive/emotional paradigms. Structural MRI studies, functional imaging techniques other than f MRI, studies involving adolescents, patients with comorbid psychiatric, neurological or medical conditions were excluded. By reading titles and abstracts, we excluded 30 records. By reading the full texts of the 28 remaining articles, we identified 18 papers meeting our inclusion criteria and therefore included in the qualitative ***: We found 18 studies fulfilling our inclusion criteria, 17 of them conducted in Asia, and including a total number of 666 tested subjects. The included studies reported data acquired during resting state or different paradigms, such as cue-reactivity, guessing or cognitive control tasks. The enrolled patients were usually males(95.4%) and very young(21-25 years). The most represented IAD subtype, reported in more than 85% of patients, was the internet gaming disorder, or videogame addiction. In the resting state studies, the more relevant abnormalities were localized in the superior temporal gyrus, limbic, medial frontal and parietal regions. When analyzing the task related fmri studies, we found that less than half of the papers reported behavioral differences between patients and normal controls, but all of them found significant diffe

关键词： Internet addiction Pathologic internet use Functional magnetic resonance imaging Internet gaming disorder Functional neuroimaging

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