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World Journal of Clinical Oncology 2013年第2期4卷 52-57页

作者： Pasquale Rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico Davide Bosso Antonella Virtuoso Michela Izzo Tania Policastro Luca Vaccaro gianfranco cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri Giuseppe Di Lorenzo Genitourinary Cancer Section and Rare-Cancer Center Medical Oncology DivisionUniversity Federico II80131 NapoliItaly Department of Dermatology University Federico II of Naples80131 NapoliItaly

AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective *** some cases,the human herpes virus 8 status was assessed by *** patients were staged according to the Mediterranean KS staging system.A multivariable model was constructed using a forward stepwise selection procedure.A P value<0.05 was considered statistically significant,and all tests were ***:Thirty-two cases were included in this *** average age at diagnosis was 70 years,with a male/female ratio of approximately 2:***-four percent of the cases had classic *** patients received systemic chemotherapy containing one of the following agents:vinca alkaloid,taxane,and pegylated liposomal *** patients(31.5%)experienced a partial response,and a complete response was achieved in four patients(12.4%)and stable disease in sixteen cases(50%).Two patients(6.2%)were refractory to the systemic *** median progression-free survival(PFS)was 11.7 mo,whereas the median overall survival was 28.5 *** multivariate analysis,the presence of nodular lesions(vs macular lesions only)was significantly related to a lower PFS(hazard ratio:3.09;95%CI:1.18-8.13,P=0.0133).CONCLUSION:Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic *** data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy.

关键词： Kaposi’s sarcoma Human herpes virus 8 Paclitaxel Pegylated liposomal doxorubicin Vinblastine

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