检索结果-南通市图书馆

Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin Lee Yeunjung Ko Hyun Woo Lee Won Joon Oh Hun gi Hong Dinuka Ariyaratne Se Jin Im tae Jin Kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

Influence of overhanging tool length and vibrator material on electromechanical impedance and amplitude prediction in ultrasonic spindle vibrator

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 292-310页

作者： Rendi KURNIAWAN Moran XU Min Ki CHOO Shuo CHEN Yein KWAK' Jielin CHEN Saood ALI Hanwei TENG Pil Wan HAN gi Soo KIM tae Jo KO Precision Machining Laboratory Department of Mechanical Engineering Yeungnam UniversityGyeongsansiGyeongbuk-doRepublic of Korea Korea Electrotechnology Research Institute(KERI) ChangwonsiGyeongsangnam-doRepublic of Korea KASWIN Co. LtdChangwon-siGyeongsangnamdoRepublic of Korea

This study presents the development of an ultrasonic transducer with a radius horn for an ultrasonic milling spindle(UMS)*** ultrasonic transducer was intended to have a working frequency of approximately 30 *** different materials were considered in the study:stainless steel(SS 316L)and titanium alloy(Ti-6Al-4V).Titanium alloy gave a higher resonance frequency(33 kHz)than stainless steel(30 kHz)under the same preload compression *** electromechanical impedance simulation was carried out to predict the impedance resonance frequency for both materials,and the effect of the overhanging toolbar was *** to the electromechanical impedance simulation,the overhanging toolbar length affected the resonance frequency,and the error was less than 3%.Harmonic analysis confirmed that the damping ratio helps determine the resonance ***,damping ratios of 0.015-0.020 and 0.005-0.020 were selected for stainless steel and titanium alloy,respectively,with an error of less than 1.5%.Experimental machining was also performed to assess the feasibility of ultrasonic-assisted milling;the result was a lesser cutting force and better surface topography of Al 6061.

关键词： Ultrasonic spindle Ultrasonic vibration assisted-milling(UVAM) 1-degree of freedom(DOF) Frequency Amplitude Milling

Gastric heterotopia of colon found cancer workup in liver abscess:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第15期10卷 5012-5017页

作者： Jun gi Park Jeong Ill Suh yeo Un Kim Department of Internal Medicine College of MedicineDongguk UniversityGyeongju 38067South Korea

BACKGROUND Recently reported cases of pyogenic liver abscess associated with colonic cancer in the absence of underlying disease,have included a small number of cases of gastric heterotopia(GHT).GHT is a congenital anomaly composed of ectopic gastric mucosa and can occur anywhere in the gastrointestinal tract but is more frequently encountered in the cervical ***,it is rarely observed in ***,most reported cases of GHT of the colon involved the rectum,and GHT involving the colon proximal to the rectum is *** SUMMARY An 83-year-old male patient presented with fever and a diagnosis of pyogenic liver *** was performed for colon cancer workup and revealed a 1.0 cm sized polyp at the transverse *** polyp was removed by endoscopic mucosal resection by monopolar electrocauterization using a *** examination revealed *** administering intravenous antibiotics,the patient recovered *** GHT in the colon could affect the development of pyogenic liver abscess by enabling hematogenous propagation of Klebsiella pneumoniae through mucosal ***,more study is needed due to the lack of cases.

关键词： Gastric heterotopia Colon Liver abscess Case report

Aqueous extract of Protaetia brevitarsis larvae increases mTOR-mediated growth rate in zebrafish larvae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 339-347页

作者： Jayasingha Arachchige Chathuranga Chanaka Jayasingha Kyoung tae Lee Yung Hyun Choi gi-Young Kim Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Forest Bioresources Department Forest Microbiology DivisionNational Institute of Forest ScienceSuwon 16631Republic of Korea Department of Biochemistry College of Korean MedicineDong-Eui UniversityBusan 47227Republic of Korea

Objective:To evaluate the effects of an aqueous extract of Protaetia brevitarsis(AEPB)on the growth of zebrafish and preosteoblast MC3T3-E1 ***:The effects of AEPB on the linear growth and the expression of growth-related genes in zebrafish and MC3T3-E1 cells were assessed using various molecular ***,the involvement of the mammalian target of rapamycin(mTOR)pathway in AEPB-induced growth was investigated by employing the mTOR inhibitor ***:AEPB administration led to a significant and dose-dependent increase in zebrafish larvae growth over ***,AEPB treatment upregulated the expression of growth hormone-1(GH-1),insulin-like growth factor-1(IGF-1),growth hormone receptor-1(GHR-1),and cholecystokinin-a(CCKA)in ***,AEPB stimulated the expression and release of IGF-1 and accelerated mTOR expression in MC3T3-E1 *** addition,rapamycin hindered AEPB-induced linear growth in zebrafish larvae and suppressed the expression of growth-promoting genes by inhibiting mTOR ***:AEPB shows growth-promoting effects by upregulating growth-related genes and activating the mTOR signaling *** investigations are warranted to elucidate its mechanisms of action and explore its potential application in the development of growth-enhancing supplements for various purposes.

关键词： Protaetia brevitarsis Growth rate Growth hormone Insulin-like growth factor mTOR MC3T3-E1

Aqueous extract of freeze-dried Protaetia brevitarsis larvae promotes osteogenesis by activating β-catenin signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2022年第3期12卷 115-123页

作者： Jayasingha Arachchige Chathuranga Chanaka Jayasingha Kyoung tae Lee Yung Hyun Choi Chang-Hee Kang Mi-Hwa Lee gi-Young Kim Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Research Institute for Basic Sciences Jeju National UniversityJeju 63243Republic of Korea Forest Biomaterials Research Center National Institute of Forest ScienceJinju 52817Republic of Korea Department of Biochemistry College of Korean MedicineDong-Eui UniversityBusan 47227Republic of Korea Nakdonggang National Institute of Biological Resources Sangju 37242Republic of Korea

Objective:To investigate the effect of an aqueous extract of Protaetia brevitarsis(AEPB)on osteogenesis using preosteoblast MC3T3-E1 cells and zebrafish ***:Flow cytometric analysis was used to measure the *** phosphatase activity was detetmined using p-nitrophenyl phosphate as a *** deposition was detected using alizarin red staining along with osteogenic marker expression in preosteoblast MC3T3E1 *** addition,vertebral formation in zebrafish larvae was detected using calcein staining and osteogenic gene ***:AEPB highly promoted the expression of osteogenic markers including runt-related transcription factor 2,osterix,and alkaline phosphatase,along with elevated levels of mineralization in MC3T3-E1 ***,AEPB accelerated vertebral formation in zebrafish larvae accompanied by upregulated expression of osteogenic ***535,an inhibitor of Wnt/β-catenin,suppressed AEPB-induced osteogenic gene expression and vertebral formation,indicating that AEPB stimulates osteogenesis by activating the Wnt/β-catenin signaling ***:AEPB stimulates osteoblast differentiation and bone formation by activatingβ-***,AEPB is a promising material that induces osteogenesis,and is useful for the treatment of bone resorption diseases.

关键词： Protaetia brevitarsis Osteoblast differentiation Bone formation β-catenin MC3T3-E1

Relationship between early structural changes at cornea incision sites and surgical outcomes after phacoemulsification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2019年第7期12卷 1139-1145页

作者： Kyung Hyun Jin tae gi Kim Department of Ophthalmology Kyung Hee University Medical Center Kyung Hee University Seoul 02447 Korea Department of Ophthalmology Kyung Hee University Hospital at Gangdong Kyung Hee University Seoul 05278 Korea

AIM: To assess the early structural changes at clear corneal cataract incision sites and surgical outcomes using anterior segment optical coherence tomography(AS-OCT).METHODS: We evaluated 80 eyes of 59 patients who underwent phacoemulsification with a clear corneal incision. All incisions were evaluated 1 wk, 1, and 3 mo postoperatively using AS-OCT and analyzed regarding angle, length of the incision, maximal corneal thickness at the incision, and if present, corneal endothelial gap length and incision gap area. The patients were divided into two groups according to whether or not an endothelial gap was present at 1 wk postoperatively(endothelial gap, group 1;no endothelial gap, group 2). We analyzed the difference in patient and surgical factors between the two groups, and compared the surgical outcome and the refractive ***: An endothelial gap was observed in 56(70.0%) of 80 eyes at 1 wk postoperatively but not at 3 mo postoperatively. The mean patient age was significantly higher in group 1 than in group 2. The longer the length of the corneal incision and the steeper the incision angle, the greater the length and area of the endothelial gap. In group 1, the mean change in mean keratometry of the anterior cornea was significantly greater than in group 2, and the spherical equivalent(SE) and mean numerical error indicated significant myopic changes at 1 wk postoperatively. CONCLUSION: The risk of an endothelial gap increases with patient age and a long corneal incision and steep incision angle. The presence of an endothelial gap aftersurgery may affect the early postoperative corneal curvature and SE.

关键词： corneal incision structure phacoemulsification corneal curvature corneal endothelial gap anterior segment optical coherence tomography

Autonomous Optimal Coordination Scheme in Protection System of Power Distribution Network by Using Multi-Agent Concept

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2008年第2期14卷 106-111页

作者： LEE Seung-Jae KIM tae-Wan LEE gi-Young Next-Generation Power System Technology Center Myongji UniversityYongin449-728KyunggidoKorea

A protection system using a multi-agent concept for power distribution networks is *** digital over current relay(OCR)is developed as an agent by adding its own intelligence,self-tuning and communication *** main advantage of the multi-agent concept is that a group of agents work together to achieve a global goal which is beyond the ability of each individual *** order to cope with frequent changes in the network operation condition and faults,an OCR agent,proposed in this paper,is able to detect a fault or a change in the network and find its optimal parameters for protection in an autonomous manner considering information of the whole network obtained by communication between other *** this kind of coordination and information exchanges,not only a local but also a global protective scheme is *** in a simple distribution network show the effectiveness of the proposed protection system.

关键词：保护系统配电网分配模式协调计划

Initial Stability Study of Calcium Phosphate Coated Dental Implants

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 246-248页

作者： Changkook YOU In-sung yeo tae-kwan EOM M W AHN Sukyoung KIM School of Materials Sci. & Eng. Yeungnam University Gyeongbuk 712-749 Korea Department of Dentistry Special War Command Seoul 138-110 Korea R&D Center Osstem Co. Ltd. Yeonsan-Gu Busan 611-073 Korea Dept.of Orthopedic Surgery College of Medicine Yeungnam Univ. Daegu Korea

Thin film of biodegradable calcium phosphate coated on threaded commercially pure titanium （ cp- Ti ） dental implants has been investigated as one of alternatives to eliminate the problem of the long- term instability of plasma sprayed HA coated implants. In order to compare in-vivo bone-to-implant response behavior among as-machined, HA coated and CMP coated groups, each group was implanted into New Zealand white mature male rabbits for 2 and 6 weeks, and then in-vivo biological behavior was examined in terms of H＆E staining. Initial stability and removable torques of implants were compared among three groups. Measured removable torque of CMP coated specimen at 6 weeks after inplantation was significantly higher than that of non-coated group, but slightly lower than that of HA coated group, without any inflammatory response at the surrounding of the implants. The initial stability （ ISQ value ; implant stability quotient ） of CMP coated specimen at 2 weeks after implantation was slightly lower than that of HA coated group and significantly higher than that of non-coated group. However, after 6 weeks, ISQ value of CMP coated group was slightly higher than that of HA coated group and significantly higher than that of non-coated group.

关键词： calcium metaphosphate initial stability RFA ISQ value osseointegration

Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2019年第6期39卷 833-841页

作者： Young-Wook Park gi Yoon Heo Min Jae Kim Seo-yeon Lee Byung tae Choi Hwa Kyoung Shin Division of Meridian and Structural Medicine School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea Korean Medical Science Research Center for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea

OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse ***:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA *** stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J *** assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days ***:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not *** number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d *** concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ***:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion.

关键词： Electroacupuncture Stroke Astrocytes Neurogenesis Post-stroke remodeling