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Blockchain(Research and Applications) 2024年第2期5卷 140-150页

作者： Heejung lee geun-cheol lee Hoon-Young Koo School of Interdisciplinary Industrial Studies Hanyang University222 Wangsimni-roSeongdong-guSeoul04763Republic of Korea College of Business Administration Konkuk University120 Neungdong-roGwangjin-guSeoul05029Republic of Korea School of Business Chungnam National University99 Daehak-roYuseong-guDaejeon34134Republic of Korea

Non-fungible token(NFT)is a digital asset whose ownership can be validated and controlled via blockchain *** NFT market is a rapidly growing field,and the rarity of NFT is an essential factor that affects its price,as scarcity leads to higher *** study focuses on the BAYC NFT collection,which is a successful and representative collection of profile picture NFT,and analyzes how rarity affects NFT *** paper investigates the relationship between the rarity and price of the BAYC NFT collection using formal concept analysis(FCA)*** results show that rarity is a major factor influencing the price of NFT and the effect is more apparent in the medium rarity *** rarity is very high or very low,other factors become significant determinants,such as the uniqueness and appeal of NFT,and even the naturalness of NFT *** research highlights the importance of considering rarity when assessing NFT and underscores the need for a comprehensive evaluation of NFT *** study also provides valuable insights into the NFT market and can be useful for NFT investors,creators,and ***,the usefulness of FCA as a tool for quantifying NFT rarity and evaluating NFT price was demonstrated.

关键词： NFT valuation Formal concept analysis Rarity

Successful removal of two magnets in the small intestine by laparoscopy and colonoscopy: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8226-8231页

作者： Ryang geun Oh cheol Gu lee You Na Park Yoo Min lee Department of Pediatrics Soonchunhyang University Bucheon HospitalBucheon 14584South Korea Department of Surgery Soonchunhyang University Bucheon HospitalBucheon 14584South Korea

BACKGROUND Ingestion of multiple magnets can cause serious gastrointestinal complications,such as obstruction,fistulae,and *** multiple magnets traverse the stomach,coordination between pediatric gastroenterologists and pediatric surgeons is recommended,and ultimate management is required dependent on clinical *** SUMMARY A 5-year-old girl swallowed 2 small magnets that then remained in the right lower quadrant(RLQ)of the abdomen for 3 d;this required endoscopic and laparoscopic *** X-ray and computed tomography revealed highdensity objects in the RLQ *** after proper bowel preparations on the third day of ingestion revealed no foreign body in the colonic area or the end of the *** two magnets were removed via colonoscopy with laparoscopic *** It is important to establish effective coordination between pediatric gastroenterologists and pediatric surgeons when using a non-invasive procedure to remove magnets.

关键词： Child Colonoscopy Foreign bodies Laparoscopy Magnets Case report

Inhibitory effect of sulfated polysaccharide from Sargassum thunbergii in PA-induced lipid accumulation in vitro

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Food Bioscience 2023年第1期51卷 308-315页

作者： Hyo-geun lee Min-cheol Kang You-Jin Jeon Young-Sang Kim Department of Marine Life Sciences Jeju National UniversityJeju63243Republic of Korea Marine Science Institute Jeju National UniversityJeju Self-Governing Province63333Republic of Korea Research Group of Food Processing Korea Food Research Institute245Nongsaengmyeong-roIseo-myeonWanju55365Republic of Korea

This study aimed to investigate the In vitro lipid inhibitory effects of sulfated polysaccharide fractions derived from fractional ethanol precipitate 1 of Celluclast assisted hydrolysate from Sargassum thunbergii(STCF1-PSs).Three polysaccharide fractions were obtained,and physical characteristics were determined by SEM,FTIR,and MALS *** analysis indicated that STCF1-PS3 contained high fucose and galactose *** intracellular lipid inhibitory effects of STCF1-PS3 were evaluated on PA-treated 3T3-L1 and HepG2 cells and was found to be ***,it suppressed intracellular triglyceride and free fatty acid levels in these *** blot analysis showed that the lipid inhibitory activity was achieved through the regulation of the adipogenesis and lipolysis pathway in PA-treated 3T3-L1 cells and the free fatty acid oxidation pathway in PAtreated HepG2 ***,sulfated polysaccharide from Sargassum thunbergii has a beneficial effect on intracellular lipid metabolism and it could be used as a functional ingredient in functional food industry.

关键词： Sargassum thunbergii Sulfated polysaccharides Adipogenesis Lipolysis Fatty acid oxidation

Regional Distribution of Perceived Temperatures Estimated by the Human Heat Budget Model (the Klima-Michel Model) in South Korea

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Advances in Atmospheric Sciences 2009年第2期26卷 275-282页

作者： Jiyoung KIM Kyu Rang KIM Byoung-cheol CHOI Dae-geun lee Jeong-Sik KIM National Institute of Meteorological Research Korea Meteorological Administration Korea Global Atmosphere Watch Center Korea Meteorological Administration

The regional distribution of perceived temperatures （PT） for 28 major weather stations in South Korea during the past 22 years （1983-2004） was investigated by employing a human heat budget model, the Klima-Michel model. The frequencies of a cold stress and a heat load by each region were compared. The sensitivity of PT in terms of the input of synoptic meteorological variables were successfully tested. Seogwipo in Jeju Island appears to be the most comfortable city in Korea. Busan also shows a high frequency in the comfortable PT range. The frequency of the thermal comfort in Seoul is similar to that of Daejeon with a relatively low frequency. In this study, inland cities like Daegu and Daejeon had very hot thermal sensations. Low frequencies of hot thermal sensations appeared in coastal cities （e.g., Busan, Incheon, and Seogwipo）. Most of the 28 stations in Korea exhibited a comfort thermal sensation over 40% in its frequency, except for the mountainous regions. The frequency of a heat load is more frequent than that of a cold stress. There are no cities with very cold thermal sensations. In this study, we found the decreasing trend of mortality with an increasing PT. If the PT is over any critical temperature point, however, the mortality rate increases again. The mortality variation with the PT of a station seems to be associated with the latitudinal location of the station, implying that it results from a regional acclimation effect of inhabitants.

关键词： Klima-Michel model perceived temperature thermal comfort

Is obesity associated with gastropharyngeal reflux disease?

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World Journal of Gastroenterology 2008年第2期14卷 265-271页

作者： cheol Woong Choi Gwang Ha Kim Chul Soo Song Soo geun Wang Byung Joo lee Hoseok I Dae Hwan Kang geun Am Song Department of Internal Medicine Pusan National University School of Medicine Busan Korea Department of Otolaryng-ology Pusan National University School of Medicine Busan Korea Department of Chest Surgery Pusan National University School of Medicine Busan Korea

AIM: To examine the association between obesity and gastropharyngeal reflux disease (GPRD) as well as gastroesophageal reflux disease (GERD) METHODS: We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dual-probe pH monitoring from July 2003 to December 2006. The association between body mass index (BMI) and parameters about gastroesophageal or gastropharyngeal reflux was examined in univariate and multivariate ***: A total of 769 patients (307 men and 462 women; mean age 50.7 years) were finally enrolled. Most variables showing gastroesophageal reflux was higher in the obese patients than the patients with normal BMI. There was no difference in all the variables showing gastropharyngeal reflux according to the BMI. After adjustment for age, sex, alcohol intake and smoking, obese patients demonstrated an about 2-fold increase in risk of GERD compared with patients with normal BMI (OR, 1.9; 95 CI, 1.3-2.9), but overweight patients did not demonstrate increased risk of GERD (OR, 1.2; 95 CI, 0.8-1.7). Both obese patients and overweight patients did not demonstrated increased risk of GPRD compared with patients with normal BMI (OR, 1.1; 95 CI, 0.8-1.7; and OR, 0.9; 95 CI, 0.6-1.3, respectively).CONCLUSION: Obesity is not associated with GPRD reflux while it is associated with GERD.

关键词： Obesity Body mass index Gastroesophageal reflux Gastropharyngeal reflux

Femoral neck stress fractures after trampoline exercise:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4783-4788页

作者： Dae cheol Nam Sun Chul Hwang Eun Chang lee Myung-geun Song Jun-Il Yoo Department of Orthopaedic Surgery Gyeongsang National University School of MedicineJinju 52727South Korea Department of Orthopaedic Surgery and Institute of Health Sciences Gyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea

BACKGROUND Femoral neck stress fractures(FNSFs)are commonly found in long-distance running *** FNSFs,early diagnosis and proper treatment are *** objective of this study was to report FNSFs that occurred after excessive exercise using trampoline in middle-aged *** SUMMARY The patient was a 43-year-old woman who exercised jumping on a trampoline for 6 wk for 1-3 h a day to *** includes repeated flexion-extension of the hip *** patient was admitted to the hospital due to sudden bilateral groin pain that occurred suddenly during a trampoline *** magnetic resonance imaging(MRI)revealed bilateral *** 2 wk of follow-up with conservative treatment,the pain slightly ***,it did not disappear *** was determined that it was difficult to control symptoms only by conservation ***,closed reduction and internal fixation using a cannulated screw were performed for the more painful left hip *** operation,the pain was *** using crutches was *** MRI showed that the right femoral head signal was decreased compared to the left femoral head ***,nonsteroidal anti-inflammatory drug and conservative treatment were *** In middle-aged people,excessive trampoline exercise can repeat hip flexion and extension for a short period of time,leading to FNSFs.

关键词： Trampoline exercise Femoral neck stress fracture Neck Fracture Case report

Effect of bonding interface on delamination behavior of drawn Cu/Al bar clad material

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中国有色金属学会会刊：英文版 2012年第S3期22卷 645-649页

作者： Sangmok lee Min-geun lee Sang-Pill lee geun-Ahn lee Yong-Bae KIM Jong-Sup lee Dong-Su BAE Advanced Forming Technology Center Korea Institute of Industrial Technology Department of Advanced Materials Engineering Dong-Eui University Department of Mechanical Engineering Dong-Eui University

Cu/Al bar clad material was fabricated by a drawing process and a subsequent heat *** these processes,intermetallic compounds have been formed at the interface of Cu/Al and have affected its bonding *** of Cu/Al interfaces were observed by OM,SEM and EDX Analyser in order to investigate the bonding properties of the *** to the microstructure a series of diffusion layers were observed at the interface and the thicknesses of diffusion layers have increased with aging time as a result of the diffusion *** interfaces were composed of 3-ply diffusion layers and their compositions were changed with aging time at 400 °*** compositional compounds were revealed to be η2,(θ+η2),(α+θ) intermetallic *** is evident from V-notch impact tests that the growth of the brittle diffusion layers with the increasing aging time directly influenced delamination distance between the Cu sleeve and the Al *** is suggested that the proper holding time at 400 °C for aging as post heat treatment of a drawn Cu/Al bar clad material would be within 1 h.

关键词： drawn Cu/Al bar clad material aging bonding interface intermetallic compound diffusion layer delamination

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network