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Complications of dexamethasone implants:risk factors,prevention,and clinical management

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1612-1620页

作者： Nil Celik Ramin Khoramnia gerd.U Auffarth Saadettin Sel christian S Mayer Department of Ophthalmology University Hospital of HeidelbergHeidelberg 69120Germany

AIM:To evaluate major complications after intravitreal injection of dexamethasone implants(Ozurdex)and their clinical ***:In a retrospective observational study between 2014 and 2016 at two university hospitals,we reviewed the clinical records of 1241 consecutive macular edema patients treated with the dexamethasone implant,and separated severe adverse events in the injection procedure from those that were post-injection *** evaluated the cause and the outcomes in each ***:In twenty-one procedures(1.69%)we noticed significant complications during and after intravitreal injection of the dexamethasone *** related to the injection procedure were in one case,that a second implant was injected by mistake in the same eye on the same *** another case,the implant lodged in the sclera during retraction of the injector *** scleral tunnel at the injection site led to hypotony in another *** were 10 cases of post-injection displacement of the implant into the anterior chamber and one case with a migrated and trapped device between the intraocular lens and an artificial *** typically occurred in patients with preexisting risk factors:eyes with complicated intraocular lens implantation,iris reconstruction or iris defects or pseudophakic eyes after vitrectomy were prone to develop this *** led to secondary corneal decompensation with *** case developed an endophthalmitis,and we observed four cases of retinal *** eyes presented with long-lasting hypotony due to ciliary ***:Treatment with the dexamethasone implant may cause various expected or unexpected complications that may have serious consequences for the patient and require further *** reduce complications,clinicians should evaluate certain risk factors before scheduling patients for dexamethasone implant treatment and use proper injection techniques.

关键词： intravitreal implants dexamethasone implants Ozurdex intravitreal injection slow release drug

气候对伊比利亚半岛尼安德特人向现代人人种转变的影响

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Science Bulletin 2023年第11期68卷 1176-1186,M0004页

作者： Konstantin Klein gerd-christian Weniger Patrick Ludwig christian Stepanek 张旭 christian Wegener 邵亚平 Institute for Geophysics and Meteorology University of CologneCologne 50923Germany Institute of Prehistory University of CologneCologne 50923Germany Institute of Meteorology and Climate Research Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Paleoclimate Dynamics Alfred Wegener InstituteHelmholtz Centre for Polar and Marine ResearchBremerhaven 27570Germany Alpine Paleoecology and Human Adaption Group State Key Laboratory of Tibetan Plateau Earth SystemChinese Academy of SciencesBeijing 100101China

伊比利亚半岛对从尼安德特人到现代人的人种转变有着特殊的意义.从东欧向西迁徙的现代人较晚才抵达伊比利亚,因此两个种群之间在这里发生任何可能接触的时间要晚于其他地方.伊比利亚半岛的人种转变发生在海洋同位素第3阶段的早期(约6万... 详细信息

伊比利亚半岛对从尼安德特人到现代人的人种转变有着特殊的意义.从东欧向西迁徙的现代人较晚才抵达伊比利亚,因此两个种群之间在这里发生任何可能接触的时间要晚于其他地方.伊比利亚半岛的人种转变发生在海洋同位素第3阶段的早期(约6万到2.7万年前),其间反复强烈的气候变化影响了种群稳定性.本文研究了气候变化和人类相互作用如何影响种群的过渡.结合气候数据与考古遗址数据重建了GI11-10(格陵兰间冰期)和GS10-9/HE4(格陵兰冰期)时期尼安德特人和现代人的生存潜力或生存概率.结果发现,由于气候变化,在GS10-9/HE4期间,伊比利亚半岛的大部分地区已不适合尼安德特人的生存.尼安德特人的定居区收缩为较为孤立的沿海热点.这可能使得尼安德特人的种群结构变得更不稳定,从而引发人口的最终崩溃.现代人大约在GI10期间抵达了伊比利亚,但仅限于半岛最北部地带的局部地区.GS10-9/HE4的寒冷气候阻止了他们的进一步扩张,甚至导致了他们定居区域的缩小.气候变化与人口迁徙使得尼安德特人和现代人两个种群的人口分散在半岛的不同区域.因此,尼安德特人和现代人在广泛的地区共存的可能性不大,而现代人对尼安德特人的最后消亡的影响也有限.

关键词：尼安德特人伊比利亚半岛数据重建气候变化影响考古遗址人口迁徙生存概率人口分散

Tracking morphologies at the nanoscale： Self-assembly of an amphiphilic designer peptide into a double helix superstructure

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Nano Research 2015年第6期8卷 1822-1833页

作者： Karin Kornmueller Ilse Letofsky-Papst Kerstin Gradauer christian Mikl Fernando Cacho-Nerin Mario Leypold Walter Keller gerd Leitinger Heinz Amenitsch Ruth Prassl Institute of Biophysics Medical University ofGraz BioTechMed-Graz 8010 Graz Austria Institute for Electron Microscopy and Nanoanalysis Graz University of Technology and Graz Centre for Electron Microscopy 80 10 Graz A us tria Institute of Inorganic Chemistry Graz University of Technology 8010 Graz Austria Institute of Organic Chemistry Graz University of Technology 8010 Graz Austria Institute for Molecular Biosciences KarI-Franzens-University Graz 8010 Graz Austria Research Unit Electron Microscopic Techniques Institute of Cell Biology Histology and Embryology Medical University of Graz 80 10 Graz A us tria Center for Medical Research Medical University of Graz 8010 Graz Austria

Hierarchical self-assembly is a fundamental principle in nature, which gives rise to astonishing supramolecular architectures that are an inspiration for the development of innovative materials in nanotechnolog）a Here, we present the unique structure of a cone-shaped amphiphilic designer peptide. While tracking its concentration-dependent morphologies, we observed elongated bilayered single tapes at the beginning of the assembly process, which further developed into novel double-helix-like superstructures at high concentrations. This architecture is characterized by a tight intertwisting of two individual helices, resulting in a periodic pitch size over their total lengths of several hundred nanometers. Solution X-ray scattering data revealed a marked 2-layered internal organization. All these characteristics remained unaltered for the investigated period of almost three months. In their collective morphology, the assemblies are integrated into a network with hydrogel characteristics. Such a peptide-based structure holds promise as a building block for next-generation nanostructured biomaterials.

关键词： double helix amphiphilic designerpeptide self-assembl)~SAXS TEM spectroscopy

Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro

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World Journal of Gastroenterology 2005年第26期11卷 4024-4031页

作者： christian Hafner Stefanie Meyer Thomas Langmann gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt Department of Dermatology University Hospital of Regensburg D-93042 Regensburg Germany Department of Clinical Chemistry University Hospital of Regensburg D-93042 Regensburg Germany Institute of Pathology University Hospital of Regensburg D-93042 Regensburg Germany Department of Internal Medicine University Hospital of Regensburg D-93042 Regensburg Germany

AIM:Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD). METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model. RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinAl, we found abundantly co-expressed EphB2 and ephrin-B1/2. Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrin- B1/2 expressing rat IEC-6-cells with recombinant EphB1-Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge. CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD.

关键词： Ephrin-B2 Crohn's disease IBD IEC-6 Wound healing Epithelial restitution

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SDE实现新一代汽车安全战略

汽车与配件 2012年第14期 36-38页

作者： Hans-gerd Krekels christian Klaus TRW汽车集团

没有谁能准确预测未来十年。基于先进汽车安全技术在全球汽车市场的增长，我们也无法准确预测汽车主、被动安全系统的集成化程度。因此，我们需要一个具有开放式电子架构的新型控制器，来满足整车制造商的技术愿景。这一想法，促使TRW... 详细信息

没有谁能准确预测未来十年。基于先进汽车安全技术在全球汽车市场的增长，我们也无法准确预测汽车主、被动安全系统的集成化程度。因此，我们需要一个具有开放式电子架构的新型控制器，来满足整车制造商的技术愿景。这一想法，促使TRW开发新一代安全域ECU（Safety Domain ECU），即SDE。

关键词：汽车市场 SDE 安全战略汽车安全技术被动安全系统 Domain 集成化控制器

Thermochemical Treatment—Technologies for Recovery and Upvaluating of Materials

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Thermochemical Treatment—Technologies for Recovery and Upva...

7th World Congress on Recovery, Recycling and Re-integration

作者： gerd Arnd Kley Rudolf Simon Brenneis Adamczyk Franz-Georg christian Burkart Adam Peter Kcher Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany Federal Research Institute for Materials Research Richard-Willsttter-StraΒe 11 Berlin D-12489 Germany BAM LinderhofstraΒe 8 Berlin D-12623 Germany

Raw and waste materials can be converted to more valuable products by biological, mechanical, chemical, thermal and thermochemical treatment technologies. Thermochemical separation is one of the most efficient ways to increase the purity of products or/and decrease the environmental impact of waste materials. The methods of thermochemical substance separation currently used at the Federal Institute for Materials Research and Testing (BAM) were initially developed to convert inferior raw materials (e.g bauxites of different origins) into high-temperature and hard materials by removal of impurities. The principle of the treatment is the chemical conversion of unwanted constituents to volatile compounds or to elements and alloys. While the volatile compounds are removed by the exhausting system, the elemental phase is separated from the mineral fraction due to its higher density. The thermochemical separation was carried out predominantly in molten state, but can also occur below the melting point by physical or chemical processes.

关键词： thermochemical separation, recovery, raw and waste materials, heavy metals, ressources, filter dust, slags, sewage sludge, fertilizer, silicate products

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草浆的改良漂白

国际造纸 2000年第6期19卷 10-15页

作者：张华 christian Blom Mrs gerd Wane Tobias Bruhn 马忻马石辉依卡化学品(苏州)有限公司瑞典依卡化学品有限公司

A soda－ cooked wheat straw pulp,representative of the type of non－ wood pulp used in China today,was bleached in the laboratory with the aim of partially and/or totally replacing chlorine containing chemicals with hydrogen *** consequences of such changes were evaluated in terms of product quality and environmental ***,when the hyplchlorite is completely replaced by hydrogen peroxide,the final brightness was marginally lower than the reference sequence,the brightness reversion was significantly *** improvements in the pulp quality were also *** the chlorine was reduced,the environmental performance was dramatically improved in terms of reduction in the effluent AOX (Absorbable organic halogens)level.

关键词：麦草浆漂白改进过氧化氢

术中二维相干光断层扫描作为前节手术的一个新工具

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美国医学会眼科杂志（中文版） 2005年第4期17卷 221-224,255页

作者： gerd Geerling Maya Müller christian Winter Hans Hoerauf Stefan Oelckers Horst Laqua Reginald Birngruber 李晓宁（译）任泽钦（校） Department of Ophthalmology Medical University of Labeck Labeck Germany 4optics Lübeck Germany Moller-Wedel Wedel Germany Medical Laser Center Lübeck Germany 不详

我们测试了1310nm相干光断层扫描仪与手术显微镜前部镜头的分光镜连接后对前节手术过程中术中的非接触性成像。这项对相干光断层成像技术的新改进可完成前节手术术中角膜、巩膜的高分辨率横断面的成像与厚度测量。其在板层切开技术如深... 详细信息

我们测试了1310nm相干光断层扫描仪与手术显微镜前部镜头的分光镜连接后对前节手术过程中术中的非接触性成像。这项对相干光断层成像技术的新改进可完成前节手术术中角膜、巩膜的高分辨率横断面的成像与厚度测量。其在板层切开技术如深层前板层角膜移植术和小梁切除术中尤为有用。

关键词：断层扫描仪手术过程相干光术中前板层角膜移植术断层成像技术工具二维手术显微镜非接触性

Age,smoking and overweight contribute to the development of intestinal metaplasia of the cardia

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World Journal of Gastroenterology 2012年第17期18卷 2076-2083页

作者： christian Felley Hanifa Bouzourene Marianne Bründler G VanMelle Antoine Hadengue Pierre Michetti Gian Dorta Laurent Spahr Emiliano Giostra Jean Louis Frossard Service of Gastroenterology University Hospital1000 LausanneSwitzerland Institute of Pathology University Hospital1000 LausanneSwitzerland Institute of Social and Preventive Medicine University of Lausanne1000 LausanneSwitzerland Service of Gastroenterology Geneva University Hospital1211 GenevaSwitzerland

AIM:To assess the role of Helicobacter pylori(***),gastroesophageal reflux disease(gerd),age,smoking and body weight on the development of intestinal metaplasia of the gastric cardia(IMC).METHODS:Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this *** biopsies from the esophagus,gastroesophageal junction and stomach were evaluated for inflammation,the presence of *** and intestinal *** correlation of these factors with the presence of IMC was assessed using logistic ***:IMC was observed in 42% of the *** age,smoking habit and body mass index(BMI) were found as potential contributors to *** risk of developing IMC can be predicted in theory by combining these factors according to the following formula:Risk of IMC = a + s-2B where a = 2,…6 decade of age,s = 0 for non-smokers or ex-smokers,1 for 10 cigarettes/d and B = 0 for BMI 25 kg/m2(BMI > 27 kg/m2 in females).Among potential factors associated with IMC,*** had borderline signif icance(P = 0.07),while gerd showed no signif ***:Age,smoking and BMI are potential factors associated with IMC,while *** and gerd show no significant *** can be predicted in theory by logistic regression analysis.

关键词： Endoscopy Gastroesophageal reflux disease Metaplasia Helicobacter pylori Obesity Smoking