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International journal of Digital Earth 2016年第1期9卷 106-111页

作者： Adam Lewis Leo Lymburner Matthew B.j.Purss Brendan Brooke Ben Evans Alex Ip Arnold g.dekker james R.Irons Stuart Minchin Norman Mueller Simon Oliver Dale Roberts Barbara Ryan Medhavy Thankappan Rob Woodcock Lesley Wyborn geoscience Australia CanberraAustralia National Computational Infrastructure Australian National UniversityCanberraAustralia Commonwealth Scientific and Industrial Research Organisation CanberraAustralia NASA goddard Space Flight Center GreenbeltMDUSA Research School of Finance Actuarial Studies and Applied StatisticsANUCanberraAustralia The group on Earth Observations Secretariate GenevaSwitzerland

The effort and cost required to convert satellite Earth Observation(EO)data into meaningful geophysical variables has prevented the systematic analysis of all available *** overcome these problems,we utilise an integrated High Performance Computing and Data environment to rapidly process,restructure and analyse the Australian Landsat data *** this approach,the EO data are assigned to a common grid framework that spans the full geospatial and temporal extent of the observations–the EO Data *** approach is pixel-based and incorporates geometric and spectral calibration and quality assurance of each Earth surface reflectance *** demonstrate the utility of the approach with rapid time-series mapping of surface water across the entire Australian continent using 27 years of continuous,25 m resolution *** preliminary analysis of the Landsat archive shows how the EO Data Cube can effectively liberate high-resolution EO data from their complex sensor-specific data structures and revolutionise our ability to measure environmental change.

关键词： Earth Observation Data Cube HPD HPC surface water Landsat Australia

Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2021年第4期6卷 572-580,I0037-I0048页

作者： Luuk dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart j Emmer Ivo g H jansen Maxim j H L Mulder Robin Lemmens Robert-jan B goldhoorn Marieke j H Wermer jelis Boiten geert j LycklamaàNijeholt Yvo B W E M Roos Adriaan C g M van Es Hester F Lingsma Diederik W j Dippel Wim H van Zwam Robert j van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators Neurology Leiden University Medical CentreLeidenThe Netherlands Neurology Erasmus MCRotterdamThe Netherlands Public Health Erasmus MCRotterdamThe Netherlands Neurology Maastricht University Medical Centre+MaastrichtThe Netherlands Radiology and Nuclear Medicine Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Neurology University Hospitals LeuvenLeuvenBelgium Neurosciences Experimental Neurology and Leuven Brain InstituteUniversity of LeuvenLeuvenBelgium VIB Center for Brain&Disease ResearchLaboratory of NeurobiologyLeuvenBelgium Neurology Haaglanden Medical CentreDen HaagThe Netherlands Radiology Haaglanden Medical CentreDen HaagThe Netherlands Neurology Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Radiology Leiden University Medical CentreLeidenThe Netherlands Radiology Maastricht University Medical Centre+MaastrichtThe Netherlands

Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen ***,outcomes after EVT in these late window patients without perfusion imaging are largely *** assessed their characteristics and outcomes in routine clinical *** The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and *** perfusion was no standard imaging *** used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous *** included 3-month mRS score,functional independence(defined as mRS 0-2),and *** Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke *** perfusion was not performed in 87/106(80.2%)late window *** window patients were younger(mean 67 vs 70 years,pghtly lower ASPECTS(median 8 vs 9,pg,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/C

关键词： treatment beyond Registry

Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World journal of gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： Manon van der Vlugt Beatriz Carvalho joelle Fliers Nahid Montazeri Christian Rausch Esmée j grobbee Manon van Engeland Manon C W Spaander gerrit A Meijer Evelien dekker Department of gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKgROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),Cpg island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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行为医学的定义与范畴：讨论、总结和更新

中华行为医学与脑科学杂志 2017年第6期26卷 485-491页

作者： joost dekker Adrienne Stauder Frank j.Penedo 济宁医学院济宁272067 荷兰自由大学医学中心精神系和康复医学系 MB阿姆斯特丹1007 芬兰于韦斯屈莱大学体育与健康科学学院于韦斯屈莱40014 匈牙利塞麦尔维斯大学行为科学研究所布达佩斯1085 美国西北大学社会医学系心理学系精神病学和行为科学系芝加哥60611

背景与目的目前行为医学的定义与范畴仍是25年以前的版本，因此，有必要对国际行为医学会章程中行为医学的定义和范畴进行修改、更新。本文旨在：（1）对建议修改行为医学定义与范畴的国际性讨论加以总结；（2）诚邀中国同道参与讨论。... 详细信息

背景与目的目前行为医学的定义与范畴仍是25年以前的版本，因此，有必要对国际行为医学会章程中行为医学的定义和范畴进行修改、更新。本文旨在：（1）对建议修改行为医学定义与范畴的国际性讨论加以总结；（2）诚邀中国同道参与讨论。方法首先确定需要澄清或修改的问题，然后提出对行为医学定义与范畴进行更新和修改的建议。结果需要澄清或修改的问题包括：行为医学的范畴，行为医学的应用，以及行为医学、精神卫生学、健康心理学和心身医学之间的关系与区别。结论建议将行为医学的定义与范畴修改为：行为医学（behavioralmedicine）是以多学科协作为特点的、涉及与健康和疾病相关的生物医学知识和行为科学知识的发展与整合及其在预防、健康促进、诊断、治疗、康复和护理中应用的领域。行为医学的范畴从生物一行为机制（即与健康和疾病相关的生物医学、心理、社会和文化环境等进程之间的相互作用），延伸至临床诊断与干预以及公共卫生领域。诚邀中国同仁对行为医学的定义与范畴的后续讨论发表观点。

关键词：行为医学定义范畴学科

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“双楔螺棱螺杆改进了单螺棱螺杆挤塑机的性能”

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塑料 1980年第3期 14-19页

作者： j.dekker 朱鸿兴荷兰、阿姆斯特丹市、柯尼里克——希尔实验室

由于对挤塑理论的研究,孕育并问世了一种新型的螺槽横断面为梯形的所谓"双楔螺棱螺杆,即 TW 型螺杆,它作为替代常用的直角螺棱螺杆的一种型式,试验比较结果表明,在大多数情况下,TW 型螺杆具有较大的挤出量和良好的操作稳定性。

关键词：螺杆挤出量聚丙烯聚合物聚烯烃大分子化合物螺棱挤塑机

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杀菌剂抗性鉴别和测量通则

世界农药 1986年第6期 48-50页

作者： S.g.georgopoulos j.dekker 周明国

植物病原菌对杀菌剂抗性的发展结果使得药剂防治病害失效,进而引起作物损失,对当地和世界粮食生产造成不利影响。因此尽快鉴别和测量杀菌剂抗性、采取适当措施是极为重要的。虽然鉴别和测量抗性的方法各不相同,但是化合物与生物结合这... 详细信息

植物病原菌对杀菌剂抗性的发展结果使得药剂防治病害失效,进而引起作物损失,对当地和世界粮食生产造成不利影响。因此尽快鉴别和测量杀菌剂抗性、采取适当措施是极为重要的。虽然鉴别和测量抗性的方法各不相同,但是化合物与生物结合这一通常的原则是一致的。只有与敏感菌株祖比较才能鉴别抗性菌株。因此确定存在问题的某种病原菌对杀菌剂的敏感性基线是十分必要的,可以用被一般认为对杀菌剂是敏感的野生型菌株进行适当的

关键词：病原菌抗性测定敏感性差异

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农用抗菌素

世界农药 1979年第4期 41-45页

作者： j.dekker 杨慧心

抗菌素是由微生物产生的物质,在很低浓度时,即可抑制或杀死其它微生物,用于农业的抗菌素称农用抗菌素。 1928年Fleming发现青霉素以后,随着青霉素在医疗上用途越来越大,抗菌素成为防治人体和动物细菌性疾病的必要手段。1946年发现了对... 详细信息

抗菌素是由微生物产生的物质,在很低浓度时,即可抑制或杀死其它微生物,用于农业的抗菌素称农用抗菌素。 1928年Fleming发现青霉素以后,随着青霉素在医疗上用途越来越大,抗菌素成为防治人体和动物细菌性疾病的必要手段。1946年发现了对真菌高度活性的抗菌素环己酰亚胺(放线酮)后,使人们认为防治植物病害的抗真菌抗菌素可能变得和防治人类细菌病害的抗菌素一样重要。由于放线酮对植物有一定的药害,所以它的应用受到一定的限制。在美国,用它来防治松树水泡锈病(whiie pine blister rust),樱桃叶斑病(cherry leaf spot)和各

关键词：抗菌素微生物渗透性作用点病原菌真菌病传染病

Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board

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Microsystems & Nanoengineering 2020年第1期6卷 106-121页

作者： A.R.Vollertsen D.de Boer S.dekker B.A.M.Wesselink R.Haverkate H.S.Rho R.j.Boom M.Skolimowski M.Blom R.Passier A.van den Berg A.D.van der Meer M.Odijk BIOS Lab on Chip group MESA+Institute for NanotechnologyUniversity of TwenteEnschedeThe Netherlands Mesoscale Chemical Systems MESA+Institute for NanotechnologyUniversity of TwenteEnschedeThe Netherlands Institute for Technology-Inspired Regenerative Medicine Maastricht UniversityMaastrichtThe Netherlands Micronit Microtechnologies EnschedeThe Netherlands Applied Stem Cell Technologies TechMed CentreUniversity of TwenteEnschedeThe Netherlands

Microfluidic systems enable automated and highly parallelized cell culture with low volumes and defined liquid *** achieve this,systems typically integrate all functions into a single,monolithic device as a“one size fits all”***,this approach limits the end users’(re)design flexibility and complicates the addition of new functions to the *** address this challenge,we propose and demonstrate a modular and standardized plug-and-play fluidic circuit board(FCB)for operating microfluidic building blocks(MFBBs),whereby both the FCB and the MFBBs contain integrated valves.A single FCB can parallelize up to three MFBBs of the same design or operate MFBBs with entirely different *** operation of the MFBBs through the FCB is fully automated and does not incur the cost of an extra external *** use this modular platform to control three microfluidic large-scale integration(mLSI)MFBBs,each of which features 64 microchambers suitable for cell culturing with high spatiotemporal *** show as a proof of principle that we can culture human umbilical vein endothelial cells(HUVECs)for multiple days in the chambers of this ***,we also use the same FCB to control an MFBB for liquid dosing with a high dynamic *** results demonstrate that MFBBs with different designs can be controlled and combined on a single *** novel modular approach to operating an automated microfluidic system for parallelized cell culture will enable greater experimental flexibility and facilitate the cooperation of different chips from different labs.

关键词： FCB operation culture

Comprehensive management of epilepsy in onchocerciasis-endemic areas:lessons learnt from community-based surveys

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Infectious Diseases of Poverty 2019年第1期8卷 98-98页

作者： joseph Nelson Siewe Fodjo Marieke C.j.dekker Richard Idro Michel Ndahura Mandro Pierre-Marie Preux Alfred K.Njamnshi Robert Colebunders global Health Institute University of AntwerpAntwerpBelgium Full list of author information is available at the end of the article 不详

Background:Onchocerciasis-endem ic regions are known to have a high epilepsy *** resources in these areas and poor access to healthcare by persons with epilepsy(PWE)result in a wide anti-epileptic treatment gap,poor seizure control and a high burden of seizure-related *** comm unity-based surveys highlight the need for epilepsy managem ent strategies suitable for remote onchocerciasis-endemic villages to ensure better health outcom es for *** this paper,we propose a feasible approach to manage PWE in such *** text:Improved management of PWE in onchocerciasis-endemic areas may be achieved by decentralizing epilepsy *** approaches for the diagnosis and treatment of epilepsy may be used by non-physicians,under the supervision of physicians or *** reduce the treatment gap,a regular supply of subsidized anti-epileptic drugs(AED)appropriate for different types of onchocerciasis-associated epilepsy should be *** up a communitybased epilepsy surveillance system will enable early diagnosis and treatment of PWE thereby preventing *** awareness programs on epilepsy must be implemented to reduce stigma and facilitate the social rehabilitation of ***,strengthening onchocerciasis elimination programs by optimizing community-directed treatment with iverm eain(CDTI)and considering alternative treatment strategies might reduce the incidence of ***:A community-based approach with task-shifting of epilepsy care from specialists to non-physician health workers will reduce epilepsy-associated *** advocacy and collaboration with various stakeholders is needed to establish a sustainable,cost-effective chronic care model for epilepsy that will significantly improve the quality of life of PWE in onchocerciasis-endemic regions.

关键词： Epilepsy Onchocerciasis Community-based approach Comprehensive management

手臂上举对胸腹部损伤多层CT检查曝光控制的影响:影像质量更高,辐射剂量更低

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国际医学放射学杂志 2009年第1期32卷 68-69页

作者： M. Brink F. de Lange L.j. Oostveen H.M. dekker D.R. Kool j. Deunk 王大丽 Department of Diagnostic Imaging Radboud University Nijmegen Medical Centre Nijmegen the Netherlands

目的对于外伤病人利用自动曝光控制（AEC）系统行多层CT胸腹部扫描，评估手臂的位置对影像质量和有效放射剂量的影响。材料和方法该研究经机构伦理委员会的批准，并准予免除病人的知情同意。回顾性研究177例外伤病人（其中117例为... 详细信息

目的对于外伤病人利用自动曝光控制（AEC）系统行多层CT胸腹部扫描，评估手臂的位置对影像质量和有效放射剂量的影响。材料和方法该研究经机构伦理委员会的批准，并准予免除病人的知情同意。回顾性研究177例外伤病人（其中117例为男性，平均年龄为39岁）的资料。这些病人用具有AEC系统的16层CT进行胸腹部扫描，其中扫描时双侧手臂都举起超过肩部的有132例，作为标准组；

关键词：多层CT检查自动曝光控制胸腹部损伤影像质量辐射剂量臂上举机构伦理委员会 AEC系统

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