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ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population

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Chinese Medical j.urnal 2012年第3期125卷 476-480页

作者： Wang Hong Hetmanski, j.cqueline B. Ruczinski, Ingo Liang, Kung Yee Fallin, M. Daniele Redett, Richard j. Raymond, gerald V. Chou, Yah-Huei Wu Chen, Philip Kuo-Ting Yeow, Vincent Chong, Samuel S. Cheah, Felicia S. H. j.bs, Ethylin Wang Scott, Alan F. Beaty, Terri H. Peking Univ Dept Epidemiol & Biostat Sch Publ Hlth Beijing 100191 Peoples R China j.hns Hopkins Bloomberg Sch Publ Hlth Dept Epidemiol Baltimore MD USA j.hns Hopkins Bloomberg Sch Publ Hlth Dept Biostat Baltimore MD USA Natl Yang Ming Univ Dept Life Sci Taipei 112 Taiwan Natl Yang Ming Univ Inst Genome Sci Taipei 112 Taiwan j.hns Hopkins Univ Sch Med Dept Surg Baltimore MD 21205 USA j.hns Hopkins Univ Sch Med Kennedy Krieger Inst Baltimore MD USA j.hns Hopkins Univ Sch Med Dept Pediat Baltimore MD 21205 USA j.hns Hopkins Univ Sch Med Dept Med Baltimore MD 21205 USA Chang Gung Mem Hosp Dept Med Res Tao Yuan Taiwan Chang Gung Mem Hosp Craniofacial Ctr Tao Yuan Taiwan KK Womens & Childrens Hosp Dept Plast Reconstruct & Aesthet Surg Singapore Singapore Natl Univ Singapore Dept Pediat Singapore 117548 Singapore Mt Sinai Sch Med New York NY USA

Background The receptor tyrosine kinase-like orphan receptor 2 （ROR2） gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non syndromic cleft lip with or without cleft palate in *** aim of this study was to investigate the possible association between ROR2 gene and non-syndromic oral *** Here we tested 38 eligible single-nucleotide polymorphisms （SNPs） in ROR2 gene in 297 non-syndromic cleft lip with or without cleft palate and in 82 non-syndromic cleft palate case parent trios recruited from Asia and *** Based Association Test was used to test for deviation from Mendelian *** software was used to test potential parent of origin *** maternally mediated in utero effects were assessed using the TRlad Multi-Marker approach under an assumption of mating symmetry in the *** Significant evidence of linkage and association was shown for 3 SNPs （rs7858435,rs10820914 and rs3905385） among 57 Asian non-syndromic cleft palate trios in Family Based Association Tests.P values for these 3 SNPs equaled to 0.000068,0.000115 and 0.000464 respectively which were all less than the significance level （0.05/38=0.0013） adj.sted by strict Bonferroni *** odds ratios for the risk allele were 3.42 （1.80-6.50）,3.45 （1.75-6.67） and 2.94 （1.56-5.56）,*** evidence of linkage and association was not shown for study groups other than non-syndromic cleft *** evidence for parent-of-origin nor maternal genotypic effect was shown for any of the ROR2 markers in our analysis for all study *** Our results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate.

关键词： receptor tyrosine kinase-like orphan receptor 2 cleft lip cleft palate association transmission disequilibrium test

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Non-physician endoscopists: A systematic review

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World j.urnal of Gastroenterology 2015年第16期21卷 5056-5071页

作者： Maximilian Stephens Luke F Hourigan Mark Appleyard George Ostapowicz Mark Schoeman Paul V Desmond j.ne M Andrews Michael Bourke David Hewitt David A Margolin gerald j.Holtmann Department of Gastroenterology and Hepatology Princess Alexandra Hospital Faculty of Medicine and Biomedical Sciences University of Queensland Department of Gastroenterology and Hepatology RBWH Department of Gastroenterology and Hepatology Gold Coast Hospital QLD 4215 Department of Gastro-enterology and Hepatology Royal Adelaide Hospital and University of Adelaide St Vincent’s Hospital University of MelbourneMelbourne VIC 3010Australia Department of Gastroenterology and Hepatology Westmead HospitalUniversity of Sydney School of Medicine University of Queensland Department of Gastroenterology Queensland Elizabeth II Jubilee HospitalCoopers PlainsBrisbane QLD 4108Australia Department of Colon and Rectal Surgery Ochsner Clinic Foundation Ochsner Clinical SchoolUniversity of Queensland

AIM:To examine the available evidence on safety, competency and cost-effectiveness of nursing staff providing gastrointestinal(GI) endoscopy ***:The literature was searched for publications reporting nurse endoscopy using several databases and specific search *** were screened against eligibility criteria and for *** searches yielded 74 eligible and relevant articles; 26 of these studies were primary research articles using original datasets relating to the ability of nonphysician *** publications included a total of 28883 procedures performed by non-physician ***:The number of publications in the field of non-specialist gastrointestinal endoscopy reached a peak between 1999 and 2001 and has decreased thereafter.17/26 studies related to flexible sigmoidoscopies,5 to upper GI endoscopy and 6 to *** studies were from metropolitan centres with nurses working under strict supervision and guidance by specialist *** distribution of publications showed the maj.rity of research was conducted in the United States(43%),the United Kingdom(39%)and the Netherlands(7%).Most studies conclude that after appropriate training nurseendoscopists safely perform ***,in relation to endoscopic competency,safety or patient satisfaction,all studies had maj.r methodological *** were often not randomized(21/26studies)and not appropriately *** relation to cost-efficiency,nurse endoscopists were less costeffective per procedure at year 1 when compared to services provided by physicians,due largely to the increased need for subsequent endoscopies,specialist follow-up and primary care ***:Contrary to general beliefs,endoscopic services provided by nurse endoscopists are not more cost effective compared to standard service models and evidence suggests the *** significant shortcomings and biases limit the validity and

关键词： Nurse endoscopist Cost-benefit Servicemodel Patient satisfaction Outcome parameter

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管节点疲劳寿命的预测

世界地震工程 1983年第6期 174-181页

作者： Henri-paul Lierade j.an p.gerald Claude j.putot 陆守德

序言一般结构尤其是海洋结构的疲劳分析是建立在将设计应力与规定的 S-N 曲线进行比较的基础上的。这种曲线通常作为画在多少是明确定义的 S-N 座标系统中的分散点群的最保守的包络线得到,这些点相应于从不同的小尺寸和大尺寸模型上获... 详细信息

序言一般结构尤其是海洋结构的疲劳分析是建立在将设计应力与规定的 S-N 曲线进行比较的基础上的。这种曲线通常作为画在多少是明确定义的 S-N 座标系统中的分散点群的最保守的包络线得到,这些点相应于从不同的小尺寸和大尺寸模型上获得的疲劳数据。断裂力学最近的进展可提供一个较合理

关键词：疲劳裂纹裂纹前缘疲劳寿命疲劳力学性质贯穿裂纹应变片应变传感器应力集中系数焊趾

Refining a Church-Based Lifestyle Intervention Targeting African-American Adults at Risk for Cardiometabolic Diseases: A Pilot Study

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Open j.urnal of Epidemiology 2017年第2期7卷 96-114页

作者： Yuan E. Zhou Cynthia D. j.ckson Veronica j. Oates gerald W. Davis Carolyn Davis Zudi-Mwak Takizala Richmond A. Akatue Konya Williams j.anguo Liu j.mes R. Hébert Kushal A. Patel Maciej.S. Buchowski David G. Schlundt Margaret K. Hargreaves Department of Internal Medicine Meharry Medical College Nashville TN USA Department of Family and Consumer Sciences Tennessee State University Nashville TN USA Ralph H Boston Wellness Center Tennessee State University Nashville TN USA Walden University Minneapolis MN USA Participant and Clinical Interactions Resources Meharry Medical College Nashville TN USA Department of Epidemiology and Biostatistics University of South Carolina Columbia USA Department of Public Health Tennessee State University Nashville USA School of Medicine Vanderbilt University Nashville TN USA Department of Psychology Vanderbilt University Nashville TN USA

Obj.ctive: The pilot study was intended to test the feasibility of a multiple-component lifestyle intervention targeting African American adults in a weight control and cardiometabolic risk reduction program on diet, activity, and stress, using community-engagement principles. Methods: Applying mixed qualitative and quantitative measures, the intervention had a two-part sequential study design consisting of 12 weekly small group sessions that provided individual and group counseling in nutrition, exercise, and mindfulness, while incorporating focus group and interactive techniques to learn about barriers and acceptable practices for this population. The program was implemented at an African-American church in Nashville, Tennessee. Results: Thirty-four participants (aged 56.1 ± 11 years, body mass index (BMI) 36.7 ± 6.6 kg/m2) completed the intervention. Lifestyle changes after the 12 weekly sessions showed some positive trends including reduced sodium intake (from 2725.3 ± 326.5 to 2132 ± 330, mg/day, P = 0.008), increased walking steps (from 4392.1 ± 497.2 to 4895.3 ± 497.9, steps/day, not significant), and slightly decreased Perceived Stress Scale (PSS) scores (from 13.7 ± 1.4 to 12.4 ± 1.5, not significant). Body fat % among male participants decreased significantly (from 33.8 ± 2.6 to 28 ± 2.6, %, P = 0.043). Among cardiometabolic risk biomarkers, hemoglobin A1c (HbA1c) decreased significantly (from 6.6 ± 0.2 to 6.1 ± 0.2, %, P β = 2.4, P = 0.006). Twenty-one participants took part in focus groups during the program to identify barriers to healthy lifestyle changes. Primary barriers reported were price, time for preparing healthy meals, unfamiliarity with mindfulness activities, their health condition, and daily schedule available for physical activities. Conclusions: This church-based pilot intervention was proven feasible by showing modest progress in reducing adiposity and decreasing HbA1c levels. The focus group and interactive methods facilitated program di

关键词： Pilot Study Life Style Risk Reduction Mind-Body Therapies Cardiometabolic Disease Weight Control Church-Based Health Program African Americans

Reconfiguring Plant Metabolism for Biodegradable Plastic Production

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BioDesign Research 2020年第1期2020卷 111-123页

作者： Haiwei Lu Guoliang Yuan Steven H.Strauss Timothy j.Tschaplinski gerald A.Tuskan j.n-Gui Chen Xiaohan Yang Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Forest Ecosystems and Society Oregon State UniversityCorvallisOR 97331USA

For decades,plants have been the subj.ct of genetic engineering to synthesize novel,value-added ***(PHAs),a large class of biodegradable biopolymers naturally synthesized in eubacteria,are among the novel products that have been introduced to make use of plant acetyl-CoA metabolic *** was hoped that renewable PHA production would help address environmental issues associated with the accumulation of nondegradable plastic ***,after three decades of effort synthesizing PHAs,and in particular the simplest form polyhydroxybutyrate(PHB),and seeking to improve their production in plants,it has proven very difficult to reach a commercially profitable rate in a normally growing *** seems to be due to the growth defects associated with PHA production and accumulation in plant ***,we review maj.r breakthroughs that have been made in plant-based PHA synthesis using traditional genetic engineering approaches and discuss challenges that have been ***,from the point of view of plant synthetic biology,we provide perspectives on reprograming plant acetyl-CoA pathways for PHA production,with the goal of maximizing PHA yield while minimizing growth ***,we suggest genetic elements that can be considered in genetic circuit design,approaches for nuclear genome and plastome modification,and the use of multiomics and mathematical modeling in understanding and restructuring plant metabolic pathways.

关键词： breakthrough seeking Plant

Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

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World j.urnal of Gastroenterology 2022年第31期28卷 4390-4398页

作者： Alnoor Ramj. Karen Doucette Curtis Cooper gerald Yosel Minuk Mang Ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong Lisa Barrett Hin Hin Ko Sarah Haylock-j.cobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin Department of Medicine University of British ColumbiaVancouver v6t 1z3Canada Department of Medicine University of AlbertaEdmonton t6g 2r7Canada Department of Medicine The Ottawa Hospital Research InstituteUniversity of OttawaOttawa ON K1H 8L6Canada Department of Medicine University of ManitobaWinnipeg r3e 3j7Canada Department of Medicine University of SaskatchewanSaskatoon s7n 5e5Canada Department of Medicine University Health NetworkToronto m5g 2c4Canada Pacific Gastroenterology Associates Vancouver v6z 2k5Canada Vancouver Infectious Disease Centre Vancouver v6z 2c7Canada Department of Medicine McGill UniversityMontreal h3a 0g4Canada Department of Microbiology and Immunology Dalhousie UniversityHalifax b3h 4r2Canada Cumming School of Medicine University of CalgaryCalgary t2n 1n4Canada

BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)*** is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSM)(i.e.,FibroScan®).METHODS Retrospective,observational cohort study from the Canadian HBV *** collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and *** were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year *** In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAM-treated with similar median duration of 3.9 and 3.7 years,*** mean baseline LSM was 11.2 kPa(TDF)vs 8.3 kPa(LAM)(P=0.003).At 5-year follow-up,the mean LSM was 7.0 kPa in TDF vs 6.7 kPa in LAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAM,P<0.05).The last available data on treatment showed that all had normal ALT,but more TDF patients were virologically suppressed(<10 IU/mL)(n=170/190,89%)vs LAM-treated(n=35/58,60%)(P<0.05).None cleared *** In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss.

关键词： Nucleos(t)ide analog therapy Functional cure Hepatitis B virus surface antigen loss Fibrosis regression Liver stiffness measurement Transient elastography

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心理咨询与治疗经典案例第6版第六版

心室起搏导线位置改变了有与无射血分数降低患者的全身血流动力学和左室功能

丛书名：心理咨询与治疗系列

2004年

作者：（美）G.科瑞（gerald Corey）石林等译

万千心理:本书为《心理咨询与治疗的理论及实践》一书的配套读物，书中包含11种咨询理论，针对露丝的案例，层层分析各种治疗方法的理论和应用。

ISBN: (数字)7501944865

ISBN: (纸本)7501944865

万千心理:本书为《心理咨询与治疗的理论及实践》一书的配套读物，书中包含11种咨询理论，针对露丝的案例，层层分析各种治疗方法的理论和应用。

关键词：咨询心理学学科:案例精神疗法

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 45-45页

作者： lieberman R. Padeletti L. Schreuder j. 郭俊 Harper Hospital DetroitMIUnited States Dr.

目的:比较在对有与无左室(LV)功能障碍的窄QRS波患者行右室(RV)、LV和双心室(BiV)起搏时的LV收缩和舒张功能。

关键词：心室起搏射血分数左室功能血流动力学起搏点双心室双腔起搏游离壁超速起搏电生理学

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