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通讯和计算机（中英文版） 2010年第10期7卷 37-44页

作者： georgios Kabouridis Mechanical Department of Technological Educational Institute Patras 26334 Greece

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停止时间的侵蚀：防腐与绝热

暖通空调 2006年第B1期36卷 31-31页

作者： georgios Eleftheriadis 德国阿乐斯国际有限公司欧洲技术发展部经理

正如美国谚语所说：“铁锈永不停息。”世界上约40％的钢铁产品用于更换被腐蚀的部件，这个事实说明腐蚀的危害性。在美国，估计每年约花费2760亿美元在修理腐蚀造成的破坏上。根据很多的研究，在欧洲工业发达国家中，每年腐蚀造成的破... 详细信息

正如美国谚语所说：“铁锈永不停息。”世界上约40％的钢铁产品用于更换被腐蚀的部件，这个事实说明腐蚀的危害性。在美国，估计每年约花费2760亿美元在修理腐蚀造成的破坏上。根据很多的研究，在欧洲工业发达国家中，每年腐蚀造成的破坏占国内生产总值的3．5％～4．2％。如果现有的防腐技术得到有效实施，那么这些成本中，大约有1／3是可以避免的。

关键词：防腐技术停止时间绝热侵蚀工业发达国家国内生产总值钢铁产品腐蚀美国美元

Restless legs syndrome is contributing to fatigue and low quality of life levels in hemodialysis patients

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World Journal of Nephrology 2017年第5期6卷 236-242页

作者： Christoforos D Giannaki Michael Hadjigavriel Akis Lazarou Aristos Michael Loukas Damianou Efthimios Atmatzidis Ioannis Stefanidis georgios M Hadjigeorgiou Giorgos K Sakkas Marios Pantzaris Department of Life and Health Sciences University of NicosiaNicosia CY 1700Cyprus the Cyprus Institute of Neurology and Genetics Nicosia CY 1683Cyprus Hemodialysis Unit Larnaca General HospitalLarnaca CY 6021Cyprus Hemodialysis Unit Limassol General HospitalLimassol CY 3304Cyprus School of Medicine University of Thessaly41110 LarisaGreece Faculty of Sport and Health Sciences University of St Mark and St JohnPlymouth PL6 8BHUnited Kingdom

AIM To examine whether hemodialysis(HD) patients with restless legs syndrome(RLS) are subjects of greater fatigue and impaired quality of life(QoL) compared to HD patients without *** Eighty five stable HD patients participated in this study. According to their RLS status, the patients were dividedinto the RLS group(n = 23) and the non-RLS group(n = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed. RESULTS The HD patients with RLS scored worse in all the questionnaires used in the study(P < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality(P < 0.05). CONCLUSION HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers.

关键词： Sleep quality Depression Secondary restless legs syndrome Fatigue Quality of life

Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract

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American Journal of Plant Sciences 2014年第26期5卷 3964-3973页

作者： Varvara Zoumpliou Maria Stamatiadi Clio Vassiliadis Michail Rallis georgios Theodoros Papaioannou Sotirios Liakos Alexandros Angelou Styliani Daskalaki Maria Kyriazi Vasilios Roussis Constantinos Vagias Department of Pharmaceutical Technology Faculty of Pharmacy National and Kapodistrian University of Athens Athens Greece Department of Pharmacognosy and Chemistry of Natural Products Faculty of Pharmacy National and Kapodistrian University of Athens Athens Greece

Compared to normal, diabetic skin is characterized by great sensitivity. Oxidative stress is directly involved, contributing to accelerated skin aging, xerodermia and poor wound healing. In the last 10 years, cigarette smoke (CS) exposure has been associated with several skin and dermatological conditions and is directly related to the oxidative stress affecting the skin. However, limited data exist concerning the effect of CS on diabetic skin. Some of the effects of cigarette smoke exposure on the skin of hairless diabetic mice were hereby studied and the potential skin protection by topical applications of Pinus halepensis bark extract was investigated. Female hairless SKH-2 diabetic mice were exposed for 8 days to tobacco smoke and topical applications were performed twice daily. Biophysical parameters such as transepidermal water loss (TEWL), skin elasticity and erythema were measured. In addition, the oxidative stress was evaluated. The results show that diabetes and CS have a synergistic negative action on skin condition, with the development of xerosis and high ROS levels whilst topical applications of Pinus halepensis bark extract protect efficiently the toxic effect of CS on skin, by decreasing skin dryness, oxidative stress and blood glucose levels.

关键词： Cigarette Smoke Skin Diabetes Mice Pinus halepensis Bark Extract

CO2激光净化种植体表面后对种植体周垂直型骨缺损的再生治疗

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中国口腔医学继续教育杂志 2010年第3期13卷 11-16页

作者： georgios E Romonos Georg H. Nentwig 贺玲（译）陈波（审）不详北京大学口腔医学院种植科北京海淀区中关村南大街22号100081

由于种植体表面及邻近组织的污染使得种植体周垂直型骨缺损的再生治疗很困难。本文通过15位患者．展示CO2激光对受累种植体的净化能力，同时采用骨移植物及屏障膜。应用自体骨移植材料（10个病例）或异种骨移植材料（BioOss）（9个病例... 详细信息

由于种植体表面及邻近组织的污染使得种植体周垂直型骨缺损的再生治疗很困难。本文通过15位患者．展示CO2激光对受累种植体的净化能力，同时采用骨移植物及屏障膜。应用自体骨移植材料（10个病例）或异种骨移植材料（BioOss）（9个病例）增加骨量．再在骨移植材料表面覆盖胶原膜。术后评估临床结果并进行X线片检查。经过27个月（±17．83）的观察期，种植体周骨缺损几乎完全获得填充。临床及X线片结果初步显示，将CO2激光净化种植体表面和骨增量技术相结合可以有效地治疗种植体周围炎。

关键词： CO2激光净化种植体表面种植体周垂直型骨缺损再生治疗

Olfactory Neuroblastoma Treated by Minimally Invasive Endoscopic Resection and Postoperative Adjuvant Radiotherapy: A Representative Case and an Updated Review of the Literature

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Journal of Cancer Therapy 2012年第6期3卷 1074-1079页

作者： George X. Papacharalampous georgios P. Kotsis Petros V. Vlastarakos Elina P. Papadopoulou Panayiotis K. Saravakos Dimitrios I. Davilis Department of General Surgery General Hospital of Kefallonia Argostoli Greece ENT Department Elpis General Hospital Athens Greece ENT Department Lister Hospital Stevenage UK

This paper presents a case of an olfactory neuroblastoma, treated with minimally invasive endoscopic resection, followed by adjuvant radiotherapy and critically reviews the current literature with regard to diagnosis and management of such malignancies. Olfactory neuroblastoma is considered to be an uncommon malignancy of the nasal cavity. The tumor arises from the specialized sensory epithelial olfactory cells, normally situated at the upper part of the nasal cavity, including the superior nasal concha, the roof of the nose and the cribriform plate. The imaging modality of choice is computed tomography and magnetic resonance imaging. Combination of surgery and radiotherapy is considered to be the standard of care for primary site disease by the majority of researchers. Combined transfacial and neurosurgical conventional approaches are adopted in most cases, mainly due to the endocranial extension and the close anatomic relationship of esthesioneuroblastomas with the ethmoid roof and cribriform plate. However, recent literature supports that endoscopic resection correlates with similar oncologic control rates, compared with open surgery, when basic oncologic surgical principles are maintained.

关键词： Olfactory Neuroblastoma Endoscopic Surgery Radiotherapy Stereotactic Radiosurgery

Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review

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世界重症医学杂志 2016年第2期5卷 121-136页

作者： Vasilios Koulouras georgios Papathanakos Athanasios Papathanasiou georgios Nakos Intensive Care Unit Univer-sity Hospital of Ioannina

Acute respiratory distress syndrome(ARDS) is a syndrome with heterogeneous underlying pathological processes. It represents a common clinical problem in intensive care unit patients and it is characterized by high mortality. The mainstay of treatment for ARDS is lung protective ventilation with low tidal volumes and positive end-expiratory pressure sufficient for alveolar recruitment. Prone positioning is a supplementary strategy available in managing patients with ARDS. It was first described 40 years ago and it proves to be in alignment with two major ARDS pathophysiological lung models; the "sponge lung"- and the "shape matching"-model. Current evidence strongly supports that prone positioning has beneficial effects on gas exchange, respiratory mechanics, lung protection and hemodynamics as it redistributes transpulmonary pressure, stress and strain throughout the lung and unloads the right ventricle. The factors that individually influence the time course of alveolar recruitment and the improvement in oxygenation during prone positioning have not been well characterized. Although patients' response to prone positioning is quite variable and hard to predict, large randomized trials and recent meta-analyses show that prone position in conjunction with a lung-protective strategy, when performed early and in sufficient duration, may improve survival in patients with ARDS. This pathophysiology-based review and recent clinical evidence strongly support the use of prone positioning in the early management of severe ARDS systematically and not as a rescue maneuver or a last-ditch effort.

关键词： Prone position Acute respiratory distress syndrome Mechanical ventilation Ventilator-induced lung injury Pathophysiology

Modified porous tantalum rod technique for the treatment of femoral head osteonecrosis

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World Journal of Orthopedics 2015年第10期6卷 829-837页

作者： Emilios E Pakos Panayiotis Megas Nikolaos K Paschos Spyridon A Syggelos Antonios Kouzelis georgios Georgiadis Theodoros A Xenakis Department of Orthopaedics and Biomechanics University of IoanninaMedical School Department of Ortho-paedic Surgery University Hospital of PatrasUniversity of PatrasMedical School Department of Anatomy HistologyEmbryologyUniversity of PatrasMedical School

AIM: To study a modified porous tantalum technique for the treatment of osteonecrosis of the femoral ***: The porous tantalum rod was combined with endoscopy,curettage,autologous bone grafting and use of bone marrow aspirates from iliac crest aspiration in 49 patients(58 hips) with a mean age of 38 *** majority of the patients had idiopathic osteonecrosis,followed by corticosteroid-induced *** hips were of Steinberg stage Ⅱ disease and 20 hips were of stage Ⅲ *** were followed for 5 years and were evaluated clinically with the Merle D'Aubigne and Postel score and *** primary outcome of the study was survival based on the conversion to total hip arthroplasty(THA).Secondary outcomes included deterioration of the osteonecrosis to a higher disease stage at 5 years compared to the preoperative period and identification of factors that were associated with *** Kaplan-Meier survival analysis was performed to evaluate the survivorship ofthe prosthesis,and the Fisher exact test was performed to test associations between various parameters with ***: No patient developed any serious intraoperative or postoperative complication including implant loosening or migration and donor site *** the 5-year follow up,1 patient died,7 patients had disease progression and 4 hips were converted to *** 5-year survival based on conversion to THA was 93.1% and the respective rate based on disease progression was 87.9%.Stage Ⅱ disease was associated with statistically significant better survival rates compared to stage Ⅲ disease(P = 0.04).The comparison between idiopathic and non-idiopathic osteonecrosis and between steroid-induced and non-steroid-induced osteonecrosis did not showed any statistically significant difference in survival *** clinical evaluation revealed statistically significantly improved Merle d'Aubigne scores at 12 mo postoperatively compared to the preoperative period

关键词： Avascular necrosis Femoral head Tantalum rod Survival Bone grafting

Inflammation in irritable bowel syndrome:Myth or newtreatment target?

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世界胃肠病学杂志：英文版 2016年第7期22卷 2242-2255页

作者： Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo Gastroenterology and Endoscopy Unit Fondazione Istituto San Raffaele GiglioContrada Pietra Pollastra Pisciotto90015 CefalùItaly PhD Course in Surgical Biotechnology and Regenerative Medicine University of Palermo90100 PalermoItaly Euro-Mediterranean Institute of Science and Technology(IEMEST) 90100 PalermoItaly Pathology Unit Fondazione Istituto San Raffaele GiglioContrada Pietra Pollastra Pisciotto90015 CefalùItaly Department of Experimental Biomedicine and Clinical Neuroscience Section of Human AnatomyUniversity of Palermo90100 PalermoItaly Unit of Gastroenterology Ospedali Riuniti Villa Sofia-Vincenzo Cervello90100 PalermoItaly DICHIRONS Department of SurgicalOncological and Stomatological DisciplinesUniversity of Palermo90100 PalermoItaly Unit of Pathology Ospedali Riuniti Villa Sofia-Vincenzo Cervello90100 PalermoItaly

Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism.

关键词： Inflammation Irritable bowel syndrome Mast cells Neuroendocrine cells Pathology

Current status of high on-treatment platelet reactivity in patients with coronary or peripheral arterial disease:Mechanisms,evaluation and clinical implications

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World Journal of Cardiology 2015年第12期7卷 912-921页

作者： Stavros Spiliopoulos georgios Pastromas Department of Interventional Radiology Patras University Hospital

Antiplatelet therapy with aspirin or clopidogrel or both is the standard care for patients with proven coronary or peripheral arterial disease,especially those undergoing endovascular revascularization procedures. However,despite the administration of the antiplatelet regiments,some patients still experience recurrent cardiovascular ischemic events. So far,it is well documented by several studies that in vitro response of platelets may be extremely variable. Poor antiplatelet effect of clopidogrel or high on-treatment platelet reactivity(HTPR) is under investigation by numerous recent studies. This review article focuses on methods used for the ex vivo evaluation of HTPR,as well as on the possible underlying mechanisms and the clinical consequences of this entity. Alternative therapeutic options and future directions are also addressed.

关键词： Coronary disease Clopidogrel Aspirin High on treatment platelet reactivity Peripheral arterial disease Antiplatelet therapy Ticagrelor Prasugrel