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B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma

World Journal of Gastroenterology 2017年第7期23卷 1250-1261页

作者： Raluca Niculina Ciurea Ion Rogoveanu Daniel Pirici georgica-costinel tartea Costin Teodor Streba Cristina Florescu Bogdan Catalin Ileana Puiu Elena-Anca tartea Cristin Constantin Vere Department of Pathology University of Medicine and Pharmacy of Craiova Department of Gastroenterology University of Medicine and Pharmacy of Craiova Department of Research Methodology University of Medicine and Pharmacy of Craiova Department of Internal Medicine University of Medicine and Pharmacy of Craiova Department of Cardiology University of Medicine and Pharmacy of Craiova Department of Physiology University of Medicine and Pharmacy of Craiova Department of Pediatrics University of Medicine and Pharmacy of Craiova

To study the morphology of the enteric nervous system and the expression of beta-2 adrenergic (B2A) receptors in primary colorectal *** this study, we included forty-eight patients with primary colorectal cancer and nine patients for control tissue from the excision of a colonic segment for benign conditions. We determined the clinicopathological features and evaluated the immunohistochemical expression pattern of B2A receptors as well as the morphological changes of the enteric nervous system (ENS). In order to assess statistical differences, we used the student t-test for comparing the means of two groups and one-way analysis of variance with Bonferroni’s post hoc analysis for comparing the means of more than two groups. Correlations were assessed using the Pearson’s correlation ***2A receptors were significantly associated with tumor grading, tumor size, tumor invasion, lymph node metastasis (P 0.05). We observed, on one hand, a decrease of the relative area for both Auerbach and Meissner plexuses with the increase of the tumor grading, and on the other hand, an increase of the relative area of other nervous elements not in the Meissner plexus or in the Auerbach plexus with the tumor grading. For G1 tumors we found that epithelial B2A area showed an inverse correlation with the Auerbach plexus areas [r(14) = -0.531, P < 0.05], while for G2 tumors, epithelial B2A areas showed an indirect variation with both the Auerbach plexus areas [r(14) = -0.453, P < 0.05] and the Meissner areas [r(14) = -0.825, P < 0.01]. For G3 tumors, the inverse dependence increased for both Auerbach [r(14) = -0.587, P < 0.05] and Meissner [r(14) = -0.934, P < 0.05] ***2A receptors play an important role in colorectal carcinogenesis and can be utilized as prognostic factors. Furthermore, study of the ENS in colorectal cancer m

关键词： Beta-2 adrenergic receptors Enteric nervous system Colorectal adenocarcinoma Spectral unmixing immunohistochemistry Tumor grading

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