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Dos detections based on association rules and frequent itemsets

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Journal of Harbin Institute of Technology(New series) 2008年第2期15卷 283-289页

作者： george s.oreku Fredrick JMtenzi 李建中 Dept.of Computer science and Engineering Harbin Institute of Technology school of Computing Dublin Institute of Technology

To detect the Dos in networks by applying association rules mining techniques, we propose that association rules and frequent itemsets can be employed to find Dos pattern in packet streams which describe traffic and user behaviors. The method extracts information from the log analysis of submitted packets using the algorithm which depends on the definition of the intrusion. Large itemsets were extracted to represent the super facts to build the association analysis for the intrusion. Network data files were analysed for experiments. The analysis and experimental results are encouraging with better performance as packet frequency number increases.

关键词： data mining intrusion packets streams

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bushman george D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Maintaining Positive Momentum Africa faces a bright economic outlook despite internal and external challenges

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ChinAfrica 2025年第1期17卷 27-29页

作者： george MUsIIME Development Watch Centre Uganda COVER STORY

It’s that time of the year again when we find ourselves reflecting on the year that was and the year *** the African continent,many countries are still recovering from the aftershocks of the COVID-19 pandemic and are doing so amid a fraught geopolitical *** tensions have,to some extent,created hurdles in the path of Africa’s *** African Development Bank has attributed the economic slowdown on the continent toastronomical inflation caused by soaring food andenergy prices. These issues have been aggravatedby the current geopolitical chaos and climatechange. Nevertheless, the continent is projectedto grow at a steady rate of 4.3 percent in *** means that Africa will retain its positionas the fastest-growing region after Asia. This isdriven by several positive factors.

关键词： continent Africa African

Quality of service in Wireless sensor Networks

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Wireless sensor Network 2014年第2期6卷 19-26页

作者： Joseph E. Mbowe george s. oreku Faculty of Economic science and Information Technology TIRDO/North West University Vanderbijlpark South Africa The Nelson Mandela African Institution of science and Technology School of Computational Science and Communication Engineering Arusha Tanzania

The growing demand of usage of wireless sensors applications in different aspects makes the quality-of-service (Qos) to be one of paramount issues in wireless sensors applications. Quality of service guarantee in wireless sensor networks (WsNs) is difficult and more challenging due to the fact that the resources available of sensors and the various applications running over these networks have different constraints in their nature and requirements. Traditionally quality of service was focused on network level with concern in metrics such as delay, throughput, jitter e.c.t. In this paper we present appropriate metrics of Qos for WsN which involve service, reliability and availability which ultimately facilitating in archiving qualitable service. We discuss the reverse look of Qos and hence present mathematically the three significant quality factors that should currently be taken into account in developing WsNs application quality services namely, availability, reliability and serviceability. We run experiments incorporating these three phenomenons (reliability, availability and serviceability—RAs) to demonstrate how to attain Qos which effectively improve reliability of the overall WsNs.

关键词： Wireless sensor Network Qos Probability Metrics serviceability

A Conceptual Framework for Threat Assessment Based on Organization’s Information security Policy

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Journal of Information security 2014年第4期5卷 166-177页

作者： Joseph Elias Mbowe Irina Zlotnikova simon s. Msanjila george s. oreku school of Computational science and Communication Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania Faculty of science and Technology Mzumbe University Morogoro Tanzania Faculty of Economics North West University Vanderbijlpark South Africa

The security breaches of sensitive information have remained difficult to solve due to increased malware programs and unauthorized access to data stored in critical assets. As risk appetite differ from one organization to another, it prompts the threat analysis tools be integrated with organization’s information security policy so as to ensure security controls at local settings. However, it has been noted that the current tools for threat assessment processes have not encompassed information security policy for effective security management (i.e.?confidentiality, integrity and availability) based on organization’s risk appetite and culture. The information security policy serves as a tool to provide guidance on how to manage and secure all business operations including critical assets, infrastructure and people in the organization. This guidance (e.g. usage and controls) facilitates the provisions for threat assessment and compliance based on local context. The lack of effective threat assessment frameworks at local context have promoted the exposure of critical assets such as database servers, mails servers, web servers and user smart-devices at the hand of attackers and thus increase risks and probability to compromise the assets. In this paper we have proposed a conceptual framework for security threat assessment based on organization’s information security policy. Furthermore, the study proposed the policy automation canvas for provision of a methodology to alert the security managers what possible threats found in their organizations for quick security mitigation without depending on security expertise.

关键词： Critical Asset Information security Information security Policy Threat Analysis Threat Assessment security Threat Visualization

On Development of Platform for Organization security Threat Analytics and Management (POsTAM) Using Rule-Based Approach

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Journal of software Engineering and Applications 2016年第12期9卷 601-623页

作者： Joseph E. Mbowe simon s. Msanjila george s. oreku Khamisi Kalegele school of Computational and Communication science and Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania Faculty of science and Technology Mzumbe University Morogoro Tanzania Faculty of Economics North West University Vanderbijlpark South Africa

The integration of organisation’s information security policy into threat modeling enhances effectiveness of security strategies for information security management. These security policies are the ones which define the sets of security issues, controls and organisation’s commitment for seamless integration with knowledge based platforms in order to protect critical assets and data. such platforms are needed to evaluate and share violations which can create security loop-hole. The lack of rules-based approaches for discovering potential threats at organisation’s context, poses a challenge for many organisations in safeguarding their critical assets. To address the challenge, this paper introduces a Platform for Organisation security Threat Analytic and Management (POsTAM) using rule-based approach. The platform enhances strategies for combating information security threats and thus improves organisations’ commitment in protecting their critical assets. R scripting language for data visualization and java-based scripts were used to develop a prototype to run on web protocol. MysQL database management system was used as back-end for data storage during threat analytic processes.

关键词： security Threats Analytic Threat Visualization security Management Automated security Policies

Chondroitinase ABC combined with schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia george smith Rui Li Nai-Kui Liu Xiao-Ming Xu spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous schwann cells to treat patients with spinal cord injury.A major challenge for schwann cell transplantation is that grafted schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,schwann cells migrated for considerable distances in both rostral and caudal *** schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration schwann cell spinal cord injury transplantation

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F U Cheng Xindan sheng Xin Yang Manzhao Ouyang george A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The second school of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELIsA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Treating amyotrophic lateral sclerosis with allogeneic schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan george Jimsheleishvili Patricia Graham Adriana Brooks Risset silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller school of Medicine University of MiamiMiamiFLUSA stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,schwann cell function may also be ***,important signaling and potential trophic activities of schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic schwann cell-derived exosomal vesicles to potentially restore impaired schwann cell and motor neuron *** confirmed that cultured schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s schwann cells to allogeneic schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction schwann cell