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Post-operative protein supplementation following orthopaedic surgery: A systematic review

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sports Medicine and Health science 2024年第1期6卷 16-24页

作者： Andrew george Brendan M.Holderread Bradley s.Lambert Joshua D.Harris Patrick C.McCulloch Houston Methodist Orthopedics and sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Methodist Orthopedic Biomechanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle *** purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery.A systematic review was conducted according to the Preferred Reporting Items for systematic Reviews and MetaAnalysis(PRIsMA).PubMed(MEDLINE),Embase,scopus,and Web of science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic measures of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after ACL reconstruction(ACLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional *** authors also demonstrated improved functional measures and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR,THA,TKA,and surgical treatment of hip *** effects often correlate with improved functional measures and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplementation systematic review Muscle atrophy

Probiotics: shaping the gut immunological responses

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World Journal of Gastroenterology 2024年第15期30卷 2096-2108页

作者： Eirini Filidou Leonidas Kandilogiannakis Anne shrewsbury george Kolios Katerina Kotzampassi Faculty of Medicine Laboratory of PharmacologyDemocritus University of ThraceAlexandroupolis 68100Greece Department of surgery Aristotle University of ThessalonikiThessaloniki 54636Greece

Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate *** the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae,Bifidobacteriaceae and *** of them have been shown,both in vitro and in vivo studies of intestinal inflammation models,to provide favorable results by means of improving the gut microbiota composition,promoting the wound healing process and shaping the immunological *** intestinal conditions,such as inflammatory bowel diseases(IBD),are characterized by an imbalance in microbiota composition,with decreased diversity,and by relapsing and persisting inflammation,which may lead to mucosal *** the results of the clinical studies investigating the effect of probiotics on patients with IBD are still controversial,it is without doubt that these microorganisms and their metabolites,now named postbiotics,have a positive influence on both the host’s microbiota and the immune system,and ultimately alter the topical tissue *** influence is achieved through three axes:(1)By dis-placement of potential pathogens via competitive exclusion;(2)by offering protection to the host through the secretion of various defensive mediators;and(3)by supplying the host with essential *** will analyze and discuss almost all the in vitro and in vivo studies of the past 2 years dealing with the possible favorable effects of certain probiotic genus on gut immunological responses,highlighting which species are the most beneficial against intestinal inflammation.

关键词： Probiotics Lactobacillaceae Bifidobacteriaceae saccharomyces Intestinal inflammation Immune responses

Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

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Plant Communications 2024年第6期5卷 246-262页

作者： george Heslop-Harrison Kazumi Nakabayashi Ana Espinosa-Ruiz Francesca Robertson Robert Baines Christopher R.L.Thompson Katrin Hermann David Alabadí Gerhard Leubner-Metzger Robin s.B.Williams Centre for Biomedical sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de Biología Molecular y Celular de Plantas(CsIC-UPV) 46022 ValenciaSpain Centre for Life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released by plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighboring *** how allelochemicals function to regulate plant responses may provide valuable new approaches to better control plant *** such allelochemical,Myrigalone A(MyA)produced by Myrica gale,inhibits seed germination and seedling growth through an unknown ***,we investigate MyA using the tractable modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carboxylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct binding of MyA to ACO within the catalytic *** ***,ablation of ACO mimics the MyA-dependent developmental delay,which is partially restored by exogenous ethylene,and MyA reduces ethylene *** Arabidopsis thaliana,MyA treatment delays seed germination,and this effect is rescued by exogenous *** also mimics the effect of established ACO inhibitors on root and hypocotyl extension,blocks ethylenedependent root hair production,and reduces ethylene ***,in silico binding analyses identify a rangeof highlypotentethylene inhibitorsthatblock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism by which the allelochemical MyA reduces ethylene biosynthesis and identify a range of ultrapotent inhibitors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carboxylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhibitors structure-activity relationship

Assessing the dynamics and impact of COVID-19 vaccination on disease spread:A data-driven approach

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Infectious Disease Modelling 2024年第2期9卷 527-556页

作者： Farhad Waseel george streftaris Bhuvendhraa Rudrusamy sarat C.Dass school of Mathematical and Computer sciences Heriot-Watt University MalaysiaPutrajayaMalaysia school of Mathematical and Computer sciences Heriot-Watt UniversityEdinburghUnited Kingdom school of Engineering and Physical sciences Heriot-Watt University MalaysiaPutrajayaMalaysia Maxwell Institute for Mathematical sciences United Kingdom Faculty of Mathematics Kabul UniversityKabulAfghanistan

The COVID-19 pandemic has significantly impacted global health,social,and economic situations since its emergence in December *** primary focus of this study is to propose a distinct vaccination policy and assess its impact on controlling COVID-19 transmission in Malaysia using a Bayesian data-driven approach,concentrating on the year *** employ a compartmental susceptible-Exposed-Infected-Recovered-Vaccinated(sEIRV)model,incorporating a time-varying transmission rate and a data-driven method for its estimation through an Exploratory Data Analysis(EDA)*** no vaccine guarantees total immunity against the disease,and vaccine immunity wanes over time,it is critical to include and accurately estimate vaccine efficacy,as well as a constant vaccine immunity decay or wane factor,to better simulate the dynamics of vaccine-induced protection over *** on the distribution and effectiveness of vaccines,we integrated a data-driven estimation of vaccine efficacy,calculated at 75%for Malaysia,underscoring the model's realism and relevance to the specific context of the *** Bayesian inference framework is used to assimilate various data sources and account for underlying uncertainties in model *** model is fitted to real-world data from Malaysia to analyze disease spread trends and evaluate the effectiveness of our proposed vaccination *** findings reveal that this distinct vaccination policy,which emphasizes an accelerated vaccination rate during the initial stages of the program,is highly effective in mitigating the spread of COVID-19 and substantially reducing the pandemic peak and new *** study found that vaccinating 57–66%of the population(as opposed to 76%in the real data)with a better vaccination policy such as proposed here is able to significantly reduce the number of new infections and ultimately reduce the costs associated with new *** study contributes to the development of a robust and informati

关键词： Bayesian inference sEIRV COVID-19 Vaccination policy Importance sampling Malaysia Data-driven

Accuracy and precision of dried urine spot method for the detection of schistosoma mansoni circulating cathodic antigens in resource-limited settings

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Infectious Diseases of Poverty 2024年第1期13卷 103-104页

作者： Abdallah Zacharia Clemence Kinabo Twilumba Makene Huda Omary george Ogweno Faraja Lyamuya Billy Ngasala Muhimbili University of Health and Allied sciences Dar es Salaam Tanzania National Institute for Medical Research Mwanza Tanzania Neglected Tropical Diseases Control Program Ministry of Health Dodoma Tanzania

Background The World Health Organization recommends the use of schisto point-of-care circulating cathodic anti-gens(schisto POC-CCA)for screening of schistosoma mansoni as it offers better sensitivity than ***,there are limitation facing the use of this method including timely availability of the test *** aim of this study was to determine the reliability of dried urine spot(DUs)method for collection of urine and detection of *** using schisto POC-CCA cassettes in a resource-limited *** A cross-sectional study was conducted between October and November 2022 among 250 primary school children in sengerema District,northwestern *** CCA was detected in filter paper-based DUss,liquid urine using DUs schisto POC-CCA(index),and direct urine schisto POC-CCA(comparator)methods *** eggs in stool were detected using duplicate Kato-Katz(KK)*** measures of accuracy were com-puted and compared between the index and comparator *** strength of agreement between inter-raters precisions was tested using Cohen's kappa(k).Results This study revealed *** prevalence rates of 28.8%,54.0%and 50.8%by duplicate KK,direct urine schisto POC-CCA and DUs schisto POC-CCA methods *** mean intensity of infection among infected participants Was 86.3 eggs per gram of stool(EPG)ranging from 12.0 EPG to 824.0 *** sensitivity of DUs schisto POC-CCA and direct urine schisto POC-CCA Was 94.44%(95%CI:89.15-99.74%)and 97.22%(95%CI:93.43-100.00%)*** DUs schisto POC-CCA method had slightly higher specificity(66.85%)than direct urine schisto POC-CCA method(63.48%).The accuracy of the DUs schisto POC-CCA Was found to be slightly high(74.80%,95%CI:68.94-79.06%)compared to that of direct urine schisto POC-CCA(73.20%,95%CI:67.25-78.59%).There was good agreement between two laboratory technologists who performed the DUs schisto POC-CCA method on similar samples(k=0.80,95%CI:0.59-0.95).Con

关键词： Accuracy Point-of-care circulating cathodic antigen Dried urine spot schistosoma mansoni sensiti specificity

secure smart contract-based digital twins for the Internet of Things

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Blockchain(Research and Applications) 2024年第1期5卷 39-49页

作者： Iakovos Pittaras Nikos Fotiou Christos Karapapas Vasilios A.siris george C.Polyzos Mobile Multimedia Laboratory Department of InformaticsSchool of Information Sciences and TechnologyAthens University of Economics and BusinessAthens10434Greece school of Data science The Chinese University of Hong KongShenzhen518172China

The proliferation of Internet of Things(IoT)devices that operate unattended providing a multitude of important and often sensitive services highlights the need for seamless interoperability and increased *** argue that digital twins of IoT devices,with the right design,can enhance the security,reliability,auditability,and interoperability of IoT *** salient features of digital twins have made them key elements for the IoT and Industry *** this paper,we leverage advances in W3C’s Web of Things(WoT)standards and distributed ledger technologies(DLTs)to present a novel design of the smart contract-based digital twins with enhanced security,transparency,interoperability,and *** provide two different variations of that general design using two different blockchains(one public and one private,permissioned blockchain),and we present design ***,we introduce an architecture for accessing and controlling IoT devices securely and reliably,providing full auditability,while at the same time using the proposed digital twins as an indirection mechanism(proxy).The proposed architecture leverages the blockchain to offer notable properties,namely,decentralization,immutability,auditability,non-repudiation,availability,and ***,it introduces mass actuation,easier management of IoT devices,and enhanced security to the IoT gateways,enables new business models,and makes consumer devices(vendor-)agnostic.

关键词： Digital twins Internet of Things Web of Things Distributed ledger technologies Hyperledger Fabric Ethereum

Dynamics of a Quantum Dissipative system Coupled with an Oscillator

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1472-1491页

作者： Emmanouil george Thrapsaniotis Athens Greece

We study the dynamics of a quantum dissipative system. Besides its linear coupling with a harmonic bath modelling the dissipation, we suppose that it is coupled with an oscillator with an interaction of the form s 2 x 2 . In our study, we integrate over the bath and the oscillator, extract the corresponding influence functionals and then solve the system’s sign problem. We apply the theory to the case of a double well and study the time evolution of the expectation value of the position.

关键词： Double Well Harmonic Bath Oscillator Influence Functional sign solved Propagator Position

Hydrodynamic simulation of the Pagasitikos Gulf, Greece

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Computational Water, Energy, and Environmental Engineering 2024年第1期13卷 58-85页

作者： george Bousbouras Panagiotis Angelidis Division of Hydraulics Department of Civil Engineering School of Engineering Democritus University of Thrace Kimmeria Campus Xanthi Greece

semi-enclosed sea basins have difficulty in recharging their waters due to limited communication with larger water bodies, with understandable consequences for their environmental status. This paper aims at the computational simulation of the hydrodynamic characteristics of the waters of the Pagasitikos Gulf (Greece), which has limited communication and water exchange with the Aegean sea and is subject to intense environmental pressures The Estuary, Lake & Coastal Ocean 3d hydrodynamic Model (ELCOM 2.2) combined with its later version Aquatic Ecosystem Model-3d (AEM3D) were used for the simulation. The simulation included the topography of the area, the bay’s bottom geometry, atmospheric loadings, tides, the influence of the Coriolis force and boundary conditions. The hydrodynamic behaviour of the bay, water circulation, velocities at the surface and in depth, water recharge and residence time throughout the bay, density variation and other factors were examined to determine the impact of all these on the aquatic ecosystem.

关键词： Hydrodynamic simulation semi-Enclosed sea Basins Pagasitikos Gulf Greece

Thermochemical co-conversion of biomass-plastic waste to biochar:a review

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Green Chemical Engineering 2024年第1期5卷 31-49页

作者： Adewale george Adeniyi Kingsley O.Iwuozor Ebuka Chizitere Emenike Oluwaseun J.Ajala samuel Ogunniyi Kabir B.Muritala Department of Chemical Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorinP.M.B.1515Nigeria Department of Chemical Engineering Landmark UniversityOmu-AranKwara StateP.M.B.1001Nigeria Department of Pure and Industrial Chemistry Nnamdi Azikiwe UniversityAwkaP.M.B.5025Nigeria Department of Chemistry Federal University of TechnologyBosso CampusMinnaNiger StateP.M.B.65Nigeria

Biomass and plastics are two of the most common municipal solid wastes globally that have continuously placed a burden on the *** is therefore important that they are properly *** coconversion offers a valuable opportunity to recycle biomass and plastics simultaneously into biochar,which reduces the time and cost of recycling them individually while producing a material with a wide range of *** study is a review of published literature that discusses the thermochemical co-processing of biomass and plastic wastes into *** was observed that co-pyrolysis and co-hydrothermal carbonization are the most commonly utilized technologies for this *** characteristics of different biomass and plastics that have been thermochemically converted into biochar were *** properties of the resulting biochar are affected by the feedstock composition,pre-treatment and blending ratio,the reactor’s configuration,reaction temperature,and the presence of a *** studies found that treating the feedstocks separately resulted in a lower yield of biochar than processing them *** biochar created by this procedure has been used as a soil additive and as an adsorbent for water *** perspectives and suggestions,such as the necessity for some technical advancement,biochar’s economic benefits,improved government participation,and raised social awareness,were also *** factors have the potential to propel this field of study to great horizons.

关键词： Biomass Co-pyrolysis Plastic Thermochemical process Valorization