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Journal of Pharmaceutical Analysis 2012年第3期2卷 188-192页

作者： Patrícia Severino george g.g.de oliveira Humberto g.Ferraz Eliana B.Souto Maria H.A.Santana department of Biotechnological Processes School of Engineering ChemicalUniversity of CampinasCampinas 13083-970Brazil department of Pharmacy Faculty of Pharmaceutical SciencesUniversity of So PauloSo Paulo 05508-900Brazil Faculty of Health Sciences Fernando Pessoa UniversityRua Carlos da Maia2964200-150 PortoPortugal Institute for Biotechnology and Bioengineering Centre of Genomics and BiotechnologyUniversity of Traás-os-Montes e Alto Douro(IBB-CGB/UTAD)5001-801 Vila RealPortugal

The purpose of this work was to introduce a new concept of coated pellets containing chitosan microspheres loaded with didadosine for oral administration,aiming at reducing the frequency of administration and improving the bioavailability by a suitable release *** microspheres were produced under fiuidized bed,followed by extrusion and spheronization to obtain pellets with a mean diameter of about 1 *** pellets were then coated with Kollidon VA64 and Kollicoat MAE100P in water dispersion to depict a sustained release *** hard gelatine capsules were loaded with these pellets and tested in vitro for their release profile of *** testing confirmed that chitosan microsphere pellets provides appropriate sustained release up to 2 h behavior for didanosine.

关键词： Didanosine Pellets gastro-resistance Coating Microspheres Chitosan

Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

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Carbon Resources Conversion 2024年第3期7卷 17-31,F0004页

作者： Eleni-Stavroula Vastaroucha Nikolaos g.Stoforos george Aggelis Seraphim Papanikolaou department of Food Science and Human Nutrition Agricultural University of Athens75 Iera Odos11855AthensGreece Unit of Microbiology Department of BiologyUniversity of Patras26504 Rio PatrasGreece

Crude glycerol,the principal by-product of biodiesel production process,was employed as substrate by three wild-type Yarrowia lipolytica strains(ACA-YC 5030,LMBF 20 and NRRL Y-323).Stressful conditions(low pH value=2.0±0.3,low incubation temperature T=20±1℃,non-aseptic conditions)were ***-esting production of yeast biomass and polyols(***,mannitol and arabitol)was noted at pH=2.0±0.3 and T=20±1℃.Strains failed to produce significant quantities of cellular lipid,while variable quantities of intra-cellular polysaccharides were *** under previously pasteurized media supported significant biomass and polyols production for most of the tested strains,while only one strain(NRRL Y-323),managed to produce polyols at media that were not previously thermally treated at *** production of mannitol was favored at low initial glycerol(glol0)concentrations,whereas higher glol0 quantities favored the biosynthesis of *** the strain NRRL Y-323,highly aerated/agitated bioreactor trials showed different physiological profiles as compared to the respective flask ***,in flask experiments with the strain NRRL Y-323 at high glol0 amounts(≈140 g/L)at low medium pH(=2.0±0.3),a significant production of polyols(=84.2 g/L)with the corresponding remarkable conversion yield on glycerol consumed=62%w/w was *** application:Renewable and biodegradable fuels,such as biodiesel,are safer and environmentally friendlier than the conventional petroleum *** is a cost-effective substrate obtained as the main side-product from biodiesel production process and is currently being employed in the realm of Industrial Microbi-ology and Biotechnology to produce metabolic products with added *** research focuses on using glycerol as a starting substrate for biotechnological conversions aiming at producing,amongst other compounds,polyols,microbial biomass,citric acid,*** selected strains of the generall

关键词： Biomass glycerol Polyols Yarrowia lipolytica

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa Wang Yifan Yang Shizhi He george g.Chen Jason YK.Chan Michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru Wang Jugao Fang department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China department of Medical genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

Flexible ultra-thin super-resolution endoscopy

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 171-172页

作者： george S.D.gordon department of Electrical and Electronic Engineering University of NottinghamNottingham NG7 2RDUK

In recent years, multimode fiber(MMF) has become an important tool for high-resolution endoscopic imaging in narrow channels(e.g., in the brain via needles or inside blood vessels) due to its high mode density and fine diameter, typically despread deployment in applications is that realistic perturbations, including bending, twisting and changes in temperature, cause unacceptable image degradation.

关键词： fiber resolution typically

Unique genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 70-78页

作者： Jasmine Tidwell george Y.Wu department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of gastroenterology-Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Non-alcoholic fatty liver disease(NAFLD)affects 25%of the global *** 20%have a normal body mass index(BMI)and a variant known as lean *** typical NAFLD cases associated with obesity and diabetes,lean NAFLD causes liver disease by mechanisms not related to excess weight or insulin *** disorders are among the major factors in developing lean NAFLD,and genome-wide association studies have identified several genes associated with the *** review aims to increase awareness by describing the genetic markers linked to NAFLD and the defects involved in developing lean NAFLD.

关键词： Lean nonalcoholic fatty liver disease Palatine-like phospholipase domain-containing-3 Transmembrane 6 superfamily member 2 Familial hypobetalipoproteinemia Abetalipoproteinemia

Heritable Chronic Cholestatic Liver Diseases:A Review

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 726-738页

Chronic cholestasis due to heritable causes is usually diagnosedin ***,many cases can present andsurvive into *** time course varies considerablydepending on the underlying *** data usuallyreveal elevated conjugated hyperbilirubinemia,alkalinephosphatase,and gamma-glutamyl *** be asymptomatic;however,when present,the typicalsymptoms are pruritus,jaundice,fatigue,and *** diagnostic methods and management requireddepend on the underlying *** development of genome-wide associated studies has allowed the identificationof specific genetic mutations related to the pathophysiologyof cholestatic liver *** aim of this review was tohighlight the genetics,clinical pathophysiology,presentation,diagnosis,and treatment of heritable etiologies of chroniccholestatic liver disease.

关键词： Chronic cholestasis Cholestatic liver disease Congenital hepatic fibrosis Caroli disease Caroli syndrome Alagille syndrome Biliary atresia

Effects of interlayer spacing and applied pressure on the lanthanide transport in MoS2-based two-dimensional channels

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International Journal of Smart and Nano Materials 2024年第3期15卷 579-592页

作者： Qinsi Xiong Chong Liu george C.Schatz department of Chemistry Northwestern UniversityEvanstonILUSA Pritzker School of Molecular Engineering University of ChicagoChicagoILUSA

Rare-earth elements(REEs)are critical to modern industry but difficult to separate due to their subtle and monotonic changes in physico-chemical ***2-based two-dimensional(2D)materials offer novel opportunities for enhancing REE separation,exhibiting a distinct volcano-shaped transport performance distribution that peaks at Sm3+.However,the specific contributions of thermodynamic and kinetic factors to ion transport within 2D confinement remain *** this study,we conducted a series of non-equilibrium all-atom molecular dynamics(MD)simulations to explore the effects of interlayer spacing and external pressure on the transport of lanthanide ions inÅ-scale acetate functionalized 2D MoS2(MoS2-COOH)*** examined ion entry and permeation rates,water flux,dehydration,and binding *** simulation results reveal that the transport trends of lanthanide ions are jointly driven by the dehydration degree and the relative-binding strengths of ions to water and to the acetate within the 2D ***,the dehydration pattern of lanthanide ions during permeation is closely linked to kinetic ***,this study provides a detailed atomistic understanding of the mechanisms under-lying lanthanide ion transport under *** findings point to the significant potential for tuning confinement and chemical functionalization withinÅ-scale channels for more efficient REE separation.

关键词： MoS_(2) 2D channels Lanthanide ions ion transport nanofluidics

Accelerated thermal ageing on performance of polypropylene-based semiconducting screen for high voltage direct current cable applications-Effect of antioxidants

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High Voltage 2024年第2期9卷 410-418页

作者： Haitian Wang Yi Luo Mingyu Zhou Xintong Ren george Chen gEIRI BerlinGermany The Tony Davies High Voltage Laboratory University of SouthamptonSouthamptonUK

The potential of using eco-friendly thermoplastic polypropylene(PP)-based insulation for high voltage direct current(HVDC)cable has been widely investigated but much less work on the PP-based semiconducting screen(SC).Considering a long service life(>30 years)under high temperature and high electrical stress is required for typical HVDC cables,and investigations on the effect of antioxidant(AO)concentration and thermal oxidative sta-bility,mechanical,and electrical properties of PP-based SCs have been *** has been demonstrated that an appropriate combination and amounts of AOs are critical for achieving high thermal stability and maintaining the mechanical properties of SC after ageing in a harsh environment(150°C,with Cu,in air,7 days).Although higher amounts of space charges have been observed in SC/PP/SC samples with higher AO concentrations,the impact on space charge behaviours is less after ageing,suggesting that ageing(or operating at high temperature)leads to microstructure evolution in SC and can potentially mitigate space accumulation in PP-based insulating materials.

关键词： microstructure thermal high

Focal Nodular Hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 182-190页

作者： Jaimy Villavicencio Kim george Y.Wu Division of gastroenterology-Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Focal nodular hyperplasia is a benign tumor of the liver that is often found incidentally with *** purpose of this review is to discuss the pathophysiology,rare complications that can occur due to these lesions,and management options.A literature review was performed on clinical trials and case reports involving focal nodular hyperplasia complications and management of these,as well as the proposed pathogenesis underlying these *** exposure to oral contraceptive pills and endogenous hormones have been thought to play a role in the development of these lesions,this has not been *** recently,they are thought to arise as a consequence of a vascular anomaly causing alterations in the expression of angiopoietin *** are rare,but previous cases have reported associated pain,rupture and compression of nearby structures(hepatic vein,stomach,biliary system).Resection of focal nodular hyperplasia is not usually ***,if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk of causing a complication,then surgical resection,radiofrequency ablation or arterial embolization should be considered.

关键词： Focal nodular hyperplasia Oral contraceptives Liver lesion

Subnormal Serum Liver Enzyme Levels:A Review of Pathophysiology and Clinical Significance

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 428-435页

作者： Elham M.Youssef george Y.Wu Biochemistry department National Research CenterCairoEgypt department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Subnormal levels of liver enzymes,below the lower limit of normal on local laboratory reports,can be useful *** instance,subnormal levels of aminotransferases can be observed in vitamin B6 deficiency and chronic kidney *** alkaline phosphatase levels may indicate the presence of hypophosphatasia,Wilson's disease,deficiencies of divalent ions,or *** levels of gamma glutamyl transferase may be seen in cases of acute intrahepatic cholestasis,the use of certain medications,and in bone ***,subnormal levels of 5'-nucleotidase have been reported in lead poisoning and nonspherocytic hemolytic *** aim of this review is to bring attention to the fact that subnormal levels of these enzymes should not be ignored as they may indicate pathological conditions and provide a means of early diagnosis.

关键词： Transaminases Vitamin B6 Celiac disease Renal insufficiency Hepatolenticular degeneration Crohn disease Malnutrition Clofibrate Bone diseases Lead poisoning Anemia Hemolytic