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Role of Biologics in the development of Autoimmune Hepatitis: A Review

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 402-409页

作者： Leon d.Averbukh george Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Autoimmune hepatitis(AIH)is a cause of chronic,immunemediated liver injury which without treatment may progress to end-stage liver *** disease state,characterized by elevations in liver enzymes,autoantibodies,and interface hepatitis on histology,has been noted to be induced by a wide range of ***,most commonly minocycline and nitrofurantoin,have long been established as potential inducers of ***,biologics,powerful immune-modulators,have also been reported to induce *** conclude that there is an association between administration of biologics in the development of AIH,and whether the relationship is causal will require appropriate studies in the future.

关键词： Autoimmune hepatitis TNF alpha inhibitors Biologics Hepatitis Infliximab Adalimumab Etanercept

Simulation of kinematic and workspace analysis of 3-PRS parallel manipulator

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International Journal of Modeling, Simulation, and Scientific Computing 2015年第1期6卷 111-122页

作者： Y.d.Patel P.M.george department of Mechanical Engineering A.d.Patel Institute of Technology New Vallabh Vidyanagar GujaratIndia department of Mechanical Engineering Birla Vishvakarma Mahavidyalaya Engineering College Vallabh Vidyanagar India

In the present era,the competitive producers are forced to use maximally newer advanced technology and its effective fast implementation using various available tools for synthesis of new product *** of current state of art computer aided technology supports the creation of flexible assemblies and their built up though unified modular *** design of robotic mechanism is a complex process involving geometric,kinematic,singularity analyses during its synthesis *** present work is aimed at the effective utilization of CAx system Pro/Engineer tools for creation,ease in modifi-cation and analysis of spatial parallel *** degrees of freedom of 3-PRS parallel manipulator is obtained using mobility *** manipulator with 3-dOF with 3-PRS configuration is *** kinematics simulation of the robot is carried out using mechanism simulation and compared with closed form *** concept of reachable,orientation and dexterous workspace is *** tip coordinates obtained through simulation are plotted for workspace *** and outer workspace boundaries are developed and analyzed for four different cases to understand the problem of interior singularity within workspace.

关键词： Parallel manipulator mobility constraints workspace

Evidence for Viral Induction of Biliary Atresia: A Review

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 410-419页

作者： Leon d.Averbukh george Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Biliary atresia(BA)is a childhood disease which manifests with abnormal narrowing,blockage or complete absence of bile ducts within the *** possible etiologies have been reported for the development of BA,including congenital,perinatal and acquired *** the 1970's,there has been increasing evidence linking BA development to viral perinatal *** viral vectors most commonly implicated include members of the herpesviridae family(cytomegalovirus and Epstein-Barr virus)as well as those of the reoviridae family(reovirus and rotavirus).While extensive work has been done on a murine model of disease,the current review focuses primarily on evidence from human studies of viral vectors in children afflicted with BA.

关键词： Biliary atresia Cytomegalovirus Epstein-Barr virus Reovirus Rotavirus

The emerging epigenetics of PARK7 and its implication in neurodegenerative disease

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Neural Regeneration Research 2018年第9期13卷 1542-1543页

作者： george d.Vavougios Sotirios G.Zarogiannis department of Neurology Athens Naval Hospital department of Physiology Faculty of MedicineUniversity of Thessaly

PARK7/dJ-1 is a multifunctional protein that acts as a regulator in stress responsive *** its original discovery as a novel oncogene,dJ-1 was further implicated in the correspondingly dubbed PARK7 autosomal recessive early onset Parkinson’s disease variant,expanding the spectrum of its pathophysiologyto neurodegenerative disease.

关键词： The emerging epigenetics of PARK7 and its implication in neurodegenerative disease

Paleoecological Response of Corals to the End-Triassic Mass Extinction： An Integrational Analysis

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Journal of Earth Science 2018年第4期29卷 879-885页

作者： george d Stanley Jr Hannah M E Shepherd Autumn J Robinson University of Montana Paleontology Center Missoula MT 59812 USA

The end-Triassic （also Triassic-Jurassic） mass extinction severely affected life on planet Earth 200 million years ago. Paleoclimate change triggered by the volcanic eruptions of the Central Atlantic Magmatic Province （CAMP） caused a great loss of marine biodiversity, among which 96% coral genera were get lost. However, there is precious little detail on the paleoecology and growth forms lost between the latest Triassic extinction and the Early Jurassic recovery. Here a new pilot study was conducted by analyzing corallite integration levels among corals from the latest Triassic and Early Jurassic times. Integration levels in corals from the Late Triassic and Early Jurassic were determined through both the Paleobiology database as well as from a comprehensive museum collection of fossil corals. Results suggest that in addition to a major loss of diversity following the end-Triassic mass extinction, there also was a significant loss of highly integrated corals as clearly evidenced by the coral data from the Early Jurassic. This confirms our hypothesis of paleoecological selectivity for corals following the end-Triassic mass extinction. This study highlights the importance of assigning sim- ple to advanced paleoecological characters with integration levels, which opens a useful approach to understanding of mass extinction and the dynamics of the recovery.

关键词： coral loss integration level end-Triassic mass extinction paleoecology

Effects of laparoscopic cholecystectomy on lung function:A systematic review

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World Journal of Gastroenterology 2014年第46期20卷 17603-17617页

作者： george d Bablekos Stylianos A Michaelides Antonis Analitis Konstantinos A Charalabopoulos department of Experimental Physiology Medical SchoolDemocritous University of Thrace68100 AlexandroupolisGreece Technological Educational Institute of Athens 12243 EgaleoGreece First Thoracic Medicine department "Sismanogleio" General Hospital15126 AthensGreece department of Hygiene Epidemiology and Medical StatisticsMedical SchoolNational and Kapodistrian University of Athens11527 GoudiAthensGreece

AIM: To present and integrate findings of studies investigating the effects of laparoscopic cholecystectomy on various aspects of lung function.

关键词： Laparoscopic Open procedure Cholecystectomy Respiratory function Respiratory physiology

Targeted Mitochondrial delivery to Hepatocytes:A Review

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 321-328页

作者： Brent d.Heineman Xiaocong Liu george Y.Wu department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

defects in mitochondria are responsible for various genetic and acquired *** transplantation,a method that involves introduction of healthy donor mitochondria into cells with dysfunctional mitochondria,could offer a novel approach to treat such *** studies have demonstrated the therapeutic benefit of mitochondrial transplantation and targeted delivery in vivo and in vitro within hepatocytes and the *** review discusses the issues regarding isolation and delivery of mitochondria to hepatocytes and the liver,and examines the existing literature in order to elucidate the utility and practicality of mito-chondrial transplantation in the treatment of liver *** reviewed demonstrate that mitochondrial uptake could specifically target hepatocytes,address the challenge of non-specific localization of donor mitochondria,and provide evidence of changes in liver function following injection of mitochondria into mouse and rat disease *** potential benefits and advantages of mitochondrial trans-plantation are evident,more research is needed to determine the practicality of mitochondrial transplantation for the treatment of genetic and acquired liver diseases.

关键词： Mitochondria Hepatocytes Transplantation Liver In vitro tech-niques

Survival of rat sciatic nerve segments preserved in storage solutions ex vivo assessed by novel electrophysiological and morphological criteria

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Neural Regeneration Research 2023年第9期18卷 2082-2088页

作者： Liwen Zhou Monzer Alatrach Ted Zhao Paul Oliphint george d.Bittner department of Neuroscience University of Texas at AustinAustinTXUSA

Most organ or tissue allografts with viable cells are sto red in solutions ex vivo for hours to seve ral *** allografts then require rapid host revascula rization upon transplantation to maintain donor-cell functions(e.g.,cardiac muscle contra ctions,hepatic secretions).In contrast,peripheral nerve allografts stored ex vivo do not require revascularization to act as scaffolds to guide outgrowth by host axons at 1-2 mm/d,likely aided by viable donor Schwann *** current storage solutions and protocols,axons in all these donor orga n/tissue/nerve transplants are expected to rapidly become non-viable due to Wallerian degeneration within ***,ex vivo storage solutions have not been assessed for preserving normal axonal functions,i.e.,conducting action potentials or maintaining myelin *** hypothesized that most or all organ storage solutions would maintain axonal *** examined several common organ/tissue storage solutions(University of Wisconsin Cold Storage Solution,Normosol-R,Normal Saline,and La ctated Ringe rs) for axonal viability in rat sciatic nerves ex vivo as assessed by maintaining:(1) conduction of artificially-induced compound action potentials;and(2) axonal and myelin morphology in a novel assay *** ten diffe rent storage solution conditions for peripheral nerves with viable axons(PNVAs) diffe red in their solution composition,osmolarity(250-318 mOsm),temperature(4℃ vs.25℃),and presence of *** action potentials and axonal morphology in PNVAs were best maintained for up to 9 days ex vivo in calcium-free hypotonic diluted(250 mOsm) Normosol-R(dNR) at 4℃.Surprisingly,compound action potentials were maintained for only 1-2 days in UW and NS at 4℃,a much shorter duration than PNVAs maintained in 4℃ dNR(9 days) or even in 25℃ dNR(5 days).Viable axons in peripheral nerve allografts are critical for successful polyethylene glycol(PEG)-fusion of viable proximal and distal ends of host axons with viable donor a

关键词： axonal morphometrics axonal viability calcium osmolarity peripheral nerve grafts peripheral nerve injury temperature tissue storage solutions tonicity Wallerian degeneration

Bit-Interleaved Polar Coded Modulation with Iterative Successive Cancellation List decoding

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China Communications 2022年第5期19卷 54-68页

作者： Hang Mu Zheng Ma george K.Karagiannidis Panagiotis d.diamantoulakis The 10th Research Institute of China Electronics Technology Group Corporation Chengdu 610036SichuanChina the School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610036SichuanChina the departmentof Electrical and Computer Engineering Aristotle University of ThessalonikiThessaloniki 54124Greece

This paper introduces bit-interleaved polar coded modulation with iterative detection/decoding(BIPCM-Id).In order to enable the soft output of successive cancellation list(SCL)decoding,two types of re-encoders are proposed,namely the max-re-encoder and min-re-encoder,*** the iterative decoding,we analytically verify that the average mutual information(AMI)between the transmitted and decoded symbols can approach the Shannon bound with the proposed ***,bit error rate(BER)and block error rate(BLER)in single-user and multi-user scenarios are ***,simulation results show that the performance of BIPCMId outperforms other bit-interleaved coded modulation(BICM)systems with LdPC and Turbo codes,while also reducing the computational complexity.

关键词： BIPCM-Id Polar code SCMA Reencoder SCL AMI