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Found in Translation

Journal of Clinical and Translational Hepatology 2013年第1期1卷 1-1页

作者： george Y. wu Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT USA

Since the identification of the hepatitis C virus (HCV) and subsequent cloning of its genome in 1989, only relatively modest progress had been made in the treatment of its chronic infection until recently. Interferon-alfa was approved in 1991 for the treatment of HCV infection, and provided a sustained virological response (SVR) of 9% for genotype 1, and 20–30% for genotypes 2 and 3. With the addition of ribavirin in 1998, the SVR of interferon-ribavirin combination therapy increased to 29% for genotype 1, and 62% for genotypes 2 and 3. The development of long-acting pegy-lated (PEG)-interferons plus ribavirin in 2001–2002 increased SVR incrementally to 41% for genotype 1, and 82% for genotypes 2 and 3. After this advance, the situation remained static for almost 10 years without significant breakthroughs, until the advent of the protease inhibitors telaprevir and boceprevir in 2011. These agents represent the vanguard of a new class of HCV drugs, the direct-acting antiviral agents, and a new era in the treatment of HCV. With the triple therapy regimen of PEG-interferon, ribavirin, and either telaprevir or boceprevir, the SVR for genotype 1 HCV ranges from 70 to 80%. Now, for the first time, persons infected with genotype 1 HCV can expect a higher than 50%chance of achieving an SVR to antiviral therapy.

关键词： interferon sustained drugs

The FRB-searching Pipeline of the Tianlai Cylinder Pathfinder Array

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Research in Astronomy and Astrophysics 2024年第8期24卷 115-134页

作者： Zijie Yu Furen Deng Shijie Sun Chenhui Niu Jixia Li Fengquan wu Wei-Yang Wang Yougang Wang Shifan Zuo Lin Shu Jie Hao Xiaohui Liu Reza Ansari Ue-Li Pen Albert Stebbins Peter Timbie Xuelei Chen National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Radio Astronomy and Technology Chinese Academy of Science Institute of Astrophysics Central China Normal University Institute of Automation Chinese Academy of Sciences Guangdong Institute of Artificial Intelligence and Advanced Computing UniversitéParis—Saclay CNRS/IN2P3IJCLab Institute of Astronomy and Astrophysics Academia Sinica Canadian Institute for Theoretical Astrophysics University of Toronto60 Saint George Street Department of Physics University of Wisconsin—Madison Fermi National Accelerator Laboratory Department of Physics College of SciencesNortheastern University Center of High Energy Physics Peking University

This paper presents the design,calibration,and survey strategy of the Fast Radio Burst (FRB) digital backend and its real-time data processing pipeline employed in the Tianlai Cylinder Pathfinder *** array,consisting of three parallel cylindrical reflectors and equipped with 96 dual-polarization feeds,is a radio interferometer array designed for conducting drift scans of the northern celestial *** FRB digital backend enables the formation of 96 digital beams,effectively covering an area of approximately 40 square degrees with the 3 dB *** pipeline demonstrates the capability to conduct an automatic search of FRBs,detecting at quasi-realtime and classifying FRB candidates *** current FRB searching pipeline has an overall recall rate of88%.During the commissioning phase,we successfully detected signals emitted by four well-known pulsars:PSR B0329+54,B2021+51,B0823+26,and B2020+*** report the first discovery of an FRB by our array,designated as FRB *** also investigate the optimal arrangement for the digitally formed beams to achieve maximum detection rate by numerical simulation.

关键词： (stars:) pulsars: general instrumentation: interferometers methods: data analysis telescopes

丙型肝炎病毒NS_5B在Hub-7细胞中的转染与表达

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中华肝脏病杂志 2000年第1期8卷 33-34页

作者：房静远 Edwin Ouyang Catheine H.wu george Y.wu 邱德凯曾民德萧树东上海第二医科大学附属仁济医院上海市消化疾病研究所200001 美国Connecticut大学医学院消化科

目的建立丙型肝炎病毒（ＨＣＶ）ＮＳ５Ｂ表达的人肝细胞系。方法以脂质体共转染ＮＳ５ＳＢ基因人Ｈｕｂ－７细胞，以ＰＣＲ和Ｓｏｕｔｈｅｒｎｂｌｏｔ在ＤＮＡ水平检测转染的结果，以ｗｅｓｔｅｒｎｂｌｏｔ证实了Ｈｕｂ－７细胞中... 详细信息

目的建立丙型肝炎病毒（ＨＣＶ）ＮＳ５Ｂ表达的人肝细胞系。方法以脂质体共转染ＮＳ５ＳＢ基因人Ｈｕｂ－７细胞，以ＰＣＲ和Ｓｏｕｔｈｅｒｎｂｌｏｔ在ＤＮＡ水平检测转染的结果，以ｗｅｓｔｅｒｎｂｌｏｔ证实了Ｈｕｂ－７细胞中有ＮＳｕＢ的蛋白表达。结累在转染过ＮＳＳＢ质粒的细胞系中有ＮＳＳＢ基因的存在和ＨＣＶ－ＲＮＡ多聚酶的表达。结论我们在Ｈｕｂ－７细胞中建立了ＨＣＶ－ＲＮＡ多聚酶表达系统，它有助于研究ＨＣＶ复制机制和为基因治疗丙型肝炎打下基础。

关键词：丙型肝炎病毒 Huh-7细胞基因转染 NS5B

新冠疫情冲击下中国有色金属期货市场效率分析

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计量经济学报 2024年第3期4卷 858-878页

作者：尹涛黄双双吴永强高汉王一鸣袁先智华东政法大学商学院上海201620 北京大学经济学院北京100871 成都大学商学院成都610106 重庆理工大学理学院重庆400054 中山大学管理学院广州510275 浙江清华长三角研究院数字金融研究中心嘉兴314107

由于全球新冠疫情的暴发,各国经济和金融市场受到了严重的冲击,而中国有色金属期货市场也不例外.因此,对于新冠疫情如何影响中国有色金属期货市场的研究,在我国期货市场的发展进程中具有重要的理论和实践意义.本文采用了MF-DFA和多重分... 详细信息

由于全球新冠疫情的暴发,各国经济和金融市场受到了严重的冲击,而中国有色金属期货市场也不例外.因此,对于新冠疫情如何影响中国有色金属期货市场的研究,在我国期货市场的发展进程中具有重要的理论和实践意义.本文采用了MF-DFA和多重分形谱分析方法,通过对沪铜、沪铝、沪锌、沪铅四种有色金属期货价格数据进行分析,探讨了新冠疫情对这些市场效率的影响,并进一步分析了市场风险的变化情况.实证结果显示,除了沪铜期货外,沪铝、沪锌、沪铅三种有色金属期货受到新冠疫情冲击后,市场效率下降、市场风险加大.具体而言,沪铝期货市场效率下降最为明显,而沪铅期货价格波动最为剧烈,市场风险增加最多.此外,本文对新冠疫情前后原始时间序列进行重排和替代处理后发现,在疫情前,时间序列的长程相关性对四种金属期货市场低效性的贡献程度更大;而在疫情之后,时间序列的厚尾分布对沪铜期货市场出现低效性的作用程度更大.而对其他三种有色金属期货来说,时间序列的长程相关性依然是其造成市场低效性更加重要的原因.以上结论阐述了较大冲击因素对市场造成的影响特征,有助于我国有色金属期货市场的成熟稳定发展.

关键词：新冠疫情 MF-DFA 有色金属期货市场多重分形市场效率

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维多利亚时代小说中的济贫院书写

外国语言文学 2024年第2期41卷 45-55,134页

作者：吾文泉江苏科技大学

1834年新《济贫法》要求每个教区建立一个联合济贫院,禁止院外救济,采取“济贫院检验”和“劣等处置”等威慑性原则,实施惩罚性“监狱”管理模式,目的是以贫治贫,淘汰老弱。狄更斯、勃朗特、特罗洛普、盖斯凯尔夫人、爱略特和哈代等一... 详细信息

1834年新《济贫法》要求每个教区建立一个联合济贫院,禁止院外救济,采取“济贫院检验”和“劣等处置”等威慑性原则,实施惩罚性“监狱”管理模式,目的是以贫治贫,淘汰老弱。狄更斯、勃朗特、特罗洛普、盖斯凯尔夫人、爱略特和哈代等一大批维多利亚时代作家们本着批判现实和改革社会的目的,控诉济贫院对贫民实施的监狱式管控的残忍,直陈英国济贫制度的虚伪,同时揭橥对自助与互助想象的幻灭、对社会贫困与人间苦难的同情。

关键词：新《济贫法》维多利亚小说济贫院济贫叙事

Achmatowicz approach to the asymmetric synthesis of(+)-and(−)-monanchorin

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Green Synthesis and Catalysis 2022年第2期3卷 156-161页

作者： Yuzhi Ma Rajender Vemula Qi Zhang Bulan wu george A.O'Doherty Department of Chemistry and Chemical Biology Northeastern UniversityBoston MA 02115United States Department of Pharmacology and Experimental Therapeutics Boston University School of MedicineBoston MA 02118United States Division of Natural Sciences College of Natural&Applied SciencesUniversity of GuamMangilao GU 96923United States

The full account of our development of a de novo asymmetric total synthesis of(+)-monanchorin has been *** optimized synthesis provided access to either enantiomer of the guanidine alkaloid natural product in nine steps from the commodity chemicals furan and caproic *** route relied upon the asymmetric Noyori hydrogen transfer reduction of an achiral acylfuran to introduce the absolute *** addition,an Achmatowicz rearrangement,a diastereoselective palladium-catalyzed glycosylation,a reductive amination and an acid-catalyzed bicyclic guanidine mixed acetal formation were used to complete the synthesis.

关键词： Monanchorin Asymmetric synthesis Achmatowicz Pd-glycosylation Reductive amination Guanidine natural product Alkaloid natural product

Validation of Non-invasive Fibrosis Scores for Predicting Advanced Fibrosis in Metabolic-associated Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 589-594页

作者： Xiaoning Chen george Boon-Bee Goh Jiaofeng Huang Yinlian wu Mingfang Wang Rahul Kumar Su Lin Yueyong Zhu Department of Hepatology Hepatology Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFu-zhouFujianChina Department of Gastroenterology&Hepatology Singapore General HospitalSingapore Duke-NUS Medical School Singapore Department of Gastroenterology and Hepatology Duke-NUS Academic Medical CentreChangi General HospitalSingapore

Background and Aims:Metabolic-associated fatty liver disease(MAFLD)is a newly proposed terminology from 2020;yet,the applicability of conventional noninvasive fi-brosis models is still unknown for *** aimed to evaluate the performance of conventional noninvasive fibrosis scores in ***:The NHANES 2017-2018 datasets were used to compare the performances of different non-invasive fibrosis scores in MAFLD,including the aspartate aminotransferase(AST)to platelet ratio index(APRI),body mass index(BMI)-AST/alanine aminotransferase(ALT)ratio and diabetes score(BARD),fibrosis-4 index(FIB-4),and NAFLD fibrosis score(NFS).Moreover,Asian patients with biopsy-proven MAFLD were enrolled to further validate the ***:A total of 2,622 participants in the Na-tional Health and Nutrition Examination Survey(NHANES)cohort and 293 patients with MAFLD in the Asian cohort were *** in the Asian cohort had a lower BMI and higher liver enzymes(p<0.001).The area under the receiver operating characteristic curve(AUROC)of NFS was the largest in the NHANES cohort and Asian cohorts(0.679 and 0.699,respectively).The AUROC of NFS was followed by APRI,FIB-4,and BARD in the NHANES cohort(0.616,0.601,and 0.589,respectively).In the Asian cohort,the AUROC of APRI,FIB-4,and BARD for predicting advanced fibrosis were 0.625,0.683,and 0.615,*** performance of FIB-4 was better in the Asian cohort than that in the NHANES ***:NFS is better for predicting advanced fibrosis in ***-4 can be an al-ternative choice for MAFLD with high liver enzymes when NFS is *** efficient noninvasive fibrosis scor-ing systems are highly required for patients with MAFLD.

关键词： FIB-4 Metabolic-associated fatty liver disease Liver fibrosis NFS Noninvasive fibrosis scores

中英服饰文化对比研究——以《唐顿庄园》和20版《花木兰》为例

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语言与文化研究

语言与文化研究 2024年第1期32卷 172-174页

作者：吴伟炜桂林理工大学桂林541006

英剧《唐顿庄园》以1912年至1927年为背景,剧情展现了英王乔治五世统治时期英国贵族及其仆人等级森严的人情世故,跌宕起伏的情节。中国电影20版《花木兰》以南北朝时期为背景,讲述花木兰替父从军,女扮男装,奋勇杀敌,成为一名巾帼英雄的... 详细信息

英剧《唐顿庄园》以1912年至1927年为背景,剧情展现了英王乔治五世统治时期英国贵族及其仆人等级森严的人情世故,跌宕起伏的情节。中国电影20版《花木兰》以南北朝时期为背景,讲述花木兰替父从军,女扮男装,奋勇杀敌,成为一名巾帼英雄的故事。服饰是人类文化的显性特征,现代服饰的民族风格取其精华与其具象征性元素,使其成为推动社会进步的力量。本文以影视作品《唐顿庄园》和《花木兰》中的人物服饰为立足点,剖析中国和英国发展过程中服饰文化的差异及其背后的历史缘由,探讨其所体现的价值意义,希望能给我国服饰设计师以及跨文化交流者在全球化交际中以启示。

关键词：服饰文化中英文化对比研究价值意义

A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery

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Science China(Life Sciences) 2023年第10期66卷 2201-2213页

作者： Lili wu Anqi Zheng Yangming Tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen wu Shaogui Zeng Hang Yang Qihui Wang george Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China Hybio Pharmaceutical Co. Ltd.Shenzhen 518109China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhen 518112China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Shenzhen Center for Disease Control and Prevention Shenzhen 518055China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Hubei Jiangxia Laboratory Wuhan 430299China Chinese Center for Disease Control and Prevention(China CDC) Beijing 102206China

Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple *** variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory *** previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral ***,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal *** results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases.

关键词： SARS-CoV-2 peptide fusion inhibitor pan-coronavirus viral infection intranasal delivery