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对“存在就是被感知”的解读

西部学刊 2024年第17期 156-159页

作者：吴婧婷黑龙江大学哈尔滨150080

“存在就是被感知”是贝克莱非物质主义哲学最重要的认识论命题之一。从思想来源出发,说明贝克莱的思想受洛克的物质主义和表象学说以及马勒布朗士对贝克莱非物质主义的促进,形成了自己的认识论命题——“存在就是被感知”。通过对这一... 详细信息

“存在就是被感知”是贝克莱非物质主义哲学最重要的认识论命题之一。从思想来源出发,说明贝克莱的思想受洛克的物质主义和表象学说以及马勒布朗士对贝克莱非物质主义的促进,形成了自己的认识论命题——“存在就是被感知”。通过对这一命题的文本分析,为理解“存在就是被感知”提供了依据。同时,对“存在”与“感知”进行分析,将“存在就是被感知”理解为“可感事物的实在性在于被感知”,即可感事物的实在性就在于被上帝或人心感知。

关键词：存在感知非物质主义

Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor

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Protein & Cell 2015年第10期6卷 771-773页

作者： Ying wu Christopher J. Vavricka Yan wu Qina Li Santosh Rudrawar Robin J.Thomson Mark yon Itzstein george F. Gao Jianxun Qi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Institute for Glycomics Griffith University Gold Coast Campus Nathan QLD 4222 Australia

Influenza virus is a member of the Orthomyxoviridae family and is the causative agent of seasonal and pandemic flu.

关键词： Influenza Influenza Virus Oseltamivir Plaque Reduction Assay I149V Mutant

一项对比从富马酸替诺福韦二吡呋酯(TDF)转换为丙酚替诺福韦(TAF)和继续TDF治疗用于病毒学抑制的慢性乙型肝炎(CHB)患者的3期研究:第48周时的疗效和安全性结果

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一项对比从富马酸替诺福韦二吡呋酯(TDF)转换为丙酚替诺福韦(TAF)...

Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice

第十届全国疑难及重症肝病大会

作者： Pietro Lampertico Maria Buti Scott Fung Sang Hoon Ahn Wan-Long Chuang Won Young Tak Alnoor Ramji Chi-Yi Chen Edward Tam Ho Bae Xiaoli Ma John F.Flaherty Anuj Gaggar Audrey Lau Becket Feierbach george wu Vithika Suri Mani Subramanian Cong Cheng Huy N.Trinh Seung Kew Yoon Kosh Agarwal Young-Suk Lim Henry Chan Università degli Studi di Milano Division of Gastroenterology and Hepatology University Hospital Vall d'Hebron University Health Network Yonsei University Kaohsiung Medical University

背景和目的TAF是替诺福韦(TFV)的一种新型前体药物,近期获批用于治疗慢性乙型肝炎。与TDF相比,TAF的血浆稳定性更高,能够更有针对性地将TFV递送至肝脏且降低了TFV的循环水平。第48周和第96周时,TAF表现出不劣于TDF的疗效且改善肾脏和骨...

背景和目的TAF是替诺福韦(TFV)的一种新型前体药物,近期获批用于治疗慢性乙型肝炎。与TDF相比,TAF的血浆稳定性更高,能够更有针对性地将TFV递送至肝脏且降低了TFV的循环水平。第48周和第96周时,TAF表现出不劣于TDF的疗效且改善肾脏和骨骼安全性。本研究评估了从TDF转换为TAF vs.继续接受1年TDF治疗用于病情稳定的病毒学抑制患者时的疗效和安全性。

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International Journal of Oral Science 2015年第2期7卷 89-94页

作者： Er-Xia Du Xiao-Fang Wang wu-Chen Yang Deborah Kaback Siu-Pok Yee Chun-Lin Qin Anne george Jian-Jun Hao Division of Orthodontics Department of Craniofacial SciencesSchool of Dental MedicineUniversity of Connecticut Department of Biomedical Sciences Texas A&M Health Science CenterBaylor College of Dentistry Department of Genetics and Developmental Biology University of Connecticut Health Center Department of Oral Biology University of Illinois

Our previous studies have demonstrated that Fam20 C promotes differentiation and mineralization of odontoblasts,ameloblasts,osteoblasts and osteocytes during tooth and bone *** of the Fam20 C gene inhibits bone and tooth growth by increasing fibroblast growth factor 23 in serum and causing hypophosphatemia in conditional knockout ***,control and regulation of the expression of Fam20 C are still *** this study,we generated a transgenic reporter model which expresses green fluorescence protein（GFP） driven by the Fam20 C *** was used to insert a 16 kb fragment of the mouse Fam20 C gene（containing the 15 kb promoter and 1.1 kb of exon 1） intoa pBluescript SK vector with the topaz variant of GFP and a bovine growth hormone polyadenylation *** expression was subsequently evaluated by histomorphometry on cryosections from E14 to adult *** was evident in the bone and teeth as early as *** GFP signal was maintained stably in odontoblasts and osteoblasts until 4 weeks after *** expression of GFP was significantly reduced in teeth,alveolar bone and muscle by 8 weeks of *** also observed colocalization of the GFP signal with the Fam20 C antibody in postnatal 1- and 7-day-old *** generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20 C gene expression and the biological function of this gene during odontogenesis and osteogenesis.

关键词： transgenic promoter pBluescript osteogenesis teeth transgene reporter Fluorescence insert alveolar

A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery

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Science China(Life Sciences) 2023年第10期66卷 2201-2213页

作者： Lili wu Anqi Zheng Yangming Tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen wu Shaogui Zeng Hang Yang Qihui Wang george Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China Hybio Pharmaceutical Co. Ltd.Shenzhen 518109China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhen 518112China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Shenzhen Center for Disease Control and Prevention Shenzhen 518055China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Hubei Jiangxia Laboratory Wuhan 430299China Chinese Center for Disease Control and Prevention(China CDC) Beijing 102206China

Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple *** variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory *** previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral ***,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal *** results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases.

关键词： SARS-CoV-2 peptide fusion inhibitor pan-coronavirus viral infection intranasal delivery

The Initial Case of COVID-19—Shulan City,Jilin Province,China,May 8,2020

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China CDC weekly 2020年第25期2卷 458-459页

作者： Cao Chen Xiang Zhao Dayan Wang Juan Li Ao Wang Donglin wu Zhixiao Chen Yuchao wu Yao Meng Weifeng Shi george FGao Guizhen wu Biao Huang Wenbo Xu National Health Commission Key Laboratory for Medical Virology and Viral Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Center for Biosafety Mega-Science Chinese Academy of SciencesWuhanChina Jilin Provincial Center for Disease Control and Prevention JilinChina Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical Universityand Shandong Academy of Medical SciencesTaianChina

Coronavirus disease 2019(COVID-19)was designated a global pandemic by the World Health Organization(WHO)on March 11,2020(1).After great effort,COVID-19 has been well-controlled in China,but new challenges have emerged due to increasing numbers of imported cases from outside of *** May 8,the Health Commission of Jilin Province reported a confirmed COVID-19 case of a 45-year-old laundry woman from Shulan City in the northeast of *** case was suspected to be associated with a possible importation event.

关键词： northeast outside Jilin

猕猴脑网络组图谱:包含分区、连接和组织学的多层面全新大脑地图

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Science Bulletin 2024年第14期69卷 2241-2259页

作者：陆玉恒崔玥曹龙董振伟程禄祺吴雯王昌硕刘新异刘有通张宝贵李德莹赵舶凯王海艳李开心马亮时维阳李雯马亚伟杜宗昌张佳琪熊辉罗娜刘妍妍侯肖逍韩景路孙洪吉蔡涛彭强冯琳清王骄健 george Paxinos 杨正宜樊令仲蒋田仔 Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou 450001China Neuroscience Research Australia and The University of New South Wales Sydney NSW 2031Australia Key Laboratory for NeuroInformation of the Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China School of Mechanical and Power Engineering Harbin University of Science and TechnologyHarbin 150080China School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004China Sino-Danish College University of Chinese Academy of ScienceBeijing 100049China Research Center for Augmented Intelligence Zhejiang LabHangzhou 311100China Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital Yongzhou 425000China

The rhesus macaque(Macaca mulatta)is a crucial experimental animal that shares many genetic,brain organizational,and behavioral characteristics with humans.A macaque brain atlas is fundamental to biomedical and evolutionary ***,even though connectivity is vital for understanding brain functions,a connectivity-based whole-brain atlas of the macaque has not previously been *** this study,we created a new whole-brain map,the Macaque Brainnetome Atlas(MacBNA),based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI *** new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and functional *** parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained *** a demonstrative application,the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain *** resulting resource includes:(1)the thoroughly delineated Macaque Brainnetome Atlas(MacBNA),(2)regional connectivity profiles,(3)the postmortem high-resolution macaque diffusion and T2-weighted MRI dataset(Brainnetome-8),and(4)multi-contrast MRI,neuronal-tracing,and histological images collected from a single *** can serve as a common reference frame for mapping multifaceted features across modalities and spatial scales and for integrative investigation and characterization of brain organization and ***,it will enrich the collaborative resource platform for nonhuman primates and facilitate translational and comparative neuroscience research.

关键词： Macaca mulatta Brain atlas Connectivity-based parcellation Diffusion MRI Cytoarchitecture Cross-species comparison

Three-dimensional nanoscale reduced-angle ptycho-tomographic imaging with deep learning(RAPID)

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eLight 2023年第1期3卷 198-210页

作者： Ziling wu Iksung Kang Yudong Yao Yi Jiang Junjing Deng Jeffrey Klug Stefan Vogt george Barbastathis Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA Argonne National Laboratory LemontIL 60439USA Singapore-MIT Alliance for Research and Technology(SMART)Centre Singapore 138602Singapore Present Address:Singapore-MIT Alliance for Research and Technology(SMART)Centre Singapore 138602Singapore Present Address:University of California BerkeleyCA 94720USA

X-ray ptychographic tomography is a nondestructive method for three dimensional(3D)imaging with nanometer-sized resolvable *** size of the volume that can be imaged is almost arbitrary,limited only by the penetration depth and the available scanning *** we present a method that rapidly accelerates the imaging operation over a given volume through acquiring a limited set of data via large angular reduction and compensating for the resulting ill-posedness through deeply learned *** proposed 3D reconstruction method“RAPID”relies initially on a subset of the object measured with the nominal number of required illumination angles and treats the reconstructions from the conventional two-step approach as ground *** is then trained to reproduce equal fidelity from much fewer *** training,it performs with similar fidelity on the hitherto unexamined portions of the object,previously not shown during training,with a limited set of *** our experimental demonstration,the nominal number of angles was 349 and the reduced number of angles was 21,resulting in a×140 aggregate speedup over a volume of 4.48×93.18×3.92μm^(3) and with(14 nm)^(3) feature size,i.e.-10^(8) ***’s key distinguishing feature over earlier attempts is the incorporation of atrous spatial pyramid pooling modules into the deep neural network framework in an anisotropic *** found that adjusting the atrous rate improves reconstruction fidelity because it expands the convolutional kernels’range to match the physics of multi-slice ptychography without significantly increasing the number of parameters.

关键词： X-ray ptychographic tomography Deep learning Reduced-angle Rapid imaging Atrous spatial pyramid pooling Anisotropic

关于单层1T-MoS_2吸附元素汞的密度泛函理论研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第1期19卷 60-67页

作者： Xue-liang MU Xiang GAO Hai-tao ZHAO Michael george Tao wu Municipal Key Laboratory of Clean Energy Conversion Technologies The University of Nottingham Ningbo China College of Energy Engineering Zhejiang University School of Chemistry The University of Nottingham

目的:探索1T-MoS_2(多型结构的二硫化钼)的除汞机制。方法:1.采用密度泛函理论(DFT)分析Hg^0在1T-MoS_2单层上的吸附机理。2.考察1T-MoS_2的不同吸附位置。3.对不同的吸附构型,研究电子吸附前后的变化,从而进一步了解吸附过程。结论:1.... 详细信息

目的:探索1T-MoS_2(多型结构的二硫化钼)的除汞机制。方法:1.采用密度泛函理论(DFT)分析Hg^0在1T-MoS_2单层上的吸附机理。2.考察1T-MoS_2的不同吸附位置。3.对不同的吸附构型,研究电子吸附前后的变化,从而进一步了解吸附过程。结论:1.化学吸附是Hg原子与1T-MoS_2单层吸附的主导因素。同时,在所有可能的吸附位置中,T_(Mo)(在钼原子上方)的位置是最强烈的吸附构型。2.汞(Hg)原子在1T-MoS_2单层上的吸附受邻近的硫(S)和钼(Mo)原子的影响。3.吸附的汞(Hg)原子在1T-MoS_2的TMo位置上会被氧化,其吸附能为-1.091 eV。4.从局部态密度(PDOS)分析来看,Hg原子和1T-MoS_2表面之间的相互作用是由汞(Hg)原子的d轨道与硫(S)原子的s轨道及钼(Mo)原子的p轨道和d轨道重叠所致。

关键词：单层1T-MoS2 汞捕捉吸附机制密度泛函理论(DFT)