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高容量大气采样机噪声影响的消减

环境研究 1983年第3期 54-58页

作者： william Van Winkle Jerry W.Crowder george J.Putnicki 方璧美

在对噪声敏感的区域里,使用高容量大气采样机(以下简称高容机),其噪声影响是令人厌恶的.判定区域里某处的噪声影响的办法是,把来自运行着的高容机的声压级(SPL)和该处的背景声压级组合起来,即可精确地予计该处的噪声影响.本研究所用,表... 详细信息

在对噪声敏感的区域里,使用高容量大气采样机(以下简称高容机),其噪声影响是令人厌恶的.判定区域里某处的噪声影响的办法是,把来自运行着的高容机的声压级(SPL)和该处的背景声压级组合起来,即可精确地予计该处的噪声影响.本研究所用,表示特性的高容机声压级是这样测定的;首先,在一个大的消音室(译者注:原文作“无回音室”)内进行,然后分别作经过草皮与沥青的被覆地面的试验.在消音室和草皮被覆面试验中,高容机的近场区向外伸展3米(10呎),而在沥青被覆面试验中,近场区向外伸展6米(20呎).在近场区之外,量得距离每增加一倍,草皮上声压级减少6分贝(A),而沥青上则减少4分贝(A).这个衰减值可用来估算在一个感受器上,来自高容机的声压级.本文还提供了把来自高容机的和周围的噪声组合起来的计算方法.在消音室中,高容机的频率分析指出,在250,1000和2000赫处都出现了声压级的峰值.250赫处的峰值,看来是由于安装在机壳架上的过滤器的共振所引起的.而1000和2000赫处的峰值则是风机装配使铝制护罩发生共振的结果.经过倍频程频谱分析之后,采用玻璃纤维/石膏板和消音泡沫塑料作为抑制噪音的技术建议.

关键词：噪声影响高容量草皮沥青消音室声压级采样机

Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric william Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

Econometric Modeling and Model Falsification

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Advances in Pure Mathematics 2019年第9期9卷 762-776页

作者： george M. Lady Carlisle E. Moody Department of Economics Temple University Philadelphia PA USA Department of Economics College of William and Mary Williamsburg VA USA

A recent literature on qualitative analysis has shown that its successful application in testing the consistency of the sign patterns of a proposed structure and an estimated reduced form was far less restricted than a previous literature had proposed. A frequent example used in this demonstration was the qualitative analysis of Klein’s Model I. For this, the proposed structural sign pattern was falsified by the sign pattern of the estimated reduced form. As a result, the subsequent application two-stage least squares would always find quantifications of the structure that could not possibly have resulted in the sign pattern of the estimated reduced form. We view this result as a diagnostic calling for further analysis. We show that the Klein model fails standard over identification tests. We make modest amendments to the model that resolves this problem but find that the resulting estimated reduced form still falsifies the structure, calling for further developmental effort. Our point is that qualitative falsification should be viewed as a diagnostic in developing a model, rather than a criterion for entirely dismissing the model.

关键词： Econometric Modeling Falsification Qualitative Analysis

Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

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Cellular & Molecular Immunology 2021年第4期18卷 1064-1066页

作者： Penghui Yang Yingze Zhao Jie Li Chuanyu Liu Linnan Zhu Jie Zhang Yeya Yu Wen-Jing Wang Guanglin Lei Jin Yan Fang Sun Chengrong Bian Fanping Meng Zhe Xu Changqing Bai Beiwei Ye Yuanyuan Guo Liumei Shu Xiaoju Yuan Ning Zhang Yuhai Bi Yi Shi Guizhen Wu Shaogeng Zhang george F.Gao Longqi Liu william J.Liu Hai-Xi Sun Fifth Medical Center of Chinese PLA General Hospital National Clinical Research Center for Infectious DiseasesBeijingChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina BGI-Shenzhen ShenzhenChina BGI Education Center University of Chinese Academic of SciencesShenzhenChina BGI College Zhengzhou UniversityZhengzhouChina School of Pharmaceutical Sciences Nanjing Tech UniversityNanjingChina CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Shenzhen Bay Laboratory ShenzhenChina

Rapidly spreading coronavirus disease 2019(COVID-19)is currently affecting the ***,cytokine storms are a key feature in a substantial num ber of COVID-19 patients,1 and studies from our group and others suggest that t... 详细信息

关键词： cytokine patients storm

On Finding Geodesic Equation of Two Parameters Logistic Distribution

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Applied Mathematics 2015年第12期6卷 2169-2174页

作者： william W. S. Chen Department of Statistics The George Washington University Washington DC USA

In this paper, we used two different algorithms to solve some partial differential equations, where these equations originated from the well-known two parameters of logistic distributions. The first method was the classical one that involved solving a triply of partial differential equations. The second approach was the well-known Darboux Theory. We found that the geodesic equations are a pair of isotropic curves or minimal curves. As expected, the two methods reached the same result.

关键词： Darboux Theory Differential Geometry Geodesic Equation Isotropic Curves Logistic Distribution Minimal Curves Partial Differential Equation

A Note on Finding Geodesic Equation of Two Parameters Gamma Distribution

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Applied Mathematics 2014年第21期5卷 3511-3517页

作者： william W. S. Chen Department of Statistics The George Washington University Washington DC USA

Engineers commonly use the gamma distribution to describe the life span or metal fatigue of a manufactured item. In this paper, we focus on finding a geodesic equation of the two parameters gamma distribution. To find this equation, we applied both the well-known Darboux Theorem and a pair of differential equations taken from Struik [1]. The solution proposed in this note could be used as a general solution of the geodesic equation of gamma distribution. It would be interesting if we compare our results with Lauritzen’s [2].

关键词： Darboux Theorem Geodesic Equation Differential Equation Gamma Distribution

On Finding Geodesic Equation of Normal Distribution and Gaussian Curvature

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Applied Mathematics 2017年第9期8卷 1336-1342页

作者： william W. S. Chen Department of Statistics The George Washington University Washington USA

In this paper, we apply two different algorithms to find the geodesic equation of the normal distribution. The first algorithm consists of solving a triply partial differential equation where these equations originated from the normal distribution. While the second algorithm applies the well-known Darboux Theory. These two algorithms draw the same geodesic equation. Finally, we applied Baltzer R.’s finding to compute the Gaussian Curvature.

关键词： Darboux Theory Differential Geometry Geodesic Equation Partial Differential Equation Normal Distribution

Finding Gaussian Curvature of Lifespan Distribution

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Applied Mathematics 2014年第21期5卷 3392-3400页

作者： william W. S. Chen Department of Statistics The George Washington University Washington DC USA

The objective of this paper is to review the lifespan model. This paper will also suggest four additional general alternative computational methods not mentioned in Kass, R.E. and Vos, P.W. [1] [2]. It is not intended to compare the four formulas to be used in computing the Gaussian curvature. Four different formulas adopted from Struik, D.J. [3] are used and labeled here as (A), (B), (C), and (D). It has been found that all four of these formulas can compute the Gaussian curvature effectively and successfully. To avoid repetition, we only presented results from formulas (B) and (D). One can more easily check other results from formulas (A) and (C).

关键词： Christoffel Symbols Gamma Gaussian Curvature Inverse Gaussian Metric Tensor Mixed Riemann Curvature Tensor Weibull

Imaging of gaucher disease

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World Journal of Radiology 2014年第9期6卷 657-668页

作者： william L Simpson george Hermann Manisha Balwani Department of Radiology Icahn School of Medicine at Mount Sinai Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai

Gaucher disease is the prototypical lysosomal storage *** results from the accumulation of undegrad-ed glucosylceramide in the reticuloendothelial system of the bone marrow,spleen and liver due to deficiency of the enzyme *** leads to he-matologic,visceral and skeletal *** up of glucosylceramide in the liver and spleen results in *** normal bone marrow is re-placed by the accumulating substrate leading to many of the hematologic signs including *** visceral and skeletal manifestations can be visualized with vari-ous imaging modalities including radiography,com-puted tomography,magnetic resonance imaging(MRI)and radionuclide *** to the development of enzyme replacement therapy,treatment was only ***,once intravenous enzyme replace-ment therapy became available in the 1990s it quickly became the standard of *** replacement therapy leads to improvement in all *** and hematologic manifestations respond more quickly usually within a few months or *** skel-etal manifestations take much longer,usually several years,to show *** recent years newer treatment strategies,such as substrate reduction thera-py,have been under *** plays a key role in both initial diagnosis and routine monitoring of patient on treatment particularly volumetric MRI of the liver and spleen and MRI of the femora for evaluating bone marrow disease burden.

关键词： Gaucher disease Lysosomal storage dis-ease Enzyme replacement therapy Genetics Medical imaging Magnetic resonance imaging Bone marrow