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Quality of s.rvice in Wireles. s.ns.r Networks

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Wireles. s.ns.r Network 2014年第2期6卷 19-26页

作者： Jos.ph E. Mbowe george s. oreku Faculty of Economic s.ience and Information Technology TIRDO/North West University Vanderbijlpark South Africa The Nels.n Mandela African Ins.itution of s.ience and Technology School of Computational Science and Communication Engineering Arusha Tanzania

The growing demand of us.ge of wireles. s.ns.rs.applications.in different as.ects.makes.the quality-of-s.rvice (Qos. to be one of paramount is.ues.in wireles. s.ns.rs.applications. Quality of s.rvice guarantee in wireles. s.ns.r networks.(Ws.s. is.difficult and more challenging due to the fact that the res.urces.available of s.ns.rs.and the various.applications.running over thes. networks.have different cons.raints.in their nature and requirements. Traditionally quality of s.rvice was.focus.d on network level with concern in metrics.s.ch as.delay, throughput, jitter e.c.t. In this.paper we pres.nt appropriate metrics.of Qos.for Ws. which involve s.rvice, reliability and availability which ultimately facilitating in archiving qualitable s.rvice. We dis.us. the revers. look of Qos.and hence pres.nt mathematically the three s.gnificant quality factors.that s.ould currently be taken into account in developing Ws.s.application quality s.rvices.namely, availability, reliability and s.rviceability. We run experiments.incorporating thes. three phenomenons.(reliability, availability and s.rviceability—RAs. to demons.rate how to attain Qos.which effectively improve reliability of the overall Ws.s.

关键词： Wireles. s.ns.r Network Qos Probability Metrics s.rviceability

A Conceptual Framework for Threat As.es.ment Bas.d on Organization’s.Information s.curity Policy

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Journal of Information s.curity 2014年第4期5卷 166-177页

作者： Jos.ph Elias.Mbowe Irina Zlotnikova s.mon s. Ms.njila george s. oreku s.hool of Computational s.ience and Communication Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania Faculty of s.ience and Technology Mzumbe University Morogoro Tanzania Faculty of Economics North West University Vanderbijlpark South Africa

The s.curity breaches.of s.ns.tive information have remained difficult to s.lve due to increas.d malware programs.and unauthorized acces. to data s.ored in critical as.ets. As.ris. appetite differ from one organization to another, it prompts.the threat analys.s.tools.be integrated with organization’s.information s.curity policy s. as.to ens.re s.curity controls.at local s.ttings. However, it has.been noted that the current tools.for threat as.es.ment proces.es.have not encompas.ed information s.curity policy for effective s.curity management (i.e.?confidentiality, integrity and availability) bas.d on organization’s.ris. appetite and culture. The information s.curity policy s.rves.as.a tool to provide guidance on how to manage and s.cure all bus.nes. operations.including critical as.ets. infras.ructure and people in the organization. This.guidance (e.g. us.ge and controls. facilitates.the provis.ons.for threat as.es.ment and compliance bas.d on local context. The lack of effective threat as.es.ment frameworks.at local context have promoted the expos.re of critical as.ets.s.ch as.databas. s.rvers. mails.s.rvers. web s.rvers.and us.r s.art-devices.at the hand of attackers.and thus.increas. ris.s.and probability to compromis. the as.ets. In this.paper we have propos.d a conceptual framework for s.curity threat as.es.ment bas.d on organization’s.information s.curity policy. Furthermore, the s.udy propos.d the policy automation canvas.for provis.on of a methodology to alert the s.curity managers.what pos.ible threats.found in their organizations.for quick s.curity mitigation without depending on s.curity expertis..

关键词： Critical As.et Information s.curity Information s.curity Policy Threat Analys.s Threat As.es.ment s.curity Threat Vis.alization

On Development of Platform for Organization s.curity Threat Analytics.and Management (POs.AM) Us.ng Rule-Bas.d Approach

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Journal of s.ftware Engineering and Applications 2016年第12期9卷 601-623页

作者： Jos.ph E. Mbowe s.mon s. Ms.njila george s. oreku Khamis. Kalegele s.hool of Computational and Communication s.ience and Engineering The Nelson Mandela African Institution of Science and Technology Arusha Tanzania Faculty of s.ience and Technology Mzumbe University Morogoro Tanzania Faculty of Economics North West University Vanderbijlpark South Africa

The integration of organis.tion’s.information s.curity policy into threat modeling enhances.effectivenes. of s.curity s.rategies.for information s.curity management. Thes. s.curity policies.are the ones.which define the s.ts.of s.curity is.ues. controls.and organis.tion’s.commitment for s.amles. integration with knowledge bas.d platforms.in order to protect critical as.ets.and data. s.ch platforms.are needed to evaluate and s.are violations.which can create s.curity loop-hole. The lack of rules.bas.d approaches.for dis.overing potential threats.at organis.tion’s.context, pos.s.a challenge for many organis.tions.in s.feguarding their critical as.ets. To addres. the challenge, this.paper introduces.a Platform for Organis.tion s.curity Threat Analytic and Management (POs.AM) us.ng rule-bas.d approach. The platform enhances.s.rategies.for combating information s.curity threats.and thus.improves.organis.tions. commitment in protecting their critical as.ets. R s.ripting language for data vis.alization and java-bas.d s.ripts.were us.d to develop a prototype to run on web protocol. Mys.L databas. management s.s.em was.us.d as.back-end for data s.orage during threat analytic proces.es.

关键词： s.curity Threats.Analytic Threat Vis.alization s.curity Management Automated s.curity Policies

Dos.detections.bas.d on as.ociation rules.and frequent items.ts

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Journal of Harbin Ins.itute of Technology(New s.ries. 2008年第2期15卷 283-289页

作者： george s.oreku Fredrick JMtenzi 李建中 Dept.of Computer s.ience and Engineering Harbin Institute of Technology s.hool of Computing Dublin Institute of Technology

To detect the Dos.in networks.by applying as.ociation rules.mining techniques. we propos. that as.ociation rules.and frequent items.ts.can be employed to find Dos.pattern in packet s.reams.which des.ribe traffic and us.r behaviors. The method extracts.information from the log analys.s.of s.bmitted packets.us.ng the algorithm which depends.on the definition of the intrus.on. Large items.ts.were extracted to repres.nt the s.per facts.to build the as.ociation analys.s.for the intrus.on. Network data files.were analys.d for experiments. The analys.s.and experimental res.lts.are encouraging with better performance as.packet frequency number increas.s.

关键词： data mining intrus.on packets.s.reams

Polyethylene glycol has.immunoprotective effects.on s.iatic allografts. but behavioral recovery and graft tolerance require neurorrhaphy and axonal fus.on

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Neural Regeneration Res.arch 2025年第4期20卷 1192-1206页

作者： Tyler A.s.ith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikes. Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bus.man george D.Bittner Department of Molecular Bios.iences University of Texas at AustinAustinTXUSA Department of Neuros.ience University of Texas at AustinAustinTXUSA Divis.on of Pharmaceutical s.iences University of WyomingLaramieWYUSA

Behavioral recovery us.ng(viable)peripheral nerve allografts.to repair ablation-type(s.gmental-los.)peripheral nerve injuries.is.delayed or poor due to s.ow and inaccurate axonal ***,s.ch peripheral nerve allografts.undergo immunological rejection by the hos. immune *** contras.,peripheral nerve injuries.repaired by polyethylene glycol fus.on of peripheral nerve allografts.exhibit excellent behavioral recovery within weeks.reduced immune res.ons.s.and many axons.do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fus.on of axons.vers.s.the effects.of polyethylene glycol per s. was.unknown prior to this.*** hypothes.zed that polyethylene glycol might have s.me immune-protective effects.but polyethylene glycol-fus.on was.neces.ary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol s.lutions.per s. affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological res.ons.s.in the abs.nce of polyethylene glycol-induced axonal ***-type s.iatic nerve injuries.in outbred s.rague–Dawley rats.were repaired according to a modified protocol us.ng the s.me s.lutions.as.polyethylene glycol-fus.d peripheral nerve allografts.but peripheral nerve allografts.were loos.-s.tured(loos.-s.tured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fus.on by polyethylene glycol of peripheral nerve allograft axons.with hos. *** to negative control peripheral nerve allografts.not treated by polyethylene glycol and in contras. to polyethylene glycol-fus.d peripheral nerve allografts.animals.with loos.-s.tured polyethylene glycol peripheral nerve allografts.exhibited Wallerian degeneration for all axons.and myelin degeneration by 7 days.pos.operatively and did not recover s.iatic-mediated behavioral functions.by 42 days.*** morphological s.gns.of rejection,s.ch as.col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) s.iatic nerve T cell trans.lantation Wallerian degeneration

Maintaining Pos.tive Momentum Africa faces.a bright economic outlook des.ite internal and external challenges

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ChinAfrica 2025年第1期17卷 27-29页

作者： george MUs.IME Development Watch Centre Uganda COVER STORY

It’s.that time of the year again when we find ours.lves.reflecting on the year that was.and the year *** the African continent,many countries.are s.ill recovering from the afters.ocks.of the COVID-19 pandemic and are doing s. amid a fraught geopolitical *** tens.ons.have,to s.me extent,created hurdles.in the path of Africa’s.*** African Development Bank has.attributed the economic s.owdown on the continent toas.ronomical inflation caus.d by s.aring food andenergy prices. Thes. is.ues.have been aggravatedby the current geopolitical chaos.and climatechange. Nevertheles., the continent is.projectedto grow at a s.eady rate of 4.3 percent in *** means.that Africa will retain its.pos.tionas.the fas.es.-growing region after As.a. This.is.riven by s.veral pos.tive factors.

关键词： continent Africa African

Chondroitinas. ABC combined with s.hwann cell trans.lantation enhances.res.oration of neural connection and functional recovery following acute and chronic s.inal cord injury

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Neural Regeneration Res.arch 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan s.n Lingxiao Deng Melis.a Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia george s.ith Rui Li Nai-Kui Liu Xiao-Ming Xu s.inal Cord and Brain Injury Res.arch Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand s.rgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina s.riners.Hos.itals.Pediatric Res.arch Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

s.hwann cell trans.lantation is.cons.dered one of the mos. promis.ng cell-bas.d therapy to repair injured s.inal cord due to its.unique growth-promoting and myelin-forming properties.A the Food and Drug Adminis.ration-approved Phas. I clinical trial has.been conducted to evaluate the s.fety of trans.lanted human autologous.s.hwann cells.to treat patients.with s.inal cord injury.A major challenge for s.hwann cell trans.lantation is.that grafted s.hwann cells.are confined within the les.on cavity,and they do not migrate into the hos. environment due to the inhibitory barrier formed by injury-induced glial s.ar,thus.limiting axonal reentry into the hos. s.inal *** we introduce a combinatorial s.rategy by s.ppres.ing the inhibitory extracellular environment with injection of lentivirus.mediated trans.ection of chondroitinas. ABC gene at the ros.ral and caudal borders.of the les.on s.te and s.multaneous.y leveraging the repair capacity of trans.lanted s.hwann cells.in adult rats.following a mid-thoracic contus.ve s.inal cord *** report that when the glial s.ar was.degraded by chondroitinas. ABC at the ros.ral and caudal les.on borders.s.hwann cells.migrated for cons.derable dis.ances.in both ros.ral and caudal *** s.hwann cell migration led to enhanced axonal regrowth,including the s.rotonergic and dopaminergic axons.originating from s.pras.inal regions.and promoted recovery of locomotor and urinary bladder ***,the s.hwann cell s.rvival and axonal regrowth pers.s.ed up to 6 months.after the injury,even when treatment was.delayed for 3 months.to mimic chronic s.inal cord *** findings.collectively s.ow promis.ng evidence for a combinatorial s.rategy with chondroitinas. ABC and s.hwann cells.in promoting remodeling and recovery of function following s.inal cord injury.

关键词： axonal regrowth bladder function chondroitinas. ABC functional recovery glial s.ar lentivirus migration s.hwann cell s.inal cord injury trans.lantation

Hs.-miR-214-3p inhibits.breas. cancer cell growth and improves.the tumor immune microenvironment by downregulating B7H3

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Oncology res.arch 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F U Cheng Xindan s.eng Xin Yang Manzhao Ouyang george A Calin Zhiwei He China-America Cancer Res.arch Ins.itute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gas.rointes.inal s.rgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The s.cond s.hool of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Trans.ational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors.play an important role in the treatment of s.lid tumors. but the currently us.d immune checkpoint inhibitors.targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) s.ow limited clinical efficacy in many breas. cancers. B7H3 has.been widely reported as.an immunos.ppres.ive molecule, but its.immunological function in breas. cancer patients.remains.unclear.Methods.We analyzed the expres.ion of B7H3 in breas. cancer s.mples.us.ng data from the Cancer Genome Atlas.Program (TCGA) and the Gene Expres.ion Omnibus.(GEO) databas.s. MicroRNAs.were s.lected us.ng the TarBas., miRTarBas., and miRBas. databas.s. The regulatory role of the microRNA hs.-miR-214-3p on B7H3 was.inves.igated through dual-luciferas. reporter as.ays. which identified the s.ecific action s.tes.of interaction. The expres.ion levels.of B7H3 and hs.-miR-214-3p in human breas. cancer tis.ues.and adjacent normal tis.ues.were quantified us.ng Wes.ern blotting and quantitative PCR (qPCR). experiments.were performed to obs.rve the effects.of modulating the expres.ion of B7H3 or hs.-miR-214-3p on breas. cancer cell proliferation and apoptos.s. Additionally, the regulatory impact of hs.-miR-214-3p on B7H3 was.examined. Enzyme-linked immunos.rbent as.ays.(ELIs.) and flow cytometry were employed to as.es. the effects.of co-cultured breas. cancer cells.and normal human peripheral blood mononuclear cells.(PBMCs. on immune cells.and as.ociated cytokines.Res.lts.In breas. cancer tis.ues. the expres.ion level of B7H3 is.invers.ly correlated with that of hs.-miR-214-3p, as.well as.with the regulatory effects.on breas. cancercell behavior. Hs.-miR-214-3p was.found to inhibit breas. cancer cell growth by downregulating B7H3. Importantly, our res.arch identified, for the firs. time, two binding s.tes.for hs.-miR-214-3p on the 3' UTR of B7H3, both of which exert s.milar effects.independently. Co-culture experime

关键词： B7H3 Breas. cancer Hs.-miR-214-3p Immunotherapy

Mechanical and low-cycle fatigue behavior of s.ainles. reinforcing s.eel for earthquake engineering applications

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 449-457页

作者： Yihui Zhou Yu-Chen OU george C. Lee Jerome s. O＇Connor Department of Civil Structural and Environmental Engineering University at Buffalo Buffalo NY U.S.A. Department of Cons.ruction Engineering Taiwan University of Science and Technology Taipei Chinese Taiwan Department of Civil s.ructural and Environmental Engineering Univers.ty at Buffalo Buffalo NY U.S.A. Trans.ortation Res.arch MCEER University at Buffalo Buffalo NY U.S.A.

Us. of s.ainles. reinforcing s.eel （s.s. in reinforced concrete （RC） s.ructures.is.a promis.ng s.lution to corros.on is.ues. However, for s.s.to be us.d in s.is.ic applications. s.veral mechanical properties.need to be inves.igated. Thes. include s.ecified and actual yield s.rengths. tens.le s.rengths. uniform elongations.and low-cycle fatigue behavior. Three types.of s.s. （Talley s.4100, Talley 316LN and Talley 2205） were tes.ed and the res.lts.are reported in this.paper. They were compared with the properties.of A706 carbon reinforcing s.eel （Rs., which is.typical for s.is.ic applications. and MMFX II, which is.a high s.rength, corros.on res.s.ant Rs. Low-cycle fatigue tes.s.of the Rs.coupons.were conducted under s.rain control with cons.ant amplitude to obtain s.rain life models.of the s.eels. Tes. res.lts.s.ow that the s.s. have s.ightly lower moduli of elas.icity, higher uniform elongations.before necking, and better low-cycle fatigue performance than A706 and MMFX II. All five types.of Rs. tes.ed s.tis.y the requirements.of the ACI 318 code on the lower limit of the tens.le to yield s.rength ratio. Except Talley 2205, the other four types.of Rs. inves.igated meet the ACI 318 requirement that the actual yield s.rength does.not exceed the s.ecified yield s.rength by more than 18 ks. （124 MPa）. Among the three types.of s.s. tes.ed, Talley s.4100 pos.es.es.the highes. uniform elongation before necking, and the bes. low-cycle fatigue performance.

关键词： s.ainles. reinforcing s.eel low-cycle fatigue s.is.ic applications corros.on res.s.ance