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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan george Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest miller School of medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Non-functional neuroendocrine tumors of the pancreas: Advances in diagnosis and management

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World Journal of Gastroenterology 2015年第32期21卷 9512-9525页

作者： Jordan m Cloyd george A Poultsides Department of Surgery Stanford University Stanford

Nonfunctional neuroendocrine tumors of the pancreas(NF-PNETs) are a heterogeneous group of neoplasms. Although rare, the incidence of NF-PNETs is increasing significantly. The classification of PNETs has evolved over the past decades and is now based on a proliferation grading system. While most NF-PNETs are slow growing, tumors with more aggressive biology may becomeincurable once they progress to unresectable metastatic disease. Tumors of higher grade can be suspected preoperatively based on the presence of calcifications, hypoenhancement on arterial phase computed tomography, positron emission technology avidity and lack of octreotide scan uptake. Surgery is the only curative treatment and is recommended for most patients for whom complete resection is possible. Liver-directed therapies(thermal ablation, transarterial embolization) can be useful in controlling unresectable hepatic metastatic disease. In the presence of unresectable progressive disease, somatostatin analogues, everolimus and sunitinib can prolong progression-free survival. This article provides a comprehensive review of NF-PNETs with special emphasis on recent advances in diagnosis and management.

关键词： Pancreas Neuroendocrine tumor Neuroendocrine carci

Comparative Analysis of Equal and Unequal Grounding Grid Configurations by Compression Ratio and Least Square Curve Fitting Techniques

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Energy Engineering 2023年第3期120卷 597-616页

作者： m.Soni Abraham george Dayananda Sagar College of Engineering Bangalore560078India

The primary aim of the power system grounding is to safeguard the person and satisfying the performance of the power systemtomaintain reliable *** equal conductor spacing grounding grid design,the distribution of the current in the grid is not ***,unequal grid conductor span in which grid conductors are concentrated more at the periphery is safer to practice than equal *** paper presents the comparative analysis of two novel techniques that create unequal spacing among the grid conductors:the least-square curve fitting technique and the compression ratio techniquewith equal grid configuration for both square and rectangular *** Swarm Optimization(PSO)is adopted for finding out one optimal feasible solution among many feasible solutions of equal grid configuration for both square and rectangular *** analysis is also carried out between square and rectangular grids using the least square curve fitting technique as it results in only one unequal grid *** results are obtained by themATLAB software *** of improvement in ground potential rise,step voltage,touch voltage,and grid resistancewith variation in compression ratios are plotted.

关键词： Ground grid design ground potential rise grid resistance compression ratio least square curve fitting touch voltage step voltage PSO

Conductive polymer scaffolds to improve neural recovery

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Neural Regeneration Research 2017年第12期12卷 1976-1978页

作者： Shang Song Paul m.george Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford CA USA Stanford stroke Center and Stanford University School of medicine Stanford CA USA

Injuries to the nervous system manifest in various forms ranging from stroke to trauma（i.e.,motor vehicle accidents,combats）to diabetic neuropathy as well as many other neurological *** regeneration remains a complex biological process that is challenging to address *** is no effective medical treatment for central nervous system repair.

关键词： Conductive polymer scaffolds improve neural recovery

Parallelization of an Implicit Algorithm for multi-Dimensional Particle-in-Cell Simulations

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Communications in Computational Physics 2014年第8期16卷 599-611页

作者： george m.Petrov Jack Davis Naval Research Laboratory Plasma Physics Division4555 Overlook Ave.SWWashingtonDC 20375USA.

The implicit 2D3V particle-in-cell(PIC)code developed to study the interaction of ultrashort pulse lasers with matter[*** and ***,Computer ***.179,868(2008);*** 18,073102(2011)]has been parallelized using mPI(message Passing Interface).The parallelization strategy is optimized for a small number of computer cores,up to about *** on the algorithm implementation are given with emphasis on code optimization by overlapping computations with *** evaluation for 1D domain decomposition has been made on a small Linux cluster with 64 computer cores for two typical regimes of PIC operation:”particle dominated”,for which the bulk of the computation time is spent on pushing particles,and”field dominated”,for which computing the fields is *** a small number of computer cores,less than 32,the mPI implementation offers a significant numerical *** the”particle dominated”regime it is close to the maximum theoretical one,while in the”field dominated”regime it is about 75-80%of the maximum *** a number of cores exceeding 32,performance degradation takes place as a result of the adopted 1D domain *** code parallelization will allow future implementation of atomic physics and extension to three dimensions.

关键词： Particle-in-cell maxwell equations mPI lasertarget interaction.

Thermomechanical analysis of long-term global modal and local deformation measurements of the Kishwaukee Bridge using the bootstrap

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Earthquake Engineering and Engineering Vibration 2004年第1期3卷 107-115页

作者： george m.Lloyd ming L.Wang Department of Civil and material Engineering University of Illinois at Chicago

In this paper we present a comparative analysis of global frequency and local deformation data for a large concrete bridge. The asymptotic probability distributions of the central statistics are presented, and compared with empirical bootstrap estimates. Bootstrapped distributions are calculated from reference data obtained during 1999–2000 and used to develop change-point alarm criteria for the structure, using reasonable sensitivity measures developed from FEm simulations and structural analysis. The implications of the frequency data are discussed in conjunction with the strain and displacement measurements in order to discern if the load carrying capacity of the bridge has been affected. The critical need for more advanced temperature compensation models for large structures continually in thermal disequilibrium is discussed.

关键词： thermomechanical effects bootstrap methods local & global monitoring long term measurement concrete bridge

A size-gradient hypothesis for alpine treeline ecotones

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Journal of mountain Science 2016年第7期13卷 1154-1161页

作者： george P.mALANSON Lynn m.RESLER Department of Geographical&Sustainability Sciences University of IowaIowa CityIA 52242 USA Department of Geography Virginia TechBlacksburgVA 24061 USA

Research on the stress gradient hypothesis recognizes that positive(i.e. facilitative) and negative(i.e. competitive) plant interactions change in intensity and effect relative to abiotic stress experienced on a gradient. motivated by observations of alpine treeline ecotones, we suggest that this switch in interaction could operate along a gradient of relative size of individual plants. We propose that as neighbors increase in size relative to a focal plant they improve the environment for that plant up to a critical point. After this critical point is surpassed, however, increasing relative size of neighbors will degrade the environment such that the net interaction intensity becomes negative. We developed a conceptual(not site or species specific) individual based model to simulate a single species with recruitment, growth, and mortality dependent on the environment mediated by the relative size of neighbors. Growth and size form a feedback. Simulation results show that the size gradient model produces metrics similar to that of a stress gradient model. Visualizations reveal that the size gradient model produces spatial patterns that are similar to the complex ones observed at alpine treelines. Size-mediated interaction could be a mechanism of the stress gradient hypothesis or it could operate independent of abiotic stress.

关键词： Competition Ecotone Environmental gradient Plant interaction Stress gradient Facilitation

Acetylation as a mechanism that regulates axonal regeneration

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Neural Regeneration Research 2015年第7期10卷 1034-1036页

作者： Shen Lin george m.Smith Shriners Hospitals for Pediatric Research Center Department of Neuroscience Temple University

The capacity for adult axons to regenerate after injury is diminished compared with developing *** the case of central nervous system（CNS）axons,injury causes a total failure to *** failure is due to both the intrins... 详细信息

关键词： gene HDAC Acetylation as a mechanism that regulates axonal regeneration

Neurotrophin treatment to promote regeneration after traumatic CNS injury

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Frontiers in Biology 2013年第5期8卷 486-495页

作者： Lakshmi KELAmANGALATH george m. SmITH Center for Neural Repair and Rehabilitation Department of Neuroscience & Shriners Hospitals for Pediatric Research Temple UniversitySchool of Medieine Philadelphia PA 19140-4106 USA

Neurotrophins are a family of growth factors that have been found to be central for the development and functional maintenance of the nervous system, participating in neurogenesis, neuronal survival, axonal growth, synaptogenesis and activity-dependent forms of synaptic plasticity. Trauma in the adult nervous system can disrupt the functional circuitry of neurons and result in severe functional deficits. The limitation of intrinsic growth capacity of adult nervous system and the presence of an inhospitable environment are the major hurdles for axonal regeneration of lesioned adult neurons. Neurotrophic factors have been shown to be excellent candidates in mediating neuronal repair and establishing functional circuitry via activating several growth signaling mechanisms including neuron-intrinsic regenerative programs. Here, we will review the effects of various neurotrophins in mediating recovery after injury to the adult spinal cord.

关键词： axonal guidance neurotrophin regeneration functional recovery sprouting