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大鼠下颌下腺神经节分离神经元P2X受体的药理学研究

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中国药理学通报 2005年第3期21卷 314-318页

作者：马蓓 Philip m Dunn geoffrey Burnstock 第二军医大学生理学教研室上海200433 英国伦敦大学学院自主神经研究所

目的研究大鼠下颌下腺副交感神经节分离神经元不同P2X受体的表达。方法用全细胞膜片钳的方法对大鼠下颌下腺神经节急性分离的神经元进行了药理学鉴定。结果在所有的神经元上,ATP都可以引起一个快速反应的缓慢失活的内向电流。但只在59%... 详细信息

目的研究大鼠下颌下腺副交感神经节分离神经元不同P2X受体的表达。方法用全细胞膜片钳的方法对大鼠下颌下腺神经节急性分离的神经元进行了药理学鉴定。结果在所有的神经元上,ATP都可以引起一个快速反应的缓慢失活的内向电流。但只在59%的神经元上,αβmeATP也可以引起一个类似的内向电流。降低pH值及同时给予Zn2+可以增强ATP及αβmeATP诱发的电流。而Ivermectin没有作用。结论在大鼠下颌下腺神经节急性分离的神经元上,主要表达同源二聚体P2X2受体和异源二聚体P2X2/3受体。

关键词：下颌下腺神经节 ATP P2X受体

SUSTAINABILITY OF OFF-SITE CONSTRUCTION:A BIBLIOmETRIC REVIEW AND VISUALIZED ANALYSIS OF TRENDING TOPICS AND THEmES

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Journal of Green Building 2020年第4期15卷 131-153页

作者： Ibrahim Yahaya Wuni geoffrey Qiping Shen Robert Osei-Kyei Department of Building and Real Estate The Hong Kong Polytechnic University11 Yuk Choi RoadHung HomKowloonHong Kong School of Computing Engineering and mathematics Western Sydney UniversitySydneyAustralia

Off-site construction(OSC)involves the fabrication and assembly of building com-ponents in a purpose-built factory which are then transported to the job site for final *** has proven to be a greener construction approach,spurring research towards benchmarking the sustainable attributes of the ***,a quantitative statistical analysis of studies on OSC sustainability and a framework of the knowledge domain are not *** on 642 bibliographic records from Scopus,this paper conducted a bibliometric and visualized analysis of research on the sustainability of OSC from 1971 to *** findings show that research publications on OSC sustainability only witnessed steady growth since 2000.A geospatial analysis revealed that at least 32%of countries are involved in the OSC sustainability research,of which the United States,China,Australia,the United Kingdom,and Canada make the greatest *** hot topics in the contemporary OSC sustainability research were identified as embodied carbon,embodied energy,construction waste,post-occupancy evaluation,resources conserva-tion,and recycling,and cost *** paper identified areas that require further ***,the paper offers an all-embracing understanding of the core research themes,trends,and patterns on OSC sustainability to stakeholders.

关键词： bibliometric bibliographic off-site construction sustainability

Pectin fractions extracted sequentially from Cerasus humilis:Their compositions,structures,functional properties and antioxidant activities

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Food Science and Human Wellness 2023年第2期12卷 564-574页

作者： Shikai Zhang geoffrey INWaterhouse Tingting Cui Dongxiao Sun-Waterhouse Peng Wu College of Food Science and Engineering Shandong Agricultural UniversityTaian 271018China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250103China

Three pectin fractions(water-soluble fraction(WSF),chelator-soluble fraction(CSF),and sodium carbonatesoluble fraction(NSF))were obtained from Chinese dwarf cherry(Cerasus humilis)*** of them were branched low methoxylated pectins with an amorphous or partially nanocrystalline nature and eight neutral monosaccharides(arabinose and galactose were most abundant).WSF,CSF and NSF had a degree of methylation(Dm)of 35.82%,14.85%and 7.13%,uronic acid(UA)content of 76.02%,83.71%and 69.01%,and total protein content of 2.4%,2.1%and 8.8%,*** molecular weights were 340.31,330.16 and 141.31 kg/mol,respectively(analyzed by gel permeation chromatography(GPC)).WSF,CSF and NSF exhibited good rheological,thermal,emulsifying,emulsion-stabilizing,water-adsorbing,oil-binding,cholesterol-binding and antioxidant *** had the highest emulsifying,emulsion stabilizing,water-/oil-/cholesterol-binding and antioxidant capacities,followed by *** had the highest viscosity(406.77 m Pa·s),flowability,and resistance to heat-induced changes/damage,which may be related to its lowest polydispersity index,Dm and UA content and highest protein *** three pectin fractions with desirable characteristics can be used as food additives/ingredients and dietary supplements.

关键词： Cerasus humilis fruits Pectin fractions Structural characteristics Processing-related functional properties

Chalcogenide Ovonic Threshold Switching Selector

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Nano-micro Letters 2024年第5期16卷 1-40页

作者： Zihao Zhao Sergiu Clima Daniele Garbin Robin Degraeve geoffrey Pourtois Zhitang Song min Zhu National Key Laboratory of materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050People’s Republic of China University of Chinese Academy of Sciences Beijing 100029People’s Republic of China ImEC Kapedreef 75LeuvenBelgium

Today’s explosion of data urgently requires memory technologies capable of storing large volumes of data in shorter time frames,a feat unattain-able with Flash or *** Optane,commonly referred to as three-dimensional phase change memory,stands out as one of the most promising *** Optane with cross-point architecture is constructed through layering a storage element and a selector known as the ovonic threshold switch(OTS).The OTS device,which employs chalcogenide film,has thereby gathered increased attention in recent *** this paper,we begin by providing a brief introduction to the discovery process of the OTS ***,we summarize the key elec-trical parameters of OTS devices and delve into recent explorations of OTS materials,which are categorized as Se-based,Te-based,and S-based material ***,we discuss various models for the OTS switching mechanism,including field-induced nucleation model,as well as several carrier injection ***,we review the progress and innovations in OTS mechanism ***,we highlight the successful application of OTS devices in three-dimensional high-density memory and offer insights into their promising performance and extensive prospects in emerging applications,such as self-selecting memory and neuromorphic computing.

关键词： Non-volatile memory Ovonic threshold switch(OTS) Chalcogenide Selector

Comparison of mantle lithosphere beneath early Triassic kimberlite fields in Siberian craton reconstructed from deep-seated xenocrysts

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Geoscience Frontiers 2016年第4期7卷 639-662页

作者： I.V.Ashchepkov S.S.Kuligin N.V.Vladykin H.downes m.A.Vavilov E.N.Nigmatulina S.A.Babushkina N.S.Tychkov O.S.Khmelnikova lnstitute of Geology and mineralogy SD RAS Koptyug ave 3NovosibirskRussia Institute of Geochemistry SD RAS Favorskky str laIrkutskRussia Department of Earth and Planetary Sciences Birkbeck University of LondonLondonUK Institute of Geology of Diamonds and Noble metals SD RAS Lenina ave 39YakutskRussia

mantle xenocrysts from early Triassic kimberlite pipes from Kharamai, Ary-mastakh and Kuranakh fields in the Anabar shield of Siberia revealing similar compositional trends were studied to estimate the superplume influence on the subcratonic lithosphere mantle （SCLm）. Pressure-temperature （PT） reconstructions using monomineral thermobarometry for 5 phases show division of the SCLm beneath the Kharamai field into 6 units： pyroxenitic Fe-rich （1-2 GPa） and mg-rich （2-3 GPa） layers; middle with two levels of Gar-Sp pyroxenites at - 3 and 4-5 GPa; Gar-dunite-harzburgites - 4.5-6.5 GPa subjected to llm-Px vein metasomatism; and a mg-rich dunite lower part. In the Anabar shield （Ary-mastakh, Dyuken and Kuranakh fields） mantle lithosphere is composed of three large units divided into two parts： upper part with amphiboles and phlogopite; two levels of pyroxenites and eclogites at 3 and 4 GPa, and a lower part composed of refertilized dunites. Diagrams showing P-Fe#Gar clusters for garnets and omphacites illustrate the differences between SCLm of these localities. Differences of Triassic SCLm from Devonian SCLm are in simple layering; abundance of Na-Cr-amphiboles and metasomatism in the upper SCLm part, thick pyroxenite-eclogite layer and lower part depletion, heated from SCLm base to 5.0 GPa. Kharamai mantle clinopyroxenes represent three geochemical types：（1） harzburgitic with inclined linear REE, HFSE troughs and elevated Th, U; （2） lherzolitic or pyroxenitic with round TRE patterns and decreasing incompatible elements; （3） eclogitic with Eu troughs, Pb peak and high LILE content. Calculated parental melts for garnets with humped REE patterns suggest dissolution of former Cpx and depression means Cpx and garnets extraction. Clinopyroxenes from Ary-mastakh fields show less in- dined REE patterns with HmREE troughs and an increase of incompatible elements. Clinopyroxenes from Kuranakh field show flatter spoon-like REE patterns and peaks in Ba, U, Pb and St, similar to th

关键词： mantle lithosphere monomineral thermobarometry mineral geochemistry Triassic kimberlite Layering

Effects of soil metal(loid)s pollution on microbial activities and environmental risks in an abandoned chemical smelting site

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Journal of Environmental Sciences 2024年第9期143卷 60-70页

作者： Hao Li Jun Yao Jianli Liu Ning min geoffrey Sunahara Dongyang men Robert Duran School of Water Resources and Environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Department of Natural Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada Equipe Environnement et microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Abandoned chemical smelting sites containing toxic substances can seriously threaten and pose a risk to the surrounding ecological *** samples were collected from different depths(0 to 13 m)and analyzed for metal(loid)s content and fractionation,as well as microbial *** potential ecological risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surface(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging between 1840.65-13,089.62,and representing extremely high environmental risks,of which Cd(and probably not arsenic)contributed to the highest environmental risk.A modified combined pollution risk index(mCR)combining total content and mobile proportion of metal(loid)s,and relative toxicities,was used to evaluate the degree of contamination and potential environmental *** the near-surface samples(S-0 and D-1 layers),the mCR considered that As,Cd,Pb,Sb,and Zn achieved high and alarming degrees of contamination,whereas Fe,mn,and Ti were negligible or low to moderate pollution *** microcalorimetry and enzymatic activity measurements of contaminated soil samples were used to assess the microbial metabolic activity *** analysis elucidated the relationship between metal(loid)s exchangeable fraction or content and microbial activity characteristics(pmicrobial metabolic activity in the D-1 layer was low presumably due to heavy metal *** activity indicators and microcalorimetric growth rate(k)measurements were considered sensitive indicators to reflect the soil microbial activities in abandoned chemical smelting sites.

关键词： Abandoned chemical smelting sites microbial activities modified combined pollution risk microcalorimetry Enzymatic activities

Immunological response in alcoholic liver disease

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World Journal of Gastroenterology 2007年第37期13卷 4938-4946页

作者： michael J Duryee Lynell W Klassen geoffrey m Thiele University of Nebraska medical Center Department of Internal Medicine 986350 Nebraska Medical Center Omaha NE 68198-6350 Veterans Administration Alcohol Research Center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States Veterans Administration Alcohol Research Center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States University of Nebraska Medical Center Department of Pathology and Microbiology 986495 Nebraska Medical Center Omaha NE 68198-6495 United States

The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD.

关键词： Alcoholic liver disease Liver endothelial cells Aldehyde adducts Oxidative stress Immune system Cytokines metabolism

Primary energy congestion of power systems

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Journal of modern Power Systems and Clean Energy 2014年第1期2卷 39-49页

作者： Yusheng XUE Bin CAI geoffrey JAmES Zhaoyang DONG Fushuan WEN Feng XUE State Grid Electric Power Research Institute(SGEPRI) Nanjing 210003China Nanjing University of Science and Technology(NJUST) Nanjing 210094China Commonwealth Scientific and Industrial Research Organisation(CSIRO) North RydeNSW 2113Australia The University of Sydney SydneyNSW 2006Australia Zhejiang University Hangzhou 310027China

Primary energy has the potential to bring challenges to the reliability,economic,and eco-friendliness of global electric power *** concept of electric power security are proposed,including many factors that are not considered in power system reliability analysis,such as coal supply for power system,fuel price for electricity power market,carbon emissions of power generation,and so *** is broader than power system reliability and security,which means that providing energy in the form of reliable,economical,and eco-friendly electric *** an account of existing blackout defence methods and systems,the processes of transforming various kinds of primary energy into electric power and the interactions between them are described,particularly with regard to flows of energy,capital,and *** that limit the liquidity of these flows are defined as“generalized congestion”,and the challenges presented by primary energy are named“primary energy congestion”.China’s dilemma on coal supply for power generation is presented in some detail as an example of primary energy *** cope with impacts of the primary energy on electric power systems,an idea is introduced to extend the scope of existing coordinated blackout defence systems to account for primary energy,which would lead to an integrated tool to provide decision support to power system operators accounting for primary energy congestion.

关键词： Power system reliability Energy security Electric power security Primary energy congestion Blackout defence