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Activation ofγ-globin expression by a common variant disrupting IKAROS-binding motif inβ-thalassemia

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Journal of Genetics and Genomics 2025年第2期52卷 157-167页

作者： Hualei Luo Jueheng Wang Lang Qin Xinhua Zhang Hailiang Liu Chao niu Mengyang Song Congwen Shao Peng Xu Miao Yu Haokun Zhang Yuhua Ye Xiangmin Xu Innovation Center for Diagnostics and Treatment of Thalassemia Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Medical Genetics School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 201114China Department of Pediatrics 923rd Hospital of the People's Liberation ArmyNanningGuangxi 530021China Cyrus Tang Medical Institute National Clinical Research Centre for Hematologic DiseasesCollaborative Innovation Centre of HematologyState Key Laboratory of Radiation Medicine and ProtectionSoochow University SuzhouSuzhouJiangsu 215031China State Key Laboratory of Genetic Engineering MOE Engineering Research Center of Gene TechnologySchool of Life SciencesFudan UniversityShanghai 200438China

Programmed silencing ofγ-globin genes in adult erythropoiesis is mediated by several chromatin remodeling complexes,which determine the stage-specific genome architecture in this *** of cis-or trans-acting mutations contributing to the diverse extent of fetal hemoglobin(Hb F)might illustrate the underlying mechanism ofγ-β-globin ***,we recruit a cohort of 1142β-thalassemia patients and dissect the natural variants in the wholeβ-globin gene cluster through a targeted next-generation sequencing panel.A previously unreported SNP rs7948668,predicted to disrupt the binding motif of IKAROS as a key component of chromatin remodeling complexes,is identified to be significantly associated with higher levels of Hb F and age at ***-editing on this SNP leads to the elevation of Hb F in both HUDEP-2 and primary CD34+cells while the extent of elevation is amplified in the context ofβ-thalassemia mutations,indicating epistasis effects of the SNP in the regulation of Hb ***,we perform ChIP-qPCR and 4C assays to prove that this variant disrupts the binding motif of IKAROS,leading to enhanced competitiveness of HBG promoters to locus control *** study highlights the significance of common regulatory SNPs and provides potential targets for treatingβ-hemoglobinopathy.

关键词： β-thalassemia Fetal hemoglobin Single nucleotidepolymorphism IKAROS Locus control region

Regulating the oxygen-atom configuration of carbon anode enabling extremely fast-charging potassium-ion hybrid capacitors

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Nano Research 2025年第1期18卷 373-381页

作者： Daping Qiu Yuehui Wang Lulu Zhang Hang Lei Haizhou Ying Jin niu Min Li Xuelin Yang Feng Wang Ru Yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering and New EnergyChina Three Gorges UniversityYichang 443002China State Key Laboratory of Chemical Resource Engineering Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials and Chemical Engineering China Three Gorges UniversityYichang 443002China

Metal-ion hybrid capacitors,such as potassium-ion hybrid capacitors(PIHCs),are regarded as promising fast-charging energy storage ***,the kinetics mismatch between the battery anode and the capacitive cathode restricts their fastcharging *** constructing carbon anodes with enhanced kinetics is an innovative approach to address this ***,using epigallocatechin gallate with high oxygen content as the precursor,oxygen-enriched carbon materials(OEC)with tunable C=O content are successfully ***,the C=O content of OEC is regulated by adjusting the pyrolysis *** as an anode for PIHCs,OEC-600 with the highest C=O content exhibits an attractive fast-charging specific capacity of 135.2 mAh·g^(-1)at 20 A·g^(-1),along with a superior fast-charging cycling *** theoretical calculations,comprehensive kinetics analysis and in-situ Raman,the positive effects of C=O on the potassium storage capability and reversibility of OEC-600 are ***,PIHCs assembled based on an OEC-600 anode deliver impressive energy/power density of 145.1 Wh·kg^(-1)/45.9 kW·kg^(-1)and superior fast-charging cycling stability with 87.5%of capacity retention over 20,000 cycles at 5 A·g^(-1).This work is anticipated to provide an optional design concept toward the carbon anode for fast-charging PIHCs.

关键词： carbon anode oxygen epigallocatechin gallate potassium-ion hybrid capacitor

Deformation mechanism analysis of roll forming for Q&P980 steel based on finite element simulation

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Journal of Iron and Steel Research International 2019年第11期26卷 1178-1187页

作者： Fei Han yun Wang Li-li niu School of Mechanical and Materials Engineering North China University of Technology.Beijing 100144China

Roll forming is a sheet metal forming process,which can form the profiles gradually to improve the formability of Q&P980 *** plastic deformation mechanism of roll forming was expounded by analysing the stress and strain distribution at the comer of a hat-type profile when the Q&P980 steel sheet passed through a series of continuous *** the plastic deformation mainly accumulated when the sheet metal was not in contact with the rolls.A simple mathematical model was derived by considering the longitudinal bending strain and the geometrical relationships of forming parameters,to analyse the longitudinal strain development in the deformation *** addition,the roll forming experiments on hat-type profile parts of Q&P980 steel were carried out,and the theoretical analysis and simulation results are consistent with the experimental results.

关键词： Roll forming Numerical simulation Q&P980 steel-Deformation area

The Influence of Microbial Community on Oil Reservoirs:A Case Study on the Mesozoic Natural Gas in the Pengyang Area,Southwestern Ordos Basin,China

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 144-158页

作者： SHANG Ting niu Xiaobing LI Mingrui ZHANG Zhongyi HUANG Xuan HAN Tianyou ZHANG Xiaolei LI Jihong CHU Meijuan LIU Xin School of Geography and the Environment Xianyang Normal UniversityXianyang712000China State Key Laboratory of Continental Dynamics Northwest UniversityXi'an 710069China PetroChina Changqing Oilfield Company Xi'an 710018China Exploration&Development Research Institute of PetroChina Changqing Oilfield Company Xi'an 710018China National Engineering Laboratory for Exploration and Development of Low-Permeability Oil&Gas Fields Xi'an 710018China Northwest University Xi’an 710069China

The formation of Mesozoic natural gas in the Pengyang area of southwestern Ordos Basin is discussed,from the perspective of microbial community characteristics,in order to clarify the relationship between the origin of natural gas and its associated indigenous microbial *** types and diversity of indigenous microbial communities associated with the oil reservoir were studied by means of collecting reservoir formation water samples from exploration *** indigenous microbial communities in the Chang 8 member of the Yanchang Formation were primarily distributed within Proteobacteria and Firmicutes,including the specific species and genera of Methylobacter,Pseudomonas,Haibacter,Toxobacillus,Acinetobacter and Adura *** results of diversity analysis shows that the number of common genes was 5448,while the number of unique genes and information was *** reflects the fact that the strata in the study area are relatively closed and not invaded by external water sources,which leads to the development of biological community *** conjunction with the analysis of geochemical characteristics of oil and gas reservoirs in this area,this indicates that the study area possesses the necessary geological conditions for microbial *** is the first time that the species and diversity of the indigenous microbial community in the Ordos Basin have been analyzed,showing that microbial degradation is the main cause of natural gas formation here,changes the characteristics of crude oil in this area and provides first-hand information on the impact of indigenous microorganisms on the reservoir.

关键词： microbial community source of natural gas Yanchang Formation Pengyang area Ordos Basin

Nitric Oxide Regulates Dark-Induced Leaf Senescence Through EIN2 in Arabidopsis

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Journal of Integrative Plant Biology 2012年第8期54卷 516-525页

作者： yun-Han niu Fang-Qing Guo The National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research(Shanghai) Institute of Plant Physiology&EcologyShanghai Institutes for Biological Sciencesthe Chinese Academy of SciencesShanghai 200032China

The nitric oxide （NO）-deficient mutant nosllnoal exhibited an early leaf senescence phenotype. ETHY- LENE INSENSITIVE 2 （EIN2） was previously reported to function as a positive regulator of ethylene- induced senescence. The aim of this study was to address the question of how NO interacts with ethylene to regulate leaf senescence by characterizing the double mutant ein2-1 nosllnoal （Arabidopsis thaliana）. Double mutant analysis revealed that the nosllnoal-mediated, dark-induced early senescence phenotype was suppressed by mutations in EIN2, suggesting that EIN2 is involved in nitric oxide signaling in the regulation of leaf senescence. The results showed that chlorophyll degradation in the double mutant leaves was significantly delayed. In addition, nosllnoal-mediated impairment in photochemical efficiency and integrity of thylakoid membranes was reverted by EIN2 mutations. The rapid upregulation of the known senescence marker genes in the nosl/noal mutant was severely inhibited in the double mutant during leaf senescence. Interestingly, the response of dark-grown nosl/noal mutant seedlings to ethylene was similar to that of wild type seedlings. Taken together, our findings suggest that EIN2 is involved in the regulation of early leaf senescence caused by NO deficiency, but NO deficiency caused by NOSIlNOA1 mutations does not affect ethylene signaling.

关键词： Arabidopsis dark EIN2 leaf senescence nitric oxide.

Stabilization of a relative equilibrium of an underactuated AUV in three-dimensional space 36

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Stabilization of a relative equilibrium of an underactuated ...

Catalytic activity of flame-synthesized Pd/TiO2 for the methane oxidation following hydrogen pretreatments

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作者： niu Hongjiao geng Zhiyong State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of EngineeringPeking University

ISBN: (纸本)9781538629185

This paper presents the stabilization of a relative equilibrium of an underactuated autonomous underwater vehicle（AUV） with three independent control inputs:moment of pitch,moment of yaw and thrust,in three-dimensional *** dynamics of an AUV can be described by the Kirchhoff’s equations which couples actuated variables and underactuated variables together and which is helpful to control underactuated variables via actuated ***,relative equilibria correspond to trim trajectories,which can save *** this study,the relative equilibrium corresponds to a marine vehicle translation along the longitudinal axis and rotation around the same axis with a desired *** on the interconnection and damping assignment（IDA） method,a new desired Hamiltonian function,in which translational and rotational velocities are coupled together,is constructed and served as a Lyapunov *** there’s no control inputs for the underactuated variables,the coupling between translational and rotational velocities in the new desired Hamiltonian function plays an essential role to stabilize the desired relative *** results complete the work.

关键词： Underactued AUV relative equilibrium energy shaping and damping assignment

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Particuology 2018年第6期16卷 58-64页

作者： Nafeng Wang Fang niu Shuhao Wang yun Huang State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy ofSdencesBeijing 100190China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China

A nanocatalyst composed of 10wt% Pd supported on TiO2 was synthesized using one-step flame spray pyrolysis with a highly-quenched premixed stagnation *** as-prepared nanoparticles,having a mean diameter of approximately 10nm,were then subjected to isothermal oxidation and reduction in a fixed bed *** potential roles of Pd and PdO as well as possible synergistic effects between these two active species were explored during methane *** lowest light-off temperature T20 was obtained at a Pd ratio of 53% and this result can be reasonably explained based on a surface Pd-PdO site pair ***,differences in the hysteresis behavior during methane oxidation were noted throughout a heating-cooling cycle over the temperature range of 200-600℃,such that the degree of hysteresis was strongly correlated with the Pd ratio.

关键词： Catalytic oxidation Palladium-based catalysts Flame-assisted spray pyrolysis Nanoparticles

Multifunctional Graphdiyne Enables Efficient Perovskite Solar Cells via Anti-Solvent Additive Engineering

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Nano-Micro Letters 2025年第5期17卷 492-507页

作者： Cong Shao Jingyi He Jiaxin Ma Yirong Wang Guosheng niu Pengfei Zhang Kaiyi Yang Yao Zhao Fuyi Wang Yongjun Li Jizheng Wang CAS Key Laboratory of Organic Solids Institute of ChemistryBeijing National Laboratory for Molecular SciencesChinese Academy of SciencesBeijing 100049People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China CAS Key Laboratory of Engineering Plastics Institute of ChemistryChinese Academy of SciencesBeijing 100049People’s Republic of China CAS Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100049People’s Republic of China National Centre for Mass Spectrometry in Beijing CAS Key Laboratory of Analytical Chemistry for Living BiosystemsBeijing National Laboratory for Molecular SciencesChinese Academy of SciencesBeijing 100049People’s Republic of China

Finding ways to produce dense and smooth perovskite films with negligible defects is vital for achieving high-efficiency perovskite solar cells(PSCs).Herein,we aim to enhance the quality of the perovskite films through the utilization of a multifunctional additive in the perovskite anti-solvent,a strategy referred to as anti-solvent additive ***,we introduce ortho-substituted-4′-(4,4″-di-tertbutyl-1,1′:3′,1″-terphenyl)-graphdiyne(o-TB-GDY)as an AAE additive,characterized by its sp/sp^2-cohybridized and highlyπ-conjugated structure,into the anti-solvent.o-TB-GDY not only significantly passivates undercoordinated lead defects(through potent coordination originating from specific highπ–electron conjugation),but also serves as nucleation seeds to effectively enhance the nucleation and growth of perovskite *** markedly reduces defects and non-radiative recombination,thereby increasing the power conversion efficiency(PCE)to 25.62%(certified as 25.01%).Meanwhile,the PSCs exhibit largely enhanced stability,maintaining 92.6%of their initial PCEs after 500 h continuous 1-sun illumination at~23°C in a nitrogen-filled glove box.

关键词： Perovskite solar cells Graphdiyne Anti-solvent additive engineering Crystallization Defect passivation

工程博士联合培养的生发机制、现实困境与纾解策略--基于多重制度逻辑的分析视角

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研究生教育研究 2025年第1期 73-80,88页

作者：牛风蕊张紫薇福州大学高等教育研究所福州350108 广州行政学院公共管理教研部广州510070

开展工程博士专业学位研究生教育是国家自主培养拔尖创新人才的重要组成部分,也是产业升级背景下强化工程领军人才队伍建设的关键举措。工程博士联合培养涉及政府、行业企业和高校等利益相关主体,受到国家逻辑、市场逻辑和高校逻辑等多... 详细信息

开展工程博士专业学位研究生教育是国家自主培养拔尖创新人才的重要组成部分,也是产业升级背景下强化工程领军人才队伍建设的关键举措。工程博士联合培养涉及政府、行业企业和高校等利益相关主体,受到国家逻辑、市场逻辑和高校逻辑等多重制度逻辑的形塑。国家科技自立自强的发展战略导向,人才和知识溢出对行业企业创新发展的辐射,以及高校提升办学实力和博士毕业生的社会契合度等多元利益相关者的目标联结推动了工程博士联合培养制度链条的启动。与此同时,工程博士联合培养中行动主体的目标偏差以及制度供需失衡和管理逻辑惯性的影响,使得行为主体间耦合失调,成为联合培养深入推进的阻滞性因素。迫切需要强化多重制度逻辑的协同互构,构建“全链条”协同机制,通过利益弥合与制度引导,提高工程博士联合培养的成效。

关键词：工程博士联合培养科技自立自强多重制度逻辑