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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Triple negative breast cancer: special histological types and emerging therapeutic methods

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Cancer Biology & Medicine 2020年第2期17卷 293-306页

作者： Lu Cao yun niu Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Breast Cancer Pathology and Research Laboratory Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China

Triple negative breast cancer(TN BC)is a complex and malignant breast cancer subtype that lacks expression of the estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(H ER2),thereby making therapeutic targeting *** is generally considered to have high malignancy and poor ***,patients diagnosed with certain rare histomorphologic subtypes of TNBC have better prognosis than those diagnosed with typical triple negative breast *** addition,with the discovery and development of novel treatment targets such as the androgen receptor(AR),PI3K/AKT/mTOR and AMPK signaling pathways,as well as emerging immunotherapies,the therapeutic options for TNBC are *** this paper,we review the literature on various histological types of TNBC and focus on newly developed therapeutic strategies that target and potentially affect molecular pathways or emerging oncogenes,thus providing a basis for future tailored therapies focused on the mutational aspects of TNBC.

关键词： Triple negative breast cancer pathological subtype androgen receptor immunotherapy targeted therapy

Dynamically self-adjustable liquid-liquid and self-adaptive softcontact solid-solid triboelectric nanogenerator for wave energy harvesting

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Nano Research 2025年第1期18卷 404-414页

作者： Yong Long Bingqi Zhao Jianan niu Yuxiu Liu Wei Sha Jiangwen Wang Zhong Lin Wang Weiguo Hu Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Water wave energy exhibits great potential toalleviate the global energy crisis. However, harvesting andutilizing wave energy are challenging due to its irregularity,randomness, and low frequency. Triboelectric nanogenerators(TENGs) have gained significant attention for harvesting waveenergy with high efficiency. This study presents a novelellipsoidal, pendulum-like TENG integrating both liquid-liquid(L-L) and solid-solid (S-S) triboelectricity (LS-TENG). Thisinnovative design enables continuous wave energy harvestingand self-powered marine environment monitoring under variousconditions, including temperature, humidity, and light intensity. The binary immiscible liquids within the LS-TENG’s innersoft balloon create dynamic, and self-adjustable L-L contact interfaces, significantly increasing the L-L contact area andenhancing L-L contact electrification (CE). The unique self-adaptive, soft S-S contact increases the S-S contact areacompared to traditional hard point contact, better adapting to the irregular movements of waves and promoting efficient S-SCE. The LS-TENG achieves highly efficient wave energy harvesting by coupling L-L and S-S CE. Furthermore, the uniquesoft contact design protects the S-S interfaces from mechanical wear and damage during long-term work. The LS-TENG’snovel structure provides an innovative and effective way for water wave energy harvesting.

关键词： self-adaptive soft-contact solid-solid liquid-liquid self-adjustable triboelectric nanogenerator

Assessment of the high-resolution estimations of global and diffuse solar radiation using WRF-Solar

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Advances in Climate Change Research 2023年第5期14卷 720-731页

作者： yun-Bo LU Lun-Che WANG Jiao-Jiao ZHOU Zi-geng niu Ming ZHANG Wen-Min QIN Hubei Key Laboratory of Regional Ecology and Environmental Change School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Hunan Key Laboratory of Remote Sensing of Ecological Environment in Dongting Lake Area School of Geography and Information EngineeringChina University of GeosciencesWuhanChina Hubei Luojia Laboratory Wuhan 430079China

Compared with physical models,WRF-Solar,as an excellent numerical forecasting model,includes abundant novel cloud physical and dynamical processes,which enablesenable the high-frequency output of radiation components which are urgently needed by the solar energy ***,the popularisation of WRF-Solar in a wide range of applications,such as the estimation of diffuse radiation,suffers from unpredictable influences of cloud and aerosol optical property *** study assessed the accuracy of the improved numerical weather prediction(WRF-Solar)model in simulating global and diffuse *** optical properties at 550 nm,which were provided by a moderate resolution imaging spectroradiometer,were used as input to analyse the differences in accuracies obtained by the model with/without aerosol *** sensitivity of WRF-Solar to aerosol and cloud optical properties and solar zenith angle(SZA)was *** results show the superiority of WRF-Solar to WRF-Dudhia in terms of their root mean square error(RMSE)and mean absolute error(MAE).The coefficients of determination between WRF-Solar and WRF-Dudhia revealed no statistically significant difference,with values greater than 0.9 for the parent and nested *** addition,the relative RMSE(RRMSE%)reached 46.60%.The experiment on WRF-Solar and WRF-Dudhia revealed a negative bias for global radiation,but WRF-Solar attained a slightly lower RMSE and higher correlation coefficient than *** WRF-Solar-simulated results on diffuse radiation under clear sky conditions were slightly poorer,with RMSE,RRMSE,mean percentage error and MAE of 181.93 W m^(−2),170.52%,93.04%and 138 W m^(−2),*** on Himawari-8 cloud data,statistical results on cloud optical thickness(COT)for cloudy days revealed that WRF-Solar overestimated diffuse radiation at COTs greater than ***,when the aerosol optical depth was greater than or equal to 0.8,WRF-Solar also overestimated the diffuse radiation

关键词： WRF-Solar Solar radiation simulation Cloud optical thickness Aerosol optical depth Dependency analysis

Time-Free Solution to 3-Coloring Problem Using Tissue P Systems

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Chinese Journal of Electronics 2016年第3期25卷 407-412页

作者： niu yunyun XIAO Jianhua JIANG yun School of Information Engineering China University of Geosciences in Beijing The Research Center of Logistics Nankai University School of Computer Science and Information Engineering Chongqing Technology and Business University

In most of traditional P systems, each rule has the same execution time. That way of using the rules is not quite realistic from a biological point of view, because external conditions always change in an unpredicted manner such that different reaction may take different time to execute. In this work, we investigate the computation efficiency of tissue P systems by removing the restriction that each rule should complete in one time unit. The timed tissue P system is constructed by adding a time mapping to the rules to specify the execution time for each rule.A uniform and time-free solution to 3-coloring problem is proposed, where the execution time of the computational processes involved can vary arbitrarily and the output produced is always the same.

关键词： Membrane computing Tissue P system Time-free solution 3-Coloring problem

Deformation mechanism analysis of roll forming for Q&P980 steel based on finite element simulation

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Journal of Iron and Steel Research International 2019年第11期26卷 1178-1187页

作者： Fei Han yun Wang Li-li niu School of Mechanical and Materials Engineering North China University of Technology.Beijing 100144China

Roll forming is a sheet metal forming process,which can form the profiles gradually to improve the formability of Q&P980 *** plastic deformation mechanism of roll forming was expounded by analysing the stress and strain distribution at the comer of a hat-type profile when the Q&P980 steel sheet passed through a series of continuous *** the plastic deformation mainly accumulated when the sheet metal was not in contact with the rolls.A simple mathematical model was derived by considering the longitudinal bending strain and the geometrical relationships of forming parameters,to analyse the longitudinal strain development in the deformation *** addition,the roll forming experiments on hat-type profile parts of Q&P980 steel were carried out,and the theoretical analysis and simulation results are consistent with the experimental results.

关键词： Roll forming Numerical simulation Q&P980 steel-Deformation area

Regulating the oxygen-atom configuration of carbon anode enabling extremely fast-charging potassium-ion hybrid capacitors

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Nano Research 2025年第1期18卷 373-381页

作者： Daping Qiu Yuehui Wang Lulu Zhang Hang Lei Haizhou Ying Jin niu Min Li Xuelin Yang Feng Wang Ru Yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering and New EnergyChina Three Gorges UniversityYichang 443002China State Key Laboratory of Chemical Resource Engineering Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials and Chemical Engineering China Three Gorges UniversityYichang 443002China

Metal-ion hybrid capacitors,such as potassium-ion hybrid capacitors(PIHCs),are regarded as promising fast-charging energy storage ***,the kinetics mismatch between the battery anode and the capacitive cathode restricts their fastcharging *** constructing carbon anodes with enhanced kinetics is an innovative approach to address this ***,using epigallocatechin gallate with high oxygen content as the precursor,oxygen-enriched carbon materials(OEC)with tunable C=O content are successfully ***,the C=O content of OEC is regulated by adjusting the pyrolysis *** as an anode for PIHCs,OEC-600 with the highest C=O content exhibits an attractive fast-charging specific capacity of 135.2 mAh·g^(-1)at 20 A·g^(-1),along with a superior fast-charging cycling *** theoretical calculations,comprehensive kinetics analysis and in-situ Raman,the positive effects of C=O on the potassium storage capability and reversibility of OEC-600 are ***,PIHCs assembled based on an OEC-600 anode deliver impressive energy/power density of 145.1 Wh·kg^(-1)/45.9 kW·kg^(-1)and superior fast-charging cycling stability with 87.5%of capacity retention over 20,000 cycles at 5 A·g^(-1).This work is anticipated to provide an optional design concept toward the carbon anode for fast-charging PIHCs.

关键词： carbon anode oxygen epigallocatechin gallate potassium-ion hybrid capacitor