检索结果-南通市图书馆

Formation of reversed microstructures inside femtosecond laser irradiated glasses by tuning the interfacial refractive index

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Formation of reversed microstructures inside femtosecond las...

Co13.8—metalloxocubes:a new class of perovskite-like neutral clusters with cubic aromaticity

战略性新兴产业的培育和发展——首届云南省科协学术年会

作者： Fangfang Luo,~(1,2. Xiao hu,~1 Juan Song,~3.Haiyi Sun,~1 geng Lin,~(1,2. huaihai Pan,~(1,2. Ya Cheng,~1 Li Liu,~1 Quanzhong Zhao,~1 Jianrong Qiu,~4 (1 State Key Laboratory of High Field Laser Physics,Shanghai Institute of Optics and Fine Mechanics,chinese academy of sciences,Shanghai 2.1800,china 2.graduate {13. of the chinese academy of sciences,beijing 10003.,china 3.{13. of Materials Science and Engineering,Jiangsu University,Zhenjiang 2.2.13. Jiangsu,china 4 State Key Laboratory of Silicon Materials,Zhejiang University,Hangzhou 3.002.,china)

＜正＞The femtosecond laser induced microstructures can be reversed by tuning of the interfacial refractive *** putting a water and an 1 -bromonaphthalene layers on the glass sample,microstructures with similar shape but opposite direction can be ***,the elemental distribution in the induced structures also can be *** simulation of laser intensity distribution along the laser propagation direction indicates that the interface spherical aberration effect is responsible for the reversion of microstructures and elemental distribution.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

National Science Review 2021年第1期8卷 89-97页

作者： Lijun geng Mouyi Weng Cong-Qiao Xu Hanyu Zhang Chaonan Cui Haiming Wu Xin Chen Mingyu hu Hai Lin Zhen-Dong Sun Xi Wang Han-Shi hu Jun Li Jiaxin Zheng Zhixun Luo Feng Pan Jiannian Yao beijing National Laboratory for Molecular sciences (BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences school of Physics Shandong University school of Advanced Materials Peking University Shenzhen Graduate School Department of Chemistry Southern University of Science and Technology University of chinese academy of {2. school of Physics and Electrical Engineering Kashi University College of Science Beijing Jiaotong University Department of Chemistry and Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Tsinghua University

Exploring stable clusters to understand structural evolution from atoms to macroscopic matter and to construct new materials is interesting yet challenging in chemistry. Utilizing our newly developed deep-ultraviolet laser ionization mass spectrometry technique, here we observe the reactions of neutral cobalt clusters with oxygen and find a very stable cluster species of Co13.8that dominates the mass distribution in the presence of a large flow rate of oxygen gas. The results of global-minimum structural search reveal a unique cubic structure and distinctive stability of the neutral Co13.8cluster that forms a new class of metal oxides that we named as ‘metalloxocubes’. Thermodynamics and kinetics calculations illustrate the structural evolution from icosahedral Co13.o the metalloxocube Co13.8with decreased energy, enhanced stability and aromaticity. This class of neutral oxygen-passivated metal clusters may be an ideal candidate for genetic materials because of the cubic nature of the building blocks and the stability due to cubic aromaticity.

关键词： metalloxocube oxygen-passivated metal cluster cubic aromaticity cluster materials magnetic property

Retrospective Clinical Study on Integrated chinese and Western Medicine in Treatment of Limited-Stage Small Cell Lung Cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Integrative Medicine 2023年第8期29卷 675-682页

作者： QI Run-zhi HE Shu-lin LI Yue ZHAO Yu-wei geng Liang HE Jie CHENG Meng-qi hu Jia-qi LI Cong-huang huA Bao-jin Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medicine SciencesBeijing(100053)China graduate school Beijing University of Chinese MedicineBeijing(100029)China Department of Integrated Traditional chinese and Western Medicine Oncology Henan Cancer HospitalZhengzhou(100053)China

Objective: To investigate the efficacy of integrated chinese and Western medicine extending the progression-free survival(PFS) and overall survival(OS) of limited-stage small-cell lung cancer(LS-SCLC) patients after the first-line chemoradiotherapy. Methods: The data of 67 LS-SCLC patients who received combined treatment of chinese medicine(CM) and Western medicine(WM) between January {2.3.and May 2.2. at the outpatient clinic of Guang’anmen Hospital were retrospectively analyzed. Thirty-six LS-SCLC patients who received only WM treatment was used as the WM control group. The medical data of the two groups were statistically analyzed. Survival analysis was performed using the product-limit method(Kaplan–Meier analysis). The median OS and PFS were calculated, and survival curves were compared by the Log rank test. The cumulative survival rates at 1, 2. and 5 years were estimated by the life table analysis. Stratified survival analysis was performed between patients with different CM administration time. Results: The median PFS in the CM and WM combination treatment group and the WM group were 19 months(95% CI: 12.3.–2..64) vs. 9 months(95% CI: 5.96–12.04), respectively, HR=0.43.95% CI: 0.2.–0.69, P 1). The median OS in the CM and WM combination group and the WM group were 3..00 months(95% CI could not be calculated) vs. 18.63.months(95% CI: 16.43.2..84), respectively, HR=0.40(95% CI: 0.2.–0.66, P1). Similar results were obtained in the further stratified analysis of whether the duration of CM administration exceeded 18 and 2. months(P1). Conclusion: The combination treatment of CM and WM with continuing oral administration of CM treatment after the first-line chemoradiotherapy for LS-SCLC patients produced better prognosis, lower risks of progression, and longer survival than the WM treatment alone.(Registration No. Chi CTR2.00056616)

关键词： limited-stage small cell lung cancer combination of chinese and Western medicine overall survival progression-free survival chinese medicine

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第4期7卷 1258-1270页

作者： Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu huiping Guo Yuxin Chen Honghai Tang Daqi Wang Mingqian huang Zheng-Yi Chen Xingxu huang huawei Li geng-Lin Li Xiaoxiang hu Yilai Shu ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200032China State Key Laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193China College of Biological sciences China Agricultural UniversityBeijing 100193China school of Life Science and Technology Southeast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck Surgery Graduate Program in Speech and Hearing Bioscience and Technology and Program in NeuroscienceHarvard Medical SchoolBostonMA 02115USA Eaton-Peabody Laboratory Massachusetts Eye and Ear InfirmaryBostonMA 02114USA school of Life Science and Technology ShanghaiTech UniversityShanghai 200031China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200031China

CRISPR/RfxCas13.(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene ***,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA3. due to a point mutation in *** first screened 3. sgRNAs in cell cultures and found that CasRx with sgRNA3.reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3..We then injected a newly developed AAV vector(***)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2.in 2.weeks with few off-target effects in the whole ***,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction ***,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 ***,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond.

关键词： CRISPR/Cas editing hearing

液相色谱-串联质谱法同时测定鸡蛋中4种抗病毒药物残留

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

质量安全与检验检测 2023年第5期33卷 6-13,30页

作者：孙玲玲霍江莲陈冬东呼秀智霍思宇耿旭浩高家政彭涛薛占永中国检验检疫科学研究院北京100176 河北工程大学生命科学与食品工程学院中国合格评定国家认可中心检科院(北京)科学技术有限公司

建立液相色谱-串联质谱法同时测定鸡蛋样品中4种抗病毒药物(金刚烷胺、金刚乙胺、利巴韦林和吗啉胍)残留量的分析方法。鸡蛋样品残留的目标物质通过1%甲酸乙腈提取,经MgSO4、N-丙基乙二胺(primary secondary amine,PSA)、十八烷基硅胶C1... 详细信息

建立液相色谱-串联质谱法同时测定鸡蛋样品中4种抗病毒药物(金刚烷胺、金刚乙胺、利巴韦林和吗啉胍)残留量的分析方法。鸡蛋样品残留的目标物质通过1%甲酸乙腈提取,经MgSO4、N-丙基乙二胺(primary secondary amine,PSA)、十八烷基硅胶C18和石墨化炭黑(graphitized carbon black,GCB)分散固相萃取净化,40℃水浴中氮气吹干后复溶。采用色谱柱Shim-pack Velox HILIC(2.1×150 mm,2.7μm),流动相A为乙腈,B为2. mM甲酸铵+0.1%甲酸溶液,进行梯度洗脱,4种目标物质正离子模式监测,内标法定量进行分析。结果显示,4种抗病毒药物在一定浓度范围内线性良好,相关系数(R2.均大于0.9960,检出限在0.1~1.5μg/kg范围之间,定量限在0.3.4.0μg/kg范围之间。4种药物在各自定量限1、1.5、2.添加浓度水平下添加回收率在75.9%~110.1%之间,相对标准偏差(relative standard deviations,RSDs)为3.2.~6.9%。该方法操作简单、灵敏度高、回收率好,可用于日常鸡蛋样品中抗病毒类药物的残留检测。

关键词：鸡蛋抗病毒类药物分散固相萃取液相色谱-串联质谱法残留

参加暴露前预防的男男性行为者HIV自我检测试剂使用现状及影响因素分析

在线全文

学校读者我要写书评

暂无评论

中华流行病学杂志 2021年第2期42卷 278-283页

作者：金霞王泓懿张晶楚振兴呼志丽包冉彤李行黄晓婕陈耀凯王辉何小庆张路坤丁海波耿文清姜拥军李尚曹徐俊杰国家卫生健康委员会艾滋病免疫学重点实验室(中国医科大学) 国家医学检验临床医学研究中心中国医科大学附属第一医院沈阳110001 首都医科大学附属北京佑安医院北京100069 重庆市公共卫生医疗救治中心 400036 深圳市第三人民医院 518000

目的分析参加暴露前预防(PrEP)MSM的HIV自我检测(自检)试剂使用现状及相关影响因素。方法2.18年12.至2.19年12.,使用"金数据"平台(***)对沈阳市、北京市、重庆市和深圳市参与多中心PrEP研究的MSM进行现况调查。结果共有12.2.MSM研究... 详细信息

目的分析参加暴露前预防(PrEP)MSM的HIV自我检测(自检)试剂使用现状及相关影响因素。方法2.18年12.至2.19年12.,使用"金数据"平台(***)对沈阳市、北京市、重庆市和深圳市参与多中心PrEP研究的MSM进行现况调查。结果共有12.2.MSM研究对象,年龄(3..5±8.7)岁,最近3.月性伴数为3.P2.,P75:2.6)个,与固定性伴、偶然性伴和商业性伴发生肛交时未使用安全套的比例分别为62.7%(456/72.)、56.3.(440/781)和41.0%(16/3.)。曾使用过HIV自检试剂的比例为74.5%(910/12.2.,最近1年HIV自检次数为3.P2.,P75:2.5)次。多因素logistic回归分析结果显示,HIV自检行为的相关影响因素中,分别相比于>40岁组、初中及以下文化程度、心理认同性别为女性、PrEP服药方式为事件驱动服药组、最近3.月未使用过新型毒品,18~岁组(aOR=2.06,95%CI:1.3.~3.14)、2.~岁组(aOR=2.72.95%CI:1.77~4.17)和3.~岁组(aOR=1.76,95%CI:1.19~2.59)、文化程度大学本科/大专(aOR=2.18,95%CI:1.3.~3.49)和研究生及以上(aOR=3.06,95%CI:1.69~5.54)、心理认同性别为男性(aOR=3.2.,95%CI:1.55~6.70)、PrEP服药方式为每日服药组(aOR=1.3.,95%CI:1.03.1.78)、最近3.月使用过新型毒品(aOR=1.72.95%CI:1.3.~2.2.)的HIV自检行为的比例更高。结论MSM参与PrEP者HIV自检行为的比例较高,但高年龄组、PrEP服药方式为事件驱动服药及未使用过新型毒品的MSM对HIV自检行为比例较低。为评估PrEP使用效果及依从性,需为HIV自检比例较低的MSM提供更完善的自检服务。

关键词：艾滋病男男性行为人群暴露前预防事件驱动型 HIV自我检测

穴位贴敷与推拿手法治疗脑梗死后便秘疗效观察

在线全文

学校读者我要写书评

暂无评论

中西医结合护理 2022年第6期8卷 93-99页

作者：果海姣刘甘露马晓旭苏容陈程马大勇胡哲刘文丽耿庆文北京中医药大学东直门医院神经内科北京100700 北京中医药大学研究生院北京100029

目的观察穴位贴敷与推拿治疗脑梗死后便秘的效果。方法筛选脑梗死后便秘的患者78例,分为对照组、穴位贴敷组(贴敷组)和推拿组(推拿组),三组患者人数分别为2.例、3.例和2.例。对照组采用常规中西医治疗及护理;在此基础上,贴敷组患者采中... 详细信息

目的观察穴位贴敷与推拿治疗脑梗死后便秘的效果。方法筛选脑梗死后便秘的患者78例,分为对照组、穴位贴敷组(贴敷组)和推拿组(推拿组),三组患者人数分别为2.例、3.例和2.例。对照组采用常规中西医治疗及护理;在此基础上,贴敷组患者采中药神阙穴贴敷;推拿组患者采用穴位推拿手法。干预2.,每日观察三组患者的排便情况,于治疗第7和14天对比三组患者的排便频率。采用Barthel指数(BI)评价患者日常生活活动能力。结果治疗第1周,贴敷组患者排便频率高于推拿组和对照组,差异有统计学意义(P2.,贴敷组患者排便频率高于同期的对照组(P2.排便频率均较第1周均升高。三组患者出院时BI均较入院时均升高。结论穴位贴敷治疗和推拿手法治疗能改善脑梗死后便秘患者排便频率,其中穴位贴敷治疗效果更明显。

关键词：推拿手法穴位贴敷脑梗死便秘中医护理

Search for hidden-charm tetraquark with strangeness in e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Physics C 2023年第3期47卷 1-14页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白羽 O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi E.Bianco J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲车国荣 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅 S.K.Choi 初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.E.de Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇丁逸董静董燎原董明义董翔杜书先段宗欢 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold 侯国一侯颖锐侯治龙胡海明 J.F.hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄性涛黄燕萍黄震 T.hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv E.Jang J.H.Jeong 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤蒋沛成姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson S.Kabana N.Kalantar-Nayestanaki 康晓琳康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷天天雷祚弘 H.Leithoff M.Lellmann T.Lenz 李聪李翠李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李彦谷李振轩李紫源梁畅梁浩梁昊梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘成刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak 裴宇鹏 M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China beijing Institute of PetrochemicalTechnology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania15213USA Central china Normal University Wuhan 430079China Central South University Changsha 410083China china Center of AdvancedScience and Technology Beijing 100190China china University of Geosciences Wuhan 430074China COMSATS University Islamabad LahoreCampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of NuclearPhysics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany GuangxiNormal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan NormalUniversity Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000People's Republic of China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DAricaChile Jilin Univers

We report a search for a heavier partner of the recently observed Z_(cs)(3.85)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682.and 4.699 GeV with the BESIII *** Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ *** find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(412..5±0.7_(sat)±4.7_(syst.))MeV/c^(2..As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.12. to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass *** upper limits of σ^(Born).B are found to be at the level of O(1)pb at each *** data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.

关键词： electron-positron collision BESIl hadron spectroscopy tetraquark