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Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer

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World Journal of Gastroenterology 2020年第45期26卷 7173-7190页

作者： Xi-Zhen Sun Dong-yan Zhao Yuan-Chen Zhou Qian-Qian wang {2. Qin Shu-Kun Yao graduate school Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Peking University china-Japan Friendship school of Clinical Medicine Peking UniversityBeijing 100029China

BACKGROUND Gut tryptophan(Trp)metabolites are produced by microbiota and/or host *** of them have been proven to promote or inhibit colorectal cancer(CRC)in vitro and animal *** hypothesized that there is an alteration of gut Trp metabolism mediated by microbiota and that it might be involved in the pathogenesis of cancer in patients with *** To investigate the features of Trp metabolism in CRC and the correlation between fecal Trp metabolites and gut *** Seventy-nine patients with colorectal neoplastic lesions(33 with colon adenoma and 46 with sporadic CRC)and 38 healthy controls(HCs)meeting the inclusion and exclusion criteria were included in the *** demographic and clinical features were *** Trp,kynurenine(KYN),and indoles(metabolites of Trp metabolized by gut microbiota)were examined by ultraperformance liquid chromatography coupled to tandem mass *** barrier marker and indoleamine 2.3-dioxygenase 1(IDO1)mRNA were analyzed by quantitative realtime polymerase chain *** occludens-1(ZO-1)protein expression was analyzed by *** gut microbiota was detected by 16S ribosomal RNA gene *** between fecal metabolites and other parameters were examined in all *** The absolute concentration of KYN[1.51(0.70,3.46)nmol/g vs 0.81(0.64,1.57)nmol/g,P=0.036]and the ratio of KYN to Trp[7.39(4.12.11.72.×10^-3 vs 5.2.(1.86,7.99)×10^-3,P=0.032.were increased in the feces of patients with CRC compared to HCs,while the indoles to Trp ratio was decreased[1.34(0.70,2.63)vs 2.46(1.2.,4.10),P=0.02.].The relative ZO-1 mRNA levels in patients with CRC(0.2.±0.2.)were significantly lower than those in HCs(1.00±0.31)(P2.46)]were increased(P=0.035).IDO1 mRNA levels were positively associated with the KYN/Trp ratio(r=0.32.,P=0.003).ZO-1 mRNA and protein levels were positively correlated with

关键词： Tryptophan metabolism Colorectal cancer Kynurenine Indoles Microbiota Colorectal adenoma

Dr, yang Zhong： An explorer on the roac Forever

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Protein & Cell 2018年第2期9卷 141-144页

作者： Fan Chen Bao-Rong Lu James C. Crabbe Jia-yuan Zhao Bo-jian Zhong Yu-peng geng Yu-fang Zheng Hong-yan {2. Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Department of Ecology and Evolutionary Biology Fudan University Shanghai 200438 China Wolfson College University of Oxford Linton Road Oxford OX2 6UD UK Department of Life sciences Institute of Biomedical and Environmental Science & Technology University of Bedfordshire Park Square Luton LU1 3JU UK College of Life sciences Nanjing Normal University Nanjing 210046 China school of Ecology and Environmental Science Institute of Ecology and Geobotany Yunnan University Kunming 650091 China Obstetrics & Gynecology Hospital Institute of Reproduction & Development Fudan University Shanghai 200090 China

On the morning of September 2.th 2.17, grievous news spread from the remote Ordos region of Inner Mongolia to Fudan University campus in Shanghai. Professor yang Zhong （Fig. 1）, a famous botanist and the Dean of Fud... 详细信息

关键词： International Society For Computational Biology (ISCB) Tibet University Relative Rate Test Plant Genome Diversity Excellent Pioneer

Effectiveness and Safety Evaluation of Qixiong Zhongzi Decoction (芪芎种子汤) in Idiopathic Asthenozoospermia Treatment:A Randomized Controlled Trial

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chinese Journal of Integrative Medicine 2020年第2期26卷 146-151页

作者： wang Fu GAO Qing-he geng Qiang HAN Qiang ZHAO Jia-you YU Guo-jin ZHANG Ji-wei {2. Bin GUO Jun SONG Chun-sheng Department of Andrology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Andrology The First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin(300193)China Department of Andrology Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical UniversityBeijing(100010)China graduate school China Academy of Chinese Medical SciencesBeijing(100700)China

Objective:To evaluate the clinical effectiveness and safety of the chinese medicine(CM)Qixiong Zhongzi Decoction(芪芎种子汤,QZD)in the treatment of patients with idiopathic ***:A total number of 66 patients with idiopathic asthenozoospermia were included and randomly divided into treatment and control groups by SAS-generated code from January 2.15 to August 2.16,33 patients in each *** in the treatment group were administered with 150 m L of QZD twice a day,whereas those in the control group were given 1 g of levocarnitine oral liquid twice a *** two groups received the indicated medication for 12.weeks and were then followed up for 4 *** primary outcome was sperm motility,and the secondary therapeutic indices were sperm volume,density,pregnancy probability,and CM syndrome *** comparison between groups was carried out at 4,8 and 12.weeks,*** safety was determined before and after ***:(1)Drop-off:5 cases(7.58%)were lost after treatment(2.from the treatment group and 3 from the control group).(2.Primary outcomes:after 8-and 12.week treatment,the progressive sperms in the two groups were significantly higher than the baseline(all P2.week treatment(2..7%±9.0%vs.14.1%±8.8%,P2.week treatment with statistical difference(all P2.week treatment(38.7%±14.1%vs.2..2.±15.4%,P2.week treatment)and pregnancy probability of patients’wives(12.week treatment)between two groups(all P>0.05),however,the CM syndrome score of the treatment group significantly declined compared with baseline level at each time points(all

关键词： idiopathic asthenozoospermia Qixiong Zhongzi Decoction chinese medicine random controlled trial

基于网络药理学及分子对接探究黄莪胶囊治疗慢性前列腺炎的作用机制

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国际生物医学工程杂志 2022年第3期45卷 232-240页

作者：耿强孙远王妍赵玉陈少峰郭军天津中医药大学第一附属医院男科天津300381 国家中医针灸临床医学研究中心天津300381 天津中医药大学研究生院天津301617 中国中医科学院西苑医院男科北京100091

目的:通过网络药理学及分子对接技术探究黄莪胶囊治疗慢性前列腺炎(CP)的作用机制。方法:查询中药系统药理学数据库与分析平台(TCMSP)及中医药百科全书数据库(ETCM)及相关文献筛选黄莪胶囊的药物成分,使用Swiss Target Prediction预测... 详细信息

目的:通过网络药理学及分子对接技术探究黄莪胶囊治疗慢性前列腺炎(CP)的作用机制。方法:查询中药系统药理学数据库与分析平台(TCMSP)及中医药百科全书数据库(ETCM)及相关文献筛选黄莪胶囊的药物成分,使用Swiss Target Prediction预测药物成分的作用靶点;运用GeneCards、OMIM及GisGeNET获取CP的疾病靶点,利用Venny 2.1.0获取交集靶点。使用STRING进行蛋白质-蛋白质相互作用(PPI)分析并使用Cytoscape构建网络图,利用Metascape进行基因本体(GO)富集分析及京都基因和基因组百科全书(KEGG)信号通路分析。使用Cytoscape软件构建"药物-成分-靶点-通路"网络图。利用PubChem、PDB及PyMoL、AutoDock软件进行分子对接。结果:研究发现黄莪胶囊中的142.有效成分通过多条通路直接作用于2.6个疾病靶点治疗CP,其中杯苋甾酮、桑色素、槲皮素、山柰酚、木犀草素、异鼠李素等是核心成分,ESR1、CDK1、APP、SYK、EGFR是重要靶点。基因功能注释分析结果显示,交集基因最可能相关的BP主要涉及细胞对含氮化合物、无机物、有机环化合物的反应等,CC主要涉及膜筏、受体复合物、膜侧等,MF主要涉及蛋白激酶活性、核受体活性、激酶结合等。通路富集分析结果提示黄莪胶囊主要参与磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(PKB/Akt)信号通路、缺氧诱导因子-1(HIF-1)等信号通路。分子对接结果提示核心成分与重要靶点间的结合性较好。结论:黄莪胶囊主要通过调节PI3K/Akt、HIF-1等信号通路的ESR1、CDK1、APP、SYK、EGFR等疾病靶点,干预酶的活性、炎症反应等生物学过程进而治疗CP。

关键词：黄莪胶囊慢性前列腺炎作用机制网络药理学分子对接

腹腔镜胆总管探查取石免留置鼻胆管引流一期缝合术临床疗效的多中心回顾性研究（附312.报告）

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中华消化外科杂志 2018年第1期17卷 68-75页

作者：杨彦张剑楼健颖李富宇牛肖雅耿智敏陈志宇毛先海郭伟何俊闯程石曾永毅王剑明海南医学院第一附属医院肝胆胰外科海口570102 华中科技大学同济医学院附属同济医院胆胰外科武汉430030 浙江大学医学院附属第二医院肝胆胰外科杭州310009 四川大学华西医院胆道外科成都610041 西安交通大学第一附属医院肝胆外科 710061 陆军军医大学(第三军医大学)第一附属医院全军肝胆外科研究所中国人民解放军西南肝胆外科医院重庆400038 湖南省人民医院肝胆外科长沙410005 首都医科大学附属北京友谊医院普通外科 100050 河南省人民医院肝胆外科郑州450003 首都医科大学附属北京天坛医院普通外科 100050 福建医科大学附属第一医院肝病中心福州350005

目的：探讨腹腔镜胆总管探查取石免留置鼻胆管引流一期缝合术的临床疗效。方法：采用回顾性队列研究方法。收集2.11年1月至2.17年6月国内11家肝胆胰疾病治疗中心收治的肝外胆管结石伴或不伴胆囊结石312.［华中科技大学同济医学院附属... 详细信息

目的：探讨腹腔镜胆总管探查取石免留置鼻胆管引流一期缝合术的临床疗效。方法：采用回顾性队列研究方法。收集2.11年1月至2.17年6月国内11家肝胆胰疾病治疗中心收治的肝外胆管结石伴或不伴胆囊结石312.［华中科技大学同济医学院附属同济医院86例、浙江大学医学院附属第二医院62.、四川大学华西医院44例、西安交通大学第一附属医院2.例、陆军军医大学（第三军医大学）第一附属医院2.例、湖南省人民医院2.例、首都医科大学附属北京友谊医院17例、海南医学院第一附属医院10例、河南省人民医院5例、首都医科大学附属北京天坛医院4例、福建医科大学附属第一医院3例］患者的临床资料。312.患者中，2.1例未留置鼻胆管引流，设为一期缝合组；81例留置鼻胆管引流，设为鼻胆管引流组。所有患者行腹腔镜胆总管探查取石胆总管一期缝合术。观察指标：（1）手术情况比较。（2.术后恢复情况比较。（3）术后并发症比较。（4）随访情况。采用门诊和电话方式进行随访，了解患者术后并发症情况。随访时间截至2.17年6月。正态分布的计量资料以x^-±s表示，组间比较采用t检验。偏态分布的计量资料以M（四分位距）表示，组间比较采用非参数检验。计数资料比较采用χ^2.验或Fisher确切概率法。结果：（1）手术情况比较：312.患者均成功行腹腔镜胆总管探查取石胆总管一期缝合术，无一例中转开腹，其中一期缝合组1例术后死亡。一期缝合组和鼻胆管引流组患者的胆总管直径、胆总管缝合方式（间断缝合和连续缝合）、缝线材料（可吸收缝线和不可吸收缝线）分别为（1.2.0.4）cm，间断缝合106例、连续缝合12.例，可吸收缝线195例、不可吸收缝线36例和（1.1±0.5）cm，间断缝合76例、连续缝合5例，可吸收缝线79例、不可吸收缝线2.，两组上述指标比较，差异均有统计学意义（t=2.497,χ^2.56.706,8.457,P〈0.05）；一期缝合组患者结石数目、结石直径、胆总管壁厚度（≤3 mm和〉3 mm）、Oddi括约肌收缩功能（功能良好和功能异常）、术中出血量、手术时间分别为（2.1±1.7）枚，（1.1±0.6）cm，148例、83例，2.6例、5例，2. mL（10～45 mL），（116±49）min，鼻胆管引流组患者分别为（1.9±1.6）枚，（1.0±0.6）cm，49例、32.，75例、6例，2. mL （15～30 mL）,（113±2.）min，两组上述指标比较，差异均无统计学意义（t=1.02.，0.32.,χ^2.0.32.，3.42.,Z=1.147,t=0.52.,P〉0.05）。进一步分析发现：312.患者中胆总管间断缝合182.，连续缝合130例，两种缝合方式手术时间分别为（133±49）min和（103±34）min，两者比较，差异有统计学意义（t=-6.605，P〈0.05）；两种缝合方式术中出血量和术后并发症分别为2. mL（15～31 mL）、2.例和2. mL（10～45 mL）、18例，两者比较，差异均无统计学意义（Z=-0.2.5,χ^2.0.369，P〉0.05）。312.患者中采用可吸收缝线缝合胆总管2.4例，不可吸收缝线38例，两种手术缝线材料的术中出血量、手术时间和术后并发症分别为2. mL（15～40 mL）、（116±44）min、33例和18 mL（10～2. mL）、（115±35）min、6例，两者比较，差异均无统计学意义（Z=0.971，t=0.02.,χ^2.0.154,P〉0.05）。（2.术后恢复情况比较：一期缝合组和鼻胆管引流组患者在术后胃肠道功能恢复时间、腹腔引流管拔除时间、抗生素使用时间、住院时间分别为（2.0±1.5）d、（4.0±2.4）d、（4.0±2.8）d、（5.5±3.0）d和（4.0±1.9）d、（6.9±3.5）d、（10.0±3.9）d、（11.1±3.7）d，两组上述指标比较，差异均有统计学意义（t=-9.507，-8.2.8，-15.103，-13.575，P〈0.05）。华中科技大学同济医学院附属同济医院一期缝合组和鼻胆管引流组患者总住院费用分别为（5.1±0.6）万元和（6.5±0.5）万元，两组比较，差异有统计学意义（t=-9.516，P〈0.05）。（3）术后并发症比较：一期缝合组患者并发症发生率为14.2.%（33/2.1），其中胆瘘16例、胆道感染11例、切口感染3例、胆道出血1例、胆总管结石残留1例、术后死亡1例；鼻胆管引流组患者并发症发生率为6.17%（5/81），其中胆瘘2.、胆道感染2.、胆道出血1例，两组并发症发生率比较，差异无统计学意义（χ^2.3.151，P〉0.05）。（4）随访情况：312.患者中2.2.获得术后随访，其中一期缝合组175例，鼻胆管引流组7

关键词：肝胆管结石病胆总管探查术一期缝合术腹腔镜检查鼻胆管引流多中心回顾性研究

Search for hidden-charm tetraquark with strangeness in e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.

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chinese Physics C 2023年第3期47卷 1-14页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白羽 O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi E.Bianco J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲车国荣 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅 S.K.Choi 初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.E.de Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇丁逸董静董燎原董明义董翔杜书先段宗欢 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv E.Jang J.H.Jeong 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤蒋沛成姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson S.Kabana N.Kalantar-Nayestanaki 康晓琳康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷天天雷祚弘 H.Leithoff M.Lellmann T.Lenz 李聪李翠李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李彦谷李振轩李紫源梁畅梁浩梁昊梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘成刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak 裴宇鹏 M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China beijing Institute of PetrochemicalTechnology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania15213USA Central china Normal University Wuhan 430079China Central South University Changsha 410083China china Center of AdvancedScience and Technology Beijing 100190China china University of Geosciences Wuhan 430074China COMSATS University Islamabad LahoreCampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of NuclearPhysics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany GuangxiNormal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan NormalUniversity Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000People's Republic of China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DAricaChile Jilin Univers

We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682.and 4.699 GeV with the BESIII *** Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ *** find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(412..5±0.7_(sat)±4.7_(syst.))MeV/c^(2..As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.12. to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass *** upper limits of σ^(Born).B are found to be at the level of O(1)pb at each *** data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.

关键词： electron-positron collision BESIl hadron spectroscopy tetraquark