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Conjugated Polymers for Combatting Antimicrobial Resistance

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Chinese Journal of Chemistry 2022年第6期40卷 759-772页

作者： Zijuan Wang hao geng Chenyao Nie Chengfen Xing School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Key Laboratory of Biotechnology and Pharmaceutical Engineering School of Pharmaceutical SciencesCixi Biomedical Research InstituteWenzhou Medical UniversityWenzhouZhejiang 325035China Key Laboratory of Hebei Province for Molecular Biophysics Institute of BiophysicsHebei University of TechnologyTianjin 300130China

Antimicrobial resistance(AMR)is one of the major challenges in pathogenic infections,which endangers human health and brings devastating public health ***,developing new materials to reduce the over-reliance on antibiotics or to replace antibiotics is in great need to solve this *** polymers(CPs)with excellent light-harvesting properties and good biocompatibility are ideal candidate materials for combat-ting AMR through photodynamic antimicrobial therapy(PACT)by sensitizing oxygen and photothermal therapy(PTT)by light to heat ***-nificant works of CPs-based antimicrobial approaches have been reported in recent ***,we summarize the types of CPs-based antimicrobial materials,illustrate their antimicrobial mechanisms,and discuss their applications in combating AMR mainly by PACT or antimicrobial *** addi-tion,we proposed some other antimicrobial treatment strategies based on CPs,hoping to provide inspiring insight for overcoming AMR.

关键词： Polymers Antimicrobial resistance Photochemistry Materials science Phototherapy

Strategies for Inhibition and Disaggregation of Amyloid-β Fibrillation

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Chinese Journal of Chemistry 2022年第4期40卷 524-538页

作者： hao geng Dong Gao Zijuan Wang Xiaoning Liu Zhanshuo Cao Chengfen Xing School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Key Laboratory of Hebei Province for Molecular Biophysics Institute of BiophysicsSchool of ScienceHebei University of TechnologyTianjin 300130China College of Chemical Engineering Hebei University of TechnologyTianjin 300130China

Comprehensive Summary Amyloid-β protein(Aβ)is a fatal cause of Alzheimer's disease,which can trigger a series of cytotoxicity by the abnormal aggregation of Aβ in human *** strategies for inhibition and disaggregat... 详细信息

关键词： Amyloid beta-peptides Inhibition and disaggregation Materials science Photooxidation Photothermal effect

Topographic controls on the annual runoff coefficient and implications for landscape evolution across semiarid Qilian Mountains, NE Tibetan Plateau

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Journal of Mountain Science 2020年第2期17卷 464-479页

作者： CAI Shun geng hao-peng PAN Bao-tian HONG Yang CHEN Li-ping Key Laboratory of Western China’s Environmental Systems (Ministry of Education) College of Earth and Environmental Sciences Lanzhou University

The combination of different topographic and climatic conditions results in varied precipitation-runoff relations, which in turn influences hillslope erosion, sediment transport and bedrock incision across mountainous landscapes. The runoff coefficient is a suitable tool to represent precipitation-runoff relations, but the spatial distribution of the runoff coefficient across tectonically active mountains in semi-arid environments has received little attention because of limited data availability. We calculated annual runoff coefficients over 22 years for 26 drainage basins across the semi-arid Qilian Mountains based on:(i) annual discharge records;and(ii) the China Meteorological Forcing Dataset to enhance our understanding of the precipitation-runoff processes. The mean annual runoff coefficients show no obvious spatial trends. When compared to potential controlling factors, mean annual runoff coefficients are highly correlated with mean slope rather than any climatic characteristics(e.g., mean annualprecipitation and Normalized Difference Vegetation Index). The slope-dependent runoff coefficient could theoretically have enhanced the topographic control on erosion rates and dampen the influence of precipitation. The enhanced discharge for drainage basins with less precipitation but steep topography in the western Qilian Mountains will enable fluvial incision to keep pace with ongoing uplift caused by the northward growth of the Qilian Mountains. The geomorphic implications are that tectonic rather than climatic factors are more significant for long-term landscape evolution in arid and semi-arid contexts.

关键词： Landscape evolution Precipitation-runoff process Qilian mountains Semiarid environments

Microstructural evolution and mechanical behavior of in situ synthesized MgAl_(2)O_(4)whiskers reinforced 6061 Al alloy composite after hot extrusion and annealing

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Rare Metals 2023年第5期42卷 1732-1742页

作者： geng hao Chun-Sheng Shi Nai-Qin Zhao En-Zuo Liu Chun-Nian He Fang He Li-Ying Ma School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin 300350China Collaborative Innovation Centre of Chemical Science and Engineering Tianjin 300072China

In situ synthesized MgAl2O4whiskers reinforced 6061 Al alloy composites were fabricated by a powder metallurgy ***-sized MgAl2O4spinel whiskers distributed uniformly in 6061 Al alloy matrix without any interfacial product and laid along the extrusion direction after hot ***-extruded composite samples were annealed at 530,580,600 and 630℃for 1 h and examined by electron backscattered diffraction to investigate the recrystallization behavior of obtained *** and texture evolution was investigated,and it is found that the recrystallization process is inhibited by whiskers because of Zener *** fibrous grains remain until 630℃,and deformation textures still exist even in specimen annealed at 630℃.Hardness and tensile tests show that the completely recrystallized sample has an ultimate tensile strength of 218 MPa and a hardness of HV52 compared with 283 MPa and HV 69 of the unannealed *** properties of the annealed samples decline slightly with annealing temperature increasing up to 600℃.

关键词： Composite In situ synthesized whiskers Recrystallization Microstructure Texture

Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice

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Journal of Traditional Chinese Medicine 2020年第3期40卷 407-413页

作者： Song Yafang geng hao Chen Lu Wu Xiaoliang Yuan Mengqian Xu Wanli Guo Jing Sun Jianhua Pei Lixia Department of acupuncture The Affiliated Hospital of Nanjing University of Chinese MeidicneNanjing 210029China Department of the First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE: To investigate the effect of electroacupuncture(EA) on irritable bowel syndrome(IBS) in mice through regulating nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6(NLRP6).METHODS: Water-avoidance stress(WAS) mice model was used to investigate the effects and the mechanism of EA. Abdominal withdrawal reflex test, open field test, and intestinal motility test were used to evaluate visceral sensitivity, anxiety,and intestinal motility in mice. The expressions of NLRP6, Mucin-2(MUC2) and E-cadherin were determined using immunofluorescence and Western blotting ***: EA significantly upregulated the expression of NLRP6 in the intestine of mice. Moreover, EA increased the expressions of MUC2 and E-cadherin in WAS ***: Our study found that the relief of IBS symptoms by EA may involve the increase in the expression of NLRP6 in WAS mice.

关键词： Electroacupuncture Nod signaling adaptor proteins Irritable bowel syndrome

Research on high strength hypoeutectic Al-Si alloy

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Research on high strength hypoeutectic Al-Si alloy

Interpretation Criteria for Standardized Western Blot for the Predominant Species of Borrelia Burgdorferi Sensu Lato in China

第八届中国功能材料及其应用学术会议

作者： JIA Ting-ting CHEN Guo-shi ZHANG Shuo WU Ming geng hao-ran School of Materials Science and Engineering University of Jinan

ISBN: (纸本)9783037859698

In this study,hypoeutectic Al-Si casting alloy was investigated to obtain high strength,according to alloying of Cu Mg,refining of Al-5Ti-B master alloy,modifing of Re and T6 heat *** experimental results show that the mechanicalproperties of the tested alloy reach peak when addition of Al-5Ti-1B alloy is 1.0%after heat treatment,especially the yield strength,correspondingly,microstructure distribution gets to the best *** Al-5Ti-1B exceeds1.0%,the mechanicalproperties descend *** metalliccompounds of MgSi phase,CuA1 phase and W phase precipitated along the grain boundary and strengthened dispersively can improve mechanical propertiesof the tested *** yield strength of samplesadded 0.1%Re(La 50%,Ce 40%) increases slightly,simultaneously,the tensile strength and elongation *** 0.1%Re,the mechanicalproperties get down.

关键词： hypoeutectic Al-Si alloy Al-5Ti-1B T6 heat treatment mechanical properties

来源： cnki会议评论

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Biomedical and Environmental Sciences 2010年第5期23卷 341-349页

作者： YI JIANG XUE-XIA HOU ZHEN geng QIN hao KANG-LIN WAN State Key Laboratory for Infectious Diseases Prevention and Control National Institute of Communicable Disease Control & Prevention Chinese Center of Disease Control & Prevention Beijing 102206 China

Objective Western blotting （WB;immunoblotting） is a widely used tool for the serodiagnosis of Lyme borreliosis （LB）,but so far,no generally accepted criteria for its performance and interpretation have been established in *** present study was designed to determine the criteria for standardized Western blot for the predominant species of Borrelia burgdorferi sensu lato in China,in which WB was produced with strain PD91 as the representative strain attributed to predominant genospecies Borrelia garinii of Borrelia burgdorferi sensu *** Approximately 13 bands between 14 and 100 kD were differentiated for strain PD91 by using Gel-Pro analysis *** a study with 631 serum samples （taken from 127 patients with Lyme borreliosis and 504 controls）,all observed bands were *** establish criteria for a positive WB result for strain PD91,receiver operating characteristic （ROC） curves were *** The following interpretation criteria were recommended：for IgG,at least one band of P83/100,P58,P39,P30,OspC,P17,P66,and OspA;for IgM,at least one band of P83/100,P58,OspA,P30,OspC,P17 or *** addition,syphilis,leptospirosis and other related diseases should be excluded when the positive band is P41 in *** IgG criteria,the sensitivity is 73.2%,the specificity is 99.4% and Youden index is 0.726;for IgM criteria,the sensitivity is 50.6%,the specificity is 93.1% and Youden index is *** Standardization of WB assays is necessary for comparison of results from different ***,the criteria of other genospecies of Borrelia burgdorferi sensu lato should be determined in the future to complete the criteria of WB for the diagnosis of the Lyme disease in China.

关键词： Criteria Western blot Borrelia burgdorferi sensu lato

Volumetric-modulated arc therapy vs c-IMRT in esophageal cancer:A treatment planning comparison

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World Journal of Gastroenterology 2012年第37期18卷 5266-5275页

作者： Li Yin hao Wu Jian Gong Jian-hao geng Fan Jiang An-Hui Shi Rong Yu Yong-Heng Li Shu-Kui Han Bo Xu Guang-Ying Zhu Department of Radiotherapy Peking University School of OncologyBeijing Cancer Hospital and InstituteBeijing 100142China

AIM： To compare the volumetric-modulated arc ther- apy （VMAT） plans with conventional sliding window intensity-modulated radiotherapy （c-IMRT） plans in esophageal cancer （EC）. METHODS： Twenty patients with EC were selected, including 5 cases located in the cervical, the upper, the middle and the lower thorax, respectively. Five plans were generated with the eclipse planning sys- tem： three using c-IMRT with 5 fields （5F）, 7 fields （7F） and 9 fields （gF）, and two using VMAT with a single arc （1A） and double arcs （2A）. The treatment plans were designed to deliver a dose of 60 Gy to the plan-ning target volume （PTV） with the same constrains in a 2.0 Gy daily fraction, 5 d a week. Plans were normal- ized to 95% of the PTV that received 100% of the pre- scribed dose. We examined the dose-volume histogram parameters of PTV and the organs at risk （OAR） such as lungs, spinal cord and heart. Monitor units （MU） and normal tissue complication probability （NTCP） of OAR were also reported. RESULTS： Both c-IMRT and VMAT plans resulted in abundant dose coverage of PTV for EC of different Io- cations. The dose conformity to PTV was improved as the number of field in c-IMRT or rotating arc in VMAT was increased. The doses to PTV and OAR in VMAT plans were not statistically different in comparison with c-IMRT plans, with the following exceptions： in cervical and upper thoracic EC, the conformity index （CI） was higher in VMAT （1A 0.78 and 2A 0.8） than in c-IMRT （5F 0.62, 7F 0.66 and 9F 0.73） and homogeneity was slightly better in c-IMRT （7F 1.09 and 9F 1.07） than in VMAT （1A 1,1 and 2A 1.09）, Lung V30 was lower in VMAT （1A 12.52 and 2A 12.29） than in c-IMRT （7F 14.35 and 9F 14.81）. The humeral head doses were significantly increased in VMAT as against c-IMRT. In the middle and lower thoracic EC, CI in VMAT （1A 0.76 and 2A 0.74） was higher than in c-IMRT （5F 0.63 Gy and 7F 0.67 Gy）, and homogeneity was almost similar between VMAT and c-IMRT. V20 （2A 21.49 Gy vs 7F 24.59 Gy and 9F 24.16

关键词： Esophageal cancer Treatment planning Intensity modulated radiotherapy Volumetric modulat-ed arc radiotherapy Normal tissue complication prob-ability

Hurst's Exponent Determination for Radial Distribution Functions of In, Sn and In-40 wt%Sn Melt

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Chinese Physics Letters 2011年第12期28卷 59-62页

作者： ZHOU Yong-Zhi LI Mei geng hao-Ran YANG Zhong-Xi SUN Chun-Jing School of Materials Science and Engineering University of Jinan Jinan 250022 Shandong Transport Vocational College Weifang 261206

Hurst's exponent of radial distribution functions(RDFs)within the short-range scope of In,Sn and In-40 wt%Sn melts are determined by the rescaled range analysis ***'s exponents H are between 0.94 and 0.97,which display long−range *** short-range scope,the number of particles from a reference particle belongs to fractional Brownian *** RDF serials are randomly scrambled,Hurst's exponents all dramatically dropped,which proves long-range dependence.H irregularly varies as the temperature rises,but the change tendency is not consistent with the correlation radius rc.

关键词： method motion belongs