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genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li Lingli Ding Yage Zhang Bingyu Zhou gene c.i wai man Min Wang Jinglan Li Yamei Liu Weiping Lin Haibin Wang Sien Lin Liangliang Xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional c.inese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and func.ional *** or disability of fracture is a major health issue with important c.inical,social,and economic.implications.1 Mesenchymal stem cells(MScs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new *** use of MScs in the treatment of fractures is very attrac.ive as they can reduce the time of healing and occurrence of nonunion.

关键词： Pi3K/Akt HiF1α healing

Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of c.inese herbal medicines for endometriosis

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genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan Hung Yiran Li Yuezhen Lin Ling Wu Tao Zhang gene c.i wai man Hui Xu Jacqueline Pui Wah chung c.i c.iu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduc.ion and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina c.inese University of Hong Kong-Sichuan University Joint Laboratory in Reproduc.ive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

Distinct molecular targets of ProEGcG from EGcG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding gene c.i wai man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah chung Tak Hang chan Roman A.Zubarev c.i c.iu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological chemistry i Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden chemical Proteomics core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden center for Reproduc.ive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduc.ion and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina c.inese University of Hong Kong-Sichuan University Joint Laboratory in Reproduc.ive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatec.in gallate(ProEGcG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatec.in gallate(EGcG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGcG can be effec.ive in preventing and treating ***,1D and 2D Proteome integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGcG and ProEGcG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGcG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGcG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HiF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGcG has superior therapeutic effects than EGcG by targeting distinct signal transduc.ion pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGcG EGcG Angiogenesis Treatment Endometriosis

Effects of SARS-coV-2 infec.ion on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan celine Sze Ling chui Franco Wing Tak cheng Esther wai Yin chan c.ing Lung cheung ivan c.i Ho Au Xi Xiong wai-Kay Seto man-Fung Yuen carlos King Ho Wong ian c.i Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Prac.ice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BAcKGROUND chronic liver disease(cLD)was associated with adverse c.inical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-coV-2)*** To determine the effects of SARS-coV-2 infec.ion on the incidence and treatment strategy of hepatocellular carcinoma(Hcc)among patients with *** A retrospec.ive,territory-wide cohort of cLD patients was identified from an electronic health database in Hong *** with confirmed SARS-coV-2 infec.ion[coronavirus disease 2019(cOViD-19)+cLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(cOViD-19-cLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to Hcc(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-coV-2 *** rate ratios(iRRs)were estimated by Poisson regression *** Of 193589 cLD patients(>95%non-cirrhotic.in the cohort,55163 patients with cOViD-19+cLD and 55163 patients with cOViD-19-cLD were included after 1:1 propensity-score *** 249-d median follow-up,cOViD-19+cLD was not associated with increased risk of incident Hcc.iRR:1.19,95%ci:0.99-1.42,P=0.06),but higher risks of rec.iving palliative care for Hcc.iRR:1.60,95%ci:1.46-1.75,Pcompared to *** both acute and post-acute phases of infec.ion,cOViD-19+cLD were associated with increased risks of allcause mortality(acute:iRR:7.06,95%ci:5.78-8.63,Pcute:iRR:1.24,95%ci:1.14-1.36,Pic outcomes(acute:iRR:1.98,95%ci:1.79-2.18,Pcute:iRR:1.24,95%ci:1.13-1.35,Pcompared to *** Although cLD patients with SARS-coV-2 infec.ion were not associated with increased risk of Hcc,they

关键词： SARS-coV-2 infec.ion chronic liver disease Long cOViD Post-cOViD-19 syndrome cirrhosis Hepatocellular carcinoma

Expression and significant roles of the long non-coding RNA cASc19/miR-491-5p/HMGA2 axis in the development of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3559-3584页

作者： Li-Xiang Zhang Pan-Quan Luo Zhi-Jian Wei A-man Xu Tao Guo Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Provincial Key Laboratory of Digestive Disease Hefei 230031Anhui ProvinceChina Department of general Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina Anhui Public Health c.inical center Hefei 230000Anhui ProvinceChina

BAcKGROUND Gastric cancer(Gc.is a common malignant tumor,long non-coding RNA and microRNA(miRNA)are important regulators that affect tumor proliferation,metastasis and chemotherapy resistance,and thus participate in tumor ***19 is a new bio-marker which can promote tumor invasion and ***,the mechanism by which cASc19 affects the progression of Gc through miRNA is not *** To explore the role of the cASc19/miR-491-5p/HMGA2 regulatory axis in *** To explore the expression and prognosis of cASc19 in Gc through c.inical samples,and investigate the effects of inhibiting cASc19 on the proliferation,migration,invasion and other func.ions of Gc cells through cell counting Kit-8(ccK-8),ethynyldeoxyuridine,Wound healing assay,Transwell,Western blot and flow cytometry *** effect of miR-491-5p and HMGA2 in Gc were also *** regulatory relationship between cASc19 and miR-491-5p,miR-491-5p and HMGA2 were validated through Dual-luciferase reporter gene assay and reverse transc.iption *** ccK-8,Transwell,Wound healing assay,flow cytometry and animal experiments verify the role of cASc19/miR-491-5p/HMGA2 regulatory *** The expression level of cASc19 is related to the T stage,N stage,and tumor size of *** of the expression of cASc19 can inhibit the ability of proliferation,migration,invasion and EMT conversion of Gc cells,and knoc.ing down the expression of cASc19 can promote the apoptosis of Gc *** the expression of miR-491-5p can inhibit the proliferation of Gc cells,miR-491-5p mimics can inhibit EMT conversion,and promote the apoptosis of Gc cells,while decreasing the expression of miR-491-5p can promote the proliferation and EMT conversion and inhibit the apoptosis of Gc *** expression of HMGA2 in Gc tissues is higher than that in adjacent *** the same time,the expression level of HMGA2 is related to the N and T stages of the *** the level of HMGA2 can pr

关键词： Gastric cancer Long non-coding RNA cASc19 miR-491-5p HMGA2 Prognosis

immunoregulatory and Anti-cancer Ac.ivities of combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast cancer Bearing Mice

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c.inese Journal of integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben chung-Lap chan Grace Gar-Lee Yue Li Pei-ting Sharon Sze-man Hon HUANG Dan-qi Miranda Sin-man Tsang clara Bik-San Lau Ping-chung Leung chun-Kwok Wong institute of c.inese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioac.ivities and c.inical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of chemical Pathology The Chinese University of Hong KongHong Kong SARChina c.ina-Australia international Research centre for c.inese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio c.in R&D centre for c.inese Medicine The Chinese University of Hong Kong SARHong KongChina

Objec.ive To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBc).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse rec.ived subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups rec.ived daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group rec.ived daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injec.ion of doxorubicin(5 mg/kg).The D group rec.ived weekly intraperitoneal injec.ions of doxorubicin(5 mg/kg).The treatment naive mice rec.ived daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injec.ion once a *** control group rec.ived daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological ac.ivities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as c-c motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Picin combination treatment demonstrated synergetic ac.ivities and was most effec.ive

关键词： adjunc.ivetherapy breast cancer cytokines c.inese medicine tumor microenvironment

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Wild soybean(Glycine soja)transc.iption factor GsWRKY40 plays positive roles in plant salt tolerance

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The crop Journal 2024年第3期12卷 766-775页

作者： Minglong Li man Xue Huiying Ma Peng Feng Tong chen Xiaohuan Sun Qiang Li Xiaodong Ding Shuzhen Zhang Jialei Xiao Key Laboratory of Agricultural Biological Func.ional genes Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Key Laboratory of Soybean Biology of c.inese Education Ministry Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China college of Life Science Leshan Normal UniversityLeshan 614000SichuanChina Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudanjiang 157401HeilongjiangChina

Wild soybean(Glycine soja),a relative of cultivated soybean,shows high adaptability to adverse environmental *** identified and characterized a wild soybean transc.iption factor gene,GsWRKY40,that promotes plant salt ***40 was highly expressed in wild soybean roots and was up-regulated by salt ***40 was localized in nucleus and demonstrated DNA-binding ac.ivities but without transc.iptional *** and overexpression of GsWRKY40 altered salt tolerance of Arabidopsis *** understand the molecular mechanism of GsWRKY40 in regulating plant salt resistance,we screened a cDNA library and identified a GsWRKY40 interac.ing protein GsbHLH92 by using yeast two-hybrid *** physical interac.ion of GsWRKY40 and GsbHLH92 was confirmed by co-immunoprecipitation(co-iP),GST pull-down,and bimolecular fluorescence complementation(BiFc)***,co-overexpression of GsWRKY40 and GsbHLH92 resulted in higher salt tolerance and lower ROS levels than overexpression of GsWRKY40 or GsbHLH92 in composite soybean plants,suggesting that GsWRKY40 and GsbHLH92 may synergistically regulate plant salt resistance through inhibiting ROS ***-PcR data indicated that the expression level of GmSPOD1 gene encoding peroxidase was cooperatively regulated by GsWRKY40 and GsbHLH92,which was confirmed by using a dual luciferase report system and yeast one-hybrid *** study reveals a pathway that GsWRKY40 and GsbHLH92 collaboratively up-regulate plant salt resistance through impeding GmSPOD1 expression and reducing ROS levels,providing a novel perspec.ive on the regulatory mechanisms underlying plant tolerance to abiotic stresses.

关键词： Wild soybean Transc.iption factor Salt stress ROS

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Small Molecule Organic Nanostructures—Fabrication and Properties

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Journal of Materials Science & Technology 2008年第4期24卷 563-568页

作者： A.B.Djurii A.M.c.Ng Kai-Yin cHEUNG man-Kin FUNG wai-Kin cHAN Department of Physics University of Hong KongPokfulam RoadHong KongHong Kong SARChina Department of chemistry University of Hong KongPokfulam RoadHong KongHong Kong SARChina

Organic materials are of great interest for the development of low cost electronic and optoelectronic devices. Although majority of research on organic materials is concerned with synthesis of novel compounds and organic thin films, organic nanostructures are attrac.ing increasing interest in recent years. We briefly review different growth methods of organic nanostructures, which can be roughly divided into vapor deposition methods and self-assembly techniques in solution. Then we highlight some interesting properties of organic nanostructures, as well as possible applications, includinf field emission, electronic and optoelectronic devices.

关键词： Organic nanostructures Self-assembly Vapor deposition

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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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cancer communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao Xue Zhi-Jie Xiao Pui-c.i Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endoc.inology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South c.ina Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery ii Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(Hcc)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BcEcF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluoresc.in,acetoxymethyl ester;BSA,bovine serum albumin;ccMR,centre for comparative Medicine Research;c.iSPR,clustered regularly interspaced short palindromic repeats;cTL,ctrl;cXcR4,c-X-c chemokine Receptor Type 4;DAPi,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycyc.ine;EEA1,early endosome antigen 1;EiPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FiTc,fluoresc.in isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;Hcc,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;iAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAiD,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PcR,polymerase chain reac.ion;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RiPA,radioimmunoprecipitation assay;SAM,synergistic ac.ivation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLc9,solute carrier gene 9;SLicE,Seamless Ligation cloning Extract;TcGA,The cancer Genome Atlas;TcL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

Heat-killed Lactobacillus paracasei JY56 can relieve ovalbumin-induced food allergy via regulating immuno-inflammatory responses and gut microbiota

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Food Science and Human Wellness 2024年

作者： Miao Zheng Ming Ma Ruxue Fang Yilin Sun Xinyan Yang chaoxin man Qianyu Zhao Yujun Jiang Key Lab of Dairy Science， Ministry of Education， college of Food Science， Northeast Agricultural University

Food allergy (FA) is an aberrant immune response triggered by the ingestion of a food antigen. Ovalbumin (OVA)-sensitized and challenged BALB/c mice were orally administered heat-killed (HK)-L. paracasei JY56. in this work， HK-L. paracasei JY56 alleviated the FA-induced decrease in body weight and rectal temperature and reduced the allergy score. Serum analysis showed that HK-L. paracasei JY56 reduced the levels of specific antibodies (OVA-sigE and OVA-sigG) and allergic mediators (histamine and mast cell protease) in FA mice. in addition， HK-L. paracasei JY56 also could alleviate OVA-induced FA by suppressing Th2 and Th17-type immune responses， which was evidenced by the regulation of splenic lymphocyte subpopulations and associated cytokine secretion. Moreover， jejunal histological analysis and intestinal barrier func.ion related gene expression measurement were performed to verify the intestinal barrier repair of HK-L. paracasei JY56. Meanwhile， the TLR4/NF-κB inflammatory pathway ac.ivation was inhibited by HK-L. paracasei JY56 at gene and protein levels. Finally， HK-L. paracasei JY56 was performed to modulate the gut microbiota structure and increase the levels of short-chain fatty acids. in conclusion， HK-L. paracasei JY56 could alleviate OVA-induced FA in multiple ways， and this study provides a theoretical basis for the application of inac.ivated probiotics in func.ional foods for FA.

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