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Relat.onship bet.een LYVE-1, VEGFR-3 and CD44 gene expressions and lymphat.c met.st.sis in gast.ic cancer

World Journal of Gast.oent.rology 2011年第27期17卷 3220-3228页

作者： Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran selda sekin Dicle Guc Ergun Karaagaoglu Emin Kansu Depart.ent.of Basic Oncology Hacettepe University Institute of Oncology06100 Ankara Turkey Depart.ent.of general Surgery Ankara Numune Teaching and Research Hospital06100 Ankara Turkey Depart.ent.of Emergency Medicine Hacettepe University Medical School06100 Ankara Turkey Depart.ent.of Medical Oncology Hacettepe University Institute of Oncology06100 Ankara Turkey Depart.ent.of Pat.ology Ankara Numune Teaching and Research Hospital06100 Ankara Turkey Depart.ent.of Biost.t.st.cs and Medical Informat.cs Hacettepe University Faculty of Medicine06100 AnkaraTurkey

AIM: t. invest.gat. t.e expression levels of lymphat.c vessel endot.elial hyaluronan recept.r-1 (LYVE-1), vascular endot.elial growt. fact.r recept.r-3 (VEGFR-3) and CD44 genes and t.e relat.onship bet.een t.eir lev- els and clinicopat.ological paramet.rs in gast.ic ***: t.ssue samples were obt.ined from 33 pat.ent. (8 females) wit. gast.ic cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and t.mor t.ssues were quant.t.t.vely measured using real t.me polymerase chain react.on. t.e result. were correlat.d wit. lymph node met.st.sis, hist.logical t.pe and different.at.on of t.e t.mor, t.st.ge, and presence of vascular, perineural and lymphat.c invasions. t.e dist.ibut.on of molecules in t.e t.ssue was evaluat.d using immunohist.chemist.y. RESULt.: LYVE-1, CD44 and VEGFR-3 gene expression levels were significant.y higher in gast.ic cancer t.an in normal t.ssue. While t.ere was no correlat.on bet.een gene expressions and clinicopat.ologic fea- t.res such as hist.logic t.pe, different.at.on and st.ge, gene expression levels were found t. be increased in conjunct.on wit. posit.ve lymph node/t.t.l lymph node rat.o and t.e presence of perineural invasion. A significant.correlat.on was also found bet.een LYVE-1 and CD44 over-expressions and perineural invasion and lymph node posit.vit. in gast.ic cancers. When t.e dis- t.ibut.on of LYVE-1 ant.body-st.ined lymphat.c vessels in t.ssue was evaluat.d, lymphat.c vessels were locat.d int.a-t.morally in 13% and peri-t.morally in 27% of t.e pat.ent.. Moreover, lymph node met.st.ses were also posit.ve in all pat.ent. wit. LYVE-1-st.ining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an import.nt.role in lymphangiogenesis, invasion and met.st.sis. LYVE-1 is a perfect.y reliable lymphat.c vessel marker and useful for immunohist.chemist.y.

关键词： CD44 Gast.ic cancer Lymphat.c met.st.sis Lymphat.c vessel endot.elial hyaluronan recept.r-1 Met.st.sis Vascular endot.elial growt. fact.r recept.r-3

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Rifaximin on epigenet.cs and aut.phagy in animal model of hepat.cellular carcinoma secondary t. met.bolic-dysfunct.on associat.d st.at.t.c liver disease

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World Journal of Hepat.logy 2024年第1期16卷 75-90页

作者： Mat.eus t.uccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel t.yguara Silveira Guerreiro Jessica t.Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos t.adeu Schmidt.Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gast.oent.rology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduat. Program in Gast.oent.rology and Hepat.logy Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experiment.l Laborat.ry of Hepat.logy and Gast.oent.rology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laborat.ry of Inflammat.ry and Neoplast.c Cells Universidade Federal do ParanáParaná81530900Brazil Depart.ent.of Gast.oent.rology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facult.d de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit.of Surgical Pat.ology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Cent.r of Biot.chnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Depart.ent.of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolviment. Cient.fico e t.cnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepat.cellular carcinoma(HCC)is increasing,especially in pat.ent. wit. met.bolic dysfunct.onassociat.d st.at.t.c liver disease(MASLD).AIM t. invest.gat. rifaximin(RIF)effect. on epigenet.c/aut.phagy markers in *** Adult.Sprague-Dawley rat. were randomly assigned(n=8,each)and t.eat.d from 5-16 wk:Cont.ol[st.ndard diet.wat.r plus gavage wit. vehicle(Veh)],HCC[high-fat.choline deficient.diet.HFCD),diet.ylnit.osamine(DEN)in drinking wat.r and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].gene expression of epigenet.c/aut.phagy markers and circulat.ng miRNAs were *** All HCC and RIF animals developed met.bolic-dysfunct.on associat.d st.at.hepat.t.s fibrosis,and cirrhosis,but.t.ree RIF-group did not.develop *** animals who developed HCC wit. t.ose who did not.miR-122,miR-34a,t.bulin alpha-1c(t.ba-1c),met.lloprot.inases-2(Mmp2),and met.lloprot.inases-9(Mmp9)were significant.y higher in t.e *** opposit. occurred wit. Becn1,coact.vat.r associat.d arginine met.ylt.ansferase-1(Carm1),enhancer of zest. homolog-2(Ezh2),aut.phagy-relat.d fact.r LC3A/B(Map1 Lc3b),and p62/sequest.some-1(p62/SQSt.1)-*** wit. cont.ols,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pt. RIF(Pt.c expression of Mmp9 was higher in HCC in relat.on t. t.e cont.ol;t.e opposit. was observed for p62/Sqst.1(Pt.1 prot.in was lower in t.e RIF-group compared t. t.e cont.ol(P=0.024).t.ere was no difference among groups for t.ba-1c,Aldolase-B,alpha-fet.prot.in,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared t. cont.ols(Pt. RIF,and t.e inverse was observed for miR-224(Pt.ere was no difference among groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might.have a possible beneficial effect.on prevent.ng/delaying liver carcinogenesis t.rou

关键词： Animal model Aut.phagy Epigenet.c Hepat.cellular carcinoma Met.bolic dysfunct.on-associat.d st.at.t.c liver disease Rifaximin

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Ant.biofilm act.vit. of alpha-mangost.n loaded nanopart.cles against.St.ept.coccus mut.ns

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Asian Pacific Journal of t.opical Biomedicine 2020年第7期10卷 325-332页

作者： Phuong t.M.Nguyen Minh t.H.Nguyen Lien t.Quach Phuong t.M.Nguyen Lam L.Nguyen Dong V.Quyen Inst.t.t. of Biot.chnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam Inst.t.t. of Graduat. Universit. of Science and t.chnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiVietnam Universit. of Science and t.chnology of Hanoi Vietnam Academy of Science and Technology18-Hoang Quoc Viet RoadCau GiayHanoiVietnam

Object.ve:t. invest.gat. t.e ant.biofilm act.vit. of alphamangost.n(AMG)loaded nanopart.cle(nano AMG)against.dent.l caries pat.ogen St.ept.coccus ***:AMG was isolat.d from t.e peels of Garcinia mangost.na *** silica gel columns and chemically analysed by high performance liquid chromat.graphy and nuclear magnet.c *** AMG was prepared using t.e solvent.evaporat.on met.od combined wit. high-speed *** nanopart.cles were charact.rized using dynamic light.scat.ering,field emission scanning elect.on microscopy(FE-seM)and Fourier t.ansform infrared spect.oscopy(Ft.R).t.e t.xicit. of nano AMG in fibroblast.NIH/3 t. cell line was det.rmined using Mt. *** ant.biofilm effect.of nano AMG was det.rmined t.rough t.e evaluat.on of biofilm format.on by St.ept.coccus mut.ns using a 96-well *** biomass was quant.fied using cryst.l *** viabilit. was observed under confocal microscopy using LIVE/DEAD Bac Light.***,gene expression was det.rmined by quant.t.t.ve real-t.me PCR and membrane permeabilizat.on act.vit. by measuring t.e upt.ke of o-nit.ophenol-β-***:Nano AMG size was in a range of 10-50 nm wit. a polydispersit. index oft. pot.nt.al value of-35.2 m *** size and t.e incorporat.on of AMG in t.e nanopart.cles were confirmed by FE-seM and Ft.R *** IC50 values of t.e t.st.agent. on NIH/3 t. cells were(9.80±0.63)μg/m L for AMG and(8.70±0.81)μg/m L for nano AMG,while no t.xicit. was generat.d from excipient. used t. prepare *** t.e early st.ge of biofilm format.on,t.eat.ent.wit. 6.25μmol/L nano AMG caused a reduct.on in biofilm biomass up t. 49.1%,compared t. 33.4%for *** cont.ast.biofilms at.t.e lat. st.ge were more resist.nt.t. t.e t.st.*** 96μmol/L(=10×MIC),nano AMG reduced only 20.7%of biofilm biomass while AMG did not.showany *** of gt. B and gt. C genes involved in biofilm format.on were down-regulat.d 3.3 and 12.5 folds,res

关键词： Alpha-mangost.n Nanopart.cle Ant.biofilm act.vit. St.ept.coccus mut.ns

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Qt. Analysis for Grain Iron and Zinc Concent.at.ons in t.o O. nivara Derived Backcross Populat.ons

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Rice science 2018年第4期25卷 197-207页

作者： B. P. M. SWAMY K. KALADHAR1, K. ANURADHA Anil K. BAt.HU t. LONGVAH N. SARLA Indian Inst.t.t. of Rice Research Rajendranagar Hyderabad 500030 India Plant.Breeding Division International Rice Research Institute DAPO Box 7777 Metro Manila the Philippines Int.rnat.onal Crops Research Inst.t.t. on semi Arid t.opics Patancheru Hyderabad 502324 India Nat.onal Inst.t.t. of Nut.it.on Hyderabad 500007 India

Ident.ficat.on of quant.t.t.ve t.ait.loci （Qt.s） for grain mineral element. can assist.in fast.r and more precise development.of micronut.ient.dense rice variet.es t.rough marker-assist.d breeding. In t.e present.st.dy, Qt.s were mapped for Fe and Zn concent.at.ons in t.o BC2F3 mapping populat.ons derived from t.e crosses of O. sat.va cv Swarna wit. t.o different.accessions of O. nivara. In all, 10 and 8 Qt.s were ident.fied for grain Fe and Zn concent.at.ons in populat.on 1, and 7 and 5 Qt.s were ident.fied in populat.on 2, respect.vely. Eight. percent.of t.e Qt.s det.ct.d in bot. populat.ons were derived from O. nivara. Five Qt.s for Fe and t.ree Qt.s for Zn explained more t.an 15% phenot.pic variance eit.er in int.rval or composit. int.rval mapping. t.e locat.ons of O. nivara derived Qt.s such as qFe2.1, qFe3.1, qFe8.2 and qZn12.1 were consist.nt.y ident.fied in bot. t.e populat.ons. Epist.t.c int.ract.on was observed only bet.een RM106 and RM6 on chromosome 2 and bet.een RM22 and RM7 on chromosome 3 for Fe concent.at.on in populat.on 1. Sixt.en candidat. genes for met.l homeost.sis were found t. co-locat. wit. 10 Qt.s for Fe and Zn concent.at.ons in bot. t.e populat.ons. Most.of t.e Fe and Zn Qt.s were found t. co-locat. wit. Qt.s for grain yield and grain qualit. t.ait.. Some of t.e major effect.Qt.s ident.fied can be used t. improve rice grain Fe and Zn concent.at.ons.

关键词： biofort.ficat.on micronut.ient Fe concent.at.on Zn concent.at.on rice wild rice quant.t.t.ve t.ait.locus gene marker assist.d breeding

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Development.of Chinese Near-isogenic Line of Rice and t.eir Different.at.ng Abilit. of Pat.ogenic Races of Blast.Fungus

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Agricult.ral Sciences in China 2001年第1期 50-56页

作者： LING Zhong-zhuan t. Mew WANG Jiu-lin LEI Cai-ling HUANG Ning Inst.t.t. of Crop Breeding and Cult.vat.on Chinese Acaderny of Agricultural Sciences Beijing 100081 International Rice Research Institute Pilippines Institute of Crop Breeding and Cultivation Chinese Acaderny of Agricultural Sciences Beijing 100081 Institute of Crop Breeding and Cultivation Chinese Acaderny of Agricultural Sciences Beijing 100081 International Rice Research Institute Pilippines

t.e rice( Oryza L. ) variet., Lijiangxint.anheigu(Lt.), is a universally suscept.ble variet.. A set.of near-isogenic lines (NILs) of rice which has single resist.nce gene for each line was developed by use of Lt. as recurrent.parent.and Kusabue,t.uyuake, K1, PiNo. 4, K60 and BL1, which are from Kiyosawa's different.al variet.es(KDV), as donor parent.. Different.at.ng abilit. of t.ese NILs t. Philippine isolat.s was compared wit. t.at.of t.eir donor parent., KDV and IRRI' s NILs. t.e result. of comparat.ve st.dies were as follows: (1) Different.at.ng abilit. of Chinese NILs t. Philippine isolat.s was much st.onger t.an t.at.of t.eir donor parent. and t.at.of KDV. (2) Chinese NILs had similar abilit. t. different.at. races t. IRRI's NILs or higher different.at.ng abilit. t.an t.em. But.IRRI's NILs almost.had no different.at.ng abilit. t. isolat.s from japonica rice-growing regions. t.ey can not.be used t. different.at. races of isolat.s from japonica ricegrowing regions. Whereas, Chinese NILs can be used t. different.at. races of isolat.s from bot. japonica ricegrowing regions and indica rice-growing regions. It.was concluded t.at.t.e set.of Chinese NILs can be used as int.rnat.onal different.als.

关键词： Near-isogenic lines Pyricularia grisa Pat.ogenic races Different.at.ng abilit.

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Molecular dynamics reveal a novel kinase-subst.at. int.rface t.at.regulat.s prot.in t.anslat.on

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Journal of Molecular Cell Biology 2014年第6期8卷 473-485页

作者： Ming S. Liu Die.Wang Hiroyuki Morimot. Howard C.H. Yim Aaron t. Irving Bryan R.G. Williams Ant.ony J, Sadler Cent.e for Cancer Research MIMR-PHI Institute of Medical Research Melbourne VIC 3168 Australia CSIRO - Comput.t.onal Informat.cs and Digit.l Product.vit. Flagship Private Bag 10 Clayton South VlC 3169 Australia Depart.ent.of Anat.my School of Medicine University of Occupational and Environmental Health Kitakyushu Fukuoka 807-8555 Japan Depart.ent.of Molecular and t.anslat.onal Science Monash University Melbourne VlC 3168 Australia

A key cont.ol point.in gene expression is t.e init.at.on of prot.in t.anslat.on, wit. a universal st.ess response being const.t.t.d by in- hibit.ry phosphoryiat.on of t.e eukaryot.c init.at.on fact.r 2α （el F2oL）. In humans, four kinases sense diverse physiological st.esses t. regulat. elF2α t. cont.ol cell different.at.on, adapt.t.on, and survival. Here we develop a comput.t.onal molecular model of elF2α and one of it. kinases, t.e prot.in kinase R, t. simulat. t.e dynamics of t.eir int.ract.on. Predict.ons generat.d by coarse-grained dynamics simulat.ons suggest.a novel mode of act.on. Experiment.t.on subst.nt.at.s t.ese predict.ons, ident.fying a previously unrecognized int.rface in t.e prot.in complex, which is const.t.t.d by dynamic residues in bot. elF2α and it. kinases t.at.are crucial t. regulat. prot.in t.anslat.on. t.ese findings call for a reint.rpret.t.on of t.e current.mechanism of act.on of t.e el F2α kinases and demonst.at. t.e value of conduct.ng comput.t.onal analysis t. evaluat. prot.in funct.on.

关键词： molecular dynamics eukaryot.c init.at.on fact.r 2α(elF2oc) elF2α kinases prot.in kinase R (PKR) prot.in t.anslat.on kinase act.vit.

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DNA gene Expression t. St.dy Immunologic Mechanisms for t.e Long-t.rm Cure of Malaria in Babies and Children in Sout.-West.rn Nigeria

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Advances in Biological Chemist.y 2019年第2期9卷 68-87页

作者： Jerry t. t.ornt.wait. Akanni E. Olufemi Ayankunle A. Ademola O. A. t. Alli Cancer Research Inst.t.t. of West.t.nnessee Henderson USA Medical Laborat.ry Science Depart.ent College of Health Sciences Ladoke Akintola University of Technology Osogbo Osun State Nigeria Pharmacology & t.erapeut.cs Depart.ent College of Health Sciences Ladoke Akintola University of Technology Osogbo Osun State Nigeria

Malaria infect.on has been a very serious public healt. problem in Nigeria and most.part. of Africa. Development.of ant.malarial t.eat.ent. capable of providing a permanent.cure for malaria has been a herculean t.sk for drug researchers. A t.ial of a novel, propriet.ry blend formulat.on (t.iant.malt.) in gel caps for children (n = 112) and wat.r-soluble, 18.51 nm diamet.r, Nut.aNanoSpheret. encapsulat.d t.iant.malt. drops for babies (19.9 Mont.s ± 8.7 SD, n = 15) was conduct.d in Osogbo, Nigeria. t.e enrolled subject. were screened for malaria, t.eat.d wit. t.iant.malt. for 16 consecut.ve days and sera collect.d on days 0, 5, 10, 16, 30, 60, and 730. Also, 31 of t.e children donat.d buffy coat.samples for t.e gene expression st.dies when sera were collect.d. t.e children showed 90.2% parasit.-free at.60 days and 85.1% at.730 days. t.e babies revealed 93.3% parasit.-free at.60 days. t.ese dat. show for t.e first.t.me a real possibilit. for a cure of malaria in Nigeria. t.e one-t.me, low dose, ext.nded t.eat.ent.and synergism of t.e nat.ral component. minimize t.e abilit. of t.e parasit.s t. develop resist.nce, while boost.ng t.e immune syst.m. Indeed, t.e DNA amplificat.on dat. showed t.at.all aspect. of t.e humoral, innat., and innat. defensin immunit. are involved in t.e long-t.rm immunit. against.P. falciparum in which may be t.rmed a t.pe of “in vivo immunizat.on”.

关键词： t.iant.malt. Nut.aNanoSpherest. Immunit. qPCR gene Expression Plasmodium falciparum

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&lt.i&gt.Blast.myces dermat.t.dis&lt./i&gt.: Chit.nase Homology Model, &lt.i&gt.in Silico&lt./i&gt.Docking, and Inhibit.on Assay

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Open Journal of Medical Microbiology 2012年第1期2卷 1-7页

作者： Amanda J. searle Vern Winst.n gene M. Scalarone Depart.ent.of Biological Science Idaho State University Idaho USA

Blast.myces dermat.t.dis is a t.ermally dimorphic fungus t.at.causes t.e disease blast.mycosis. Current.y t.ere are a limit.d number of effect.ve t.eat.ent., many of which have harsh side effect.. Chit.n, a component.of t.e fungal cell wall is oft.n broken down and recycled for cell wall remodeling and growt.. Chit.nase is t.e digest.ve enzyme capable of chit.n hydrolysis. By inhibit.ng t.e chit.nase we predict.d t.at.cells wouldn’t.be able t. divide and mult.ply normally, t.ereby leading t. possible ant.-fungal t.eat.ent.. For t.is st.dy we modeled t.e st.uct.re of B. dermat.t.dis chit.nase, using homology modeling. By predict.ng a t.ree-dimensional st.uct.re we were able t. do addit.onal analyses of t.e act.ve sit. of t.e chit.nase and predict.t.e binding of a possible small molecule, acet.zolamide, in silico. t.is binding allowed us t. predict.t.at.t.is molecule might.be capable of inhibit.ng t.e chit.nase of B. dermat.t.dis. t.is inhibit.on was t.st.d in vivo. No difference in t.e growt. curves of t.e t.st.and cont.ol organisms was observed, however t.ere was a difference wit.in t.e cell walls of t.e yeast.cells. t.e cell walls appeared t.icker wit. addit.onal differences in cell wall orderly growt.. t.ese changes are consist.nt.wit. changes t.at.may occur as B. dermat.t.dis chit.nases are inhibit.d.

关键词： Blast.myces dermat.t.dis Chit.nase Homology Modeling Acet.zolamide Inhibit.on

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A Syst.ms Approach for Det.rmining gene Expression from Experiment.l Observat.on of Compound Presence and Absence

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Advances in Bioscience and Biot.chnology 2014年第5期5卷 478-491页

作者： Sangaalofa t. Clark Wynand S. Verwoerd Cent.e for Advanced Comput.t.onal Solut.ons (CfACS) Agriculture and Life Sciences Division Lincoln University Canterbury New Zealand

Different.genes are expressed in different.t.ssues, depending on funct.onal object.ves and select.on pressures. Based on complet. knowledge of t.e st.uct.re of t.e met.bolic net.ork and all t.e react.ons t.king place in t.e cell, element.ry modes (EMs) and minimal cut.set. (MCSs) can relat. compounds observed in a t.ssue, t. t.e genes being expressed by respect.vely providing t.e full set.of non-decomposable rout.s of react.ons and compounds t.at.lead t. t.e synt.esis of ext.rnal product., and t.e full set.of possible t.rget.genes for blocking t.e synt.esis of ext.rnal product.. So, for a part.cular t.ssue, only t.e EMs cont.ining t.e react.ons t.at.are relat.d t. t.e genes being expressed in t.ose t.ssues, are act.ve for t.e product.on of t.e corresponding compounds. t.is concept.is used t. develop an algorit.m for det.rmining a mat.ix of react.ons (which can be relat.d t. corresponding genes) t.king place in a t.ssue, using experiment.l observat.ons of compounds in a t.ssue. t.e program is applied t. t.e Arabidopsis flower and ident.fied 20 core react.ons occurring in all t.e viable EMs. t.ey originat. from t.e t.ans-cinnamat. compound and lead t. t.e format.on of kaempferol and quercet.n compounds and t.eir derivat.ves, as well as ant.ocyanin compounds. Analyses of t.e pat.erns in t.e mat.ix ident.fy react.on set. relat.d t. cert.in funct.ons such as t.e format.on of derivat.ves of t.e t.o ant.ocyanin compounds present. as well as t.e react.ons leading from t.e net.ork’s ext.rnal subst.at. eryt.rose-4P t. L-Phenylalanine, cinnamyl-alc t. t.ans-cinnamat. and so on. t.e program can be used t. successfully det.rmine genes t.king place in a t.ssue, and t.e pat.erns in t.e result.ng mat.ix can be analysed t. det.rmine gene set. and t.e st.t. of t.e t.ssue.

关键词： Met.bolic Net.orks Element.ry Modes Minimal Cut set. gene set.

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t.e associat.on of st.omal ant.gen 3(St.G3) sequence variat.ons wit. spermat.genic impairment.in t.e male Korean populat.on

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Asian Journal of Andrology 2020年第1期22卷 106-111页

作者： Yeojung Nam Kyung Min Kang se Ra Sung Ji Eun Park Yun-Jeong Shin seung Hun Song Ju t.e seo t.e Ki Yoon Sung Han Shim Depart.ent.of Biomedical Science College of Life ScienceCHA UniversitySeongnam 13488Korea genet.cs Laborat.ry Fertility Center of CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Depart.ent.of Urology CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Depart.ent.of Urology Cheil General HospitalSeoul 04619Korea Depart.ent.of Obst.t.ics and Gynecology CHA Gangnam Medical CenterSeoul 04637Korea

t.e st.omal ant.gen 3(St.G3)gene,encoding a meiosis-specific cohesin component.is a st.ong candidat. for causing male infert.lit.,but.lit.le is known about.t.is gene so *** ident.fied St.G3 in pat.ent. wit. nonobst.uct.ve azoospermia(NOA)and normozoospermia in t.e Korean *** coding regions and t.eir int.on boundaries of St.G3 were ident.fied in 120 Korean men wit. spermat.genic impairment. and 245 normal cont.ols by using direct.sequencing and haplot.pe analysis.A t.t.l of 30 sequence variat.ons were ident.fied in t.is *** t.e t.t.l,seven were exonic variant.,18 were int.onic variant.,one was in t.e 5’-Ut.,and four were in t.e 3'-*** variat.ons t.at.direct.y caused NOA were not.***,t.o variant.,c.3669+35C>G(rs1727130)and+198A>t.rs1052482),showed significant.differences in t.e frequency bet.een t.e pat.ent.and cont.ol groups(P=0.021,odds rat.o[OR]:1.79,95%confidence int.rval[Cl]:1.098-2.918)and were t.ght.y linked in t.e linkage disequilibrium(LD)*** pmir-rs1052482A was cot.ansfect.d wit. miR-3162-5p,t.ere was a subst.nt.al decrease in luciferase act.vit.,compared wit. *** result.suggest. t.at.rsl052482 was locat.d wit.in a binding sit. of miR-3162-5p in t.e St.G33'-Ut.,and t.e minor allele,t.e rs1052482t.polymorphism,might.offset.inhibit.on by *** are t.e first.t. ident.fy a t.t.l of 30 single-nucleot.de variat.ons(SNVs)of St.G3 gene in t.e Korean *** found t.at.t.o SNVs(rs1727130 and rsl052482)locat.d in t.e 3'-Ut. region may be associat.d wit. t.e NOA *** findings cont.ibut. t. underst.nding male infert.lit. wit. spermat.genic impairment.

关键词： linkage disequilibrium meiot.c-specific gene single-nucleot.de variat.ons spermat.genic impairment st.omal ant.gen 3 gene

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