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Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 395-401页

作者： Wei-xing CHEN Chuan-qin xu Shao-hua CHEN gen-yun xu Huai-zhuang YE Department of Gastroenterology the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Public Health School of MedicineZhejiang UniversityHangzhou 310003China

Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with al- cohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant dif- ferences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citri

关键词： Ethanol Citric acid Event-related potential (ERP) P300 Cognitive function Acetaldehyde

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Synthesis and NHE1 inhibitory activity of ligustrazine derivatives

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Chinese Chemical Letters 2007年第5期18卷 539-541页

作者： Mei Ren yun gen xu Na Wen Da Yong Zhang Wei Yi Hua Center of Drug Discovery China Pharmaceutical University Nanjing 210009 China Department of Pharmacology China Pharmaceutical University Nanjing 210009 China

A series of novel derivatives of ligustrazine linked with substituted benzoyl guanidine were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, ^1H NMR and MS. The results of NHE1 inhibitory activity test showed that compounds I2, I3, I4, I6, and I7 possess more potent NHE1 inhibitory activity than cariporide.

关键词： Na^+/H^+ exchanger inhibitors Ligustrazine derivatives Benzoyl guanidine derivatives Synthesis

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Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice

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World Journal of Gastroenterology 2014年第28期20卷 9513-9518页

作者： Guo-Qiang xu Cheng-Fu xu Hong-Tan Chen Shan Liu Xiao-Dong Teng gen-yun xu Chao-Hui Yu Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Laboratory Medicine the First Affiliated HospitalCollege of MedicineZhejiang University

AIM: To investigate the role of caveolin-3 (CAV3) and cholecystokinin A receptor (CCKAR) in cholesterol gallstone disease (CGD).

关键词： Cholesterol gallstone disease Caveolin-3 Cholecystokinin A receptor Lithogenic diet Mechanism

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Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study

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World Journal of Gastroenterology 2014年第33期20卷 11865-11870页

作者： Ping xu Cheng-fu xu Xing-yong Wan Chao-hui yu Chao Shen Peng Chen gen-yun xu You-ming Li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University International Health Care Center the First Affiliated Hospital College of Medicine Zhejiang University Department of Laboratory Medicine the First Affiliated Hospital College of Medicine Zhejiang University

AIM: To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population.

关键词： Fatty liver Alpha-fetoprotein Association Obesity Risk factor

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Correlation of polymorphism in the interleukin-1 receptor antagonist gene intron 2 with alcoholic liver disease

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 41-45页

作者： Wei-Xing Chen gen-yun xu Chao-Hui Yu Ping Wang Min Yu Ping xu You-Shi Liu You-Ming Li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China.

BACKGROUND: Interleukin-1 receptor antagonist (IL-1ra) can inhibit the pro-inflammatory effects of IL-1, which recently has been thought to involve the pathogenesis of alcoholic liver disease (ALD). This study was undertaken to determine whether there is any association between IL-1ra gene polymorphism and ALD in a Chinese population.METHODS: The polymorphism of IL-1ra gene intron 2 (VNTR) was assessed in 165 alcoholics (43 alcohol-dependent subjects without liver diseases, 30 patients with alcoholic fatty liver, 61 patients with alcoholic hepatitis and 31 patients with alcoholic cirrhosis) and 65 healthy control subjects by PCR with DNA of peripheral blood mononuclear cells.RESULTS: The rate of IL-1RN*1 carriage was statistically higher in the alcoholics than in the control group (98.79% vs 93.85%, chi2=4.48, Pgene polymorphism is closely associated with race. IL-1RN*2 allele doesn't influence the susceptibility to ALD, but the gene carriers with ALD have additional risk for aggravation of the illness.

关键词： interleukin-1 receptor antagonist gene polymorphism alcoholic liver disease

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Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study

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World Journal of Gastroenterology 2008年第14期14卷 2255-2261页

作者： Zhe Shen You-Ming Li Chao-Hui Yu Yi Shen Lei xu Cheng-Fu xu Jin-Jin Chen Hua Ye gen-yun xu Department of Gastroenterology The First Affiliated Hospital Medicine School Zhejiang University Hangzhou 310003 Zhejiang Province China Department of Statistics Medicine School Zhejiang University Hangzhou 310000 Zhejiang Province China Department of Clinical Laboratory The First Affiliated Hospital Medicine School Zhejiang University Hangzhou 310003 Zhejiang Province China

AIM:To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of ***:Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done. RESULTS:Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury (P < 0.05). The odds-ratio (OR) (95% CI) was 1.965 (1.122-3.442), 3.412 (1.789-6.507) and 1.887 (1.261-2.824), respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and < 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking ***:The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned.

关键词： Alcohol Liver injury Prevalence Case-control study Epidemiology

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Effect of acute alcoholism on hepatic enzymes and oxidation/antioxidation in rats

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 241-244页

作者： You-Ming Li, Shao-Hua Chen, Chao-Hui Yu, Yu Zhang and gen-yun xu Hangzhou, China Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 . Chi- na Department of Digestive Medicine First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

BACKGROUND: Around the world more and more people suffer from acute alcoholism. The purpose of this study was to determine hepatic enzymes and oxidation/antioxidation in rats with acute alcoholism. METHODS: Rats were randomly divided into three groups; control, low-dose alcohol, and high-dose alcohol. Each al- cohol group ( n = 12) was intravenously infused with etha- nol at a dose of 0.3 or 0.7 g/kg body weight respectively. The control group (n =11) was intravenously infused with normal saline at a dose of 0.5 g/kg body weight. Blood was collected for detection of hepatic enzymes and index of oxidation/antioxidation. RESULTS: The ratio of AST to ALT was 2.44±0.46, 2.57± 0.60 and 3.03 ±0.46 in the three groups, and the difference was significant between the control and high-dose alcohol groups (P^0.05). No significant changes were observed in the levels of serum alanine aminotransferase (ALT), aspar- tate aminotransferase (AST), total protein (Tp), albumin (Alb), alkaline phosphatase (ALP), cholinesterase (ChE), total bilirubin (TB), C-reactive protein (CRP) and amy- lase. The levels of serum nitric oxide (NO) in the 3 groups were 39.2 ±73.25 mol/L, 42.30 ±4.60 mol/L and 47.86± 4.66 mol/L, and significant difference was seen between the control group and the high-dose alcohol group (P < 0.01). No significant difference was found in the levels of serum superoxide dismutase (SOD), glutathione (GSH), malondiethylaldehyde (MDA), and CRP in the 3 groups. CONCLUSION: The ratio of AST to ALT appears to be a useful index for acute alcohol intoxication. NO is involved in the mechanism of acute alcohol intoxication.

关键词： alcoholism infusion nitric oxide oxidation/antioxidation animal model hepatic enzyme

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Monitoring the level of serum paraoxonase 1 activity in liver transplantation patients

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 178-181页

作者： gen-yun xu, Guo-Cai Lv, Yu Chen, Yong-Chuan Hua, Shen-Mei Zhu and Yi-Da Yang Hangzhou, China Clinical Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Clinical Laboratory First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. genyunxu@***

BACKGROUND: Paraoxonase 1(PON1) is an ester hydro- lase in serum and in the liver. Studies have suggested that PON1 measurement to the current battery of tests may im- prove the evaluation of chronic liver diseases. The aim of this study was to investigate the clinical significance of mo- nitoring the level of serum PON1 activity in liver transplan- tation patients. METHODS: A series of biochemical indexes were moni- tored in preoperative, operative and postoperative serum samples of 17 liver-transplanted patients. The change of se- rum PON1 level and its relations with other biochemical in- dexes were analyzed. RESULTS: PON1 was distributed normally in the healthy population and its reference value ranged from 45.5 to 265.8 U/mL. The PON1 level of all patients was lower than that of control group significantly (P<0.001); the level be- gan to elevate continuously 5 minutes after opening of the portal vein and was higher than that 90 minutes after open- ing of the portal vein ( P <0.05). Two days after operation it was still higher than the normal. The levels of serum ALT and AST elevated more significantly after opening of the portal vein than before operation and they were higher than the normal values till 2 days after the operation. CONCLUSIONS: The level of PON1 in serum may be taken as one of the effective indexes to assess whether the implant is alive and to monitor liver function of the patient together with other tests.

关键词： paraoxonase 1 liver transplantation alanine transaminase aspartate transaminase γ-glutamyltransferase cholinesterase

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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