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Traditional Chinese surgical treatment for anal fistulae with secondary tracks and abscess

World Journal of Gastroenterology 2012年第40期18卷 5702-5708页

作者： Chen Wang Jin-gen lu Yong-Qing Cao Yi-Bo Yao Xiu-Tian Guo Hao-Qiang Yin Department of Anorectal Surgery Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medi- cine Shanghai 200032 China Department of Imaging Longhua Hospital Af- filiated to Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

AIM:To evaluate the efficacy and safety of traditional Chinese surgical treatment for anal fistulae with secondary tracks and ***:Sixty patients with intersphincteric or transsphincteric anal fistulas with secondary tracks and abscess were randomly divided into study group [suture dragging combined with pad compression(SDPC)] and control group [fistulotomy(FSLT)].In the SDPC group,the internal opening was excised and incisions at external openings were made for *** sutures were put through every two incisions and knotted in loose *** suture dragging process started from the first day after surgery and the pad compression process started when all sutures were removed as wound tissue became fresh and without *** the FSLT group,the internal opening and all tracts were laid open and cleaned by normal saline postoperatively till all wounds *** time of healing,postoperative pain score(visual analogue scale),recurrence rate,patient satisfaction,incontinence evaluation and anorectal manometry before and after the treatment were ***:There were no significant differences between the two groups regarding age,gender and fistulae *** time of healing was significantly shorter(24.33 d in SDPC vs 31.57 d in FSLT,P < 0.01) and the patient satisfaction score at 1 mo postoperative followup was significantly higher in the SDPC group(4.07 in SDPC vs 3.37 in FSLT,P < 0.05).The mean maximal postoperative pain scores were 5.83 ± 2.5 in SDPC vs 6.37 ± 2.33 in FSLT and the recurrence rates were 3.33 in SDPC vs 0 in *** of the patients in the two groups experienced liquid and solid fecal incontinence and lifestyle alteration *** Wexner score after treatment of intersphincter fistulae were 0.17 ± 0.41 in SDPC vs 0.40 ± 0.89 in FSLT and transsphincter fistulae were 0.13 ± 0.45 in SDPC vs 0.56 ± 1.35 in *** maximal squeeze pressure and resting pressure declined after treatment in both *** maximal anal

关键词： Traditional Chinese surgical treatment Su- ture dragging Pad compression Anal fistulae Second-ary tracks and abscess

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Lactobacillus crispatus M206119 exacerbates murine DSS-colitis by interfering with inflammatory responses

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World Journal of Gastroenterology 2012年第19期18卷 2344-2356页

作者： Fu-Xi Zhou lu Chen Xiao-Wei Liu Chun-Hui Ouyang Xiao-Ping Wu Xue-Hong Wang Chun-Lian Wang Fang-gen lu Division of Digestive Disease Xiangya Second-HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM： TO investigate the role of Lactobacillus crispatus （L. crispatus） strain China Center for Type Culture Col- lection （CCTCC） M206119 in intestinal inflammation.METHODS： Forty 8-wk-old Balb/c mice （20± 2 g） were divided into four groups of 10 mice each. Three groups that had received dextran sulfate sodium （DSS） were administered normal saline, sulfasalazine or CCTCC M206119 strain, and the fourth group received none of these. We assessed the severity of colitis using a disease activity index, measured the colon length and weight, collected stools and mesenteric lymph nodes for bacterial microflora analysis. One centimeter of the proximal colon, middle colon and distal colon were collected and fixed in 10% buffered formalin, dehydrated in ethanol, and embedded in paraffin. Interleukin （IL）- 1β, IL-6 and tumor necrosis factor （TNF）-α expression was detected using reverse transcription polymerase chain reaction. Protective factors zonula occludens （ZO）-1 and β-defensin 2 were detected by immunoblot-ting. The features of CCTCC M206119 strain were identified based on morphology, biochemical profile, and 16S RNA sequencing.RESULTS： DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease, with greater weight loss, diarrhea, fecal bleeding, and shortened colon length. In addition, the CCTCC-M206119- treated group had comparatively higher histologi- cal scores and more neutrophil infiltration than the controls. Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment. An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells. Intestinal proinflam- matory or anti-inflammatory cytokine responses were evaluated. Proinflammatory colonic cytokine （IL-Iβ, IL-6 and TNF-α） levels were clearly increased in CCTCC- M206119-treated animals, whereas anti-inflammatory colonic cytokine （IL-

关键词： Colitis Lactobacillus crispatus Intestine Dextra sodium sulfate Mice

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Correlation between ultrasonographic and pathologic diagnosis of liver fibrosis due to chronic virus hepatitis

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World Journal of Gastroenterology 2006年第8期12卷 1292-1295页

作者： Lei Shen Ji- Qiang Li Min-De Zeng lun-gen lu Si-Tao Fan Han Bao Department of Gastroenterology Shanghai Second Medical University Renji Hospital Shanghai Institute of Digestive Disease Shanghai 200001 China

AIM： TO evaluate the validity of ultrasonographic and pathologic diagnosis of liver fibrosis in patients with chronic viral hepatitis. METHODS： The liver fibrosis status in 324 patients was evaluated by both needle biopsy and ultrasonography. Liver fibrosis was divided into SO -S4 stages. S4 stage was designated as definite cirrhosis. The ultrasonographic examination included qualitative variables, description of liver surface and parenchyma, and quantitative parameters, such as diameter of vessels, blood flow velocity and spleen size. RESULTS： Ultrasonographic qualitative description of liver surface and parenchyma was related with the severity of fibrosis. Among the quantitative ultrasonographic parameters, cut-off value of spleen length （12.1 cm） had a sensitivity of 0.600 and a specificity of 0.753 for diagnosis of liver cirrhosis. The diameters of spleen （8 mm） and portal vein （12 mm） had a diagnostic sensitivity of 0.600 and 0.767, and a diagnostic specificity of 0.781 and 0.446, respectively. The diagnostic accuracy for liver cirrhosis was moderately satisfactory, and the negative predictive values of these parameters reached near 0.95. CONCluSION： Ultrasonography can predict the degree of liver fibrosis or cirrhosis. A single ultrasonographic parameter is limited in sensitivity and specificity for the diagnosis of early cirrhosis. The presence or absence of liver cirrhosis in patients with chronic virus hepatitis can be detected using 2 or 3 quantitative and qualitative pa- rameters, especially the length of spleen, the diameter of spleen vein and echo pattern of liver surface.

关键词： Chronic viral hepatitis Liver biopsy Ultrasonography

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ABSTRACTS OF CHINESE MEDICAL LITERATURE

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Chinese Medical Journal 1995年第6期 14-,21+24+29+35+39+45页

作者： lu gen, Feng Jiemei,Huang Jian, et al. Guangzhou Institute of Tuberculosis, Guangzhou 510180. Chin J Tuberculosis & Respirat Dis 1995

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Light Pollution in Beijing and Effects on Xinglong Station of National Astronomical Observatory

Light Pollution in Beijing and Effects on Xinglong Station o...

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中国科协第249次青年科学家论坛——照明对生态环境影响的量化观测与评价

作者： Li-gen lu Bao-zhou Zhang Jian Liu Shan-shan Zeng Dept.of Astronomy Beijing Normal University Beijing Key Laboratory of Applied Optics Dept.of Physics Beijing Normal University

A night-sky luminance survey was carried on in Beijing to assess the level of light *** luminance of the zenith night sky and skies in four directions at six sites almost in line with different distances from the city center was measured by using a photometric luminance *** Xinglong Station of National Astronomical Observatory was included to study the impacts of city lightings on an astronomical *** survey shows that the night-sky luminance at zenith decreases with increasing distance from the city center,and time is also an important determining factor of the night-sky *** with the night-sky luminance at Lingshan observation site which is closer to the city center,the night-sky luminance at Xinglong Station is about 21.4 mag/arcsec,indicating that night sky at Xinglong Station has been brightened by outdoor lighting of the county town of Xinglong.

关键词： night-sky luminance astronomical observatory outdoor lighting light pollution

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儿童重症腺病毒肺炎的早期识别与诊治进展

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中华实用儿科临床杂志 2023年第11期38卷 833-837页

作者：樊慧峰卢根广州医科大学附属广州市妇女儿童医疗中心呼吸科广州510623

腺病毒肺炎是儿童常见的呼吸道感染,重症患儿具有起病急、进展快、并发症多的特点,因此早期识别与诊断尤为重要。近年来从病原、宿主、实验室检查及生物标志物等多方面进行了研究,为儿童重症腺病毒肺炎早期识别与诊断提供了新的临床线... 详细信息

腺病毒肺炎是儿童常见的呼吸道感染,重症患儿具有起病急、进展快、并发症多的特点,因此早期识别与诊断尤为重要。近年来从病原、宿主、实验室检查及生物标志物等多方面进行了研究,为儿童重症腺病毒肺炎早期识别与诊断提供了新的临床线索。目前尚无用于重症腺病毒肺炎的特效抗病毒药物,主要治疗策略为免疫调节及呼吸支持,大量临床研究为规范治疗策略、改善患儿预后提供了新的思路。

关键词：重症腺病毒肺炎儿童早期识别诊断治疗

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儿童肺部马尔尼菲篮状菌感染的诊治进展

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中国实用儿科杂志 2024年第2期39卷 107-111,160页

作者：徐雪花卢根广州医科大学附属妇女儿童医疗中心呼吸科广东广州510623

马尔尼菲篮状菌是一种地方性机会致病真菌,主要流行于东南亚国家及中国南部。近年来,马尔尼菲篮状菌感染的发病率不断增加,在儿童中多见于免疫出生错误者。马尔尼菲篮状菌主要通过呼吸道入侵人体,感染可累及全身多组织器官,最常见的是... 详细信息

马尔尼菲篮状菌是一种地方性机会致病真菌,主要流行于东南亚国家及中国南部。近年来,马尔尼菲篮状菌感染的发病率不断增加,在儿童中多见于免疫出生错误者。马尔尼菲篮状菌主要通过呼吸道入侵人体,感染可累及全身多组织器官,最常见的是肺部受累。儿童马尔尼菲篮状菌感染缺乏特异性的临床表现,易导致误诊或诊断延迟,病死率高。该文主要介绍马尔尼菲篮状菌及其感染的致病机制、临床特点、诊断和治疗进展。

关键词：马尔尼菲篮状菌儿童肺部诊治

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A multi-center study on genetic variations in the fusion protein of respiratory syncytial virus from children with Acute Lower Respiratory Tract Infections in China during 2017-2021

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Virologica Sinica 2024年第5期39卷 727-736页

作者： Yiliang Fu Fei Li Yun Zhu luci Huang Qiuping Li Hanwen Zhang Lili Zhong Hailin Zhang Zheng-xiu luo gen lu Jikui Deng Lingfeng Cao Ying Wu Rong Jin Lei Li Lili Xu Xiangpeng Chen Zhengde Xie Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesNational Key Discipline of Pediatrics(Capital Medical University)Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Research Unit of Critical Infection in Children Chinese Academy of Medical SciencesBeijing 100045China Hunan Provincial People's Hospital The First Afﬁliated Hospital of Hunan Normal UniversityChangsha 410005China Department of Children's Respiration Disease The Second Afﬁliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhou 325027China Department of Respiratory Medicine National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChildren's Hospital of Chongqing Medical UniversityChongqing 400015China Guangzhou Women and Children's Medical Center Guangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518026China Department of Clinical Laboratory Children's Hospital of Fudan UniversityShanghai 201102China Department of Clinical Laboratory Medicine National Children's Medical CenterShanghai Children's Medical CenterSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Guiyang Maternal and Child Health Hospital Guiyang 550003China Yinchuan Maternal and Child Health Care Hospital Yinchuan 750001China

Respiratory syncytial virus(RSV)is a signiﬁcant cause of acute lower respiratory tract infection(ALRTI)in children underﬁve years of *** 2017 and 2021,396 complete sequences of the RSV F gene were obtained from 500 RSV-positive throat swabs collected from ten hospitals across nine provinces in *** addition,151 sequences from China were sourced from genBank and GISAID,making a total of 549 RSV F gene sequences subjected to *** and genetic diversity analyses revealed that the RSV F genes circulating in China from 2017 to 2021 have remained relatively conserved,although some amino acids(AAs)have undergone *** mutations with frequencies10%were identiﬁed at six sites and the p27 region:V384I(site I),N276S(site II),R213S(siteØ),and K124N(p27)for RSV A;F45L(site I),M152I/L172Q/S173 L/I185V/K191R(site V),and R202Q/I206M/Q209R(siteØ)for RSV *** mutational frequencies in RSV-F before and after 2020 revealed minor changes for RSV A,while the K191R,I206M,and Q209R frequencies increased by over 10%in RSV ***,the nirsevimab-resistant mutation,S211N in RSV B,increased in frequency from 0%to 1.15%.Both representative strains aligned with the predicted RSV-F structures of their respective prototypes exhibited similar conformations,with low root-mean-square deviation *** results could provide foundational data from China for the development of RSV mAbs and vaccines.

关键词： Human respiratory syncytial virus(RSV) Children Fusion glycoprotein Antigenic epitope Variation

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植物篱技术在湖北坡耕地治理中的应用和效益分析

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长江科学院院报 2009年第3期26卷 9-12页

作者：马根录湖北省水土保持监测中心武汉430071

坡耕地是湖北省水土流失的主要策源地之一,坡耕地治理是小流域综合治理的重要组成部分。肯定了湖北目前采用最为广泛的坡耕地治理措施——坡改梯措施发挥的巨大作用,同时指出其存在的缺点。植物篱技术作为一种很有潜力的坡地持续利用技... 详细信息

坡耕地是湖北省水土流失的主要策源地之一,坡耕地治理是小流域综合治理的重要组成部分。肯定了湖北目前采用最为广泛的坡耕地治理措施——坡改梯措施发挥的巨大作用,同时指出其存在的缺点。植物篱技术作为一种很有潜力的坡地持续利用技术,能把发挥坡地资源优势与防治坡地退化有机结合起来,在湖北坡耕地治理中应用前景广阔。

关键词：坡耕地治理坡改梯植物篱湖北省

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湖北丹江口库区及上游水土保持工程建设存在的问题及对策

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中国水土保持 2009年第6期 58-59页

作者：马根录湖北省水土保持监测中心湖北武汉430071

介绍了湖北丹江口库区及上游水土保持重点防治工程的基本情况,总结了工程实施过程中存在的主要问题并提出了对策及建议,包括增强认识建设意义、明确建设目标和投资方向、落实项目配套、调整措施单价、加大宣传力度、建立长效机制等,对... 详细信息

介绍了湖北丹江口库区及上游水土保持重点防治工程的基本情况,总结了工程实施过程中存在的主要问题并提出了对策及建议,包括增强认识建设意义、明确建设目标和投资方向、落实项目配套、调整措施单价、加大宣传力度、建立长效机制等,对于加快丹江口库区水土保持重点防治工程的顺利实施具有十分重要的意义。

关键词：水土保持工程问题对策丹江口库区及上游湖北

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