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Therapeutic Roles of Bile Acid Signaling in Chronic Liver Diseases

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 425-430页

作者： Yan Li lun-gen lu Department of Gastroenterology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghaiChina

Bile acids(BAs)are the major metabolic product of cholesterol,having detergent-like activities and being responsible for absorption of lipid and lipid-soluble *** addition,it has been increasingly recognized that BAs are important signaling molecules,regulating energy metabolism and *** physiological circumstances,synthesis and transport of BAs are precisely regulated to maintain bile acid *** of bile acid homeostasis results in pathological cholestasis and metabolic liver *** the last decades,BAs have been gradually recognized as an important therapeutic target for novel treatment in chronic liver *** review will provide an update on the current understanding of synthesis,transport and regulation of BAs,with a focus on the therapeutic roles of bile acid signaling in chronic liver diseases.

关键词： BAs Cholestasis Chronic liver diseases FXR TGR5

Antihepatic Fibrosis Drugs in Clinical Trials

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 304-312页

作者： Yue-Cheng Guo lun-gen lu Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiao Tong University School of MedicineShanghaiChina Department of GastroenterologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Liver fibrosis is not an independent *** refers to the abnormal proliferation of connective tissues in the liver caused by various pathogenic *** far,liver fibrosis has been considered to be associated with a set of factors,such as viral infection,alcohol abuse,non-alcoholic fatty liver disease,and autoimmune hepatitis,as well as genetic *** date,clinical therapeutics for liver fibrosis still face challenges,as elimination of potential causes and conventional antifibrotic drugs cannot alleviate fibrosis in most ***,potential therapeutic targets of liver fibrosis,such as metabolism,inflammation,cell death and the extracellular matrix,have been explored through basic and clinical ***,it is extremely urgent to review the antihepatic fibrosis therapeutics for treatment of liver fibrosis in current clinical trials.

关键词： Liver fibrosis Therapeutics Clinical trial Cholestatic liver diseases Non-alcoholic steatohepatitis

Structure Evolution Mechanism of Poly(acrylonitrile/itaconic acid/acrylamide) during Thermal Oxidative Stabilization Process

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Chinese Journal of Polymer Science 2017年第8期35卷 1020-1034页

作者： zhao-po zeng ze-chun shao 肖茹 yong-gen lu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of Materials Science and Engineering Donghua University Shanghai 201620 China

Polyacrylonitrile （PAN） polymers with different compositions were prepared by an efficient aqueous free-radical polymerization technique. Thermal properties of polyacrylonitrile homopolymer （PAN）, poly（acrylonitrile/itaconic acid） [P（AN/IA）] and poly（acrylonitrile/itaconic acid/acrylamide） [P（AN/IA/AM）] were studied by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and thermogravimetry in detail. It was found that AM had the ability to initiate and accelerate thermal oxidative stabilization process, which was confirmed by the lower initiation temperature and broader exothermic peak in P（AN/IA/AM） as compared with that in P（AN/IA） and PAN. The intensity of heat releasing during the thermal treatment was relaxed due to the presence of two separated exothermic peaks. Accompanied by DSC analysis and calculation of the apparent activation energy of cyclization reaction, two peaks were assigned to the ionic and free radical induction mechanisms, respectively. The higher rate constant in P（AN/IA/AM） indicated that the ionic mechanism actually had a kinetic advantage at promoting thermal stability over the free radical mechanism. This study clearly show that the synthesized P（AN/IA/AM） terpolymers possess larger room to adjust manufacture parameters to fabricate high performance of PAN-based carbon fibers.

关键词： PAN terpolymers Structural evolution Thermal oxidative stabilization Thermal analysis Kinetics

β-Cyclodextrin and its derivatives-enhanced solubility and biodegradation of 2-nitrobiphenyl

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Journal of Environmental Sciences 2006年第6期18卷 1157-1160页

作者： CAI Bang-cheng GAO Shi-xiang lu gen-fa State Key Laboratory of Pollution Control and Resource Reuse School of Environment Nanjing University Nanjing 210093 China

This paper investigated the effects of β-cyclodextrins （I3-CD） and its two derivatives, hydroxypropyl-β-cyclodextrin （HPCD） and carboxymethyl-β-cyclodextrin （CMCD）, on the solubility and biodegradation of 2-nitrophenyl by an A cinetbacter sp. Results showed that β-CD, HPCD and CMCD could not be utilized by A cinetbacter sp. as sole carbon source and none of the CDs had toxic effects on the growth of the bacteria in the experiments; all the CDs could enhance the apparent solubility and accelerate the biodegradation of 2-nitrobipheny. It showed that biodegradation-accelerating effects of CDs on 2-nitrobiphenyl were correlated with their solubility-enhancing effects. Among three CDs investigated, CMCD had the most obvious effects both on the apparent solubility and the biodegradation, followed by β-CD and HPCD.

关键词： β-CD HPCD CMCD 2-nitrophenyl biodegradation

Antiviral Therapy of Liver Cirrhosis Related to Hepatitis B Virus Infection

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Journal of Clinical and Translational Hepatology 2014年第3期2卷 197-201页

作者： lun-gen lu Department of Gastroenterology Shanghai First People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China

Hepatitis B virus (HBV) infection is a leading cause of liver disease worldwide,with 75% of those affected distributed in the Asia-Pacific *** one million HBV-infected patients die of liver cirrhosis and hepatocellular carcinoma (HCC) each *** left untreated,6-20% of chronic hepatitis B (CrHB) patients will develop cirrhosis over five *** cumulative incidence of HBV-related cirrhosis,disease progression,and prognosis are closely associated with serum HBV DNA *** therapy in HBV-related cirrhosis has been documented by several long-term cohort studies to decrease disease progression to hepatic decompensation and *** approval and availability of oral antiviral agents with better safety profiles has greatly improved the prognosis for HBV-related ***,we discuss the significance of antiviral therapy for HBV-related cirrhosis and the management of HBV-related diseases in the future.

关键词： Hepatitis B virus Chronic HBV infection Liver cirrhosis Antiviral therapy

An On-line Galvanic Cell generated Electrochemiluminescence and Flow Injection Determination of Calcium in Milk and Vegetable

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Chinese Chemical Letters 2003年第6期14卷 599-602页

作者： Li Rong luo Jia gen lu Zhu Jun Zhang Department of Chemistry Shaanxi Normal University

An on-line Ag/Al galvanic cell is investigated and employed to generate electrochemiluminescence (ECL). The potential of the galvanic cell could be adjusted by varying the components of flow reagent. The cell performed perfect capability of supplying a stable potential for ECL generation. Based on the weak ECL of calcein blue could be greatly sensitized by the presence of calcium in alkaline solution, calcium contents in milk samples and in cabbage were assayed and the results were compared with those from ICP-AES method.

关键词： On-line galvanic cell electrochemiluminescence calcium.

Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number

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Chinese Journal of Aeronautics 2021年第3期34卷 71-81页

作者： Mingyang WANG Chengwu YANG Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen lu Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were *** showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the *** all the roughness locations,the variation trend for the profile loss with the roughness magnitude was *** the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,***,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss *** comparison,the leading edge roughness played a dominant role in the boundary layer development and performance *** take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively.

关键词： Aerodynamic performance Compressor airfoil Low Reynolds number Separation bubble Surface roughness Viscous dissipation

The influence of the underpassing frozen connecting passage on the deformation of the existing tunnel

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Research in Cold and Arid Regions 2022年第4期14卷 258-266页

作者： JunHao Chen Jian Zhang BiJian Chen gen lu School of Civil Engineering Fujian University of TechnologyFuzhouFujian350118China Key Laboratory of Underground Engineering Fujian Province UniversityFuzhouFujian350118China

Based on the engineering background of the contact channel between Shangyang and Gushan of Fuzhou Metro Line 2 undercrossing the existing tunnel line,the freezing temperature field of the contact channel,the displacement field of the existing tunnel line and the contact channel with different net distances and horizontal angles are analyzed by ANSYS finite element software and field measurement *** obtained results indicate that during the freezing period,the temperature drops at different measuring holes are almost the *** temperature near the bottom freezing tube drops faster than that far from the *** is found that the bilateral freezing technique improves the formation of the freezing wall in the intersection *** this case,the intersection time of the cross-section is 7 days faster than that of the adjacent ordinary *** change curve of the displacement of the surface uplift in different freezing periods with the distance from the center of the channel is“M”*** maximum uplift displacement at 12 m from channel center is 25 *** vertical displacement of the measuring point located above the central axis of the connecting channel is *** farther the point from the central axis,the smaller the corresponding vertical *** the horizontal angle between the existing tunnel and the connecting channel is less than 60,the existing vertical displacement of the tunnel changes rapidly with the horizontal angle,reaching 0.17 mm/.Meanwhile,when the net distance is less than 6.1 m,the change rate of the vertical displacement of the tunnel is up to 2.4 mm/m.

关键词： Existing tunnel Displacement field Connecting passage Freezing method Down crossing

Numerical investigation of flow mechanisms of tandem impeller inside a centrifugal compressor

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Chinese Journal of Aeronautics 2019年第12期32卷 2627-2640页

作者： Ziliang LI Xin’gen lu Shengfeng ZHAO Ge HAN Chengwu YANG Yanfeng ZHANG Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

This study numerically investigated a single stage centrifugal compressor "Radiver" with a wedge diffuser and several tandem-designed impellers to explore the flow phenomena within the tandem impeller and the potential to enhance compressor *** results demonstrate that tandem design and clocking fraction(ks)significantly affects the compressor *** compressor stage with tandem impellers of Series A of boundary layer growth interruption alone are observed to have a widely operating range but efficiency and total pressure ratio penalty compared with that of conventional *** tandem impeller with at least the same impeller efficiency as the conventional design is considered as a critical design criteria so that further modification process based on the flow characteristic of tandem impeller is *** order to restrain the inducer wake and exducer shock losses,parameters modification of blade angle and thickness distributions are necessary and the modified tandem impeller of Series B is *** modified tandem impeller with 25%clocking arrangement shows an 8.45%stall margin increase and maintains the total pressure ratio and efficiency as the conventional design,which proves the potential of tandem impeller to improve compressor stage *** is noteworthy that the tandem impellers of Radiver have not shown obviously balanced exit flow field and the fundamental mechanism of stall margin extending of tandem impeller lies on the improved impeller/diffuser matching performance resulting from the incidence angle variation at diffuser inlet.

关键词： Centrifugal compressor stage Flow mechanism Impeller/diffuser matching Stall margin Tandem impeller