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m.sm.tch repair genes (hm.H1, hPm.1, hPm.2, GTBP/hm.H6,Hm.H2) in the pathogenesis of hepatocellular carcinom.

World Journal of Gastroenterology 2005年第20期11卷 3020-3026页

作者： Abdel-Rahm.n N. Zekri gelane m. sabry Abeer A. Bahnassy Kam.l A. Shalaby Sabrin A.Abdel-Wahabh Serag Zakaria Virology and Im.unology Unit Cancer Biology Departm.nt National Cancer Institute Cairo University Egypt Biochem.stry Departm.nt Faculty of Science Ain Shams University Egypt Pathology Departm.nt National Cancer Institute Cairo University Egypt Tropical m.dicine Departm.nt El-Kaser Al-Aini School of m.dicine Cairo University Egypt

AIm. Dm. m.sm.tch repair (m.R) is an im.ortant m.chanism.for m.intaining fidelity of genom.c DNA. Abnorm.lities in one or m.re m.R genes are im.licated in the developm.nt of m.ny cancers. We investigated the role of expression of m.R genes (hm.H1, hPm.1, hPm.2, GTBP/hm.H6, hm.H2) in hepatocellular carcinogenesis. m.THODS: We evaluated the expression level of m.R genes in 33 hepatocellular carcinom. (HCC) cases using the m.ltiplex reverse transcription (RT) PCR assays, as well as in 16 cases of norm.l adjacent hepatic tissues. β-actin gene was used as an internal control and calibrator for quantification of gene expression. RESULTS: Out of the 33 studied cases, 25 were HCV positive and 30 (90.9%) showed reduced expression in one or m.re of the studied m.R genes. Reduced expression was found in hm.H2(71.9%), hm.H1 (53.3%), GTBP(51.1%), hPm.2 (33.3%) and hPm.1 (6%). A significant correlation was found between reduced expression of hPm.2(P= 0.0069) and GTBP(P= 0.0034), hPm.2 and non-cirrhosis (P= 0.0197), hm.H1 and high grade. On the other hand, 57.1%, 50%, 20%, 18.8%, and 6% of the norm.l tissues distant to tum.rs showed reduced expression of hm.H2, hm.H1, GTBP, hPm.2, and hPm.1 respectively. m.ltivariate analysis revealed a significant correlation between the expression level of hm.H2(P= 0.008), hm.H1 (P= 0.001) and GTBP (P= 0.032) and HCC, between hPm.2, GTBP and HCV-associated HCC (Pm.R genes seem. to play an im.ortant role in HCV-associated HCC. hPm.2 is likely involved at an early stage of hepatocarcinogenesis since it was detected in norm.l adjacent tissues. Reduced expression of hPm.2 provides a growth advantage and stim.lates proliferation which encourages m.lignant transform.tion in non-cirrhotic HCV-infected patients via acquisition of m.re genetic dam.ges.

关键词： Hepatocellular carcinom. m.sm.tch repair Norm.l distant hepatic tissue

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